{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T05:46:07Z","timestamp":1773467167236,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":322,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Following large resection, proposing a watch-and-wait strategy in selected grade 3 glioma, isocitrate dehydrogenase (IDH)-mutant patients is an emerging practice. We compared the watch-and-wait approach to the standard postoperative adjuvant oncological treatment for grade 3 gliomas, IDH-mutant.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Observational, retrospective, single-institution cohort (2011\u20132023) of 106 consecutive adult patients harboring supratentorial grade 3 gliomas, IDH-mutant treated by maximal awake resection and who received a watch-and-wait approach (surgery group) or an adjuvant oncological treatment (oncological group) postoperatively. Case-matched analysis (1:1) criteria between the surgery group and oncological group: extent of resection, tumor volume, Karnofsky Performance Status (KPS) score, tumor location and size, and age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients of the surgery group (n\u2005=\u200526) had significantly better KPS scores, less preoperative neurological and\/or neurocognitive deficits, less hyperperfusion, less corpus callosum infiltration, smaller tumor volume, higher rate of total resection, and smaller residual tumor than patients of the oncological group (n\u2005=\u200580). The 5-year progression-free survival (66.2 vs. 77.9 months, P\u2005=\u2005.713) and the 5-year overall survival (88.9 vs. 83.9 months, P\u2005=\u2005.291) did not differ between surgery and oncological groups. In the whole series, a preoperative KPS score &amp;gt;70, a total resection, and the oligodendroglioma subtype were independent predictors of longer progression-free survival and overall survival. After case matching, no difference in survival was observed between watch-and-wait and oncological treatment both in astrocytomas (n\u2005=\u200514 per group) and oligodendrogliomas (n\u2005=\u200512 per group).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Watch-and-wait following radical resection appears to be feasible in highly selected grade 3 gliomas, IDH-mutant patients without impairing survival both in astrocytoma and in oligodendroglioma subgroups.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/noajnl\/vdae189","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T11:05:12Z","timestamp":1731927912000},"source":"Crossref","is-referenced-by-count":2,"title":["Watch-and-wait approach versus adjuvant treatment after radical awake resection in selected adult-type grade 3 gliomas, <i>isocitrate dehydrogenase<\/i> mutant: A case-matched cohort"],"prefix":"10.1093","volume":"6","author":[{"given":"Angela","family":"Elia","sequence":"first","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Roux","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9n\u00e9dicte","family":"Trancart","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences - Sainte-Anne Hospital , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Moiraghi","sequence":"additional","affiliation":[{"name":"Inserm, U1266, IMA-Brain, Centre de Psychiatrie et Neurosciences , Paris ,","place":["France"]},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences - Sainte-Anne Hospital , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maimiti","family":"Seneca","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Dezamis","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences - Sainte-Anne Hospital , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Varlet","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, GHU Paris Psychiatrie et Neurosciences - Sainte-Anne Hospital , Paris ,","place":["France"]},{"name":"Inserm, U1266, IMA-Brain, Centre de Psychiatrie et Neurosciences , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Chretien","sequence":"additional","affiliation":[{"name":"Inserm, U1266, IMA-Brain, Centre de Psychiatrie et Neurosciences , Paris ,","place":["France"]},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Oppenheim","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, GHU Paris Psychiatrie et Neurosciences - Sainte-Anne Hospital , Paris ,","place":["France"]},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Zanello","sequence":"additional","affiliation":[{"name":"Inserm, U1266, IMA-Brain, Centre de Psychiatrie et Neurosciences , Paris ,","place":["France"]},{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-9844","authenticated-orcid":false,"given":"Johan","family":"Pallud","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de M\u00e9decine, Universit\u00e9 Paris Cit\u00e9 , Paris ,","place":["France"]},{"name":"Department of Neurosurgery, GHU Paris Psychiatrie et Neurosciences - 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