{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:44:51Z","timestamp":1786124691374,"version":"build-2736575974"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:00:00Z","timestamp":1532649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Insulin-like growth factor 1 (IGF-1) was found to stimulate Schwann cell mitosis. Exogenous IGF-1 may improve nerve regeneration after cryopreservation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To evaulate the effect of intraneural administration of IGF-1 in cryopreserved nerve isografts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Eighteen millimeter grafts were used for bridging an 18-mm defect in the rat sciatic nerve. A total of 57 rats were randomly divided into three groups: (1) autograft (Group 1); (2) cryopreserved isograft (Group 2); (3) cryopreserved isograft with intraneural IGF-1 administration (Group 3). 12 weeks after surgery, functional recovery (Sciatic functional index [SFI], Swing speed [SS], nerve conduction velocity [NCV], amplitude of compound motor action potentials [CMAP], and gastrocnemius muscle index [GMI]) and nerve regeneration (myelin sheath area, total fiber counts, fiber density, and fiber width) were all evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The intraneural injection of IGF-1 significantly improved SFI and SS at weeks 10 and 12. There were no statistical differences between Groups 1 and 3 in any of the SFI or SS evaluations. CMAP and NCV in Group 1 were significantly higher than in Groups 2 and 3, and Group 3 had significantly higher CMAP and NCV compared to Group 2. No significant differences were found in fiber width. The number of nerve fibers, percentage of myelinated fibers, fiber density, and GMI was significantly higher in Group 1 compared to Group 2, but no significant differences were found between Groups 1 and 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The results show that intraneural injection of IGF-1 in an 18 mm cryopreserved isograft improve axonal regeneration and functional recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyy339","type":"journal-article","created":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T15:14:32Z","timestamp":1529939672000},"page":"423-431","source":"Crossref","is-referenced-by-count":6,"title":["Intraneural IFG-1 in Cryopreserved Nerve Isografts Increase Neural Regeneration and Functional Recovery in the Rat Sciatic Nerve"],"prefix":"10.1227","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0285-9110","authenticated-orcid":false,"given":"Sara Alicia","family":"Gonz\u00e1lez Porto","sequence":"first","affiliation":[{"name":"Servicio de Cirug\u00eda Pl\u00e1stica, Hospital POVISA, Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nieves","family":"Domenech","sequence":"additional","affiliation":[{"name":"Biobanco A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Servicio Galego de Sa\u00fade (SERGAS), A Coru\u00f1a, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J","family":"Blanco","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n de Prote\u00f3mica-PBR2-ProteoRed\/ISCIII-Servicio de Reumatolog\u00eda, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Complexo Hospitalario Universitario de A Coru\u00f1a (CHUAC), Servicio Galego de Sa\u00fade (SERGAS), Universidade da Coru\u00f1a (UDC), A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Centeno Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Centro Tecnol\u00f3gico de Formaci\u00f3n XXIAC, Instituto de Investigaci\u00f3ns Biom\u00e9dicas de A Coru\u00f1a (INIBIC), Servicio Galego de Sa\u00fade (SERGAS), A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casto","family":"Rivadulla Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencia e Control Motor, NEUROcom, Facultade de Ciencias da Sa\u00fade, Departamento de Ciencias Biom\u00e9dicas, Fisioterapia e Medicina, Instituto de Investigaci\u00f3ns Biom\u00e9dicas de A Coru\u00f1a (INIBIC), A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"\u00c1lvarez Jorge","sequence":"additional","affiliation":[{"name":"Servicio de Cirug\u00eda Pl\u00e1stica, Complexo Hospitalario Universitario de A Coru\u00f1a (CHUAC), Servicio Galego de Sa\u00fade (SERGAS), A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacinto","family":"S\u00e1nchez Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Unidad de Criobiolog\u00eda, Banco de Tejidos, Complexo Hospitalario Universitario de A Coru\u00f1a (CHUAC), Servicio Galego de Sa\u00fade (SERGAS), A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rendal V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Unidad de Criobiolog\u00eda, Banco de Tejidos, Complexo Hospitalario Universitario de A Coru\u00f1a (CHUAC), Servicio Galego de Sa\u00fade (SERGAS), A Coru\u00f1a, 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