{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:10:12Z","timestamp":1788455412233,"version":"build-2803163510"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>There have been some reports on the use of intra-arterial tirofiban in ruptured intracranial aneurysms, but few studies have reported on the use of 24 h of intravenous tirofiban infusion in patients with subarachnoid hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To present our experience with intravenous tirofiban infusion, in the form of a monotherapy as well as in addition to intra-arterial tirofiban, as a prophylactic, and as a rescue management for thrombus in patients who have undergone embolization with coils for ruptured intracranial aneurysms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Between December 2008 and January 2015, we retrospectively reviewed 249 ruptured intracranial aneurysms that were treated with coiling at our institutions. A total of 28 patients harboring 28 ruptured and 3 unruptured intracranial aneurysms underwent intravenous tirofiban infusion during or after coil embolization of an aneurysm. Intra-arterial infusion of tirofiban via a microcatheter was also performed in 26 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Thromboembolic formation during the procedure was detected in 25 cases. Intra-arterial tirofiban dissolved the thromboembolus under angiographic control after 10 or more minutes in 19 (76%) of 25 patients. Two intracranial hemorrhagic complications (increase in the extent of hematoma) occurred during the follow-up period. Two cases of other complications occurred: hematuria and perioral bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Intravenous tirofiban, as a monotherapy or in addition to intra-arterial tirofiban for thrombotic complications, seems to be useful as a treatment for acute aneurysm. However, alternatives to tirofiban should be considered if an associated hematoma is discovered before a patient receives a tirofiban infusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyx177","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T08:13:49Z","timestamp":1489565629000},"page":"76-84","source":"Crossref","is-referenced-by-count":28,"title":["Preliminary Study of Tirofiban Infusion in Coil Embolization of Ruptured Intracranial Aneurysms"],"prefix":"10.1227","volume":"82","author":[{"given":"Chang Hyo","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Neurology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Soo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurosur-gery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosur-gery, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong A","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Roh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Kug","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Radiology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,1]]},"reference":[{"issue":"3","key":"bib1-20231011","first-page":"506","article-title":"Periprocedural morbidity and mortality associated with endovascular treatment of intracranial aneurysms","volume":"26","author":"Park","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"issue":"1","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3171\/jns.1998.89.1.0081","article-title":"Endovascular embolization of 150 basilar tip aneurysms with guglielmi detachable coils: results of the food and drug administration multicenter clinical trial","volume":"89","author":"Eskridge","year":"1998","journal-title":"J Neurosurg"},{"issue":"11","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.3174\/ajnr.A3574","article-title":"Stent-assisted coiling in endovascular treatment of 500 consecutive cerebral aneurysms with long-term follow-up","volume":"34","author":"Geyik","year":"2013","journal-title":"AJNR Am J Neuroradiol"},{"issue":"4","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1227\/NEU.0b013e318228490c","article-title":"Delayed thrombosis or stenosis following enterprise-assisted stent-coiling: Is it safe? 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