{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:02:31Z","timestamp":1753876951209,"version":"3.41.2"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Anita Veldman Foundation","award":["CCA2018-2-17"],"award-info":[{"award-number":["CCA2018-2-17"]}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Glioma surgery aims to maximize tumor removal while preserving functional integrity. Functional outcome usually focuses on neurological and neurocognitive functions, but surgery may also affect mood regulation. We determined the occurrence of depressive symptoms after surgery and investigated associated factors, including preoperative depressive symptoms and the location of the resection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We included a single-center retrospective cohort of patients with supratentorial diffuse glioma (WHO grade 2\u20134) who underwent first-time surgical resection between 2009 and 2021 and who completed the Center for Epidemiologic Studies Depression Scale (CES-D) before and one year after surgery. Resection cavities were segmented on postoperative MRI scans. White matter disconnections were computed, the so-called disconnectome, to examine distant effects. Multivariable regression analysis was used to relate patient, tumor, and treatment characteristics to postoperative depression scores and changes after surgery. Lesion-symptom mapping was used to relate resection and disconnectome locations to these scores and changes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The study included 83 patients. Before surgery, 25% of patients had depressive symptoms and one year after surgery 34%, which was not statistically different. Resections of gliomas in the right hemisphere were significantly associated with increased depression scores after surgery. A resection involving the left anterior temporal region was significantly associated with low postoperative depression scores. Disconnectome locations were not associated with either postoperative or change in depression scores.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Resection locations affect depressive symptoms in glioma patients. This information may be useful for patient counseling.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/noajnl\/vdae222","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T15:15:41Z","timestamp":1734362141000},"source":"Crossref","is-referenced-by-count":0,"title":["Impact of resection location on depressive symptoms following glioma surgery"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5980-8202","authenticated-orcid":false,"given":"Vera","family":"Belgers","sequence":"first","affiliation":[{"name":"Cancer Center Amsterdam, Brain Tumor Center , Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Neurology , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-9888","authenticated-orcid":false,"given":"Maisa N G","family":"van Genderen","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam, Brain Tumor Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel Thiebaut","family":"de Schotten","sequence":"additional","affiliation":[{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Neurosurgery , Amsterdam ,","place":["The Netherlands"]},{"name":"Groupe d\u2019Imagerie Neurofonctionelle, Institut de Maladies Neurod\u00e9g\u00e9n\u00e9ratives-UMR 5293, CNRS, CEA University of Bordeaux , Bordeaux ,","place":["France"]},{"name":"Brain Connectivity and Behaviour Labratory, Sorbonne University , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Cakmak","sequence":"additional","affiliation":[{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Neurosurgery , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-4062","authenticated-orcid":false,"given":"Linda","family":"Douw","sequence":"additional","affiliation":[{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Anatomy and Neurosciences , Amsterdam ,","place":["The Netherlands"]},{"name":"Cancer Center Amsterdam, Brain Tumor Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Ferles","sequence":"additional","affiliation":[{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Radiology and Nuclear Medicine , Amsterdam ,","place":["The Netherlands"]},{"name":"Cancer Center Amsterdam, Brain Tumor Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Barkhof","sequence":"additional","affiliation":[{"name":"Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London , London ,","place":["UK"]},{"name":"Amsterdam UMC, Amsterdam Neuroscience , Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Radiology and Nuclear Medicine , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5553-7911","authenticated-orcid":false,"given":"Martin","family":"Klein","sequence":"additional","affiliation":[{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Medical Psychology , Amsterdam ,","place":["The Netherlands"]},{"name":"Cancer Center Amsterdam, Brain Tumor Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna