{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:50:15Z","timestamp":1792003815220,"version":"4.4.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Predicting the displacement of cranial nerves by tumors could make surgery safer and the outcome better. Recent advances in imaging and processing have overcome some of the limits associated with cranial nerve tractography, such as spatial resolution and fiber crossing. Among others, probabilistic algorithms yield to a more accurate depiction of cranial nerve trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To report how cranial nerve probabilistic tractography can help the surgical strategy in a series of various skull base tumors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>After distortion correction and region of interest seeding, a probabilistic tractography algorithm used the constrained spherical deconvolution model and attempted the reconstruction of cranial nerve trajectories in both healthy and displaced conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Sixty-two patients were included and presented: vestibular schwannomas (n\u00a0=\u00a033); cerebellopontine angle meningiomas (n\u00a0=\u00a015); arachnoid or epidermoid cysts (n\u00a0=\u00a06); cavernous sinus and lower nerves schwannomas (n\u00a0=\u00a04); and other tumors (n\u00a0=\u00a04). For each patient, at least one \u2018displaced\u2019 cranial nerve was not clearly identified on classical anatomical MRI images. All 372 cranial nerves were successfully tracked on each healthy side; among the 175 cranial nerves considered \u2018displaced\u2019 by tumors, 152 (87%) were successfully tracked. Among the 127 displaced nerves of operated patients (n\u00a0=\u00a051), their position was confirmed intraoperatively for 118 (93%) of them. Conditions that led to tractography failure were detailed. On the basis of tractography, the surgical strategy was adjusted for 44 patients (71%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This study reports a cranial nerve probabilistic tractography pipeline that can: predict the position of most cranial nerves displaced by skull base tumors, help the surgical strategy, and thus be a pertinent tool for future routine clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyy538","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:40:00Z","timestamp":1539564000000},"page":"E125-E136","source":"Crossref","is-referenced-by-count":38,"title":["Probabilistic Tractography to Predict the Position of Cranial Nerves Displaced by Skull Base Tumors: Value for Surgical Strategy Through a Case Series of 62 Patients"],"prefix":"10.1227","volume":"85","author":[{"given":"Timoth\u00e9e","family":"Jacquesson","sequence":"first","affiliation":[{"name":"Skull Base Multi-disciplinary Unit, Department of Neurosurgery B, Neurological Hospital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France"},{"name":"Department of Anatomy, University of Lyon 1, Lyon, France"},{"name":"CREATIS Laboratory CNRS UMR5220, Inserm U1206, INSA-Lyon, University of Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Cotton","sequence":"additional","affiliation":[{"name":"CREATIS Laboratory CNRS UMR5220, Inserm U1206, INSA-Lyon, University of Lyon 1, Lyon, France"},{"name":"Department of Radiology, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Atty\u00e9","sequence":"additional","affiliation":[{"name":"Department of Radiology, Grenoble University Hospital, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Zaouche","sequence":"additional","affiliation":[{"name":"Department of ENT Surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Tringali","sequence":"additional","affiliation":[{"name":"Department of ENT Surgery, Lyon Sud Hospital, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Bosc","sequence":"additional","affiliation":[{"name":"CREATIS Laboratory CNRS UMR5220, Inserm U1206, INSA-Lyon, University of Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Innovation, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Jouanneau","sequence":"additional","affiliation":[{"name":"Skull Base Multi-disciplinary Unit, Department of Neurosurgery B, Neurological Hospital Pierre Wertheimer, Hospices Civils de Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Frindel","sequence":"additional","affiliation":[{"name":"CREATIS Laboratory CNRS UMR5220, Inserm U1206, INSA-Lyon, University of Lyon 1, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,7]]},"reference":[{"issue":"3-4","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.wneu.2010.12.035","article-title":"Petroclival meningiomas: quo vadis?","volume":"75","author":"Samii","year":"2011","journal-title":"World Neurosurg"},{"issue":"2","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1055\/s-2001-14466","article-title":"Petroclival Meningioma","volume":"11","author":"Al-Mefty","year":"2001","journal-title":"Skull Base"},{"issue":"7","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s003300000452","article-title":"Visualization of cranial nerves I-XII: value of 3D CISS and T2-weighted FSE sequences","volume":"10","author":"Yousry","year":"2000","journal-title":"Eur Radiol"},{"issue":"4","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/1522-2594(200010)44:4<625::AID-MRM17>3.0.CO;2-O","article-title":"In vivo fiber tractography using DT-MRI data","volume":"44","author":"Basser","year":"2000","journal-title":"Magn Reson Med"},{"issue":"1","key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/nimg.2002.1136","article-title":"Virtual in vivo interactive dissection of white matter fasciculi in the human brain","volume":"17","author":"Catani","year":"2002","journal-title":"Neuroimage"},{"issue":"8","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.cortex.2008.05.004","article-title":"A diffusion tensor imaging tractography atlas for