{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:53:55Z","timestamp":1786125235435,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2020,5]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n The Management of Myelomeningocele Study (MOMS) demonstrated that fetal myelomeningocele (fMMC) closure results in improved hydrocephalus and hindbrain herniation when compared to postnatal closure.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE<\/jats:title>\n To report on the outcomes of a single institution's experience in the post-MOMS era, with regard to hydrocephalus absence and hindbrain herniation resolution.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n A single-center retrospective study of a subset of post-MOMS patients who underwent fetal\/postnatal myelomeningocele closure was performed. Primary outcomes included cerebrospinal fluid (CSF) diversion status and hindbrain herniation resolution. Families were contacted via telephone for outcome information if care was transitioned to outside institutions. Univariate\/multivariable analyses were performed using several prenatal and postnatal variables.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n From January 2011 to May 2016, data were reviewed from families of 62 postnatal and 119 fMMC closure patients. In the postnatal group, 80.6% required CSF diversion compared to 38.7% fetal cases (\n P<\/jats:italic>\n \u00a0<\u00a0.01). Hindbrain herniation resolution occurred in 81.5% fetal repairs compared to 32.6% postnatal (\n P<\/jats:italic>\n \u00a0<\u00a0.01). In the fetal group, fetal\/premature neonatal demise occurred in 6\/119 (5.0%) patients. There was a 42.0% decrease (95% CI \u201355.2 to \u201328.8) and 48.9% increase (95% CI 33.7 to 64.1) in risk difference for CSF diversion and hindbrain herniation resolution, respectively, in the fetal group. On univariate analysis for both groups, prenatal atrial diameter, frontal\u2013occipital horn ratio, and hindbrain herniation resolution were significantly associated with the absence of clinical hydrocephalus. The treatment of hydrocephalus was significantly delayed in the fetal group compared to the postnatal group (10 mo vs 13.8 d).\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n This study demonstrates the benefits of fMMC closure with regard to CSF dynamics.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/neuros\/nyz302","type":"journal-article","created":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T15:09:54Z","timestamp":1562944194000},"page":"637-645","source":"Crossref","is-referenced-by-count":41,"title":["Detailed Analysis of Hydrocephalus and Hindbrain Herniation After Prenatal and Postnatal Myelomeningocele Closure: Report From a Single Institution"],"prefix":"10.1227","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9111-705X","authenticated-orcid":false,"given":"Tracy M","family":"Flanders","sequence":"first","affiliation":[{"name":"Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory G","family":"Heuer","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"},{"name":"The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Madsen","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek P","family":"Buch","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M","family":"Mackell","sequence":"additional","affiliation":[{"name":"The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie S","family":"Moldenhauer","sequence":"additional","affiliation":[{"name":"The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M","family":"Zarnow","sequence":"additional","affiliation":[{"name":"The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"},{"name":"Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan W","family":"Flake","sequence":"additional","affiliation":[{"name":"The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"},{"name":"Division of Pediatric General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Scott","family":"Adzick","sequence":"additional","affiliation":[{"name":"The Center for Fetal Diagnosis and Treatment, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"},{"name":"Division of Pediatric General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,5]]},"reference":[{"issue":"8","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/bdra.23259","article-title":"Population-based study to determine mortality 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