{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:45:51Z","timestamp":1786124751814,"version":"build-2736575974"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The postoperative outcomes and the predictors of seizure control are poorly studied for supratentorial cavernous angiomas (CA) within or close to the eloquent brain area.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To assess the predictors of preoperative seizure control, postoperative seizure control, and postoperative ability to work, and the safety of the surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Multicenter international retrospective cohort analysis of adult patients benefitting from a functional-based surgical resection with intraoperative functional brain mapping for a supratentorial CA within or close to eloquent brain areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 109 patients (66.1% women; mean age 38.4\u00a0\u00b1\u00a012.5 yr), were studied. Age &gt;38 yr (odds ratio [OR], 7.33; 95% confidence interval [CI], 1.53-35.19;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.013) and time to surgery &gt; 12 mo (OR, 18.21; 95% CI, 1.11-296.55;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.042) are independent predictors of uncontrolled seizures at the time of surgery. Focal deficit (OR, 10.25; 95% CI, 3.16-33.28;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) is an independent predictor of inability to work at the time of surgery. History of epileptic seizures at the time of surgery (OR, 7.61; 95% CI, 1.67-85.42;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.003) and partial resection of the CA and\/or of the hemosiderin rim (OR, 12.02; 95% CI, 3.01-48.13;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) are independent predictors of uncontrolled seizures postoperatively. Inability to work at the time of surgery (OR, 19.54; 95% CI, 1.90-425.48;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.050), Karnofsky Performance Status\u00a0\u2264\u00a070 (OR, 51.20; 95% CI, 1.20-2175.37;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.039), uncontrolled seizures postoperatively (OR, 105.33; 95% CI, 4.32-2566.27;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.004), and worsening of cognitive functions postoperatively (OR, 13.71; 95% CI, 1.06-176.66;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0=\u00a0.045) are independent predictors of inability to work postoperatively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The functional-based resection using intraoperative functional brain mapping allows safe resection of CA and the peripheral hemosiderin rim located within or close to eloquent brain areas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyz063","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T23:24:48Z","timestamp":1550445888000},"page":"E702-E713","source":"Crossref","is-referenced-by-count":11,"title":["Predictors of Epileptic Seizures and Ability to Work in Supratentorial Cavernous Angioma Located Within Eloquent Brain Areas"],"prefix":"10.1227","volume":"85","author":[{"given":"Marc","family":"Zanello","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Sainte-Anne Hospital, Paris, France"},{"name":"Sorbonne Paris Cit\u00e9, Paris Descartes University, Paris, France"},{"name":"Inserm, U894, IMA-Brain, Centre de Psychiatrie et Neurosciences, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Goodden","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Colle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, St Lucas Hospital, Gand, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Wager","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, La Mil\u00e9trie University Hospital, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip C De Witt","family":"Hamer","sequence":"additional","affiliation":[{"name":"Neurosurgical Center Amsterdam, VU University Medical Center, Amsterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Smits","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"},{"name":"Department of Neuroscience, Neurology, Uppsala University, University Hospital, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bello","sequence":"additional","affiliation":[{"name":"NeuroOncological Surgery Unit, Humanitas Research Hospital, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Tate","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannantonio","family":"Spena","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, ASST Spedali Civili, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Bresson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Lariboisi\u00e8re Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Capelle","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Piti\u00e9-Salp\u00eatri\u00e8re University Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago Gil","family":"Robles","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Universitario Quironsalud, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Sarubbo","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Structural and Functional Connectivity Lab Project, \u201cS. 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