{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T14:05:34Z","timestamp":1784729134756,"version":"3.55.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":179,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,12]]},"DOI":"10.1093\/noajnl\/vdag168","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:50:32Z","timestamp":1782751832000},"source":"Crossref","is-referenced-by-count":0,"title":["Cerebrospinal fluid liquid biopsy identifies primary CNS lymphoma in a patient with concurrent lung adenocarcinoma and indeterminate brain lesion"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2285-1928","authenticated-orcid":false,"given":"Connor J","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Johns Hopkins University School of Medicine , Baltimore, Maryland (C.J.L)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryn M","family":"Burkholder","sequence":"additional","affiliation":[{"name":"Wilmer Eye Institute, Johns Hopkins University School of Medicine , Baltimore, Maryland (B.M.B.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliyah","family":"Pabani","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins University School of Medicine and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore, Maryland (A.P., S.Z., M.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuodan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins University School of Medicine and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore, Maryland (A.P., S.Z., M.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3285-3484","authenticated-orcid":false,"given":"Matthias","family":"Holdhoff","sequence":"additional","affiliation":[{"name":"Department of Oncology, Johns Hopkins University School of Medicine and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins , Baltimore, Maryland (A.P., S.Z., M.H.)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,29]]},"reference":[{"key":"2026072209415401200_vdag168-B1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers18020256","article-title":"Analytical validation and clinical sensitivity of the belay SummitTM 2.0 cerebrospinal fluid liquid biopsy Test-An expanded comprehensive genomic profiling platform for Central nervous system malignancies","volume":"18","author":"Khurana","year":"2026","journal-title":"Cancers (Basel)"},{"key":"2026072209415401200_vdag168-B2","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1182\/blood-2017-11-764332","article-title":"Genetics of diffuse large B-cell lymphoma","volume":"131","author":"Pasqualucci","year":"2018","journal-title":"Blood"},{"key":"2026072209415401200_vdag168-B3","doi-asserted-by":"publisher","first-page":"3061","DOI":"10.1200\/JCO.2012.46.9957","article-title":"Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (alliance 50202)","volume":"31","author":"Rubenstein","year":"2013","journal-title":"J Clin Oncol"},{"key":"2026072209415401200_vdag168-B4","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.6004\/jnccn.2020.7667","article-title":"Challenges in the treatment of newly diagnosed and recurrent primary Central nervous system lymphoma","volume":"18","author":"Holdhoff","year":"2020","journal-title":"J Natl Compr Canc Netw"},{"key":"2026072209415401200_vdag168-B5","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1038\/s41467-022-30050-y","article-title":"The genomic and transcriptional landscape of primary central nervous system lymphoma","volume":"13","author":"Radke","year":"2022","journal-title":"Nat Commun"},{"key":"2026072209415401200_vdag168-B6","doi-asserted-by":"publisher","first-page":"e108747","DOI":"10.1371\/JOURNAL.PONE.0108747","article-title":"The truncate mutation of Notch2 enhances cell proliferation through activating the NF-\u03baB signal pathway in the diffuse large B-cell lymphomas","volume":"9","author":"Zhang","year":"2014","journal-title":"PLoS One"},{"key":"2026072209415401200_vdag168-B7","first-page":"837","article-title":"The role of oncogenic Notch2 signaling in cancer: a novel therapeutic target","volume":"9","author":"Xiu","year":"2019","journal-title":"Am J Cancer Res"},{"key":"2026072209415401200_vdag168-B8","doi-asserted-by":"publisher","DOI":"10.3390\/diseases13100336","article-title":"Molecular analysis of cerebrospinal fluid tumor-derived DNA to aid in the diagnosis and targeted treatment of breast cancer brain metastasis","volume":"13","author":"Youssef","year":"2025","journal-title":"Diseases"},{"key":"2026072209415401200_vdag168-B9","doi-asserted-by":"publisher","first-page":"100318","DOI":"10.1016\/j.jlb.2025.100318","article-title":"Analysis