{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:56:06Z","timestamp":1785779766261,"version":"3.56.0"},"reference-count":362,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":189,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fund for Scientific Research (F.R.S-FNRS)-T\u00e9l\u00e9vie grants","award":["7.6604.23"],"award-info":[{"award-number":["7.6604.23"]}]},{"name":"Fund for Scientific Research (F.R.S-FNRS)-T\u00e9l\u00e9vie grants","award":["7.8508.23"],"award-info":[{"award-number":["7.8508.23"]}]},{"name":"the Luxembourg National Research Fund","award":["PRIDE21\/16763386\/CANBIO2"],"award-info":[{"award-number":["PRIDE21\/16763386\/CANBIO2"]}]},{"name":"The Action Lions \u201cVaincre le Cancer\u201d"},{"name":"Fondation du P\u00e9lican de Mie et Pierre Hippert-Faber, under the aegis of the Fondation de Luxembourg"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Replication stress (RS) encompasses states of impaired DNA replication progression associated with fork slowing, stalling, or collapse. RS triggers a specialized branch of the DNA damage response (DDR) called the RS response (RSR) and constitutes a major source of genomic instability, which is a key hallmark of cancer. Cancer cells face high basal levels of RS due to sustained proliferative signaling. Besides endogenous stimuli, RS can be induced by exogenous sources such as chemotherapeutic drugs. In glioblastoma (GBM), the most aggressive primary brain tumor, chronic RS leading to DDR activation is thought to drive enhanced DNA repair and treatment resistance. While chromosomal instability associated with DDR defects drives tumorigenesis, the need to preserve genomic stability to maintain fitness fosters addiction to redundant pathways promoting fork integrity. Targeting these pathways is a promising anti-cancer strategy currently undergoing clinical evaluation. In this review, we provide a molecular overview of RS and the RSR. We also explore the sources of RS in gliomas, along with the biological processes and tumor-specific features that influence the RSR in GBM cells. We then delve into the strategies developed to exploit RS, including strategies harnessing the DDR to foster antitumor immunity.<\/jats:p>","DOI":"10.1093\/noajnl\/vdag177","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T11:36:41Z","timestamp":1783424201000},"source":"Crossref","is-referenced-by-count":0,"title":["Targeting replication stress in glioblastoma: From genotoxic treatment and inhibitors of the DNA damage response to immunotherapy"],"prefix":"10.1093","volume":"8","author":[{"given":"Alexandros","family":"Pailas","sequence":"first","affiliation":[{"name":"DNA Repair and Chemoresistance Group, Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH) , Luxembourg,","place":["Luxembourg"]},{"name":"Faculty of Science, Technology and Communication, University of Luxembourg , Esch-sur-Alzette,","place":["Luxembourg"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Catarina","family":"Vales de Almeida","sequence":"additional","affiliation":[{"name":"DNA Repair and Chemoresistance Group, Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH) , Luxembourg,","place":["Luxembourg"]},{"name":"Faculty of Science, Technology and Communication, University of Luxembourg , Esch-sur-Alzette,","place":["Luxembourg"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Torres-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"DNA Repair and Chemoresistance Group, Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH) , Luxembourg,","place":["Luxembourg"]},{"name":"Faculty of Science, Technology and Communication, University of Luxembourg , Esch-sur-Alzette,","place":["Luxembourg"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Chalmers","sequence":"additional","affiliation":[{"name":"School of Cancer Sciences, University of Glasgow , Glasgow,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Mittelbronn","sequence":"additional","affiliation":[{"name":"Department of Health, Medicine and Life Sciences (DHML), Faculty of Science, Technology and Medicine (FSTM), University of Luxembourg , Esch-sur-Alzette,","place":["Luxembourg"]},{"name":"Division of Neuropathology, Department of Pathology and Neuropathology, Medical Faculty, University of Cologne , Cologne,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8614-2402","authenticated-orcid":false,"given":"Eric","family":"Van Dyck","sequence":"additional","affiliation":[{"name":"DNA Repair and Chemoresistance Group, Department of Cancer Research (DoCR), Luxembourg Institute of Health (LIH) , Luxembourg,","place":["Luxembourg"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"2026080313313974000_vdag177-B1","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1158\/2159-8290.CD-17-1461","article-title":"Mechanisms of oncogene-induced replication stress: jigsaw falling into place","volume":"8","author":"Kotsantis","year":"2018","journal-title":"Cancer Discov"},{"key":"2026080313313974000_vdag177-B2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1038\/nrc3916","article-title":"Replication stress and cancer","volume":"15","author":"Gaillard","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"2026080313313974000_vdag177-B3","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1016\/j.molcel.2022.05.004","article-title":"Hallmarks of DNA replication stress","volume":"82","author":"Saxena","year":"2022","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B4","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/s41573-022-00558-5","article-title":"Targeting replication stress in cancer therapy","volume":"22","author":"da Costa","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"2026080313313974000_vdag177-B5","doi-asserted-by":"publisher","first-page":"S875","DOI":"10.21037\/tcr.2017.06.02","article-title":"Translational research in radiation-induced DNA damage signaling and repair","volume":"6","author":"Nickoloff","year":"2017","journal-title":"Transl Cancer Res"},{"key":"2026080313313974000_vdag177-B6","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"2026080313313974000_vdag177-B7","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1146\/annurev-pathol-012414-040424","article-title":"DNA replication stress as a hallmark of cancer","volume":"10","author":"Macheret","year":"2015","journal-title":"Annu Rev Pathol"},{"key":"2026080313313974000_vdag177-B8","doi-asserted-by":"publisher","first-page":"R435","DOI":"10.1016\/j.cub.2014.04.012","article-title":"DNA replication and oncogene-induced replicative stress","volume":"24","author":"Hills","year":"2014","journal-title":"Curr Biol"},{"key":"2026080313313974000_vdag177-B9","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrc.2015.2","article-title":"DNA damage and the balance between survival and death in cancer biology","volume":"16","author":"Roos","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"2026080313313974000_vdag177-B10","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.dnarep.2018.08.009","article-title":"R-loop generation during transcription: formation, processing and cellular outcomes","volume":"71","author":"Belotserkovskii","year":"2018","journal-title":"DNA Repair (Amst)"},{"key":"2026080313313974000_vdag177-B11","doi-asserted-by":"publisher","author":"Zhang","year":"2024","DOI":"10.1101\/2023.10.03.560768"},{"key":"2026080313313974000_vdag177-B12","doi-asserted-by":"publisher","first-page":"12483","DOI":"10.1093\/nar\/gkaa1002","article-title":"A unified model for the G1\/S cell cycle transition","volume":"48","author":"Hume","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B13","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202302067","article-title":"RB loss sensitizes cells to replication-associated DNA damage after PARP inhibition by trapping","volume":"6","author":"Zamalloa","year":"2023","journal-title":"Life Sci Alliance"},{"key":"2026080313313974000_vdag177-B14","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1091\/mbc.E10-11-0895","article-title":"RB deletion disrupts coordination between DNA replication licensing and mitotic entry in vivo","volume":"22","author":"Bourgo","year":"2011","journal-title":"Mol Biol Cell"},{"key":"2026080313313974000_vdag177-B15","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1158\/0008-5472.CAN-17-2802","article-title":"CDKN2A\/p16 deletion in head and neck cancer cells is associated with CDK2 activation, replication stress, and vulnerability to CHK1 inhibition","volume":"78","author":"Gadhikar","year":"2018","journal-title":"Cancer Res"},{"key":"2026080313313974000_vdag177-B16","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1038\/s43018-024-00881-3","article-title":"Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer","volume":"6","author":"Link","year":"2025","journal-title":"Nat Cancer"},{"key":"2026080313313974000_vdag177-B17","doi-asserted-by":"publisher","author":"Gini","year":"2025","DOI":"10.1101\/2024.03.12.584638"},{"key":"2026080313313974000_vdag177-B18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1146\/annurev-genet-080320-031523","article-title":"Transcription-replication conflicts as a source of genome instability","author":"Goehring","year":"2024","journal-title":"Annu Rev Genet"},{"key":"2026080313313974000_vdag177-B19","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1038\/nrc.2017.52","article-title":"Fragile