{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:56:33Z","timestamp":1786125393290,"version":"build-2736575974"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/ mailto:journals.permissions@oup.com"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurosurg.","NEUROS"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Woven EndoBridge (WEB; Sequent Medical) treatment is an innovative endovascular approach for treatment of wide-neck bifurcation aneurysms. Initial studies have shown high safety with good efficacy at short term confirmed by trials conducted in United States (WEB-Intrasaccular Therapy) and in Europe (WEB Clinical Assessment of Intrasaccular Aneurysm Therapy [WEBCAST], French Observatory, and WEBCAST-2).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>To report the 2-yr clinical and anatomical results of WEB treatment in the combined population of 3 European trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In a French Observatory, 2-yr clinical and anatomical data were collected. In WEBCAST and WEBCAST-2, 2-yr follow-up was optional, and data were collected when follow-up was performed. Aneurysm occlusion was evaluated using a 3-grade scale: complete occlusion, neck remnant, and aneurysm remnant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>The population for safety was 138\/168 patients (82.1%), including 89 females (64.5%), with mean age of 55.5\u00a0\u00b1\u00a010.2 yr. The population for efficacy was 121\/169 aneurysms (71.6%). Aneurysm locations were middle cerebral artery in 65\/121 aneurysms (53.7%), anterior-communicating artery in 25\/121 (20.7%), basilar artery in 17\/121 (14.0%), and internal carotid artery terminus in 14\/121 (11.6%). No clinically relevant adverse events occurred between years 1 and 2. At 2 yr, complete occlusion was observed in 62\/121 (51.2%) aneurysms, neck remnant in 36\/121 (29.8%) aneurysms, and aneurysm remnant in 23\/121 (19.0%) aneurysms. The global retreatment rate at 2 yr was 9.3%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>This analysis confirms the high safety profile of WEB treatment at 2 yr. Aneurysm occlusion is generally stable at 2 yr, and the retreatment rate between 1 yr and 2 yr is low (2.0%).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/neuros\/nyz557","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T07:12:38Z","timestamp":1576048358000},"page":"357-367","source":"Crossref","is-referenced-by-count":73,"title":["Aneurysm Treatment With Woven EndoBridge in the Cumulative Population of 3 Prospective, Multicenter Series: 2-Year Follow-Up"],"prefix":"10.1227","volume":"87","author":[{"given":"Laurent","family":"Pierot","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Maison-Blanche, Universit\u00e9 Reims-Champagne-Ardenne, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Moret","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Bic\u00eatre, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Barreau","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istvan","family":"Szikora","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, National Institute of Clinical Neurosciences, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Herbreteau","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Tours, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Turjman","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Lyon, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Holtmannsp\u00f6tter","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Christine","family":"Januel","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Toulouse, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Costalat","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Fiehler","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Klisch","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Helios General Hospital, Erfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Yves","family":"Gauvrit","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Rennes, Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Universit\u00e4tsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Desal","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Nantes, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Velasco","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, CHU Poitiers, Poitiers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Liebig","sequence":"additional","affiliation":[{"name":"Institut of Neuroradiology, Ludwig-Maximilian University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Stockx","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, ZOL (Ziekenhuis Oost-Limburg) Genk, Genk, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Berkefeld","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Institut f\u00fcr Neuroradiologie, Klinikum der Johann Wolfgang Goethe-Universitaet, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Molyneux","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James