{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:50:18Z","timestamp":1786125018566,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    Dissection of the carotid and vertebral arteries is an important cause of stroke in young patients.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>OBJECTIVE:<\/jats:bold>\n                    The objective of this study is to compare antithrombotic treatments in patients with carotid and vertebral dissections.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS:<\/jats:bold>\n                    Three hundred seventy patients with carotid and vertebral artery dissections were included. Univariate and multivariate analyses were conducted to analyze the association between treatment and new or recurrent events and clinical outcome.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Mean follow-up was 24.3 months. In patients with spontaneous dissection, 55% received antiplatelets, 29.4% anticoagulation, and 12.6% combined treatment. New or recurrent ischemic and hemorrhagic events occurred in 9.6% of patients on antiplatelets, 10.4% on anticoagulation, and 13.3% on combined treatment. For traumatic dissection, 58.3% received antiplatelets, 26.9% anticoagulation, and 10.2% combined treatment. New or recurrent ischemic and hemorrhagic events occurred in 6.9% on antiplatelets, 11.1% on anticoagulation, and 20% on combined treatment. In patients with intracranial dissection, 63.1% were started on antiplatelets, 19.7% on anticoagulation, and 14.5% on combined treatment. Ischemic and hemorrhagic events occurred in 8.5% on antiplatelet treatment, 15.4% on anticoagulation, and 18.2% on combined treatment. In patients with extracranial dissection, 54.4% were on antiplatelets, 28.9% on anticoagulation, and 11.2% on combined treatment. Ischemic and hemorrhagic events occurred in 10.1% on antiplatelet treatment, 9.3% on anticoagulation, and 13.8% on combined treatment. The association between antithrombotic treatment and ischemic\/hemorrhagic events and clinical outcome was not significant for all subtypes of dissection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    The rate of new or recurrent events is similar with antiplatelet and anticoagulation treatment in treating intracranial and extracranial carotid and vertebral artery dissection.\n                  <\/jats:p>","DOI":"10.1093\/neuros\/nyw086","type":"journal-article","created":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T00:31:39Z","timestamp":1486168299000},"page":"368-379","source":"Crossref","is-referenced-by-count":61,"title":["Anticoagulation vs Antiplatelet Treatment in Patients with Carotid and Vertebral Artery Dissection: A Study of 370 Patients and Literature Review"],"prefix":"10.1227","volume":"80","author":[{"given":"Badih","family":"Daou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Mouchtouris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Starke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravanthi","family":"Koduri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Jabbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Rosenwasser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavropoula","family":"Tjoumakaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,3]]},"reference":[{"issue":"2","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/jnnp.2004.040543","article-title":"Ischaemic stroke in young adults: predictors of outcome and recurrence","volume":"76","author":"Nedeltchev","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1212\/WNL.59.1.26","article-title":"Clinical outcome in 287 consecutive young adults (15 to 45 years) with ischemic stroke","volume":"59","author":"Leys","year":"2002","journal-title":"Neurology"},{"issue":"2","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1017\/S0317167100008556","article-title":"Extracranial carotid and vertebral artery dissection: a review","volume":"35","author":"Redekop","year":"2008","journal-title":"Can J Neurol Sci."},{"issue":"12","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1056\/NEJM200103223441206","article-title":"Spontaneous dissection of the carotid and vertebral arteries","volume":"344","author":"Schievink","year":"2001","journal-title":"N Engl J Med"},{"issue":"4","key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1177\/0003319712475154","article-title":"Current optimal assessment and management of carotid and vertebral spontaneous and traumatic dissection","volume":"65","author":"Mohan","year":"2014","journal-title":"Angiology"},{"issue":"5","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1097\/00001573-200009000-00002","article-title":"The treatment of spontaneous carotid and vertebral artery dissections","volume":"15","author":"Schievink","year":"2000","journal-title":"Curr Opin Cardiol"},{"issue":"21","key":"bib7-20231011","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1212\/WNL.0b013e3181a2a50a","article-title":"Aspirin vs anticoagulation in carotid artery dissection: a study of 298 patients","volume":"72","author":"Georgiadis","year":"2009","journal-title":"Neurology"},{"issue":"4","key":"bib8-20231011","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1474-4422(15)70018-9","article-title":"Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial","volume":"14","year":"2015","journal-title":"Lancet Neurol"},{"issue":"7","key":"bib9-20231011","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S1474-4422(09)70084-5","article-title":"Cervical-artery dissections: predisposing factors, diagnosis, and outcome","volume":"8","author":"Debette","year":"2009","journal-title":"Lancet Neurol."