sites in cancer: more than meets the eye","volume":"17","author":"Glover","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"2026080313313974000_vdag177-B20","doi-asserted-by":"publisher","first-page":"102313","DOI":"10.1016\/j.isci.2021.102313","article-title":"Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolution","volume":"24","author":"Matsuno","year":"2021","journal-title":"iScience"},{"key":"2026080313313974000_vdag177-B21","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/s41580-020-0236-x","article-title":"The regulation and functions of DNA and RNA G-quadruplexes","volume":"21","author":"Varshney","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026080313313974000_vdag177-B22","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.tibs.2022.03.013","article-title":"Consequences of telomere replication failure: the other end-replication problem","volume":"47","author":"Brenner","year":"2022","journal-title":"Trends Biochem Sci"},{"key":"2026080313313974000_vdag177-B23","doi-asserted-by":"publisher","first-page":"220011","DOI":"10.1098\/rsob.220011","article-title":"Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers","volume":"12","author":"Lu","year":"2022","journal-title":"Open Biol"},{"key":"2026080313313974000_vdag177-B24","doi-asserted-by":"publisher","first-page":"6622","DOI":"10.1073\/pnas.85.18.6622","article-title":"A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes","volume":"85","author":"Moyzis","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080313313974000_vdag177-B25","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041706","article-title":"Epigenetics of human telomeres","volume":"17","author":"Bettin","year":"2025","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"2026080313313974000_vdag177-B26","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nrg.2017.58","article-title":"Non-coding RNA: a protective role for TERRA at telomeres","volume":"18","author":"Koch","year":"2017","journal-title":"Nat Rev Genet"},{"key":"2026080313313974000_vdag177-B27","doi-asserted-by":"publisher","first-page":"6334","DOI":"10.1093\/nar\/gkv598","article-title":"Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death","volume":"43","author":"Sun","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B28","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.dnarep.2016.05.022","article-title":"DNA damage processing at telomeres: the ends justify the means","volume":"44","author":"Fouquerel","year":"2016","journal-title":"DNA Repair (Amst)"},{"key":"2026080313313974000_vdag177-B29","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1038\/nsmb.3319","article-title":"Oxidative guanine base damage regulates human telomerase activity","volume":"23","author":"Fouquerel","year":"2016","journal-title":"Nat Struct Mol Biol"},{"key":"2026080313313974000_vdag177-B30","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1021\/acscentsci.5b00202","article-title":"A role for the fifth G-track in G-quadruplex forming oncogene promoter sequences during oxidative stress: do these \"spare tires\" have an evolved function?","volume":"1","author":"Fleming","year":"2015","journal-title":"ACS Cent Sci"},{"key":"2026080313313974000_vdag177-B31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1146\/annurev-genet-032918-021921","article-title":"Shelterin-mediated telomere protection","volume":"52","author":"de Lange","year":"2018","journal-title":"Annu Rev Genet"},{"key":"2026080313313974000_vdag177-B32","doi-asserted-by":"publisher","first-page":"6908","DOI":"10.1158\/0008-5472.CAN-06-1581","article-title":"The G-quadruplex ligand telomestatin inhibits POT1 binding to telomeric sequences in vitro and induces GFP-POT1 dissociation from telomeres in human cells","volume":"66","author":"Gomez","year":"2006","journal-title":"Cancer Res"},{"key":"2026080313313974000_vdag177-B33","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/j.cell.2012.03.030","article-title":"RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity","volume":"149","author":"Vannier","year":"2012","journal-title":"Cell"},{"key":"2026080313313974000_vdag177-B34","doi-asserted-by":"publisher","DOI":"10.3390\/genes8040112","article-title":"DNA replication origins and fork progression at Mammalian Telomeres","volume":"8","author":"Higa","year":"2017","journal-title":"Genes (Basel)"},{"key":"2026080313313974000_vdag177-B35","doi-asserted-by":"publisher","first-page":"5678","DOI":"10.3390\/cancers13225678","article-title":"Impact of chromatin dynamics and DNA repair on genomic stability and treatment resistance in pediatric high-grade