M","family":"Niers","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam, Brain Tumor Center , Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Neurology , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roelant S","family":"Eijgelaar","sequence":"additional","affiliation":[{"name":"Cancer Center Amsterdam, Brain Tumor Center , Amsterdam ,","place":["The Netherlands"]},{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Neurosurgery , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2988-8544","authenticated-orcid":false,"given":"Philip C","family":"de Witt Hamer","sequence":"additional","affiliation":[{"name":"Amsterdam UMC location Vrije Universiteit Amsterdam, Neurosurgery , Amsterdam ,","place":["The Netherlands"]},{"name":"Cancer Center Amsterdam, Brain Tumor Center , Amsterdam ,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"issue":"1","key":"2025052714105640100_CIT0001","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2217\/cns.13.65","article-title":"Symptom management and quality of life in glioma patients","volume":"3","author":"Boele","year":"2014","journal-title":"CNS Oncol"},{"issue":"3","key":"2025052714105640100_CIT0002","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41571-020-00447-z","article-title":"EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood","volume":"18","author":"Weller","year":"2021","journal-title":"Nat Rev Clin Oncol."},{"issue":"6","key":"2025052714105640100_CIT0003","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s00701-013-1653-9","article-title":"The \u201conco-functional balance\u201d in surgery for diffuse low-grade glioma: Integrating the extent of resection with quality of life","volume":"155","author":"Duffau","year":"2013","journal-title":"Acta Neurochir (Wien)."},{"issue":"April","key":"2025052714105640100_CIT0004","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.clineuro.2018.06.016","article-title":"Depression and survival of glioma patients: A systematic review and meta-analysis","volume":"172","author":"Shi","year":"2018","journal-title":"Clin Neurol Neurosurg."},{"issue":"1","key":"2025052714105640100_CIT0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/jnci\/djq458","article-title":"Depression in cerebral glioma patients: A systematic review of observational studies","volume":"103","author":"Rooney","year":"2011","journal-title":"J Natl Cancer Inst."},{"issue":"1","key":"2025052714105640100_CIT0006","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1023\/A:1015728825642","article-title":"Quality of life in brain tumor patients: The relative contributions of depression, fatigue, emotional distress, and existential issues","volume":"57","author":"Pelletier","year":"2002","journal-title":"J Neurooncol."},{"issue":"2","key":"2025052714105640100_CIT0007","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s11060-018-2962-x","article-title":"Interaction of quality of life, mood and depression of patients and their informal caregivers after surgical treatment of high-grade glioma: A prospective study","volume":"140","author":"Sacher","year":"2018","journal-title":"J Neurooncol."},{"issue":"July","key":"2025052714105640100_CIT0008","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s44220-024-00275-5","article-title":"Tumor location is associated with mood dysfunction in patients with diffuse glioma","volume":"2","author":"Genderen","year":"2024","journal-title":"Nat Mental Health"},{"key":"2025052714105640100_CIT0009","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.wneu.2019.10.020","article-title":"Lesion network mapping analysis identifies potential cause of postoperative depression in a case of cingulate low-grade glioma","volume":"133","author":"Mansouri","year":"2020","journal-title":"World Neurosurg"},{"issue":"4","key":"2025052714105640100_CIT0010","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1093\/brain\/awac361","article-title":"Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience","volume":"146","author":"Trapp","year":"2023","journal-title":"Brain."},{"issue":"3","key":"2025052714105640100_CIT0011","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/cercor\/bhs351","article-title":"Damage to white matter pathways in subacute and chronic spatial neglect: A group study and 2 single-case studies with complete virtual \u201cin vivo\u201d tractography dissection","volume":"24","author":"Thiebaut De Schotten","year":"2014","journal-title":"Cereb Cortex"},{"issue":"5","key":"2025052714105640100_CIT0012","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1093\/brain\/awad013","article-title":"Latent disconnectome prediction of long-term cognitive-behavioural symptoms in stroke","volume":"146","author":"Talozzi","year":"2023","journal-title":"Brain."