{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:38:33Z","timestamp":1793864313939,"version":"4.6.1"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/ mailto:journals.permissions@oup.com"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Intractable neck and upper limb pain has historically been challenging to treat with conventional spinal cord stimulation (SCS) being limited by obtaining effective paresthesia coverage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To assess the safety and effectiveness of the 10-kHz SCS system, a paresthesia-independent therapy, in the treatment of neck and upper limb pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Subjects with chronic, intractable neck and\/or upper limb pain of \u22655 cm (on a 0-10 cm visual analog scale [VAS]) were enrolled in 6 US centers following an investigational device exemption from the Food and Drug Administration (FDA) and institutional review board approval. Each subject was implanted with 2 epidural leads spanning C2-C6 vertebral bodies. Subjects with successful trial stimulation were implanted with a Senza\u00ae system (Nevro Corp) and included in the evaluation of the primary safety and effectiveness endpoints.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In the per protocol population, the primary endpoint (\u226550% pain relief at 3 mo) was achieved in 86.7% (n\u00a0=\u00a039\/45) subjects. Compared to baseline, subjects reported a significant reduction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) in their mean (\u00b1 standard error of the mean) VAS scores at 12-mo assessment for neck pain (7.6\u00a0\u00b1\u00a00.2 cm, n\u00a0=\u00a042 vs 1.5\u00a0\u00b1\u00a00.3 cm, n\u00a0=\u00a037) and upper limb pain (7.1\u00a0\u00b1\u00a00.3 cm, n\u00a0=\u00a024 vs 1.0\u00a0\u00b1\u00a00.2 cm, n\u00a0=\u00a020). At 12-mo assessment, 89.2% of subjects with neck pain and 95.0% with upper limb pain had \u226550% pain relief from baseline, 95.0% reported to be \u201csatisfied\/very satisfied\u201d and 30.0% either eliminated or reduced their opioid intake.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>In conclusion, 10-kHz SCS can treat intractable neck and upper limb pain with stable long-term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyz495","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T23:15:02Z","timestamp":1571354102000},"page":"176-185","source":"Crossref","is-referenced-by-count":75,"title":["High-Frequency Spinal Cord Stimulation at 10 kHz for the Treatment of Combined Neck and Arm Pain: Results From a Prospective Multicenter Study"],"prefix":"10.1227","volume":"87","author":[{"given":"Kasra","family":"Amirdelfan","sequence":"first","affiliation":[{"name":"IPM Medical Group Inc., Walnut Creek, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Vallejo","sequence":"additional","affiliation":[{"name":"Millennium Pain Center, Bloomington, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramsin","family":"Benyamin","sequence":"additional","affiliation":[{"name":"Millennium Pain Center, Bloomington, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Yu","sequence":"additional","affiliation":[{"name":"Swedish Pain Center, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Yang","sequence":"additional","affiliation":[{"name":"Swedish Pain Center, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bundschu","sequence":"additional","affiliation":[{"name":"Coastal Orthopedics and Pain Medicine, Bradenton, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L","family":"Yearwood","sequence":"additional","affiliation":[{"name":"Comprehensive Pain and Rehabilitation, Pascagoula, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B Todd","family":"Sitzman","sequence":"additional","affiliation":[{"name":"Advanced Pain Therapy, PLLC, Hattiesburg, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradford","family":"Gliner","sequence":"additional","affiliation":[{"name":"Nevro Corp, Redwood City, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeyakumar","family":"Subbaroyan","sequence":"additional","affiliation":[{"name":"Nevro Corp, Redwood City, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Rotte","sequence":"additional","affiliation":[{"name":"Nevro Corp, Redwood City, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Caraway","sequence":"additional","affiliation":[{"name":"Nevro Corp, Redwood City, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,8]]},"reference":[{"issue":"15","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1097\/00007632-199808010-00015","article-title":"The Saskatchewan Health and Back Pain Survey. 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