{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T18:59:34Z","timestamp":1780945174467,"version":"3.54.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuro-ophthalmological disturbances present frequently in pediatric posterior fossa (PF) tumors, contributing significantly to morbidity. This study evaluates their prevalence, risk factors, and outcomes in affected children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed 119 children with PF tumors treated over a decade at a tertiary care center, including 94 presenting at initial diagnosis and 25 at relapse.<\/jats:p>\n                    <jats:p>Clinical and ophthalmologic evaluations were performed preoperatively and three months, one-year and two-years postoperatively. Prevalence of visual disturbances, central and\/or peripheral oculomotor dysfunctions, optic nerve changes, and corrective ophthalmological interventions were evaluated over time.<\/jats:p>\n                    <jats:p>Associations between visual\/oculomotor outcomes and tumor location, histology, hydrocephalus, cerebellar mutism syndrome (CMS) and intraventricular chemotherapy were analyzed using \u03c72-tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At diagnosis n\u2009=\u200921\/94 presented due to visual symptoms, while thorough preoperative examination revealed central and peripheral oculomotor disturbances in n\u2009=\u200912\/27 and n\u2009=\u20096\/27, respectively. Their prevalence increased postoperatively but improved over time in one third of patients, with earlier resolution in peripheral disturbances. Vermis\/brainstem location and CMS were associated with higher rates of postoperative oculomotor disorders. Medulloblastomas exhibited an elevated risk of central disturbances. Prism-correction was initially required in n\u2009=\u200916\/94 of cases, decreasing to n\u2009=\u20094\/64 after two years; strabismus surgery was performed in n\u2009=\u20094\/64. Papilledema was common (n\u2009=\u200910\/33) at diagnosis, and n\u2009=\u20098\/56 developed optic atrophy during follow-up.<\/jats:p>\n                    <jats:p>Among patients presenting at relapse, neuro-ophthalmological disorders were frequent (central: n\u2009=\u200924\/25; peripheral: n\u2009=\u200915\/25), while visual acuity remained satisfactory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Neuro-ophthalmological disturbances are common in pediatric PF tumors and evolve throughout treatment. Regular ophthalmologic examinations including detailed orthoptic assessments are essential for timely intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/noajnl\/vdag151","type":"journal-article","created":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T11:42:57Z","timestamp":1780746177000},"source":"Crossref","is-referenced-by-count":0,"title":["Neuro-ophthalmological disturbances in pediatric posterior fossa tumors: Prevalence, risk factors, and outcomes"],"prefix":"10.1093","author":[{"given":"Maria","family":"Aliotti Lippolis","sequence":"first","affiliation":[{"name":"Medical University of Vienna Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Center for Pediatrics, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Cancer Center, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Koinig","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Ophthalmology and Optometry, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Dorfer","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Neurosurgery, , Spitalgasse 23, A-1090, ., Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Conci","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Cardiac Surgery, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bertich","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Ophthalmology and Optometry, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Stapf","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Ophthalmology and Optometry, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Mayr","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Center for Pediatrics, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Cancer Center, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Stepien","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Center for Pediatrics, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Cancer Center, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora","family":"Hedrich","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Center for Pediatrics, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Cancer Center, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia-Christina","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Center for Pediatrics, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Cancer Center, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Schned","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Center for Pediatrics, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Cancer Center, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"K\u00f6ller","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Center for Pediatrics, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Cancer Center, , Spitalgasse 23, 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Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Center for Pediatrics, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]},{"name":"Medical University of Vienna Comprehensive Cancer Center, , Spitalgasse 23, Vienna, A-1090,","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Czech","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Neurosurgery, , Spitalgasse 23, A-1090, ., Vienna","place":["Austria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"R\u00f6ssler","sequence":"additional","affiliation":[{"name":"Medical University of Vienna Department of Neurosurgery, , Spitalgasse 23, A-1090, ., 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