{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:51:41Z","timestamp":1786125101537,"version":"build-2736575974"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    Whether primary or metastatic, tumors of the craniovertebral junction (CVJ) are rare and challenging.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>OBJECTIVE:<\/jats:bold>\n                    To examine the surgical indications, operative variables, and outcomes in patients with tumors of the CVJ undergoing occipitocervical (OC) stabilization.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS:<\/jats:bold>\n                    A single-institution, retrospective case series was performed from a prospectively maintained spine database. Patients with primary or metastatic tumors of the CVJ who underwent OC stabilization were identified. Out of 46 patients who underwent OC fusion, 39 were for tumor. Paired\n                    <jats:italic toggle=\"yes\">t<\/jats:italic>\n                    -tests and Wilcoxon rank-sum tests were performed to assess for postoperative changes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Ten patients (26%) harbored primary tumors, and the remaining 29 (74%) had metastatic disease. Of the metastatic patients, 14 had a neurological deficit, 10 had severe neck pain, and 5 were deemed mechanically unstable. Postoperative visual analog pain scores were significantly reduced at all 3 follow-up times (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; .001, 95% confidence interval [CI; 3.2, 6.0];\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .001, 95% CI [2.6, 7.7];\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .020, 95% CI [0.6, 5.5]). The percentage of patients who were ambulatory and neurologically improved or intact remained stable postoperatively with no significant declines. There were 2 perioperative mortalities (5%), and 13 patients (33%) experienced a major complication.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSIONS:<\/jats:bold>\n                    In patients with primary or metastatic tumor of the CVJ, OC stabilization using a cervical screw-rod system affixed to a midline-keel buttress plate, with or without posterior decompression, is a reliable method for CVJ stabilization in the oncologic setting. Improvement in pain and preservation of neurological function was seen.\n                  <\/jats:p>","DOI":"10.1093\/neuros\/nyx070","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T08:27:36Z","timestamp":1485764856000},"page":"251-258","source":"Crossref","is-referenced-by-count":15,"title":["Stabilization of Tumor-Associated Craniovertebral Junction Instability: Indications, Operative Variables, and Outcomes"],"prefix":"10.1227","volume":"81","author":[{"given":"Scott L.","family":"Zuckerman","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Kreines","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Memorial Sloan\u2013Ketter-ing\u2009Cancer Center, New\u2009York, New\u2009York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Memorial Sloan\u2013Ketter-ing\u2009Cancer Center, New\u2009York, New\u2009York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Bryan","family":"Iorgulescu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Brigham and Women's Hospital, Boston, Mas-sachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Elder","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark H.","family":"Bilsky","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Memorial Sloan\u2013Ketter-ing\u2009Cancer Center, New\u2009York, New\u2009York"},{"name":"Department of Neurological Surgery, Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Laufer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Memorial Sloan\u2013Ketter-ing\u2009Cancer Center, New\u2009York, New\u2009York"},{"name":"Department of Neurological Surgery, Weill Cornell Medical College, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,8]]},"reference":[{"issue":"9","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1007\/s00132-013-2069-1","article-title":"Tumors and metastases of the upper cervical spine (C0-2). 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