virtual in vivo dissections","volume":"44","author":"Catani","year":"2008","journal-title":"Cortex"},{"issue":"2","key":"bib7-20231011","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1227\/NEU.0b013e3182592faa","article-title":"High-definition fiber tractography of the human brain: neuroanatomical validation and neurosurgical applications","volume":"71","author":"Fernandez-Miranda","year":"2012","journal-title":"Neurosurgery"},{"issue":"4","key":"bib8-20231011","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.neuroimage.2008.03.036","article-title":"Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers","volume":"41","author":"Wedeen","year":"2008","journal-title":"Neuroimage"},{"issue":"9","key":"bib9-20231011","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1109\/TMI.2010.2045126","article-title":"Generalized q-sampling imaging","volume":"29","author":"Yeh","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"issue":"1","key":"bib10-20231011","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1227\/NEU.0000000000001241","article-title":"Visualization of cranial nerves using high-definition fiber tractography","volume":"79","author":"Yoshino","year":"2016","journal-title":"Neurosurgery"},{"issue":"4","key":"bib11-20231011","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/mrm.10268","article-title":"High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity","volume":"48","author":"Tuch","year":"2002","journal-title":"Magn Reson Med"},{"issue":"3","key":"bib12-20231011","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.neuroimage.2004.07.037","article-title":"Direct estimation of the fiber orientation density function from diffusion-weighted MRI data using spherical deconvolution","volume":"23","author":"Tournier","year":"2004","journal-title":"Neuroimage"},{"issue":"1","key":"bib13-20231011","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroimage.2006.09.018","article-title":"Probabilistic diffusion tractography with multiple fibre orientations: What can we gain?","volume":"34","author":"Behrens","year":"2007","journal-title":"Neuroimage"},{"issue":"2","key":"bib14-20231011","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuroimage.2008.05.002","article-title":"Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion-weighted imaging phantom data","volume":"42","author":"Tournier","year":"2008","journal-title":"Neuroimage"},{"issue":"3","key":"bib15-20231011","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.eplepsyres.2014.01.017","article-title":"Visualizing Meyer's loop: A comparison of deterministic and probabilistic tractography","volume":"108","author":"Lilja","year":"2014","journal-title":"Epilepsy Res"},{"issue":"6","key":"bib16-20231011","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.3171\/2013.2.JNS121294","article-title":"White matter fiber tractography: why we need to move beyond DTI","volume":"118","author":"Farquharson","year":"2013","journal-title":"J Neurosurg"},{"issue":"2","key":"bib17-20231011","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3171\/2014.4.JNS131160","article-title":"Quantifying accuracy and precision of diffusion MR tractography of the corticospinal tract in brain tumors","volume":"121","author":"Mandelli","year":"2014","journal-title":"J Neurosurg"},{"issue":"6","key":"bib18-20231011","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3171\/2011.7.JNS11495","article-title":"Diffusion tensor imaging-based fiber tracking for prediction of the position of the facial nerve in relation to large vestibular schwannomas","volume":"115","author":"Gerganov","year":"2011","journal-title":"J Neurosurg"},{"issue":"4","key":"bib19-20231011","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1227\/NEU.0b013e31820c6cbe","article-title":"Three-dimensional in vivo modeling of vestibular schwannomas and surrounding cranial nerves with diffusion imaging tractography","volume":"68","author":"Chen","year":"2011","journal-title":"Neurosurgery"},{"issue":"0","key":"bib20-20231011","article-title":"Preoperative prediction of the location and shape of the facial nerve in patients with large vestibular schwannomas using diffusion tensor imaging-based fiber tracking","volume":"0","author":"Zhang","year":"2016","journal-title":"World Neurosurg"},{"issue":"1","key":"bib21-20231011","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3340\/jkns.2014.56.1.11","article-title":"Preoperative identification of facial nerve in vestibular schwannomas surgery using diffusion tensor tractography","volume":"56","author":"Choi","year":"2014","journal-title":"J Korean Neurosurg Soc"},{"issue":"7","key":"bib22-20231011","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s00701-015-2431-7","article-title":"Identification of cranial nerves near large vestibular schwannomas using superselective diffusion tensor tractography: experience with 23 cases","volume":"157","author":"Wei","year":"2015","journal-title":"Acta Neurochir"},{"issue":"5","key":"bib23-20231011","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4103\/0028-3886.190270","article-title":"Prediction of facial nerve position in large vestibular schwannomas using diffusion tensor imaging tractography and its intraoperative correlation","volume":"64","author":"Borkar","year":"2016","journal-title":"Neurol India"},{"issue":"4","key":"bib24-20231011","doi-asserted-by":"crossref","first-page":"787","DOI":"10.3171\/2015.7.JNS142922","article-title":"In vivo visualization of the facial nerve in patients with acoustic neuroma using diffusion tensor imaging\u2013based fiber tracking","volume":"125","author":"Song","year":"2016","journal-title":"J Neurosurg"},{"issue":"4","key":"bib25-20231011","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1097\/MAO.0000000000000984","article-title":"Diffusion tensor imaging tractography