{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:50:50Z","timestamp":1786125050785,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>BACKGROUND AND IMPORTANCE:<\/jats:bold>\n                    Myxoid liposarcoma is not an uncommon form of sarcoma. However, it usually affects the lower extremity long bones. Scapular involvement is extremely rare, as is a metastasis to the parasellar region. We present a case of liposarcoma of the skull base originating in the scapular region and metastasizing to the sellar and parasellar regions and provide a review of the pertinent literature.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CLINICAL PRESENTATION:<\/jats:bold>\n                    A 43-year-old female patient diagnosed with left scapular myxoid liposarcoma was treated with surgical resection. She had clear resection margins and was treated pre- and postoperatively with radiotherapy to the region. She remained asymptomatic for 2 years following surgery, after which she abruptly developed diplopia with right lateral gaze. There were no symptoms of raised intracranial pressure or impaired vision. Her examination was normal apart from complete right sixth nerve palsy. Imaging studies of the brain showed a large mass in the clivus eroding into the floor of the sella, encircling the right internal carotid artery in the cavernous sinus. The mass also displaced the sellar contents superiorly. An endonasal, endoscopic skull base approach was undertaken, and a subtotal resection was performed in an effort to avoid multiple cranial nerve pareses.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSION:<\/jats:bold>\n                    Our literature search revealed that this case report is the first to document liposarcoma metastasis to the skull base originating from the scapular region. Subtotal surgical resection resulted in minimal improvement of the patient's sixth nerve palsy. Postoperative radiation was undertaken. A multidisciplinary approach on an individual patient basis is recommended.\n                  <\/jats:p>","DOI":"10.1093\/neuros\/nyw157","type":"journal-article","created":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T15:32:52Z","timestamp":1488814372000},"page":"219-223","source":"Crossref","is-referenced-by-count":14,"title":["Metastatic Liposarcoma of the Skull Base: A Case Report and Review of Literature"],"prefix":"10.1227","volume":"80","author":[{"given":"Nirmeen","family":"Zagzoog","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greta","family":"Ra","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital Centre for Inflammatory Bowel Disease, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Koziarz","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Provias","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doron","family":"Sommer","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Head and Neck Surgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh A.","family":"Almenawer","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kesava","family":"Reddy","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Department of Surgery, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,4]]},"reference":[{"issue":"7","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1002\/1097-0142(19891001)64:7<1514::AID-CNCR2820640726>3.0.CO;2-2","article-title":"The prognostic value of histologic subtypes in primary extremity liposarcoma","volume":"64","author":"Chang","year":"1989","journal-title":"Cancer"},{"issue":"5","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1148\/rg.255055106","article-title":"From the archives of the AFIP: imaging of musculoskeletal liposarcoma with radiologic \u2013 pathologic correlation","volume":"25","author":"Murphy","year":"2005","journal-title":"Radiographics"},{"issue":"8","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"e20294","DOI":"10.1371\/journal.pone.0020294","article-title":"Incidence of sarcoma histotypes and molecular subtypes in a prospective epidemiological study with central pathology review and molecular testing","volume":"6","author":"Ducimeti\u00e8re","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00000421-199608000-00006","article-title":"Late onset of isolated central nervous system metastasis of liposarcoma: a case report","volume":"19","author":"Arepally","year":"1996","journal-title":"Am J Clin Oncol"},{"issue":"4","key":"bib5-20231011","first-page":"267","article-title":"Myxoid and round cell liposarcoma: a spectrum of myxoid adipocytic neoplasia","volume":"18","author":"Orvieto","year":"2001","journal-title":"Semin Diagn Pathol"},{"issue":"2","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/jso.10093","article-title":"Metastatic patterns of extremity myxoid liposarcoma and their outcome","volume":"80","author":"Estourgie","year":"2002","journal-title":"J Surg Oncol"},{"issue":"12","key":"bib7-20231011","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1136\/bjo.72.12.912","article-title":"Primary myxoid liposarcoma of the orbit","volume":"72","author":"Lane","year":"1988","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"bib8-20231011","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/(SICI)1097-0142(19990101)85:1<85::AID-CNCR12>3.0.CO;2-A","article-title":"Patterns of recurrence in extremity liposarcoma. 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