{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:48:55Z","timestamp":1786124935723,"version":"build-2736575974"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T00:00:00Z","timestamp":1509148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The response of the brain to obstetric brachial plexus palsy (OBPP) is not clearly understood. We propose that even a peripheral insult at the developmental stage may result in changes in the volume of white matter of the brain, which we studied using corpus callosum volumetry and resting-state functional magnetic resonance imaging (rsfMRI) of sensorimotor network.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To study the central neural effects in OBPP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We performed an MRI study on a cohort of 14 children who had OBPP and 14 healthy controls. The mean age of the test subjects was 10.07\u00a0\u00b1\u00a01.22 yr (95% confidence interval). Corpus callosum volumetry was compared with that of age-matched healthy subjects. Hofer and Frahm segmentation was used. Resting-state fMRI data were analyzed using the FSL software (FMRIB Software Library v5.0, Oxford, United Kingdom), and group analysis of the sensorimotor network was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Statistical analysis of corpus callosum volume revealed significant differences between the OBPP cohort and healthy controls, especially in the motor association areas. Independent t-test revealed statistically significant volume loss in segments I (prefrontal), II (premotor), and IV (primary sensory area). rsfMRI of sensorimotor network showed decreased activation in the test hemisphere (the side contralateral to the injured brachial plexus) and also decreased activation in the ipsilateral hemisphere, when compared with healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>OBPP occurs in an immature brain and causes central cortical changes. There is secondary corpus callosum atrophy which may be due to retrograde transneuronal degeneration. This in turn may result in disruption of interhemispheric coactivation and consequent reduction in activation of sensorimotor network even in the ipsilateral hemisphere.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyx495","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T15:11:30Z","timestamp":1509117090000},"page":"905-914","source":"Crossref","is-referenced-by-count":10,"title":["Novel Findings in Obstetric Brachial Plexus Palsy: A Study of Corpus Callosum Volumetry and Resting-State Functional Magnetic Resonance Imaging of Sensorimotor Network"],"prefix":"10.1227","volume":"83","author":[{"given":"Kishore","family":"Kislay","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery, Nation-al Institute of Mental Health and Neu-rosciences (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagavatula Indira","family":"Devi","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Nation-al Institute of Mental Health and Neu-rosciences (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhananjaya Ishwar","family":"Bhat","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Nation-al Institute of Mental Health and Neu-rosciences (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhaval Prem","family":"Shukla","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery, Nation-al Institute of Mental Health and Neu-rosciences (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kumar","family":"Gupta","sequence":"additional","affiliation":[{"name":"Departments of Neuroimaging and In-terventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajanikant","family":"Panda","sequence":"additional","affiliation":[{"name":"Departments of Neuroimaging and In-terventional Radiology, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2018,11]]},"reference":[{"issue":"10","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/adc.48.10.757","article-title":"Quantitative growth and development of human brain","volume":"48","author":"Dobbing","year":"1973","journal-title":"Arch Dis Child"},{"issue":"3","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00005072-198705000-00005","article-title":"Sequence of central nervous system myelination in human infancy. 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