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This review introduces examples from neuro-oncology, highlighting legal aspects and providing suggestions for the application of the Medical Device Regulation, the European Regulation on Artificial Intelligence (AI Act), the General Data Protection Regulation, and potential liability issues. AI systems for medical use are medical devices and high-risk AI systems that require the necessary certifications and entail strict requirements for clinical use. Since this may also apply to general AI tools if they are used for medical purposes other than their intended use cases, such use must be critically examined. 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