{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:56:54Z","timestamp":1792033014729,"version":"4.4.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T00:00:00Z","timestamp":1525737600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/ mailto:journals.permissions@oup.com"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Idiopathic normal pressure hydrocephalus (iNPH) is a progressive and potentially treatable neurodegenerative disease affecting elderly people, characterized by gait impairment and ventricular enlargement in brain imaging. Similar findings are seen in some patients with schizophrenia (SCZ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To determine the prevalence of SCZ among patients suffering from probable or possible iNPH and the specific effects of comorbid SCZ on the outcome of the cerebrospinal fluid (CSF) shunting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>All medical records of the 521 iNPH patients in the NPH registry were retrospectively analyzed from 1991 until 2017. The prevalence of comorbidity of SCZ was determined and compared to that of general aged (\u226565 yr) population in Finland.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      We identified a total of 16 (3.1%) iNPH patients suffering from comorbid SCZ. The prevalence of SCZ among the iNPH patients was significantly higher compared to the general population (3.1% vs 0.9%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). All iNPH patients with comorbid SCZ were CSF shunted and 12 (75%) had a clinically verified shunt response 3 to 12 mo after the procedure. The CSF shunt response rate did not differ between patients with and without comorbid SCZ.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>SCZ seems to occur 3 times more frequently among iNPH patients compared to the general aged population in Finland. The outcome of the treatment was not affected by comorbid SCZ and therefore iNPH patients suffering from comorbid SCZ should not be left untreated. These results merit validation in other populations. In addition, further research towards the potential connection between these chronic conditions is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyy147","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T16:47:29Z","timestamp":1521823649000},"page":"883-889","source":"Crossref","is-referenced-by-count":29,"title":["Prevalence of Schizophrenia in Idiopathic Normal Pressure Hydrocephalus"],"prefix":"10.1227","volume":"84","author":[{"given":"Vasco","family":"Vanhala","sequence":"first","affiliation":[{"name":"Neurosurgery of NeuroCenter, Kuopio University Hospital (KUH) and University of Eastern Finland (UEF), Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8715-1749","authenticated-orcid":false,"given":"Antti","family":"Junkkari","sequence":"additional","affiliation":[{"name":"Neurosurgery of NeuroCenter, Kuopio University Hospital (KUH) and University of Eastern Finland (UEF), Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville E","family":"Korhonen","sequence":"additional","affiliation":[{"name":"Neurosurgery of NeuroCenter, Kuopio University Hospital (KUH) and University of Eastern Finland (UEF), Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitja I","family":"Kurki","sequence":"additional","affiliation":[{"name":"Neurosurgery of NeuroCenter, Kuopio University Hospital (KUH) and University of Eastern Finland (UEF), Kuopio, Finland"},{"name":"Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, and Stanley Center for Psychiatric Research, Broad Institute for Harvard and MIT, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Hiltunen","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, UEF, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Rauramaa","sequence":"additional","affiliation":[{"name":"Department of Pathology, KUH and UEF, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ossi","family":"Nerg","sequence":"additional","affiliation":[{"name":"Neurology of NeuroCenter, KUH and UEF, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M","family":"Koivisto","sequence":"additional","affiliation":[{"name":"Neurology of NeuroCenter, KUH and UEF, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M","family":"Remes","sequence":"additional","affiliation":[{"name":"Medical Research Center, Oulu University Hospital, Oulu, Finland"},{"name":"Unit of Clinical Neuroscience, Neurology, University of Oulu, Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonna","family":"Per\u00e4l\u00e4","sequence":"additional","affiliation":[{"name":"Department Health, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland"},{"name":"Turku University Hospital and University of Turku, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaana","family":"Suvisaari","sequence":"additional","affiliation":[{"name":"Department Health, Mental Health Unit, National Institute for Health and Welfare, Helsinki, Finland"},{"name":"Department of Social Psychiatry, School of Public Health, University of Tampere, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soili M","family":"Lehto","sequence":"additional","affiliation":[{"name":"Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland"},{"name":"Psychiatry and Clinical Research Centre, UEF, Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heimo","family":"Viinam\u00e4ki","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, KUH and UEF, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilkka","family":"Soininen","sequence":"additional","affiliation":[{"name":"Department of Neurology, UEF, Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha E","family":"J\u00e4\u00e4skel\u00e4inen","sequence":"additional","affiliation":[{"name":"Neurosurgery of NeuroCenter, Kuopio University Hospital (KUH) and University of Eastern Finland (UEF), Kuopio, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Leinonen","sequence":"additional","affiliation":[{"name":"Neurosurgery of NeuroCenter, Kuopio University Hospital (KUH) and University of Eastern Finland (UEF), Kuopio, Finland"},{"name":"Medical Research 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