{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:27:55Z","timestamp":1790076475390,"version":"4.0.1"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T00:00:00Z","timestamp":1498694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Resective surgery established treatment for pharmacoresistant frontal lobe epilepsy (FLE), but seizure outcome and prognostic indicators are poorly characterized and vary between studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To study long-term seizure outcome and identify prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We retrospectively analyzed 42 FLE patients having undergone surgical resection, mostly preceded by invasive recordings with stereoelectroencephalography (SEEG). Postsurgical outcome up to 10-yr follow-up and prognostic indicators were analyzed using Kaplan\u2013Meier analysis and multivariate and conditional inference procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>At the time of last follow-up, 57.1% of patients were seizure-free. The estimated chance of seizure freedom was 67% (95% confidence interval [CI]: 54-83) at 6 mo, 59% (95% CI: 46-76) at 1 yr, 53% (95% CI: 40-71) at 2 yr, and 46% (95% CI: 32-66) at 5 yr. Most relapses (83%) occurred within the first 12 mo. Multivariate analysis showed that completeness of resection of the epileptogenic zone (EZ) as defined by SEEG was the main predictor of seizure outcome. According to conditional inference trees, in patients with complete resection of the EZ, focal cortical dysplasia as etiology and focal EZ were positive prognostic indicators. No difference in outcome was found in patients with positive vs negative magnetic resonance imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Surgical resection in drug-resistant FLE can be a successful therapeutic approach, even in the absence of neuroradiologically visible lesions. SEEG may be highly useful in both nonlesional and lesional FLE cases, because complete resection of the EZ as defined by SEEG is associated with better prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyx342","type":"journal-article","created":{"date-parts":[[2017,5,20]],"date-time":"2017-05-20T15:07:42Z","timestamp":1495292862000},"page":"217-225","source":"Crossref","is-referenced-by-count":51,"title":["Predictive Factors of Surgical Outcome in Frontal Lobe Epilepsy Explored with Stereoelectroencephalography"],"prefix":"10.1227","volume":"83","author":[{"given":"Francesca","family":"Bonini","sequence":"first","affiliation":[{"name":"APHM, Timone Hospital, Clinical Ne-urophysiology and Epileptology De-partment, Marseille, France"},{"name":"Aix-Mar-seille Universit\u00e9, Institut de Neuroscience des Syst\u00e8mes, INSERM UMR_S 1106, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen","family":"McGonigal","sequence":"additional","affiliation":[{"name":"APHM, Timone Hospital, Clinical Ne-urophysiology and Epileptology De-partment, Marseille, France"},{"name":"Aix-Mar-seille Universit\u00e9, Institut de Neuroscience des Syst\u00e8mes, INSERM UMR_S 1106, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Scavarda","sequence":"additional","affiliation":[{"name":"APHM, Timone Hospital, Paedia-tric Neurosurgery Department, Marse-ille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Carron","sequence":"additional","affiliation":[{"name":"APHM, Timone Hospital, Functional and Stereotactical Neuro-surgery Department, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"R\u00e9gis","sequence":"additional","affiliation":[{"name":"APHM, Timone Hospital, Functional and Stereotactical Neuro-surgery Department, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Dufour","sequence":"additional","affiliation":[{"name":"APHM, Timone Hospital, Neurosurgery Department, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"P\u00e9ragut","sequence":"additional","affiliation":[{"name":"APHM, Timone Hospital, Functional and Stereotactical Neuro-surgery Department, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Laguitton","sequence":"additional","affiliation":[{"name":"H\u00f4pital Henri Gastaut, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Villeneuve","sequence":"additional","affiliation":[{"name":"H\u00f4pital Henri Gastaut, Marseille, France"},{"name":"Service de Neurop\u00e9diatrie, Assistance Publique des H\u00f4pitaux de Marseille, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Chauvel","sequence":"additional","affiliation":[{"name":"APHM, Timone Hospital, Clinical Ne-urophysiology and Epileptology De-partment, Marseille, France"},{"name":"Aix-Mar-seille Universit\u00e9, Institut de Neuroscience des Syst\u00e8mes, INSERM UMR_S 1106, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Giusiano","sequence":"additional","affiliation":[{"name":"Aix-Mar-seille Universit\u00e9, Institut de Neuroscience des Syst\u00e8mes, INSERM UMR_S 1106, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Tr\u00e9buchon","sequence":"additional","affiliation":[{"name":"APHM, Timone Hospital, Clinical Ne-urophysiology and Epileptology De-partment, Marseille, France"},{"name":"Aix-Mar-seille Universit\u00e9, Institut de Neuroscience des Syst\u00e8mes, INSERM UMR_S 1106, Marseille, 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