{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:44:50Z","timestamp":1786124690356,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS-007222"],"award-info":[{"award-number":["NS-007222"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Autosomal dominant polycystic kidney disease (ADPKD) is a risk factor for formation of intracranial aneurysms (IAs), though the ideal screening and treatment strategies in this population are unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To report outcomes of observation, open surgical, or endovascular management of ruptured and unruptured aneurysms in patients with ADPKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We performed a retrospective analysis of all patients with ADPKD and IAs at a single center from 2000 to 2016.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Forty-five patients with ADPKD harboring 71 aneurysms were identified, including 11 patients with subarachnoid hemorrhage (SAH). Of 22 aneurysms managed with observation, none ruptured in 136 yr of clinical follow-up. Thirty-five aneurysms were treated with open surgery and 14 with an endovascular approach. Among treated aneurysms, poor neurologic outcome (modified Rankin scale\u00a0&gt;2) was seen only in patients presenting with SAH (17% SAH vs 0% elective,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.06). Acute kidney injury (AKI) was also significantly associated with SAH presentation (22% SAH vs 0% elective,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.05). Neither procedural complications nor AKI were associated with treatment modality. Among 175 yr of radiographic follow-up in patients with known IAs, 8 de novo aneurysms were found, including 3 that were treated. Of 11 patients with SAH, 7 ruptured in the setting of previously known ADPKD, including 2 with prior angiographic screening and 5 without screening.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Poor outcomes occurred only with ruptured presentation but were equivalent between treatment modalities. Screening is performed only selectively, and 64% (7 of 11) of patients presenting with SAH had previously known ADPKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyy336","type":"journal-article","created":{"date-parts":[[2018,6,23]],"date-time":"2018-06-23T07:09:15Z","timestamp":1529737755000},"page":"E352-E361","source":"Crossref","is-referenced-by-count":16,"title":["Cerebral Aneurysms in Autosomal Dominant Polycystic Kidney Disease: A Comparison of Management Approaches"],"prefix":"10.1227","volume":"84","author":[{"given":"D Andrew","family":"Wilkinson","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Heung","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrit","family":"Deol","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeraj","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J","family":"Gemmete","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Gregory","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya S","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,6]]},"reference":[{"issue":"9569","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","article-title":"Autosomal dominant polycystic kidney disease","volume":"369","author":"Torres","year":"2007","journal-title":"Lancet"},{"issue":"2","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJMra022161","article-title":"Polycystic kidney disease","volume":"350","author":"Wilson","year":"2004","journal-title":"N Engl J Med"},{"issue":"1","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1161\/STROKEAHA.110.578740","article-title":"Screening for intracranial aneurysm in 355 patients with autosomal-dominant polycystic kidney disease","volume":"42","author":"Xu","year":"2011","journal-title":"Stroke"},{"issue":"8","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1161\/STR.0000000000000070","article-title":"Guidelines for the management of patients with unruptured intracranial aneurysms: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"46","author":"Thompson","year":"2015","journal-title":"Stroke"},{"issue":"1","key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ki.2015.59","article-title":"Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"88","author":"Chapman","year":"2015","journal-title":"Kidney Int"},{"issue":"8","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.2215\/CJN.00780110","article-title":"Renal function and healthcare costs in patients with polycystic kidney disease","volume":"5","author":"Lentine","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"8","key":"bib7-20231011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0135834","article-title":"Validity of diagnostic codes for acute stroke in administrative databases: A systematic review","volume":"10","author":"McCormick","year":"2015","journal-title":"PLoS One"},{"key":"bib8-20231011","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jbi.2015.05.003","article-title":"Supporting information retrieval from electronic health records: A report of University of Michigan's nine-year experience in developing and using the Electronic Medical Record Search Engine (EMERSE)","volume":"55","author":"Hanauer","year":"2015","journal-title":"J Biomed Inform"},{"issue":"1","key":"bib9-20231011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc11454","article-title":"Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)","volume":"17","author":"Kellum","year":"2013","journal-title":"Crit Care"},{"issue":"9378","key":"bib10-20231011","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(03)13860-3","article-title":"Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment","volume":"362","author":"Wiebers","year":"2003","journal-title":"Lancet"},{"issue":"1","key":"bib11-20231011","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3171\/2012.9.JNS111512","article-title":"Risk of hemorrhage from de novo cerebral aneurysms","volume":"118","author":"Kemp","year":"2013","journal-title":"J Neurosurg"},{"issue":"5","key":"bib12-20231011","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1046\/j.1523-1755.2003.00918.x","article-title":"Recurrence of intracranial aneurysms in autosomal-dominant polycystic kidney disease","volume":"63","author":"Belz","year":"2003","journal-title":"Kidney Int"},{"issue":"2","key":"bib13-20231011","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0022-5347(05)67347-8","article-title":"Intracranial aneurysms and autosomal dominant polycystic kidney disease: followup study by magnetic resonance angiography","volume":"164","author":"Nakajima","year":"2000","journal-title":"J Urol"},{"issue":"18","key":"bib14-20231011","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1212\/WNL.0000000000004597","article-title":"Polycystic kidney disease among 4,436 intracranial aneurysm patients from a defined population","volume":"89","author":"Nurmonen","year":"2017","journal-title":"Neurology"},{"issue":"3","key":"bib15-20231011","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1227\/NEU.0000000000001068","article-title":"Endovascular treatment of intracranial aneurysms in patients with autosomal dominant polycystic kidney