gliomas","volume":"13","author":"Pinto","year":"2021","journal-title":"Cancers (Basel)"},{"key":"2026080313313974000_vdag177-B36","doi-asserted-by":"publisher","first-page":"3760","DOI":"10.1038\/s41467-021-24097-6","article-title":"TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells","volume":"12","author":"Silva","year":"2021","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B37","doi-asserted-by":"publisher","first-page":"5220","DOI":"10.1038\/ncomms6220","article-title":"RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells","volume":"5","author":"Arora","year":"2014","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B38","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/1873-3468.14844","article-title":"TERRA and the alternative lengthening of telomeres: a dangerous affair","volume":"599","author":"Azzalin","year":"2025","journal-title":"FEBS Lett"},{"key":"2026080313313974000_vdag177-B39","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1007\/s00401-016-1619-0","article-title":"Frequent alternative lengthening of telomeres and ATRX loss in adult NF1-associated diffuse and high-grade astrocytomas","volume":"132","author":"Rodriguez","year":"2016","journal-title":"Acta Neuropathol"},{"key":"2026080313313974000_vdag177-B40","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B41","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"2026080313313974000_vdag177-B42","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s41580-020-0257-5","article-title":"The plasticity of DNA replication forks in response to clinically relevant genotoxic stress","volume":"21","author":"Berti","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026080313313974000_vdag177-B43","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.molcel.2017.05.015","article-title":"ATM, ATR, and DNA-PK: the trinity at the heart of the DNA damage response","volume":"66","author":"Blackford","year":"2017","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B44","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nrm.2017.67","article-title":"The essential kinase ATR: ensuring faithful duplication of a challenging genome","volume":"18","author":"Saldivar","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026080313313974000_vdag177-B45","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310488","article-title":"The adaptive mechanisms and checkpoint responses to a stressed DNA replication fork","volume":"24","author":"Saldanha","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026080313313974000_vdag177-B46","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.pbiomolbio.2021.03.007","article-title":"Roles of ATM and ATR in DNA double strand breaks and replication stress","volume":"163","author":"Williams","year":"2021","journal-title":"Prog Biophys Mol Biol"},{"key":"2026080313313974000_vdag177-B47","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/j.molcel.2015.07.029","article-title":"Distinct but concerted roles of ATR, DNA-PK, and Chk1 in countering replication stress during S phase","volume":"59","author":"Buisson","year":"2015","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B48","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.1016\/j.molcel.2022.08.028","article-title":"DNA-PKcs promotes fork reversal and chemoresistance","volume":"82","author":"Dibitetto","year":"2022","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B49","doi-asserted-by":"publisher","first-page":"12889","DOI":"10.1038\/ncomms12889","article-title":"Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks","volume":"7","author":"Chanut","year":"2016","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B50","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.dnarep.2014.04.008","article-title":"DNA-PK phosphorylation of RPA32 Ser4\/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe","volume":"21","author":"Ashley","year":"2014","journal-title":"DNA Repair (Amst)"},{"key":"2026080313313974000_vdag177-B51","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.molcel.2017.05.001","article-title":"Replication catastrophe: when a checkpoint fails because of exhaustion","volume":"66","author":"Toledo","year":"2017","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B52","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1074\/jbc.M106287200","article-title":"S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function","volume":"277","author":"Cliby","year":"2002","journal-title":"J Biol Chem"},{"key":"2026080313313974000_vdag177-B53","doi-asserted-by":"publisher","first-page":"15201","DOI":"10.1074\/jbc.M110.101808","article-title":"Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison","volume":"285","author":"Sakasai","year":"2010","journal-title":"J