},{"issue":"3","key":"2025052714105640100_CIT0013","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1007\/s11764-023-01355-8","article-title":"Symptom networks in glioma patients: Understanding the multidimensionality of symptoms and quality of life","volume":"18","author":"R\u00f6ttgering","year":"2024","journal-title":"J Cancer Surviv"},{"issue":"5","key":"2025052714105640100_CIT0014","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0022-3999(99)00004-5","article-title":"Measurement of depressive symptoms in cancer patients: Evaluation of the center for epidemiological studies depression scale (CES-D)","volume":"46","author":"Hann","year":"1999","journal-title":"J Psychosom Res."},{"issue":"3","key":"2025052714105640100_CIT0015","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1177\/014662167700100306","article-title":"The CES-D scale: A self-report depression scale for research in the general population","volume":"1","author":"Radloff","year":"1977","journal-title":"Appl Psychol Meas"},{"volume-title":"Het meten van symptomen van depressie met de CES-D: Een handleiding.","year":"1995","author":"Bouma","key":"2025052714105640100_CIT0016"},{"volume-title":"Intelligentie En Leeftijd Onderzoek Bij Nederlanders van Twaalf Tot Zevenenzeventig Jaar [Intelligence and Age: Research Study in Dutch Individuals Aged Twelve to Seventy-Seven]","year":"1964","author":"Verhage","key":"2025052714105640100_CIT0017"},{"issue":"3","key":"2025052714105640100_CIT0018","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1200\/JCO.1984.2.3.187","article-title":"Karnofsky performance status revisited: Reliability, validity, and guidelines","volume":"2","author":"Schag","year":"1984","journal-title":"J Clin Oncol"},{"issue":"6","key":"2025052714105640100_CIT0019","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: A summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"1","key":"2025052714105640100_CIT0020","doi-asserted-by":"crossref","first-page":"18897","DOI":"10.1038\/s41598-023-45456-x","article-title":"Segmentation of glioblastomas in early post-operative multi-modal MRI with deep neural networks","volume":"13","author":"Helland","year":"2023","journal-title":"Sci Rep."},{"key":"2025052714105640100_CIT0021","first-page":"277","article-title":"3D slicer: A platform for subject-specific image analysis, visualization, and clinical support","volume-title":"Intraoperative Imaging and Image-Guided Therapy","author":"Kikinis","year":"2013"},{"issue":"9","key":"2025052714105640100_CIT0022","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","article-title":"3D slicer as an image computing platform for the quantitative imaging network","volume":"30","author":"Fedorov","year":"2012","journal-title":"Magn Reson Imaging."},{"issue":"1","key":"2025052714105640100_CIT0023","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Med Image Anal."},{"issue":"17","key":"2025052714105640100_CIT0024","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1002\/hbm.24750","article-title":"Automated brain extraction of multisequence MRI using artificial neural networks","volume":"40","author":"Isensee","year":"2019","journal-title":"Hum Brain Mapp."},{"issue":"3","key":"2025052714105640100_CIT0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/gigascience\/giy004","article-title":"Advanced lesion symptom mapping analyses and implementation as BCBtoolkit","volume":"7","author":"Foulon","year":"2018","journal-title":"GigaScience."},{"issue":"1","key":"2025052714105640100_CIT0026","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1038\/s41467-020-18920-9","article-title":"Brain disconnections link structural connectivity with function and behaviour","volume":"11","author":"Thiebaut de Schotten","year":"2020","journal-title":"Nat Commun."},{"key":"2025052714105640100_CIT0027","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.neuroimage.2015.08.004","article-title":"High resolution whole brain diffusion imaging at 7T for the human connectome project","volume":"122","author":"Vu","year":"2015","journal-title":"Neuroimage."},{"key":"2025052714105640100_CIT0028","first-page":"3720","article-title":"Diffusion toolkit: A software package for diffusion imaging data processing and tractography","volume":"15","author":"Wang","year":"2007","journal-title":"Proc Intl Soc Mag Reson Med"},{"issue":"5","key":"2025052714105640100_CIT0029","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nn1050","article-title":"Voxel-based lesion-symptom mapping","volume":"6","author":"Bates","year":"2003","journal-title":"Nat Neurosci."},{"issue":"2","key":"2025052714105640100_CIT0030","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"FSL","volume":"62","author":"Jenkinson","year":"2012","journal-title":"Neuroimage."},{"key":"2025052714105640100_CIT0031","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage."},{"key":"2025052714105640100_CIT0032","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.neuroimage.2014.01.060","article-title":"Permutation inference for the general linear model","volume":"92","author":"Winkler","year":"2014","journal-title":"Neuroimage."