of the facial nerve in patients with cerebellopontine angle tumors","volume":"37","author":"Hilly","year":"2016","journal-title":"Otol Neurotol"},{"issue":"2","key":"bib26-20231011","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/neuros\/nyy229","article-title":"Overcoming challenges of cranial nerve tractography: a targeted review","volume":"84","author":"Jacquesson","year":"2019","journal-title":"Neurosurgery"},{"issue":"2","key":"bib28-20231011","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S1053-8119(03)00336-7","article-title":"How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging","volume":"20","author":"Andersson","year":"2003","journal-title":"Neuroimage"},{"key":"bib29-20231011","article-title":"Parotid gland tumours: MR tractography to assess contact with the facial nerve","author":"Atty\u00e9","year":"2015","journal-title":"Eur Radiol"},{"issue":"9","key":"bib30-20231011","doi-asserted-by":"crossref","first-page":"3861","DOI":"10.1007\/s00330-018-5318-1","article-title":"Facial nerve tractography: A new tool for the detection of perineural spread in parotid cancers","volume":"28","author":"Rouchy","year":"2018","journal-title":"Eur Radiol"},{"issue":"1","key":"bib31-20231011","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3171\/jns.2000.92.1.0070","article-title":"Microanatomical variations in the cerebellopontine angle associated with vestibular schwannomas (acoustic neuromas): a retrospective study of 1006 consecutive cases","volume":"92","author":"Sampath","year":"2000","journal-title":"J Neurosurg"},{"issue":"2","key":"bib32-20231011","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1177\/019459988509300202","article-title":"Facial nerve grading system","volume":"93","author":"House","year":"1985","journal-title":"Otolaryngol Head Neck Surg"},{"key":"bib33-20231011","article-title":"Diffusion tensor tractography of normal facial and vestibulocochlear nerves","author":"Yoshino","year":"2014","journal-title":"Int J Comput Assist Radiol Surg"},{"issue":"4","key":"bib34-20231011","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3171\/2011.12.JNS111404","article-title":"Preoperative identification of the facial nerve in patients with large cerebellopontine angle tumors using high-density diffusion tensor imaging","volume":"116","author":"Roundy","year":"2012","journal-title":"J Neurosurg"},{"issue":"10","key":"bib35-20231011","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1007\/s00701-013-1815-9","article-title":"Facial nerve preservation with preoperative identification and intraoperative monitoring in large vestibular schwannoma surgery","volume":"155","author":"Zhang","year":"2013","journal-title":"Acta Neurochir"},{"issue":"3","key":"bib36-20231011","first-page":"1","article-title":"Comparison of probabilistic and deterministic fiber tracking of cranial nerves","volume":"127","author":"Zolal","year":"2016","journal-title":"J Neurosurg"},{"key":"bib37-20231011","doi-asserted-by":"crossref","first-page":"554","DOI":"10.3389\/fnins.2017.00554","article-title":"Comparison of diffusion-weighted mri reconstruction methods for visualization of cranial nerves in posterior fossa surgery","volume":"11","author":"Behan","year":"2017","journal-title":"Front. Neurosci"},{"key":"bib38-20231011","doi-asserted-by":"crossref","DOI":"10.1016\/j.wneu.2017.07.102","article-title":"Probabilistic tractography of the cranial nerves in vestibular schwannoma","author":"Zolal","year":"2017","journal-title":"World Neurosurg"},{"issue":"1","key":"bib39-20231011","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/brb3.588","article-title":"Fiber up-sampling and quality assessment of tractograms - towards quantitative brain connectivity","volume":"7","author":"Sommer","year":"2017","journal-title":"Brain Behav"},{"issue":"4","key":"bib40-20231011","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.neuroimage.2010.07.024","article-title":"Track-density imaging (TDI): super-resolution white matter imaging using whole-brain track-density mapping","volume":"53","author":"Calamante","year":"2010","journal-title":"Neuroimage"},{"issue":"4","key":"bib41-20231011","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s11682-014-9334-8","article-title":"Fiber bundle length and cognition: a length-based tractography MRI study","volume":"9","author":"Behrman-Lay","year":"2015","journal-title":"Brain Imaging Behav"},{"key":"bib42-20231011","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroimage.2015.08.008","article-title":"Global tractography of multi-shell diffusion-weighted imaging data using a multi-tissue model","volume":"123","author":"Christiaens","year":"2015","journal-title":"Neuroimage"},{"issue":"11","key":"bib43-20231011","doi-asserted-by":"crossref","first-page":"e80713","DOI":"10.1371\/journal.pone.0080713","article-title":"Deterministic diffusion fiber tracking improved by quantitative anisotropy","volume":"8","author":"Yeh","year":"2013","journal-title":"PLoS One"},{"key":"bib44-20231011","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neuroimage.2013.12.047","article-title":"Track orientation density imaging (TODI) and track orientation distribution (TOD) based tractography","volume":"94","author":"Dhollander","year":"2014","journal-title":"Neuroimage"}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00006123-201907000-00038","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:50:50Z","timestamp":1786121450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00006123-201907000-00038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,26]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1093\/neuros\/nyy538","relation":{},"ISSN":["0148-396X","1524-4040"],"issn-type":[{"value":"0148-396X","type":"print"},{"value":"1524-4040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,26]]}}}