Biol Chem"},{"key":"2026080313313974000_vdag177-B54","doi-asserted-by":"publisher","first-page":"103731","DOI":"10.1016\/j.dnarep.2024.103731","article-title":"Mechanisms and regulation of replication fork reversal","volume":"141","author":"Adolph","year":"2024","journal-title":"DNA Repair (Amst)"},{"key":"2026080313313974000_vdag177-B55","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.molcel.2021.01.012","article-title":"To skip or not to skip: choosing repriming to tolerate DNA damage","volume":"81","author":"Quinet","year":"2021","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B56","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.molcel.2017.01.031","article-title":"The SMX DNA repair tri-nuclease","volume":"65","author":"Wyatt","year":"2017","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B57","doi-asserted-by":"publisher","first-page":"e49367","DOI":"10.15252\/embr.201949367","article-title":"Homologous recombination and Mus81 promote replication completion in response to replication fork blockage","volume":"21","author":"Pardo","year":"2020","journal-title":"EMBO Rep"},{"key":"2026080313313974000_vdag177-B58","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.1038\/s41467-021-24665-w","article-title":"Abraxas suppresses DNA end resection and limits break-induced replication by controlling SLX4\/MUS81 chromatin loading in response to TOP1 inhibitor-induced DNA damage","volume":"12","author":"Wu","year":"2021","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B59","doi-asserted-by":"publisher","first-page":"5806","DOI":"10.1128\/MCB.02278-06","article-title":"The intra-S-phase checkpoint affects both DNA replication initiation and elongation: single-cell and -DNA fiber analyses","volume":"27","author":"Seiler","year":"2007","journal-title":"Mol Cell Biol"},{"key":"2026080313313974000_vdag177-B60","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.molcel.2024.10.032","article-title":"Repair of replication-dependent double-strand breaks differs between the leading and lagging strands","volume":"85","author":"Kimble","year":"2025","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B61","doi-asserted-by":"publisher","first-page":"eado3867","DOI":"10.1126\/science.ado3867","article-title":"Structure and repair of replication-coupled DNA breaks","volume":"385","author":"Pavani","year":"2024","journal-title":"Science (1979)"},{"key":"2026080313313974000_vdag177-B62","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.dnarep.2007.02.006","article-title":"DNA double-strand break repair: from mechanistic understanding to cancer treatment","volume":"6","author":"Helleday","year":"2007","journal-title":"DNA Repair (Amst)"},{"key":"2026080313313974000_vdag177-B63","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.tig.2022.03.011","article-title":"Break-induced replication: unraveling each step","volume":"38","author":"Liu","year":"2022","journal-title":"Trends Genet"},{"key":"2026080313313974000_vdag177-B64","doi-asserted-by":"publisher","first-page":"9710","DOI":"10.1093\/nar\/gkaa723","article-title":"ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaks","volume":"48","author":"Britton","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B65","doi-asserted-by":"publisher","first-page":"9906","DOI":"10.1093\/nar\/gkab785","article-title":"XAB2 promotes Ku eviction from single-ended DNA double-strand breaks independently of the ATM kinase","volume":"49","author":"Sharma","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B66","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nrm.2017.48","article-title":"Non-homologous DNA end joining and alternative pathways to double-strand break repair","volume":"18","author":"Chang","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026080313313974000_vdag177-B67","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/s41467-018-07729-2","article-title":"ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks","volume":"10","author":"Balmus","year":"2019","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B68","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.1158\/0008-5472.CAN-20-1672","article-title":"Exploiting the microhomology-mediated end-joining pathway in cancer therapy","volume":"80","author":"Patterson-Fortin","year":"2020","journal-title":"Cancer Res"},{"key":"2026080313313974000_vdag177-B69","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1016\/j.molcel.2026.02.016","article-title":"Microhomology-mediated end joining acts directly on replication forks to repair single-ended double-strand