{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T09:14:42Z","timestamp":1776417282702,"version":"3.51.2"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Friedrich-Baur-Stiftung to VMS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Low grade glioma (LGG) is a disease associated with survival &amp;gt;10 years in most cases. Some patients, however, do not respond well to treatment and exhibit early progression as well as low overall survival. It is a challenge to identify these at-risk patients. Here, we used resting-state functional MRI (rsfMRI) to identify patients with LGG at risk for poor clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-five patients with suspected LGG were prospectively enrolled. All patients underwent rsfMRI before any invasive procedure. Patient data was compared to a reference cohort of 1000 healthy controls to determine abnormality of functional connectivity on an individual level, resulting in a relative numerical measure called the dysconnectivity index (DCI). A median split was performed in order to divide the cohort into 2 groups with low and high DCI, respectively. Progression-free survival (PFS) as a primary outcome measure was calculated in both groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twelve patients were diagnosed with astrocytoma, IDH-mutated, CNS WHO grade 2, and 13 patients were diagnosed with oligodendroglioma, IDH-mutated, 1p\/19q-codeleted, CNS WHO grade 2. Eight patients had tumor progression, and 2 patients died during the observation period. 1\/12 patients in the low DCI group and 7\/13 patients in the high DCI group had tumor progression, resulting in significantly shorter PFS for patients with high DCI (P\u2009\u00a0=\u00a00.028). No patient in the low DCI group died while 2 patients in the high DCI group died. Malignant transformation occurred in 4 patients with high DCI and in 0 patients with low DCI. There was no statistically significant difference in age, sex, diagnosis, and RANO resect class between the 2 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Greater disturbance of functional connectivity at the time of diagnosis as determined by rsfMRI was associated with shorter PFS in our cohort of patients with LGG. This suggests that rsfMRI might be used to identify LGG patients who are at risk of poor clinical outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/noajnl\/vdag051","type":"journal-article","created":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T12:44:39Z","timestamp":1772023479000},"source":"Crossref","is-referenced-by-count":0,"title":["Disturbance of functional connectivity in patients with low grade glioma is associated with worse progression\u2013free survival"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6206-0621","authenticated-orcid":false,"given":"Veit M","family":"Stoecklein","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Wunderlich","sequence":"additional","affiliation":[{"name":"Department of Radiology, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Weller","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Papazov","sequence":"additional","affiliation":[{"name":"Department of Radiology, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Suvak","sequence":"additional","affiliation":[{"name":"Department of Radiology, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Katzendobler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schmutzer-Sondergeld","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6684-3578","authenticated-orcid":false,"given":"Christian","family":"Schichor","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklas","family":"Thon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6634-0927","authenticated-orcid":false,"given":"Louisa","family":"Von Baumgarten","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darius","family":"Kalasauskas","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick N","family":"Harter","sequence":"additional","affiliation":[{"name":"Center for Prion Research and Neuropathology, Ludwig-Maximilians-University , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Ricke","sequence":"additional","affiliation":[{"name":"Department of Radiology, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Liebig","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, LMU University Hospital , Munich, (T.L.)","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Ringel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-4674","authenticated-orcid":false,"given":"Sophia","family":"Stoecklein","sequence":"additional","affiliation":[{"name":"Department of Radiology, LMU University Hospital , Munich,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"issue":"Supplement_6","key":"2026041704200239500_vdag051-B1","doi-asserted-by":"publisher","first-page":"vi1","DOI":"10.1093\/neuonc\/noae145","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2017\u20132021","volume":"26","author":"Price","year":"2024","journal-title":"Neuro-Oncology"},{"key":"2026041704200239500_vdag051-B2","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/s41571-020-00447-z","article-title":"EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood","volume":"18","author":"Weller","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"2026041704200239500_vdag051-B3","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1056\/NEJMoa1500925","article-title":"Radiation