{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:26:24Z","timestamp":1792794384051,"version":"4.5.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":170,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"American Epilepsy Society Research and Training Fellowship for Clinicians","award":["1282834"],"award-info":[{"award-number":["1282834"]}],"id":[{"id":"https:\/\/ror.org\/01sx4nq39","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurologic Disorders and Stroke","doi-asserted-by":"crossref","award":["5T32NS091008-07"],"award-info":[{"award-number":["5T32NS091008-07"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurologic Disorders and Stroke","doi-asserted-by":"crossref","award":["5K23NS121520-05"],"award-info":[{"award-number":["5K23NS121520-05"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pleomorphic xanthoastrocytomas (PXAs) are rare brain tumors that are often associated with seizures. There are limited data characterizing epilepsy phenotypes in relation to PXA tumor biology and survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a retrospective observational study of 35 patients with PXA who received treatment at the University of Pennsylvania or Dana-Farber Cancer Institute. Demographic and clinical features were assessed in PXA patients with or without seizures and with respect to seizure freedom following tumor resection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During their clinical course, 27 (77%) developed tumor-related epilepsy (TRE), with 25 (71%) initially presenting with a seizure. Compared to those without TRE, patients with TRE were more likely to have a BRAF-mutated PXA and less likely to have frontal lobe tumor localization. Patients with TRE who became seizure-free after the initial resection up to the time of progressive disease were found to have a lower age of seizure onset, smaller tumor diameter, and more likely to have BRAF-mutated tumors compared to those who were not seizure-free. However, following the last tumor resection and accounting for tumor recurrences, there were no significant differences in clinical features between those who were seizure-free and those who were not. Overall survival was 88% after 5 years and 59% after 10 years, with similar survival rates between patients with and without TRE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings indicate that BRAF-mutated and BRAF-wildtype PXAs have distinct epilepsy phenotypes. Further investigation of the interplay between tumor biology and seizures may help guide counseling and targeted therapeutic strategies for PXA-related epilepsy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/noajnl\/vdaf134","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T07:58:51Z","timestamp":1750406331000},"source":"Crossref","is-referenced-by-count":1,"title":["Seizure characteristics and outcomes in patients with pleomorphic xanthoastrocytoma"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-8348","authenticated-orcid":false,"given":"Daniel J","family":"Zhou","sequence":"first","affiliation":[{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Penn Epilepsy Center, Department of Neurology, University of Pennsylvania , Philadelphia, Pennsylvania 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,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2090-4889","authenticated-orcid":false,"given":"Nishant","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon X","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Biostatistics, Epidemiology and Informatics, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A","family":"Davis","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Penn Epilepsy Center, Department of Neurology, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0741-1780","authenticated-orcid":false,"given":"Joel M","family":"Stein","sequence":"additional","affiliation":[{"name":"Division of Neuroradiology, Department of Radiology, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]},{"name":"Center for Neuroengineering and Therapeutics, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Jennings","sequence":"additional","affiliation":[{"name":"Penn Epilepsy Center, Department of Neurology, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7117-0539","authenticated-orcid":false,"given":"Stephen J","family":"Bagley","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arati","family":"Desai","sequence":"additional","affiliation":[{"name":"Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School , Boston, Massachusetts ,","place":["USA"]},{"name":"Division of Hematology\/Oncology, Department of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick Y","family":"Wen","sequence":"additional","affiliation":[{"name":"Center for Neuro-Oncology, Department of Medical 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