{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:50:36Z","timestamp":1792176636297,"version":"4.4.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NEUROSURGERY","NEUROS"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Facial pain response (PR) to various surgical interventions in patients with multiple sclerosis (MS)-related trigeminal neuralgia (TN) is much less optimal. No large patient series regarding stereotactic radiosurgery (SRS) has been published.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaluate the clinical outcomes of MS-related TN treated with SRS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This is a retrospective cohort study. A total of 263 patients contributed by 9 member tertiary referral Gamma Knife centers (2 in Canada and 7 in USA) of the International Gamma Knife Research Consortium (IGKRF) constituted this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The median latency period of PR after SRS was 1 mo. Reasonable pain control (Barrow Neurological Institute [BNI] Pain Scores I-IIIb) was achieved in 232 patients (88.2%). The median maintenance period from SRS was 14.1 months (range, 10 days to 10 years). The actuarial reasonable pain control maintenance rates at 1 yr, 2 yr, and 4 yr were 54%, 35%, and 24%, respectively. There was a correlation between the status of achieving BNI-I and the maintenance of facial pain recurrence-free rate. The median recurrence-free rate was 36 mo and 12.2 mo in patients achieving BNI-I and BNI &gt; I, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .046). Among 210 patients with known status of post-SRS complications, the new-onset of facial numbness (BNI-I or II) after SRS occurred in 21 patients (10%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>In this largest series SRS offers a reasonable benefit to risk profile for patients who have exhausted medical management. More favorable initial response to SRS may predict a long-lasting pain control.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyy142","type":"journal-article","created":{"date-parts":[[2018,3,21]],"date-time":"2018-03-21T00:10:59Z","timestamp":1521591059000},"page":"499-505","source":"Crossref","is-referenced-by-count":33,"title":["Stereotactic Radiosurgery for Trigeminal Neuralgia in Patients With Multiple Sclerosis: A Multicenter Study"],"prefix":"10.1227","volume":"84","author":[{"given":"Zhiyuan","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Univer-sity of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, University of Sherbrooke, Sherbrooke, Quebec, 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Neurological Surgery, Univer-sity of Pittsburgh, Pittsburgh, Pennsyl-vania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Caruso","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Univer-sity of Virginia, Charlottesville, Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Hsun","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Univer-sity of Virginia, Charlottesville, Virginia"},{"name":"Department of Anesthesiology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga S","family":"Grills","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Beaumont Health System, Royal Oak, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuei","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Beaumont Health System, Royal Oak, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Section of Neurosurgery, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Y K","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Otolaryngology, Univer-sity of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Alonso-Basanta","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Pennsylva-nia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Kerr","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Otolaryngology, Univer-sity of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Pierce","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Otolaryngology, Univer-sity of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Kondziolka","sequence":"additional","affiliation":[{"name":"Depart-ment of Neurosurgery, New York University Langone Medical Center, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A","family":"Hess","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yale University School of Medicine, New Haven, 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