{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:57:10Z","timestamp":1786125430997,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01-AG025831"],"award-info":[{"award-number":["P01-AG025831"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["M01-RR00865"],"award-info":[{"award-number":["M01-RR00865"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Toulmin Foundation"},{"name":"Sheridan Lorenz, and Robert and Marion Wilson"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Currently, only presumptive diagnosis of chronic traumatic encephalopathy (CTE) can be made in living patients. We present a modality that may be instrumental to the definitive diagnosis of CTE in living patients based on brain autopsy confirmation of [F-18]FDDNP-PET findings in an American football player with CTE. [F-18]FDDNP-PET imaging was performed 52 mo before the subject's death. Relative distribution volume parametric images and binding values were determined for cortical and subcortical regions of interest. Upon death, the brain was examined to identify the topographic distribution of neurodegenerative changes. Correlation between neuropathology and [F-18]FDDNP-PET binding patterns was performed using Spearman rank-order correlation. Mood, behavioral, motor, and cognitive changes were consistent with chronic traumatic myeloencephalopathy with a 22-yr lifetime risk exposure to American football. There were tau, amyloid, and TDP-43 neuropathological substrates in the brain with a differential topographically selective distribution. [F-18]FDDNP-PET binding levels correlated with brain tau deposition (r\n                    <jats:sub>s<\/jats:sub>\n                    = 0.59,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    = .02), with highest relative distribution volumes in the parasagittal and paraventricular regions of the brain and the brain stem. No correlation with amyloid or TDP-43 deposition was observed. [F-18]FDDNP-PET signals may be consistent with neuropathological patterns of tau deposition in CTE, involving areas that receive the maximal shearing, angular\u2013rotational acceleration\u2013deceleration forces in American football players, consistent with distinctive and differential topographic vulnerability and selectivity of CTE beyond brain cortices, also involving midbrain and limbic areas. Future studies are warranted to determine whether differential and selective [F-18]FDDNP-PET may be useful in establishing a diagnosis of CTE in at-risk patients.\n                  <\/jats:p>","DOI":"10.1093\/neuros\/nyx536","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T15:11:30Z","timestamp":1509117090000},"page":"237-246","source":"Crossref","is-referenced-by-count":70,"title":["Postmortem Autopsy-Confirmation of Antemortem [F-18]FDDNP-PET Scans in a Football Player With Chronic Traumatic Encephalopathy"],"prefix":"10.1227","volume":"82","author":[{"given":"Bennet","family":"Omalu","sequence":"first","affiliation":[{"name":"Department of Medical Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W","family":"Small","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Bailes","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda M","family":"Ercoli","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Merrill","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, The David Geffen School of Medicine, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koon-Pong","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Cheng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagichettiar","family":"Satyamurthy","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Hammers","sequence":"additional","affiliation":[{"name":"Office of Chief Medical Examiner, City of New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology, North Shore University Health System and University of Chicago Pritzker School of Medicine, Evanston, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P","family":"Fitzsimmons","sequence":"additional","affiliation":[{"name":"Fitzsimmons Law Firm PLLC, Wheeling, West Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge R","family":"Barrio","sequence":"additional","affiliation":[{"name":"Department of Molecular and Medical Pharmacology, The David Geffen School of Medicine, University of California, Los Angeles, 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