{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:44:58Z","timestamp":1786124698495,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471392"],"award-info":[{"award-number":["81471392"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671371"],"award-info":[{"award-number":["81671371"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Education Commission-Gaofeng Clinical Medicine","award":["20161407"],"award-info":[{"award-number":["20161407"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND AND IMPORTANCE<\/jats:title>\n                    <jats:p>Metastasis to the pituitary gland is uncommon in patients with systemic disseminated cancer. Individual articles have reported cases of pituitary metastasis mimicking a prolactinoma, but no case of a prolactin-secreting tumor metastasizing to the pituitary mimicking a prolactinoma has been reported so far.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CLINICAL PRESENTATION<\/jats:title>\n                    <jats:p>This article reports a 67-yr-old man with a recent onset of headaches, ophthalmoplegia, hypopituitarism, and hyperprolactinemia who was initially diagnosed with prolactinoma and given bromocriptine in the local hospital. Because of vomiting after taking drugs, he was transferred to our hospital for further diagnosis and treatment. Serum prolactin was elevated up to 1022 ng\/mL, and pituitary magnetic resonance imaging revealed a 2.9 \u00d7 2.8 \u00d7 2.3 cm sellar mass with pituitary apoplexy, for which endoscopic transsphenoidal surgery was performed. Postoperative pathology and western blotting disclosed a prolactin-positive metastatic lung adenocarcinoma. Whole exome sequencing revealed a number of gene mutations including KRAS, PIK3CA, ALK, and CTNNB1. The patient died of deterioration of the lung disease 3 mo after the initial diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>To the best of our knowledge, this is the first report of a prolactin-secreting tumor metastasizing to the pituitary mimicking a prolactinoma as confirmed by both immunohistochemistry and western blot. Prolactin secretion is rare and elusive, and may associate with specified gene mutations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyy386","type":"journal-article","created":{"date-parts":[[2018,7,22]],"date-time":"2018-07-22T15:06:34Z","timestamp":1532271994000},"page":"E773-E778","source":"Crossref","is-referenced-by-count":8,"title":["Prolactin-Secreting Lung Adenocarcinoma Metastatic to the Pituitary Mimicking a Prolactinoma: A Case Report"],"prefix":"10.1227","volume":"85","author":[{"given":"Hong","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Rui","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojian","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhebao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Center of Pituitary Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,10]]},"reference":[{"key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1210\/jc.2003-030395","article-title":"Tumors metastatic to the pituitary gland: case report and literature review","volume":"89","author":"Komninos","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00165159","article-title":"Metastatic small cell carcinoma of the lung presenting as pituitary apoplexy and Cushing's syndrome","volume":"2","author":"Chandra","year":"1984","journal-title":"J Neurooncol"},{"key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1210\/jc.2006-0610","article-title":"Acromegaly and somatotroph hyperplasia with adenomatous transformation due to pituitary metastasis of a growth hormone-releasing hormone-secreting pulmonary endocrine carcinoma","volume":"91","author":"Nasr","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.wneu.2016.11.057","article-title":"Endoscopic endonasal management of rare sellar lesions: clinical and surgical experience of 78 cases and review of the literature","volume":"100","author":"Somma","year":"2017","journal-title":"World Neurosurg"},{"key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2265.2006.02562.x","article-title":"Guidelines of the Pituitary Society for the diagnosis and management of prolactinomas","volume":"65","author":"Casanueva","year":"2006","journal-title":"Clin Endocrinol"},{"key":"bib6-20231011","article-title":"Prolactinoma","author":"Yatavelli","year":"2017"},{"key":"bib7-20231011","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3171\/jns.1998.89.6.1043","article-title":"Excessively high prolactin level in a patient with a nonprolactin-secreting adenoma","volume":"89","author":"Albuquerque","year":"1998","journal-title":"J. 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