{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:18:50Z","timestamp":1791919130623,"version":"4.3.4"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T00:00:00Z","timestamp":1529107200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/ mailto:journals.permissions@oup.com"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Many patients with primary brain tumors suffer from cognitive deficits, which negatively impact their quality of life. However, cognitive rehabilitation programs for these patients are scarce. We developed an iPad-based cognitive rehabilitation program for brain tumor patients, which was based on our effective face-to-face cognitive rehabilitation program. After successful completion of a feasibility study, a randomized controlled trial has been started.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaluate the immediate and long-term effects of the iPad-based program on cognitive performance and patient-reported outcome measures (PROMs) in patients with primary brain tumors in an early stage of the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Prior to surgery, patients with presumed low-grade glioma and meningioma are included. Before surgery and 3 mo after surgery, neuropsychological assessments are conducted. After the second neuropsychological assessment, patients are assigned to the intervention group or waiting-list control group. The intervention consists of psychoeducation, compensation training, and retraining. Patients are advised to spend 3 h per week on the program for 10 wk. Immediately after completion of the program and a half-year thereafter, postintervention assessments take place. Patients in the control group are offered the opportunity to follow the program after all study assessments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>EXPECTED OUTCOMES<\/jats:title>\n                    <jats:p>We expect that early cognitive rehabilitation has beneficial effects on cognitive performance and PROMs in brain tumor patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The iPad-based program allows brain tumor patients to follow a cognitive rehabilitation program from their homes. Forthcoming results may contribute to further improvement of supportive care for brain tumor patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyy254","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T15:10:46Z","timestamp":1526310646000},"page":"273-279","source":"Crossref","is-referenced-by-count":11,"title":["Study Protocol for a Randomized Controlled Trial Evaluating the Efficacy of an Evidence-Based iPad-App for Cognitive Rehabilitation in Patients with Primary Brain Tumors"],"prefix":"10.1227","volume":"85","author":[{"given":"Sophie Dorothee","family":"van der Linden","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands"},{"name":"Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margriet Maria","family":"Sitskoorn","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert-Jan Maria","family":"Rutten","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Gehring","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands"},{"name":"Department of Cognitive Neuropsychology, Tilburg University, Tilburg, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,8]]},"reference":[{"issue":"3","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S1474-4422(04)00680-5","article-title":"Cognitive deficits in adult patients with brain tumours","volume":"3","author":"Taphoorn","year":"2004","journal-title":"Lancet Neurol"},{"issue":"5","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11940-016-0406-5","article-title":"Neurocognitive deficits and neurocognitive rehabilitation in adult brain tumors","volume":"18","author":"Day","year":"2016","journal-title":"Curr Treat Options Neurol"},{"issue":"22","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1200\/JCO.2008.20.5765","article-title":"Cognitive rehabilitation in patients with gliomas: a randomized, controlled trial","volume":"27","author":"Gehring","year":"2009","journal-title":"J Clin Oncol"},{"issue":"1","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11060-013-1153-z","article-title":"Cognitive rehabilitation for early post-surgery inpatients affected by primary brain tumor: a randomized, controlled trial","volume":"114","author":"Zucchella","year":"2013","journal-title":"J Neurooncol"},{"key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/3041824","article-title":"Cognitive rehabilitation in gliomas and other brain tumors: state of the art","volume":"2016","author":"Bergo","year":"2016","journal-title":"Biomed Res Int"},{"issue":"11","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1007\/s00520-016-3333-9","article-title":"Rehabilitation pathways in adult brain tumor patients in the first 12 months of disease. 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