{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:19:35Z","timestamp":1788261575745,"version":"build-2803163510"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":42,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Health","award":["R01 NS107813"],"award-info":[{"award-number":["R01 NS107813"]}]},{"name":"National Institute of Health","award":["R01 CA271431"],"award-info":[{"award-number":["R01 CA271431"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fibroblast growth factor-inducible 14 (Fn14) belongs to the TNFR superfamily. Fn14 overexpression can drive receptor-autonomous signaling, increase both cell invasion and tumor-associated macrophages\/microglia (TAMMs) recruitment, and correlates with reduced survival in glioblastoma (GBM) patients and rat gliomas. While prior studies report Fn14 expression in non-tumor cells within the GBM tumor microenvironment (TME), their relative contributions to glioma pathobiology remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using tumor-host pairings of Fn14-positive and -knockout (-KO) cells and mice, we examined the role of Fn14 in glioma biology. Mouse glioma and human GBM datasets were analyzed at the cellular, protein, and transcriptomic levels to assess Fn14-associated changes in the glioma TME and survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fn14 was found to be highly expressed in tumor cells and TAMMs in human GBM and 2 well-characterized murine glioma models. Fn14 KO in both tumor and host cells increased overall survival. Notably, this survival benefit was greater in the glioma model characterized by a more immunologically activated TME. Immunophenotyping revealed that Fn14 loss reshapes the tumor-immune landscape, reducing the presence of immunosuppressive macrophages and exhausted T-cells, suggesting that Fn14 modulates both innate and adaptive immune responses. These findings were supported by analyses of human GBM datasets, where high Fn14 expression correlated with immunosuppressive shifts and poor patient responses to immune checkpoint inhibitor therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study provides the first description of the contributions of both tumor- and host-derived Fn14 expression to tumor immunity and survival and identifies Fn14 as an important mediator of innate and adaptive immune responses in gliomas.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/noajnl\/vdag023","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:36:19Z","timestamp":1770122179000},"source":"Crossref","is-referenced-by-count":0,"title":["The TNFR superfamily member Fn14 impacts immunity and survival in experimental gliomas and response to immune checkpoint inhibitor therapy in glioblastoma patients"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-4979","authenticated-orcid":false,"given":"Pranjali P","family":"Kanvinde","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Maryland School of Medicine , Baltimore, Maryland,","place":["USA"]},{"name":"Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Cancer Center , Baltimore, Maryland,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adarsha P","family":"Malla","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Maryland School of Medicine , Baltimore, Maryland,","place":["USA"]},{"name":"Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Cancer Center , Baltimore, Maryland,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra 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Maryland Marlene and Stewart Greenebaum Cancer Center , Baltimore, Maryland,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Flick","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Mayo Clinic Arizona , Phoenix, Arizona,","place":["USA"]},{"name":"Mayo Clinic Alix School of Medicine, Mayo Clinic Arizona , Phoenix, Arizona,","place":["USA"]},{"name":"Department of Radiology, Mayo Clinic Arizona , Phoenix, Arizona,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina P","family":"Connolly","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Maryland School of Medicine , Baltimore, Maryland,","place":["USA"]},{"name":"Brain Tumor Program, University of Maryland Marlene and Stewart Greenebaum Cancer Center , Baltimore, Maryland,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angad","family":"Beniwal","sequence":"additional","affiliation":[{"name":"Mayo Clinic Alix School of Medicine, Mayo Clinic Arizona , Phoenix, Arizona,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4992-3629","authenticated-orcid":false,"given":"Nima","family":"Sharifai","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Maryland School of Medicine , Baltimore, Maryland,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5474-2833","authenticated-orcid":false,"given":"Chixiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Maryland School of Medicine , Baltimore, Maryland,","place":["USA"]},{"name":"Department of Epidemiology & Public Health, University of Maryland School of 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