{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:20:15Z","timestamp":1790328015617,"version":"4.1.0"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Whether delayed cerebral infarction (DCIn) after aneurysmal subarachnoid hemorrhage (aSAH) is driven by large artery vasospasm is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To study the association between DCIn and vasospasm by using quantitative assessment of vasospasm up to distal arteries with time and territorial-based correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Clinical and imaging data of 392 patients with aSAH treated at our center between 2012 and 2017 were reviewed. DCIn was defined as any cerebral infarction occurring within 3 to 21 d after ictus and not related to other specific cause. In patients with DCIn, vasospasm was assessed within 24 h around DCIn for each cerebral artery up to the end of the 2nd segments. DCIn and vasospasm analyses were blinded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      DCIn was found in 11% of patients (inter-rater k\u00a0=\u00a00.90, computed tomography (CT)-scan\u00a0=\u00a0100%, follow-up MRI\u00a0=\u00a091%). Vasospasm was quantified in 258 artery territories including 66 with and 192 without DCIn (DSA\u00a0=\u00a093%, computed tomography angiography =\u00a07%). Vasospasm was more severe in DCIn than in non-DCIn territories (60% [55-69] vs 20% [0-50],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). Vasospasm was associated with DCIn in a \u201cdose-dependent\u201d manner (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      for trend\u00a0=\u00a0.022). Every DCIn territory had a vasospasm\u00a0\u2265\u00a050%, including 39% only of distal artery segments. Only 9% of non-DCIn territories had vasospasm\u00a0\u2265\u00a0vasospasm in DCIn territories.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>The necessary association between severe vasospasm and DCIn in our study brings additional arguments in favor of large artery vasospasm (especially of distal segments) as a major determinant of DCIn and a potential therapeutic target.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyz340","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T15:23:34Z","timestamp":1566573814000},"page":"E175-E183","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":39,"title":["Delayed Cerebral Infarction is Systematically Associated with a Cerebral Vasospasm of Large Intracranial Arteries"],"prefix":"10.1227","volume":"86","author":[{"given":"Jonathan","family":"Brami","sequence":"first","affiliation":[{"name":"Department of Interventional Neuroradiology, H\u00f4pital Lariboisi\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Chousterman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Saint Louis Lariboisi\u00e8re University Hospitals, Assistance Publique \u2013 Hopitaux de Paris, Paris, France"},{"name":"INSERM U942 MASCOT, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8422-9205","authenticated-orcid":false,"given":"Gr\u00e9goire","family":"Boulouis","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Centre Hospitalier Saint-Anne, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthieu Le","family":"Dorze","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Saint Louis Lariboisi\u00e8re University Hospitals, Assistance Publique \u2013 Hopitaux de Paris, Paris, France"},{"name":"INSERM U942 MASCOT, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Majlath","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, H\u00f4pital Lariboisi\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Saint-Maurice","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, H\u00f4pital Lariboisi\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Civelli","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, H\u00f4pital Lariboisi\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Froelich","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, H\u00f4pital Lariboisi\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Houdart","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, H\u00f4pital Lariboisi\u00e8re, Paris, France"},{"name":"EA 7334 REMES (MAL, EH), Universit\u00e9 Paris 7, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Antoine","family":"Labeyrie","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology, H\u00f4pital Lariboisi\u00e8re, Paris, France"},{"name":"EA 7334 REMES (MAL, EH), Universit\u00e9 Paris 7, Paris, 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