},{"issue":"4","key":"bib10-20231011","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1159\/000008236","article-title":"Long-term follow-up after extracranial internal carotid artery dissection","volume":"44","author":"Engelter","year":"2000","journal-title":"Eur Neurol"},{"issue":"12","key":"bib11-20231011","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1161\/01.STR.0000098649.39767.BC","article-title":"Cervical arterial dissection: time for a therapeutic trial?","volume":"34","author":"Beletsky","year":"2003","journal-title":"Stroke"},{"issue":"12","key":"bib12-20231011","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1212\/WNL.0b013e31822f03fc","article-title":"Differential features of carotid and vertebral artery dissections: the CADISP study","volume":"77","author":"Debette","year":"2011","journal-title":"Neurology"},{"key":"bib13-20231011","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1159\/000088157","article-title":"Prognosis of cervical artery dissection","volume":"20","author":"Touze","year":"2005","journal-title":"Front Neurol Neurosci"},{"issue":"10","key":"bib14-20231011","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1212\/01.WNL.0000094325.95097.86","article-title":"Risk of stroke and recurrent dissection after a cervical artery dissection: a multicenter study","volume":"61","author":"Touze","year":"2003","journal-title":"Neurology"},{"issue":"2","key":"bib15-20231011","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0022-510X(97)00287-6","article-title":"Internal carotid artery dissection: an update","volume":"153","author":"Guillon","year":"1998","journal-title":"J Neurol Sci"},{"issue":"2-3","key":"bib16-20231011","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000093244","article-title":"Dissection of cervical arteries: long-term follow-up study of 130 consecutive cases","volume":"22","author":"Arauz","year":"2006","journal-title":"Cerebrovasc Dis"},{"issue":"10","key":"bib17-20231011","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1136\/jnnp.2007.138800","article-title":"Treatment of cervical artery dissection: a systematic review and meta-analysis","volume":"79","author":"Menon","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"9","key":"bib18-20231011","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/STROKEAHA.107.489666","article-title":"Antiplatelets versus anticoagulation in cervical artery dissection","volume":"38","author":"Engelter","year":"2007","journal-title":"Stroke"},{"issue":"7","key":"bib19-20231011","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1212\/WNL.0b013e318264e36b","article-title":"Antiplatelets vs anticoagulation for dissection: CADISS nonrandomized arm and meta-analysis","volume":"79","author":"Kennedy","year":"2012","journal-title":"Neurology"},{"issue":"10","key":"bib20-20231011","first-page":"Cd000255","article-title":"Antithrombotic drugs for carotid artery dissection","author":"Lyrer","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"9","key":"bib21-20231011","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1161\/01.STR.0000177504.72886.6b","article-title":"Extracranial arterial dissection: anticoagulation is the treatment of choice: for","volume":"36","author":"Norris","year":"2005","journal-title":"Stroke"},{"issue":"12","key":"bib22-20231011","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1161\/01.STR.29.12.2646","article-title":"Stroke patterns of internal carotid artery dissection in 40 patients","volume":"29","author":"Lucas","year":"1998","journal-title":"Stroke"},{"issue":"5","key":"bib23-20231011","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1136\/jnnp.2007.127639","article-title":"Results of a UK questionnaire of diagnosis and treatment in cervical artery dissection","volume":"79","author":"Menon","year":"2008","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"bib24-20231011","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1161\/STROKEAHA.113.001057","article-title":"Differences and similarities between spontaneous dissections of the internal carotid artery and the vertebral artery","volume":"44","author":"von Babo","year":"2013","journal-title":"Stroke"},{"issue":"10","key":"bib25-20231011","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00415-003-0174-5","article-title":"Cervical artery dissection\u2013clinical features, risk factors, therapy and outcome in 126 patients","volume":"250","author":"Dziewas","year":"2003","journal-title":"J Neurol"},{"issue":"4","key":"bib26-20231011","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/STROKEAHA.109.570655","article-title":"Differences in demographic characteristics and risk factors in patients with spontaneous vertebral artery dissections with and without ischemic events","volume":"41","author":"Arnold","year":"2010","journal-title":"Stroke"},{"issue":"4","key":"bib27-20231011","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1227\/NEU.0b013e318209ce03","article-title":"Endovascular stenting of extracranial carotid and vertebral artery dissections: a systematic review of the literature","volume":"68","author":"Pham","year":"2011","journal-title":"Neurosurgery"},{"issue":"12","key":"bib28-20231011","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/01.STR.0000101915.11128.3D","article-title":"Emergent stenting to treat patients with carotid artery dissection: clinically and radiologically directed therapeutic decision making","volume":"34","author":"Cohen","year":"2003","journal-title":"Stroke"},{"issue":"3-4","key":"bib29-20231011","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000353124","article-title":"A systematic review of endovascular management of internal carotid artery dissections","volume":"1","author":"Xianjun","year":"2013","journal-title":"Interv Neurol"},{"key":"bib1a-20231011"},{"key":"bib2a-20231011"},{"key":"bib3a-20231011"},{"key":"bib4a-20231011"},{"key":"bib5a-20231011"},{"key":"bib6a-20231011"},{"key":"bib7a-20231011"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/80\/3\/368\/32596481\/nyw086.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/00006123-201703000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:48:58Z","timestamp":1786121338000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006123-201703000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1093\/neuros\/nyw086","relation":{},"ISSN":["0148-396X","1524-4040"],"issn-type":[{"value":"0148-396X","type":"print"},{"value":"1524-4040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,3]]}}}