{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T08:36:41Z","timestamp":1785314201833,"version":"3.55.0"},"reference-count":106,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":255,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Childhood Cancer Data Initiative","award":["75N91019D00024"],"award-info":[{"award-number":["75N91019D00024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>With medical software platforms moving to cloud environments with scalable storage and computing, the translation of predictive artificial intelligence (AI) models to aid in clinical decision-making and facilitate personalized medicine for cancer patients is becoming a reality. Medical imaging, namely radiologic and histologic images, has immense analytical potential in neuro-oncology, and models utilizing integrated radiomic and pathomic data may yield a synergistic effect and provide a new modality for precision medicine. At the same time, the ability to harness multi-modal data is met with challenges in aggregating data across medical departments and institutions, as well as significant complexity in modeling the phenotypic and genotypic heterogeneity of pediatric brain tumors. In this paper, we review recent pathomic and integrated pathomic, radiomic, and genomic studies with clinical applications. We discuss current challenges limiting translational research on pediatric brain tumors and outline technical and analytical solutions. Overall, we propose that to empower the potential residing in radio-pathomics, systemic changes in cross-discipline data management and end-to-end software platforms to handle multi-modal data sets are needed, in addition to embracing modern AI-powered approaches. These changes can improve the performance of predictive models, and ultimately the ability to advance brain cancer treatments and patient outcomes through the development of such models.<\/jats:p>","DOI":"10.1093\/noajnl\/vdad119","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T13:28:05Z","timestamp":1694525285000},"source":"Crossref","is-referenced-by-count":5,"title":["Radio-pathomic approaches in pediatric neuro-oncology: Opportunities and challenges"],"prefix":"10.1093","volume":"5","author":[{"given":"Ariana M","family":"Familiar","sequence":"first","affiliation":[{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aria","family":"Mahtabfar","sequence":"additional","affiliation":[{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Neurosurgery, Thomas Jefferson University Hospital , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Fathi Kazerooni","sequence":"additional","affiliation":[{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Kiani","sequence":"additional","affiliation":[{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arastoo","family":"Vossough","sequence":"additional","affiliation":[{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Radiology, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Radiology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Viaene","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip B","family":"Storm","sequence":"additional","affiliation":[{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C","family":"Resnick","sequence":"additional","affiliation":[{"name":"Center for Data-Driven Discovery in Biomedicine, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"},{"name":"Department of Neurosurgery, Children\u2019s Hospital of Philadelphia , Philadelphia, PA , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-4552","authenticated-orcid":false,"given":"Ali","family":"Nabavizadeh","sequence":"additional","affiliation":[{"name":"Center for 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