{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:36:01Z","timestamp":1791246961137,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":236,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA193982"],"award-info":[{"award-number":["K08CA193982"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS107313"],"award-info":[{"award-number":["R01NS107313"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012869","name":"Morgan Adams Foundation","doi-asserted-by":"publisher","award":["CA235200"],"award-info":[{"award-number":["CA235200"]}],"id":[{"id":"10.13039\/100012869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012869","name":"Morgan Adams Foundation","doi-asserted-by":"publisher","award":["GN-000522"],"award-info":[{"award-number":["GN-000522"]}],"id":[{"id":"10.13039\/100012869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002203","name":"Brain Tumour Charity","doi-asserted-by":"publisher","award":["R03 CA212800"],"award-info":[{"award-number":["R03 CA212800"]}],"id":[{"id":"10.13039\/501100002203","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Colorado Shared Resources Cancer Center Support","award":["P30CA046934"],"award-info":[{"award-number":["P30CA046934"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The mitogen-activated protein kinases\/extracelluar signal-regulated kinases pathway is involved in cell growth and proliferation, and mutations in BRAF have made it an oncogene of interest in pediatric cancer. Previous studies found that BRAF mutations as well as KIAA1549\u2013BRAF fusions are common in intracranial low-grade gliomas (LGGs). Fewer studies have tested for the presence of these genetic changes in spinal LGGs. The aim of this study was to better understand the prevalence of BRAF and other genetic aberrations in spinal LGG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively analyzed 46 spinal gliomas from patients aged 1\u201325 years from Children\u2019s Hospital Colorado (CHCO) and The Hospital for Sick Children (SickKids). CHCO utilized a 67-gene panel that assessed BRAF and additionally screened for other possible genetic abnormalities of interest. At SickKids, BRAFV600E was assessed by droplet digital polymerase chain reaction and immunohistochemistry. BRAF fusions were detected by fluorescence in situ hybridization, reverse transcription polymerase chain reaction, or NanoString platform. Data were correlated with clinical information.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 31 samples with complete fusion analysis, 13 (42%) harbored KIAA1549\u2013BRAF. All 13 (100%) patients with confirmed KIAA1549\u2013BRAF survived the entirety of the study period (median [interquartile range] follow-up time: 47 months [27\u201385 months]) and 15 (83.3%) fusion-negative patients survived (follow-up time: 37.5 months [19.8\u201369.5 months]). Other mutations of interest were also identified in this patient cohort including BRAFV600E, PTPN11, H3F3A, TP53, FGFR1, and CDKN2A deletion.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>KIAA1549\u2013BRAF was seen in higher frequency than BRAFV600E or other genetic aberrations in pediatric spinal LGGs and experienced lower death rates compared to KIAA1549\u2013BRAF negative patients, although this was not statistically significant.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/noajnl\/vdaa103","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T17:47:06Z","timestamp":1598291226000},"source":"Crossref","is-referenced-by-count":5,"title":["Clinical and molecular characterization of a multi-institutional cohort of pediatric spinal cord low-grade gliomas"],"prefix":"10.1093","volume":"2","author":[{"given":"Sydney T","family":"Grob","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA"},{"name":"The Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children\u2019s Hospital Colorado, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Nobre","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen R","family":"Campbell","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurtis D","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Ryall","sequence":"additional","affiliation":[{"name":"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dara L","family":"Aisner","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Colorado Denver, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Center for Cancer and Blood Disorders, Phoenix Children\u2019s Hospital, Phoenix, Arizona, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Zahedi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA"},{"name":"The Morgan Adams Foundation Pediatric Brain Tumor Research 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H","family":"Handler","sequence":"additional","affiliation":[{"name":"The Morgan Adams Foundation Pediatric Brain Tumor Research Program, Children\u2019s Hospital Colorado, Aurora, Colorado, USA"},{"name":"Department of Neurosurgery, University of Colorado Denver, Aurora, Colorado, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Hawkins","sequence":"additional","affiliation":[{"name":"The Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario, Canada"},{"name":"Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada"},{"name":"Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Tabori","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology, Hospital for Sick Children, Toronto, Ontario, 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