V","family":"Byrne","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Spelle","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, H\u00f4pital Bic\u00eatre, Assistance Publique-H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,8]]},"reference":[{"issue":"7","key":"bib1-20231011","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1161\/STROKEAHA.113.000733","article-title":"Endovascular treatment of intracranial aneurysms","volume":"44","author":"Pierot","year":"2013","journal-title":"Stroke"},{"issue":"3","key":"bib2-20231011","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.neurad.2016.02.001","article-title":"Endovascular techniques for the management of wide-neck intracranial bifurcation aneurysms: a critical review of the literature","volume":"43","author":"Pierot","year":"2016","journal-title":"J Neuroradiol."},{"issue":"7","key":"bib3-20231011","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3174\/ajnr.A3191","article-title":"Intrasaccular flow disruption: a new endovascular approach for the treatment of intracranial aneurysms. Results of a preliminary clinical evaluation in a multicenter series","volume":"33","author":"Pierot","year":"2012","journal-title":"AJNR Am J Neuroradiol."},{"issue":"1","key":"bib4-20231011","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1227\/01.neu.0000429860.04276.c1","article-title":"Endovascular WEB flow disruption in middle cerebral artery aneurysms","volume":"73","author":"Pierot","year":"2013","journal-title":"Neurosurgery"},{"issue":"11","key":"bib5-20231011","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.3174\/ajnr.A4028","article-title":"Flow disruption with WEB device: report of a prospective, multicenter series of 83 patients with 85 aneurysms","volume":"35","author":"Papagiannaki","year":"2014","journal-title":"AJNR Am J Neuroradiol."},{"issue":"3","key":"bib6-20231011","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1586\/17434440.2014.907741","article-title":"Intrasaccular flow-diversion for treatment of intracranial aneurysms: the Woven EndoBridge","volume":"11","author":"Mine","year":"2014","journal-title":"Expert Rev Med Devices"},{"issue":"3","key":"bib7-20231011","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3174\/ajnr.A3869","article-title":"WEB-DL endovascular treatment of wide-neck bifurcation aneurysms: short- and midterm results in a european study","volume":"35","author":"Lubicz","year":"2014","journal-title":"AJNR Am J Neuroradiol."},{"issue":"5","key":"bib8-20231011","doi-asserted-by":"crossref","first-page":"922","DOI":"10.3174\/ajnr.A4230","article-title":"WEB treatment of intracranial aneurysms: feasibility, complications, and 1-month safety results with the WEB DL and WEB SL\/SLS in the French Observatory","volume":"36","author":"Pierot","year":"2015","journal-title":"AJNR Am J Neuroradiol."},{"issue":"5","key":"bib9-20231011","first-page":"1250","article-title":"Safety and efficacy of aneurysm treatment with WEB: results of the WEBCAST study","volume":"124","author":"Pierot","year":"2016","journal-title":"J NeuroIntervent Surg"},{"issue":"4","key":"bib10-20231011","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3174\/ajnr.A4578","article-title":"WEB treatment of intracranial aneurysms: clinical and anatomic results in the French Observatory","volume":"37","author":"Pierot","year":"2016","journal-title":"AJNR Am J Neuroradiol."},{"issue":"6","key":"bib11-20231011","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3174\/ajnr.A5178","article-title":"Safety and efficacy of aneurysm treatment with the WEB: results of the WEBCAST 2 study","volume":"38","author":"Pierot","year":"2017","journal-title":"AJNR Am J Neuroradiol."},{"issue":"12","key":"bib12-20231011","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1136\/neurintsurg-2016-012841","article-title":"Demographic, procedural and 30-day safety results from the WEB intra-saccular therapy study (WEB-IT)","volume":"9","author":"Fiorella","year":"2017","journal-title":"J NeuroIntervent Surg"},{"issue":"6","key":"bib13-20231011","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/neurintsurg-2017-013448","article-title":"Safety and efficacy of aneurysm treatment with WEB in the cumulative population of three prospective, multicenter series","volume":"10","author":"Pierot","year":"2018","journal-title":"J NeuroIntervent Surg"},{"issue":"12","key":"bib14-20231011","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.3174\/ajnr.A4445","article-title":"WEB-DL endovascular treatment of wide-neck bifurcation aneurysms: long-term results in a European series","volume":"36","author":"Pierot","year":"2015","journal-title":"AJNR Am J Neuroradiol."},{"issue":"7","key":"bib15-20231011","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/neurintsurg-2018-014354","article-title":"Delayed parent artery occlusions following use of silk flow diverters for treatment of intracranial aneurysms","volume":"11","author":"Macdonald","year":"2018","journal-title":"J Neurointerv Surg"},{"issue":"4","key":"bib16-20231011","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3174\/ajnr.A2571","article-title":"Very late thrombosis of flow-diverting constructs after the treatment of large fusiform posterior circulation aneurysms","volume":"32","author":"Klisch","year":"2011","journal-title":"AJNR Am J Neuroradiol."