of cerebrospinal fluid tumor-derived DNA to obviate biopsy of IDH-mutant brainstem glioma in an adult","volume":"9","author":"Youssef","year":"2025","journal-title":"J Liq Biopsy"},{"key":"2026072209415401200_vdag168-B10","doi-asserted-by":"publisher","first-page":"224ra24","DOI":"10.1126\/scitranslmed.3007094","article-title":"Detection of circulating tumor DNA in early- and late-stage human malignancies","volume":"6","author":"Bettegowda","year":"2014","journal-title":"Sci Transl Med"},{"key":"2026072209415401200_vdag168-B11","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1093\/neuonc\/noz156","article-title":"The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors","volume":"21","author":"Mattox","year":"2019","journal-title":"Neuro Oncol"},{"key":"2026072209415401200_vdag168-B12","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.jmoldx.2025.03.010","article-title":"Analytical validation and clinical sensitivity of the belay summit assay for the detection of DNA variants in cerebrospinal fluid of primary and metastatic central nervous system cancer","volume":"27","author":"Nie","year":"2025","journal-title":"J Mol Diagn"},{"key":"2026072209415401200_vdag168-B13","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1182\/BLOOD.2024023832","article-title":"Rapid tumor DNA analysis of cerebrospinal fluid accelerates treatment of central nervous system lymphoma","volume":"144","author":"Gupta","year":"2024","journal-title":"Blood"},{"key":"2026072209415401200_vdag168-B14","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1200\/JCO.22.00826","article-title":"Circulating tumor DNA profiling for detection, risk stratification, and classification of brain lymphomas","volume":"41","author":"Mutter","year":"2023","journal-title":"J Clin Oncol"},{"key":"2026072209415401200_vdag168-B15","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/NEUONC\/NOAE032","article-title":"Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: a RANO review","volume":"26","author":"Nayak","year":"2024","journal-title":"Neuro Oncol"},{"key":"2026072209415401200_vdag168-B16","doi-asserted-by":"publisher","first-page":"4161","DOI":"10.21037\/TLCR-21-536","article-title":"NOTCH alteration in EGFR-mutated lung adenocarcinoma leads to histological small-cell carcinoma transformation under EGFR-TKI treatment","volume":"10","author":"Koba","year":"2021","journal-title":"Transl Lung Cancer Res"},{"key":"2026072209415401200_vdag168-B17","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.3390\/CANCERS12082277","article-title":"Clonal hematopoiesis in liquid biopsy: from biological noise to valuable clinical implications","volume":"12","author":"Chan","year":"2020","journal-title":"Cancers (Basel)"},{"key":"2026072209415401200_vdag168-B18","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1093\/neuonc\/noae267","article-title":"NCCN CNS tumor guidelines update for 2024","volume":"27","author":"Nabors","year":"2025","journal-title":"Neuro Oncol"},{"key":"2026072209415401200_vdag168-B19","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1016\/j.ccell.2021.09.012","article-title":"Serial assessment of measurable residual disease in medulloblastoma liquid biopsies","volume":"39","author":"Liu","year":"2021","journal-title":"Cancer Cell"},{"key":"2026072209415401200_vdag168-B20","doi-asserted-by":"publisher","DOI":"10.3390\/cells14030161","article-title":"Circulating tumor DNA testing for minimal residual disease and its application in colorectal cancer","volume":"14","author":"Abidoye","year":"2025","journal-title":"Cells"}],"container-title":["Neuro-Oncology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/noa\/advance-article-pdf\/doi\/10.1093\/noajnl\/vdag168\/68645779\/vdag168.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/noa\/article-pdf\/8\/1\/vdag168\/68645779\/vdag168.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/noa\/article-pdf\/8\/1\/vdag168\/68645779\/vdag168.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:41:59Z","timestamp":1784727719000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/noa\/article\/doi\/10.1093\/noajnl\/vdag168\/8721584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,12]]}},"URL":"https:\/\/doi.org\/10.1093\/noajnl\/vdag168","relation":{},"ISSN":["2632-2498"],"issn-type":[{"value":"2632-2498","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2026,1]]},"article-number":"vdag168"}}