plus procarbazine, CCNU, and vincristine in low-grade glioma","volume":"374","author":"Buckner","year":"2016","journal-title":"N Engl J Med"},{"key":"2026041704200239500_vdag051-B4","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s11060-024-04826-9","article-title":"Determinants of long-term survival in patients with IDH-mutant gliomas","volume":"170","author":"Katzendobler","year":"2024","journal-title":"J Neurooncol"},{"key":"2026041704200239500_vdag051-B5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1158\/2159-8290.CD-24-0194","article-title":"Cancer neuroscience of brain tumors: from multicellular networks to Neuroscience-Instructed cancer therapies","volume":"15","author":"Venkataramani","year":"2025","journal-title":"Cancer Discov"},{"key":"2026041704200239500_vdag051-B6","doi-asserted-by":"publisher","first-page":"e2417420121","DOI":"10.1073\/pnas.2417420121","article-title":"Widespread neuroanatomical integration and distinct electrophysiological properties of glioma-innervating neurons","volume":"121","author":"Hsieh","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026041704200239500_vdag051-B7","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1038\/s41586-019-1563-y","article-title":"Electrical and synaptic integration of glioma into neural circuits","volume":"573","author":"Venkatesh","year":"2019","journal-title":"Nature"},{"key":"2026041704200239500_vdag051-B8","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/s41586-023-06036-1","article-title":"Glioblastoma remodelling of human neural circuits decreases survival","volume":"617","author":"Krishna","year":"2023","journal-title":"Nature"},{"key":"2026041704200239500_vdag051-B9","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J\u00a0Neurophysiol"},{"key":"2026041704200239500_vdag051-B10","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1093\/neuonc\/noaa044","article-title":"Resting-state fMRI detects alterations in whole brain connectivity related to tumor biology in glioma patients","volume":"22","author":"Stoecklein","year":"2020","journal-title":"Neuro Oncol"},{"key":"2026041704200239500_vdag051-B11","doi-asserted-by":"publisher","first-page":"5187","DOI":"10.1200\/JCO.23.01059","article-title":"RANO 2.0: update to the response assessment in neuro-oncology criteria for high- and low-grade gliomas in adults","volume":"41","author":"Wen","year":"2023","journal-title":"J Clin Oncol"},{"key":"2026041704200239500_vdag051-B12","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1016\/S1470-2045(25)00534-0","article-title":"A prognostic classification system for extent of resection in IDH-mutant grade 2 glioma: an international, multicentre, retrospective cohort study with external validation by the RANO resect group","volume":"26","author":"Karschnia","year":"2025","journal-title":"Lancet Oncol"},{"key":"2026041704200239500_vdag051-B13","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","article-title":"fMRIPrep: a robust preprocessing pipeline for functional MRI","volume":"16","author":"Esteban","year":"2019","journal-title":"Nat Methods"},{"key":"2026041704200239500_vdag051-B14","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1006\/nimg.2002.1132","article-title":"Improved optimization for the robust and accurate linear registration and motion correction of brain images","volume":"17","author":"Jenkinson","year":"2002","journal-title":"Neuroimage"},{"key":"2026041704200239500_vdag051-B15","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.neuroimage.2015.02.064","article-title":"Ica-AROMA: a robust ICA-based strategy for removing motion artifacts from fMRI data","volume":"112","author":"Pruim","year":"2015","journal-title":"Neuroimage"},{"key":"2026041704200239500_vdag051-B16","doi-asserted-by":"publisher","first-page":"150031","DOI":"10.1038\/sdata.2015.31","article-title":"Brain genomics superstruct project initial data release with structural, functional, and behavioral measures","volume":"2","author":"Holmes","year":"2015","journal-title":"Sci Data"},{"key":"2026041704200239500_vdag051-B17","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature26000","article-title":"DNA methylation-based classification of central nervous system tumours","volume":"555","author":"Capper","year":"2018","journal-title":"Nature"},{"key":"2026041704200239500_vdag051-B18","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"key":"2026041704200239500_vdag051-B19","doi-asserted-by":"publisher","first-page":"e431450","DOI":"10.1200\/EDBK_431450","article-title":"State of the art in low-grade glioma management: insights from isocitrate dehydrogenase and