},{"issue":"4","key":"bib17-20231011","first-page":"929","article-title":"Very late ischemic complications in flow-diverter stents: a retrospective analysis of a single-center series","volume":"125","author":"Guedon","year":"2016","journal-title":"J NeuroIntervent Surg"},{"issue":"4","key":"bib18-20231011","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1227\/NEU.0b013e3182257b30","article-title":"Results of embolization used as the first treatment choice in a consecutive nonselected population of ruptured aneurysms: clinical results of the Clarity GDC study","volume":"69","author":"Cognard","year":"2011","journal-title":"Neurosurgery"},{"issue":"9","key":"bib19-20231011","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1161\/STROKEAHA.107.512756","article-title":"Immediate clinical outcome of patients harboring unruptured intracranial aneurysms treated by endovascular approach","volume":"39","author":"Pierot","year":"2008","journal-title":"Stroke."},{"issue":"9778","key":"bib20-20231011","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0140-6736(11)60408-X","article-title":"Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial","volume":"377","author":"White","year":"2011","journal-title":"Lancet North Am Ed."},{"issue":"5","key":"bib21-20231011","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1474-4422(09)70080-8","article-title":"Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-up","volume":"8","author":"Molyneux","year":"2009","journal-title":"Lancet Neurol."},{"issue":"4","key":"bib22-20231011","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3174\/ajnr.A3755","article-title":"Stent-assisted coiling versus coiling alone in unruptured intracranial aneurysms in the matrix and platinum science trial: safety, efficacy, and mid-term outcomes","volume":"35","author":"Hetts","year":"2014","journal-title":"Am J Neuroradiol."},{"issue":"1","key":"bib23-20231011","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/jnnp-2011-302068","article-title":"Safety and occlusion rates of surgical treatment of unruptured intracranial aneurysms: a systematic review and meta-analysis of the literature from 1990 to 2011","volume":"84","author":"Kotowski","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"bib24-20231011","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/neurintsurg-2018-014230","article-title":"Treatment strategies for recurrent and residual aneurysms after Woven Endobridge implantation","volume":"11","author":"Kabbasch","year":"2019","journal-title":"J NeuroIntervent Surg"},{"key":"bib25-20231011","doi-asserted-by":"crossref","DOI":"10.1136\/neurintsurg-2019-014903","article-title":"Clipping of recanalized intracerebral aneurysms initially treated by WEB device","author":"Pierot","year":"2019","journal-title":"J NeuroIntervent Surg."},{"issue":"11","key":"bib26-20231011","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3174\/ajnr.A4857","article-title":"Geographic differences in endovascular treatment and retreatment of cerebral aneurysms","volume":"37","author":"Turk","year":"2016","journal-title":"AJNR Am J Neuroradiol."},{"issue":"9","key":"bib27-20231011","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.3174\/ajnr.A4791","article-title":"Contrast-enhanced and time-of-flight mra at 3t compared with DSA for the follow-up of intracranial aneurysms treated with the WEB device","volume":"37","author":"Timsit","year":"2016","journal-title":"AJNR Am J Neuroradiol."},{"issue":"5","key":"bib28-20231011","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1227\/NEU.0000000000000669","article-title":"Remnants and recurrences after the use of the WEB intrasaccular device in large-neck bifurcation aneurysms","volume":"76","author":"Cognard","year":"2015","journal-title":"Neurosurgery"},{"issue":"12","key":"bib29-20231011","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.3174\/ajnr.A4918","article-title":"Are anatomic results influenced by WEB shape modification? Analysis in a prospective, single-center series of 39 patients with aneurysms treated with the WEB","volume":"37","author":"Herbreteau","year":"2016","journal-title":"AJNR Am J Neuroradiol."}],"container-title":["Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/neurosurgery\/article-pdf\/87\/2\/357\/39647372\/nyz557.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyz557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:54:52Z","timestamp":1786121692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.1093\/neuros\/nyz557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1093\/neuros\/nyz557","relation":{},"ISSN":["0148-396X","1524-4040"],"issn-type":[{"value":"0148-396X","type":"print"},{"value":"1524-4040","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,20]]}}}