{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:26:12Z","timestamp":1776849972891,"version":"3.51.2"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":60,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We report a 19-year-old female with a non-enhancing, diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype, harboring a germline ATM alteration. She presented with headaches, diplopia, papilledema, and obstructive hydrocephalus, and had a Karnofsky Performance Status of 70. MRI revealed infiltrative signal abnormality, and amino acid [F18]Fluciclovine PET\/MRI identified increased avidity in the right lateral thalamus which guided biopsy sampling. Histopathology showed a hypercellular infiltrative glioma with high mitotic activity. DNA sequencing analysis with matched germline whole-exome sequencing identified a pathogenic ATM mutation, with biallelic ATM deficiency in tumor. Genome-wide DNA methylation confirmed the diagnosis. The patient received craniospinal radiation with a boost and concurrent temozolomide. She achieved rapid and significant neurologic recovery of function with KPS increasing to 90, accompanied by radiographic improvement. This case highlights the utility of PET\/MRI in biopsy planning and underscores the importance of integrated histological and molecular diagnosis for management of non-enhancing gliomas.<\/jats:p>","DOI":"10.1093\/noajnl\/vdag059","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:40:42Z","timestamp":1772109642000},"source":"Crossref","is-referenced-by-count":0,"title":["Remarkable response to radiation in a non-enhancing diffuse pediatric-type high-grade glioma with germline\n                    <i>ATM<\/i>\n                    mutation: The role of PET imaging and integrated histological and molecular analysis"],"prefix":"10.1093","volume":"8","author":[{"suffix":"II","given":"Barry","family":"Cheaney","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Oregon Health & Science University , Portland (B.C., S.P., A.D., A.H.V.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew 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and Blood Disorders Research and the Division of Hematology, Oncology, Bone Marrow Transplant & Cellular Therapy, Department of Pediatrics, Seattle Children\u2019s Hospital, University of Washington , Seattle (R.R., E.C.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2362-695X","authenticated-orcid":false,"given":"Erin","family":"Crotty","sequence":"additional","affiliation":[{"name":"Ben Towne Center for Childhood Cancer and Blood Disorders Research and the Division of Hematology, Oncology, Bone Marrow Transplant & Cellular Therapy, Department of Pediatrics, Seattle Children\u2019s Hospital, University of Washington , Seattle (R.R., E.C.)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oregon Health & Science University , Portland 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