{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:24:16Z","timestamp":1790429056189,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Epileptic seizures impair quality of life in diffuse low-grade glioma (DLGG) patients. Tumor resection significantly impacts postoperative seizure control, but the precise extent of resection (EOR) required for optimal seizure control is not clear yet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To identify the EOR and residual tumor volume that correlated to postoperative seizure control, defined as a total seizure freedom (Class 1A in reference to Engel classification system) with and without antiepileptic drugs in patients undergoing surgical resection of supratentorial DLGG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective review was conducted of all patients who underwent first-line surgical resection of supratentorial DLGG who presented with preoperative seizures without adjuvant oncological treatment. EOR and residual tumor volume were quantified from pre- and post-operative magnetic resonance imagings. Receiver operating characteristic curves were plotted to determine the EOR and residual tumor volume that corresponded to optimal postoperative seizure control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Of the 346 included patients, 65.5% had controlled seizures postoperatively, with higher age at resection (adjusted OR per unit, 1.03 [95% confidence interval:1.01-1.06],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .043) and higher percentage of resection (adjusted OR per unit, 1.02 [95% confidence interval:1.00-1.03],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001) found as independent predictors of postoperative seizure control. Optimal EOR was \u226591% and optimal residual tumor volume was \u226419 cc to improve postoperative seizure control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Postoperative seizure control is more likely when EOR is \u226591% and\/or when residual tumor volume is \u226419 cc in supratentorial DLGG gliomas who present with seizures. Resected peritumoral cortex should, however, be taken into account in future studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyy481","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:34:34Z","timestamp":1537317274000},"page":"E332-E340","source":"Crossref","is-referenced-by-count":64,"title":["Extent of Resection and Residual Tumor Thresholds for Postoperative Total Seizure Freedom in Epileptic Adult Patients Harboring a Supratentorial Diffuse Low-Grade Glioma"],"prefix":"10.1227","volume":"85","author":[{"given":"Megan E H","family":"Still","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Sainte-Anne Hospital, Paris, France"},{"name":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"University of Texas Southwestern Medical Center, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Roux","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sainte-Anne Hospital, Paris, France"},{"name":"Paris Descartes University, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Inserm, U894, IMA-Brain, Centre de Psychiatrie et Neurosciences, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Huberfeld","sequence":"additional","affiliation":[{"name":"Department of Neurophysiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, UPMC, Sorbonne Universit\u00e9, Paris, France"},{"name":"Infantile Epilepsy and Brain Plasticity, INSERM U1129 Paris Descartes University, PRES Sorbonne, Paris, France"},{"name":"Neuroglial Interactions in Cerebral Physiopathology, Center for Interdisciplinary Research in Biology, Coll\u00e8ge de France, CNRS UMR 7241, INSERM U1050, Labex Memolife, PSL Research University, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Bauchet","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier, France"},{"name":"INSERM U1051, 80 avenue Augustin Fliche, 34091, Montpellier, France"},{"name":"R\u00e9seau d\u2019Etude des Gliomes, REG, Groland, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Baron","sequence":"additional","affiliation":[{"name":"R\u00e9seau d\u2019Etude des Gliomes, REG, Groland, France"},{"name":"Department of Radiotherapy, Institut de Canc\u00e9rologie de Lorraine, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denys","family":"Fontaine","sequence":"additional","affiliation":[{"name":"R\u00e9seau d\u2019Etude des Gliomes, REG, Groland, France"},{"name":"Department of Neurosurgery, Nice University Hospital, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Blonski","sequence":"additional","affiliation":[{"name":"R\u00e9seau d\u2019Etude des Gliomes, REG, Groland, France"},{"name":"Department of Neuro-Oncology, Nancy Neurological Hospital, Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Mandonnet","sequence":"additional","affiliation":[{"name":"R\u00e9seau d\u2019Etude des Gliomes, REG, Groland, France"},{"name":"Department of Neurosurgery, Lariboisi\u00e8re Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Guillevin","sequence":"additional","affiliation":[{"name":"R\u00e9seau d\u2019Etude des Gliomes, REG, Groland, France"},{"name":"Radiology and DACTIM-MIS\/LMA\/CNRS 7348, CHU de Poitiers, Universit\u00e9 de Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Guyotat","sequence":"additional","affiliation":[{"name":"R\u00e9seau d\u2019Etude des Gliomes, REG, Groland, France"},{"name":"Department of Neurosurgery, P. 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