{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:44:16Z","timestamp":1786124656296,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>BACKGROUND:<\/jats:bold>\n                    Extracranial vertebral artery disease is seen in patients with internal carotid artery stenosis, although the clinical significance is not well understood.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>OBJECTIVE:<\/jats:bold>\n                    To determine the prevalence and natural history of extracranial vertebral artery disease in patients with recently symptomatic internal carotid artery stenosis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>METHODS:<\/jats:bold>\n                    We analyzed data collected for patients with recently symptomatic internal carotid artery stenosis in the Stent-Protected Angioplasty vs Carotid Endarterectomy trial. We used Cox proportional hazards analysis to compare the relative risk of various endpoints (any stroke, ipsilateral stroke, and death) between the 3 categories of extracranial vertebral artery disease (normal\/hypoplastic, moderate\/severe stenosis, occlusion) adjusting for age, gender, severity of internal carotid artery stenosis at baseline (&lt;70% and \u226570%), allocated procedure (carotid angioplasty and stent placement or carotid endarterectomy) and hypertension.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>RESULTS:<\/jats:bold>\n                    Moderate to severe stenosis and occlusion of 1 of both extracranial vertebral arteries were diagnosed in 152 (12.9%) and 57 (4.8%) of 1181 subjects, respectively. Comparing subjects with normal or hypoplastic vertebral artery, there was nonsignificant 30%, 40%, and 50% higher risk of any stroke (hazard ratio [HR] 1.3, 95% confidence interval [CI] 0.7-2.3), ipsilateral stroke (HR 1.4, 95% CI 0.7-2.5), and death (HR 1.5, 95% CI 0.7-3.1) among subjects with moderate to severe vertebral artery stenosis after adjusting for potential confounders.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>CONCLUSIONS:<\/jats:bold>\n                    There may be an increased risk of stroke and death in patients with symptomatic internal carotid artery stenosis with concurrent asymptomatic extracranial vertebral artery stenosis.\n                  <\/jats:p>","DOI":"10.1093\/neuros\/nyx092","type":"journal-article","created":{"date-parts":[[2017,3,22]],"date-time":"2017-03-22T20:47:53Z","timestamp":1490215673000},"page":"531-536","source":"Crossref","is-referenced-by-count":3,"title":["Asymptomatic Extracranial Vertebral Artery Disease in Patients with Internal Carotid Artery Stenosis"],"prefix":"10.1227","volume":"81","author":[{"given":"Adnan I.","family":"Qureshi","sequence":"first","affiliation":[{"name":"Zeenat Qureshi Stroke Institute, St. Cloud, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqib A.","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Neur-ology and Ophthalmology, Michigan State University, Lansing, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Medical Center, Technical University of Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Radio-logy and Neuroradiology, University of Kiel, Arnold-Heller Str.3, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Ringleb","sequence":"additional","affiliation":[{"name":"Department of Neurology, Universit\u00e4-tsklinikum Heidelberg, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,9]]},"reference":[{"issue":"4","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1001\/archneur.55.4.470","article-title":"Proximal extracranial vertebral artery disease in the New England medical center posterior circulation registry","volume":"55","author":"Wityk","year":"1998","journal-title":"Arch Neurol"},{"issue":"9","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1161\/STROKEAHA.110.610451","article-title":"Vertebral artery ostium atherosclerotic plaque as a potential source of posterior circulation ischemic stroke: result from borgess medical center 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