{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:07:53Z","timestamp":1792130873669,"version":"4.4.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":73,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Austrian Alzheimer Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>With aging populations, the incidence of brain tumors and neurodegenerative diseases is rising. Recently, Alzheimer\u2019s disease neuropathological change (ADNC) has been documented in the tumor-adjacent cortex of 50% of patients with glioblastoma, with isolated hyperphosphorylated tau (pTau) deposits already present in younger individuals. This study extends ADNC screening to younger patients with IDH-mutant glioma, focusing on pTau and amyloid beta (Abeta) deposits, microglial activation, and amyloid precursor protein (APP) expression in the context of cortical tumor cell infiltration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Material and Methods<\/jats:title>\n                  <jats:p>We included 85 patients with IDH-mutant gliomas (37 astrocytomas, median age: 39; 48 oligodendrogliomas, median age: 50) classified as CNS-WHO grades 2\u20133. Tumor-adjacent cortex was immunohistochemically stained for b-A4, t-AT8, NeuN, APP, Ki67, and Iba1, and cells were quantified using Matlab and QuPath script. Longitudinal samples were available for 15 patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median cell density in the tumor-adjacent cortex was significantly higher in glioma patients (astrocytoma: 1395\/mm2, oligodendroglioma: 1492\/mm2) compared to non-tumor cortex (1098\/mm2, P\u2005&amp;lt;\u2005.0001). ADNC, including pTau (36%, N\u2005=\u200531\/85) and Abeta (14%, N\u2005=\u200512\/85), was observed in 38% (N\u2005=\u200532\/85) of individuals. pTau and A beta positively correlated with age (Hazard ratio\u2005=\u20050.1, P\u2005=\u2005.02), tumor cell infiltration (Kendall\u2019s tau\u2005=\u20050.100, P\u2005=\u20054.7*10\u22124), and diffuse axonal injury (P\u2005=\u2005.018). ADNC was commonly found in the temporal cortex (53%, N\u2005=\u20059\/17).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our study reveals an unexpectedly high prevalence of ADNC, particularly isolated pTau deposits, in the tumor-adjacent cortex of younger individuals with IDH-mutant glioma. These findings suggest tumor-driven tau accumulation, prompting further research into potential long-term cognitive effects.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/noajnl\/vdaf057","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T17:56:51Z","timestamp":1742061411000},"source":"Crossref","is-referenced-by-count":2,"title":["Alzheimer\u2019s disease neuropathological change in younger individuals with IDH-mutant glioma"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4801-4764","authenticated-orcid":false,"given":"Lisa","family":"Greutter","sequence":"first","affiliation":[{"name":"University of Applied Sciences FH Campus Wien, Section Biomedical Sciences , Vienna ,","place":["Austria"]},{"name":"Comprehensive Center for Clinical Neurosciences and Mental Health \u2013 C\u00b3NMH, Division of Neuropathology and Neurochemistry, Medical University of Vienna , Vienna 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