{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:43:36Z","timestamp":1775522616185,"version":"3.50.1"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:00:00Z","timestamp":1720051200000},"content-version":"vor","delay-in-days":185,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Choroid plexus tumors are rare intraventricular brain tumors predominantly arising in children but also affecting adults. Chromosome-wide copy-number alterations and TP53 mutations do occur, but in most choroid plexus tumors, driver mutations have not been identified. Here we give a brief overview of the histopathological and clinical diversity of choroid plexus tumors and their genetic and epigenetic heterogeneity. Preliminary data indicate that choroid plexus carcinomas comprise at least 2 epigenetic subgroups, one of which is associated with TP53 mutation status. These findings strongly encourage us to further investigate the genetic and epigenetic heterogeneity in a larger cohort and to align molecular subgroup status with clinical annotations, in order to identify prognostic markers that may also aid stratification within future international trials.<\/jats:p>","DOI":"10.1093\/noajnl\/vdae101","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T12:20:29Z","timestamp":1720009229000},"source":"Crossref","is-referenced-by-count":1,"title":["Molecular genetics and diversity of choroid plexus tumors"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6642-7774","authenticated-orcid":false,"given":"Christian","family":"Thomas","sequence":"first","affiliation":[{"name":"Institute of Neuropathology, University Hospital M\u00fcnster , M\u00fcnster , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-8484","authenticated-orcid":false,"given":"Martin","family":"Hasselblatt","sequence":"additional","affiliation":[{"name":"Institute of Neuropathology, University Hospital M\u00fcnster , M\u00fcnster , Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,4]]},"reference":[{"issue":"6","key":"2024071914103589200_CIT0001","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00401-015-1434-z","article-title":"Pediatric atypical choroid plexus papilloma reconsidered: Increased mitotic activity is prognostic only in older children","volume":"129","author":"Thomas","year":"2015","journal-title":"Acta Neuropathol."},{"issue":"5","key":"2024071914103589200_CIT0002","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/gcc.22148","article-title":"Choroid plexus carcinomas are characterized by complex chromosomal alterations related to patient age and prognosis","volume":"53","author":"Ruland","year":"2014","journal-title":"Genes Chromosomes Cancer."},{"issue":"4","key":"2024071914103589200_CIT0003","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/neuonc\/noaa267","article-title":"The genetic landscape of choroid plexus tumors in children and adults","volume":"23","author":"Thomas","year":"2021","journal-title":"Neuro Oncol"},{"issue":"6","key":"2024071914103589200_CIT0004","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1093\/neuonc\/nov322","article-title":"Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups","volume":"18","author":"Thomas","year":"2016","journal-title":"Neuro Oncol"},{"issue":"1","key":"2024071914103589200_CIT0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11060-020-03509-5","article-title":"Epigenetics impacts upon prognosis and clinical management of choroid plexus tumors","volume":"148","author":"Thomas","year":"2020","journal-title":"J Neurooncol."}],"container-title":["Neuro-Oncology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/noa\/advance-article-pdf\/doi\/10.1093\/noajnl\/vdae101\/58443739\/vdae101.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/noa\/article-pdf\/6\/1\/vdae101\/58596548\/vdae101.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/noa\/article-pdf\/6\/1\/vdae101\/58596548\/vdae101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T14:10:46Z","timestamp":1721398246000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/noa\/article\/doi\/10.1093\/noajnl\/vdae101\/7706147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/noajnl\/vdae101","relation":{},"ISSN":["2632-2498"],"issn-type":[{"value":"2632-2498","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2024,1,1]]},"article-number":"vdae101"}}