disease","volume":"78","author":"Jung","year":"2016","journal-title":"Neurosurgery"},{"issue":"3","key":"bib16-20231011","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1227\/01.NEU.0000154697.75300.C2","article-title":"Analysis of intraoperative rupture in the surgical treatment of 1694 saccular aneurysms","volume":"56","author":"Leipzig","year":"2005","journal-title":"Neurosurgery"},{"issue":"11","key":"bib17-20231011","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1136\/neurintsurg-2016-012704","article-title":"Stent-assisted coiling of cerebrovascular aneurysms: experience at a large tertiary care center with a focus on predictors of recurrence","volume":"9","author":"Linzey","year":"2017","journal-title":"J NeuroInterv Surg"},{"issue":"4","key":"bib18-20231011","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/neurintsurg-2014-011133","article-title":"Conventional endovascular treatment of small intracranial aneurysms is not associated with additional risks compared with treatment of larger aneurysms","volume":"7","author":"Stetler","year":"2015","journal-title":"J NeuroInterv Surg"},{"issue":"13","key":"bib19-20231011","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1056\/NEJM199209243271303","article-title":"Intracranial aneurysms in autosomal dominant polycystic kidney disease","volume":"327","author":"Chapman","year":"1992","journal-title":"N Engl J Med"},{"issue":"2","key":"bib20-20231011","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3174\/ajnr.A4490","article-title":"Autosomal dominant polycystic kidney disease and intracranial aneurysms: Is there an increased risk of treatment?","volume":"37","author":"Rozenfeld","year":"2016","journal-title":"AJNR Am J Neuroradiol"},{"issue":"1","key":"bib21-20231011","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000342620","article-title":"Characteristics of intracranial aneurysms in the Else Kr\u00f6ner-Fresenius registry of autosomal dominant polycystic kidney disease","volume":"2","author":"Neumann","year":"2012","journal-title":"Cerebrovasc Dis Extra"},{"issue":"2","key":"bib22-20231011","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1017\/S031716710004230X","article-title":"Cerebral aneurysms and polycystic kidney disease: a critical review","volume":"19","author":"Lozano","year":"1992","journal-title":"Can J Neurol Sci"},{"issue":"1","key":"bib23-20231011","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1681\/ASN.V3188","article-title":"Saccular intracranial aneurysms in autosomal dominant polycystic kidney disease","volume":"3","author":"Schievink","year":"1992","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"bib24-20231011","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1073\/pnas.040550097","article-title":"Polycystin 1 is required for the structural integrity of blood vessels","volume":"97","author":"Kim","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"bib25-20231011","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/01.RES.0000163278.68142.8a","article-title":"[Ca2+]i reduction increases cellular proliferation and apoptosis in vascular smooth muscle cells: relevance to the ADPKD phenotype","volume":"96","author":"Kip","year":"2005","journal-title":"Circ Res"},{"issue":"15","key":"bib26-20231011","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/hmg\/ddg190","article-title":"Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells","volume":"12","author":"Qian","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"17","key":"bib27-20231011","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1056\/NEJM198304283081702","article-title":"Occult intracranial aneurysms in polycystic kidney disease. When is cerebral arteriography indicated?","volume":"308","author":"Levey","year":"1983","journal-title":"N Engl J Med"},{"issue":"3","key":"bib28-20231011","first-page":"506","article-title":"Patients with polycystic kidney disease would benefit from routine magnetic resonance angiographic screening for intracerebral aneurysms: a decision analysis","volume":"38","author":"Butler","year":"1996","journal-title":"Neurosurgery"},{"issue":"9","key":"bib29-20231011","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1056\/NEJMra052760","article-title":"Cerebral aneurysms","volume":"355","author":"Brisman","year":"2006","journal-title":"N Engl J Med"},{"issue":"6","key":"bib30-20231011","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.2215\/CJN.09731110","article-title":"Extended follow-up of unruptured intracranial aneurysms detected by presymptomatic screening in patients with autosomal dominant polycystic kidney disease","volume":"6","author":"Irazabal","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"bib31-20231011","doi-asserted-by":"crossref","first-page":"b3763","DOI":"10.1136\/bmj.b3763","article-title":"Screening for intracranial aneurysms in ADPKD","volume":"339","year":"2009","journal-title":"BMJ"},{"issue":"11","key":"bib32-20231011","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/sj.ki.5002488","article-title":"Risk of intracranial aneurysm bleeding in autosomal-dominant polycystic kidney disease","volume":"72","author":"Ring","year":"2007","journal-title":"Kidney Int"},{"issue":"4","key":"bib33-20231011","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1053\/ajkd.2001.27694","article-title":"Familial clustering of ruptured intracranial aneurysms in autosomal dominant polycystic kidney disease","volume":"38","author":"Belz","year":"2001","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"bib34-20231011","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/ki.1994.151","article-title":"Intracranial aneurysms in autosomal dominant polycystic kidney disease","volume":"45","author":"Chauveau","year":"1994","journal-title":"Kidney Int"},{"issue":"4","key":"bib35-20231011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0153176","article-title":"Screening for unruptured intracranial aneurysms in autosomal dominant polycystic kidney disease: A survey of 420 nephrologists","volume":"11","author":"Flahault","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"bib36-20231011","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3174\/ajnr.A3437","article-title":"Should patients with autosomal dominant polycystic kidney disease be screened for cerebral aneurysms?","volume":"35","author":"Rozenfeld","year":"2014","journal-title":"AJNR Am J Neuroradiol"},{"issue":"5","key":"bib37-20231011","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1161\/STROKEAHA.115.012573","article-title":"De novo aneurysm formation in carriers of saccular intracranial aneurysm disease in eastern Finland","volume":"47","author":"Lindgren","year":"2016","journal-title":"Stroke"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006123-201906000-00027","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:44:19Z","timestamp":1786121059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006123-201906000-00027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,27]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1093\/neuros\/nyy336","relation":{},"ISSN":["0148-396X","1524-4040"],"issn-type":[{"value":"0148-396X","type":"print"},{"value":"1524-4040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,27]]}}}