},{"key":"2025052714105640100_CIT0033","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/j.neuroimage.2008.10.055","article-title":"Bayesian analysis of neuroimaging data in FSL","volume":"45","author":"Woolrich","year":"2009","journal-title":"Neuroimage."},{"issue":"July","key":"2025052714105640100_CIT0034","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuropsychologia.2017.08.027","article-title":"Improved accuracy of lesion to symptom mapping with multivariate sparse canonical correlations","volume":"115","author":"Pustina","year":"2018","journal-title":"Neuropsychologia."},{"issue":"1","key":"2025052714105640100_CIT0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3171\/2022.9.JNS221139","article-title":"Recognizing the psychological impact of a glioma diagnosis on mental and behavioral health: A systematic review of what neurosurgeons need to know","volume":"139","author":"Young","year":"2023","journal-title":"J Neurosurg."},{"issue":"4","key":"2025052714105640100_CIT0036","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1016\/S0360-3016(02)04205-0","article-title":"Prospective study of neuropsychologic testing and quality-of-life assessment of adults with primary malignant brain tumors","volume":"55","author":"Hahn","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"1","key":"2025052714105640100_CIT0037","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3390\/brainsci12010112","article-title":"Revisiting hemispheric asymmetry in mood regulation: Implications for rTMS for major depressive disorder","volume":"12","author":"Gibson","year":"2022","journal-title":"Brain Sci"},{"issue":"10","key":"2025052714105640100_CIT0038","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1080\/09638288.2019.1668486","article-title":"Hemispheric tumor location and the impact on health-related quality of life, symptomatology, and functional performance outcomes in patients with glioma: An exploratory cross-sectional study","volume":"43","author":"Hansen","year":"2021","journal-title":"Disabil Rehabil."},{"issue":"6","key":"2025052714105640100_CIT0039","doi-asserted-by":"crossref","first-page":"e2318411","DOI":"10.1001\/jamanetworkopen.2023.18411","article-title":"A cognitive biotype of depression and symptoms, behavior measures, neural circuits, and differential treatment outcomes: A prespecified secondary analysis of a randomized clinical trial","volume":"6","author":"Hack","year":"2023","journal-title":"JAMA Netw Open"},{"issue":"3","key":"2025052714105640100_CIT0040","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s44220-023-00038-8","article-title":"Altered brain activity in unipolar depression unveiled using connectomics","volume":"1","author":"Cash","year":"2023","journal-title":"Nat Mental Health"},{"issue":"8","key":"2025052714105640100_CIT0041","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1007\/s00429-022-02573-z","article-title":"A depression network caused by brain tumours","volume":"227","author":"Li","year":"2022","journal-title":"Brain Struct Funct."},{"key":"2025052714105640100_CIT0042","doi-asserted-by":"crossref","first-page":"812410","DOI":"10.3389\/fnins.2022.812410","article-title":"Neural substrates of poststroke depression: Current opinions and methodology trends","volume":"16","author":"Pan","year":"2022","journal-title":"Front Neurosci."},{"issue":"10","key":"2025052714105640100_CIT0043","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.biopsych.2019.07.023","article-title":"A human depression circuit derived from focal brain lesions","volume":"86","author":"Padmanabhan","year":"2019","journal-title":"Biol Psychiatry."},{"issue":"June","key":"2025052714105640100_CIT0044","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fnins.2020.00585","article-title":"Accurate MR image registration to anatomical reference space for diffuse glioma","volume":"14","author":"Visser","year":"2020","journal-title":"Front Neurosci."},{"issue":"February","key":"2025052714105640100_CIT0045","doi-asserted-by":"crossref","first-page":"101727","DOI":"10.1016\/j.nicl.2019.101727","article-title":"Inter-rater agreement in glioma segmentations on longitudinal MRI","volume":"22","author":"Visser","year":"2019","journal-title":"Neuroimage Clin"}],"container-title":["Neuro-Oncology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/noa\/advance-article-pdf\/doi\/10.1093\/noajnl\/vdae222\/61201680\/vdae222.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/noa\/article-pdf\/7\/1\/vdae222\/61201680\/vdae222.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/noa\/article-pdf\/7\/1\/vdae222\/61201680\/vdae222.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T18:11:10Z","timestamp":1748369470000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/noa\/article\/doi\/10.1093\/noajnl\/vdae222\/7925563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/noajnl\/vdae222","relation":{},"ISSN":["2632-2498"],"issn-type":[{"type":"electronic","value":"2632-2498"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,12,16]]},"article-number":"vdae222"}}