Beyond","volume":"44","author":"Schaff","year":"2024","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"2026041704200239500_vdag051-B20","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1200\/JCO.21.02929","article-title":"Interactive effects of molecular, therapeutic, and patient factors on outcome of diffuse low-grade glioma","volume":"41","author":"Hervey-Jumper","year":"2023","journal-title":"J Clin Oncol"},{"key":"2026041704200239500_vdag051-B21","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1093\/neuonc\/noae107","article-title":"The biological significance of tumor grade, age, enhancement, and extent of resection in IDH-mutant gliomas: how should they inform treatment decisions in the era of IDH inhibitors?","volume":"26","author":"van den Bent","year":"2024","journal-title":"Neuro Oncol"},{"key":"2026041704200239500_vdag051-B22","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1007\/s00234-023-03175-0","article-title":"Correlating MRI features with additional genetic markers and patient survival in histological grade 2-3 IDH-mutant astrocytomas","volume":"65","author":"Lasocki","year":"2023","journal-title":"Neuroradiology"},{"key":"2026041704200239500_vdag051-B23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejca.2018.10.019","article-title":"Contrast enhancement is a prognostic factor in IDH1\/2 mutant, but not in wild-type WHO grade II\/III glioma as confirmed by machine learning","volume":"107","author":"Suchorska","year":"2019","journal-title":"Eur J Cancer"},{"key":"2026041704200239500_vdag051-B24","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s11060-019-03183-2","article-title":"Contrast-enhancement in supratentorial low-grade gliomas: a classic prognostic factor in the molecular age","volume":"143","author":"Castet","year":"2019","journal-title":"J Neurooncol"},{"key":"2026041704200239500_vdag051-B25","doi-asserted-by":"publisher","first-page":"2023","DOI":"10.3174\/ajnr.A4407","article-title":"Patterns of tumor contrast enhancement predict the prognosis of anaplastic gliomas with IDH1 mutation","volume":"36","author":"Wang","year":"2015","journal-title":"AJNR Am J Neuroradiol"},{"key":"2026041704200239500_vdag051-B26","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/neuonc\/noae258","article-title":"Canonical amplifications and CDKN2A\/B loss refine IDH1\/2-mutant astrocytoma prognosis","volume":"27","author":"Ghosh","year":"2025","journal-title":"Neuro Oncol"},{"key":"2026041704200239500_vdag051-B27","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1158\/1078-0432.CCR-23-1180","article-title":"Tumor volume growth rates and doubling times during active surveillance of IDH-mutant low-grade glioma","volume":"30","author":"Bhatia","year":"2024","journal-title":"Clin Cancer Res"},{"key":"2026041704200239500_vdag051-B28","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/s41586-023-06678-1","article-title":"Glioma synapses recruit mechanisms of adaptive plasticity","volume":"623","author":"Taylor","year":"2023","journal-title":"Nature"},{"key":"2026041704200239500_vdag051-B29","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/s41586-025-08634-7","article-title":"Brain-wide neuronal circuit connectome of human glioblastoma","volume":"641","author":"Sun","year":"2025","journal-title":"Nature"},{"key":"2026041704200239500_vdag051-B30","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/S1474-4422(24)00160-1","article-title":"Glioblastoma and brain connectivity: the need for a paradigm shift","volume":"23","author":"Salvalaggio","year":"2024","journal-title":"Lancet Neurol"},{"key":"2026041704200239500_vdag051-B31","doi-asserted-by":"publisher","first-page":"vdaf023","DOI":"10.1093\/noajnl\/vdaf023","article-title":"Functional connectivity between tumor region and resting-state networks as imaging biomarker for overall survival in recurrent gliomas diagnosed by O-(2-[(18)F]fluoroethyl)-l-tyrosine PET","volume":"7","author":"Friedrich","year":"2025","journal-title":"Neurooncol Adv"},{"key":"2026041704200239500_vdag051-B32","doi-asserted-by":"publisher","first-page":"104202","DOI":"10.1016\/j.bas.2025.104202","article-title":"Tumor resting-state fMRI connectivity to extralesional brain is associated with cognitive performance in glioma patients","volume":"5","author":"Na","year":"2025","journal-title":"Brain Spine"}],"container-title":["Neuro-Oncology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/noa\/advance-article-pdf\/doi\/10.1093\/noajnl\/vdag051\/67165442\/vdag051.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/noa\/article\/doi\/10.1093\/noajnl\/vdag051\/8501933","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/noa\/article\/doi\/10.1093\/noajnl\/vdag051\/8501933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T08:20:10Z","timestamp":1776414010000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/noa\/article\/doi\/10.1093\/noajnl\/vdag051\/8501933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,12]]}},"URL":"https:\/\/doi.org\/10.1093\/noajnl\/vdag051","relation":{},"ISSN":["2632-2498"],"issn-type":[{"value":"2632-2498","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2026,1]]},"article-number":"vdag051"}}