{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:14:50Z","timestamp":1789002890762,"version":"build-2803163510"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T00:00:00Z","timestamp":1561334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Preservation of functional integrity during vestibular schwannoma surgery has become critical in the era of patient-centric medical decision-making. Subtotal tumor removal is often necessary when dense adhesions between the tumor and critical structures are present. However, it is unclear what the rate of tumor control is after subtotal resection (STR) and what factors are associated with recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To determine the rate of residual tumor growth after STR and identify clinical and radiographic predictors of tumor progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A single-institution retrospective study was performed on all sporadic vestibular schwannomas that underwent surgical resection between January 1, 2002 and December 31, 2015. Clinical charts, pathology, radiology, and operative reports were reviewed. Volumetric analysis was performed on all pre- and postoperative MR imaging. Univariate and multivariate logistic regression was performed to identify predictors of the primary endpoint of tumor progression. Kaplan\u2013Meier analysis was performed to compare progression free survival between 2 groups of residual tumor volumes and location.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>In this cohort of 66 patients who underwent primary STR, 30% had documented progression within a median follow up period of 3.1 yr. Greater residual tumor volume (OR 2.0 [1.1-4.0]) and residual disease within the internal auditory canal (OR 3.7 [1.0-13.4]) predicted progression on multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>These longitudinal data provide insight into the behavior of residual tumor, helping clinicians to determine if and when STR is an acceptable surgical strategy and to anchor expectations during shared medical decision-making consultation with patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyz200","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T07:11:28Z","timestamp":1557299488000},"page":"410-416","source":"Crossref","is-referenced-by-count":32,"title":["Residual Tumor Volume and Location Predict Progression After Primary Subtotal Resection of Sporadic Vestibular Schwannomas: A Retrospective Volumetric Study"],"prefix":"10.1227","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1964-1225","authenticated-orcid":false,"given":"Jonathan D","family":"Breshears","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin A","family":"Morshed","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette M","family":"Molinaro","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, San Francisco, California"},{"name":"Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W","family":"McDermott","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W","family":"Cheung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip V","family":"Theodosopoulos","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of California, San Francisco, San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,3]]},"reference":[{"issue":"5","key":"bib1-20231011","first-page":"216","article-title":"Clinicopathological factors related to regrowth of vestibular schwannoma after incomplete resection","volume":"114","author":"Fukuda","year":"2011","journal-title":"Stereotact Funct Neurosurg"},{"issue":"6","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.wneu.2015.02.005","article-title":"Growth of primary and remnant vestibular schwannomas: a three-year follow-up study","volume":"83","author":"Tomita","year":"2015","journal-title":"World Neurosurg"},{"key":"bib3-20231011","first-page":"1","article-title":"Long-term risk of recurrence and regrowth after gross-total and subtotal resection of sporadic vestibular schwannoma","author":"Nakatomi","year":"2017","journal-title":"J Neurosurg"},{"issue":"5","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.3171\/2010.11.JNS10257","article-title":"Extent of resection and the long-term durability of vestibular schwannoma surgery: clinical article","volume":"114","author":"Sughrue","year":"2011","journal-title":"J Neurosurg"},{"issue":"1","key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/neuros\/nyy019","article-title":"Temporal Dynamics of pseudoprogression after gamma knife radiosurgery for vestibular schwannomas\u2014A retrospective volumetric study","volume":"84","author":"Breshears","year":"2019","journal-title":"Neurosurgery"},{"issue":"1","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3171\/jns.2006.104.1.157","article-title":"Assessment of imaging studies used with radiosurgery: a volumetric algorithm and an estimation of its error. 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