breaks","volume":"86","author":"Li","year":"2026","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B70","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12929-021-00743-5","article-title":"Histone dynamics during DNA replication stress","volume":"28","author":"Hsu","year":"2021","journal-title":"J Biomed Sci"},{"key":"2026080313313974000_vdag177-B71","doi-asserted-by":"publisher","first-page":"773426","DOI":"10.3389\/fgene.2021.773426","article-title":"Chromatin and nuclear dynamics in the maintenance of replication fork integrity","volume":"12","author":"Wootton","year":"2021","journal-title":"Front Genet"},{"key":"2026080313313974000_vdag177-B72","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.semcancer.2018.04.005","article-title":"DNA replication stress and its impact on chromosome segregation and tumorigenesis","volume":"55","author":"Zhang","year":"2019","journal-title":"Semin Cancer Biol"},{"key":"2026080313313974000_vdag177-B73","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/nrclinonc.2017.198","article-title":"Determinants and clinical implications of chromosomal instability in cancer","volume":"15","author":"Sansregret","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"2026080313313974000_vdag177-B74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gde.2014.03.003","article-title":"The origins and processing of ultra fine anaphase DNA bridges","volume":"26","author":"Liu","year":"2014","journal-title":"Curr Opin Genet Dev"},{"key":"2026080313313974000_vdag177-B75","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1038\/s12276-020-00529-z","article-title":"Small but mighty: the causes and consequences of micronucleus rupture","volume":"52","author":"Kwon","year":"2020","journal-title":"Exp Mol Med"},{"key":"2026080313313974000_vdag177-B76","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1016\/j.molcel.2023.08.023","article-title":"Completing genome replication outside of S phase","volume":"83","author":"Bhowmick","year":"2023","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B77","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1101\/sqb.2015.80.027649","article-title":"Resolution of recombination intermediates: mechanisms and regulation","volume":"80","author":"West","year":"2015","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"2026080313313974000_vdag177-B78","doi-asserted-by":"publisher","first-page":"102765","DOI":"10.18632\/oncotarget.22420","article-title":"SMX makes the cut in genome stability","volume":"8","author":"Wyatt","year":"2017","journal-title":"Oncotarget"},{"key":"2026080313313974000_vdag177-B79","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1042\/BST20220049","article-title":"Processing DNA lesions during mitosis to prevent genomic instability","volume":"50","author":"Audrey","year":"2022","journal-title":"Biochem Soc Trans"},{"key":"2026080313313974000_vdag177-B80","author":"Gaillard","year":"2017"},{"key":"2026080313313974000_vdag177-B81","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"2026080313313974000_vdag177-B82","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO classification of tumors of the central nervous system: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B83","doi-asserted-by":"publisher","first-page":"5562","DOI":"10.1158\/1078-0432.CCR-12-1773","article-title":"IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives","volume":"18","author":"Yang","year":"2012","journal-title":"Clin Cancer Res"},{"key":"2026080313313974000_vdag177-B84","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1101\/gad.217406.113","article-title":"What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer","volume":"27","author":"Losman","year":"2013","journal-title":"Genes Dev"},{"key":"2026080313313974000_vdag177-B85","doi-asserted-by":"publisher","first-page":"e0118781","DOI":"10.1371\/journal.pone.0118781","article-title":"Metabolic reprogramming in mutant IDH1 glioma cells","volume":"10","author":"Izquierdo-Garcia","year":"2015","journal-title":"PLoS One"},{"key":"2026080313313974000_vdag177-B86","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.15252\/emmm.201707729","article-title":"Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways","volume":"9","author":"Fack","year":"2017","journal-title":"EMBO Mol Med"},{"key":"2026080313313974000_vdag177-B87","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1038\/s41416-020-0814-x","article-title":"IDH mutation in glioma: molecular mechanisms and potential therapeutic targets","volume":"122","author":"Han","year":"2020","journal-title":"Br J Cancer"},{"key":"2026080313313974000_vdag177-B88","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fonc.2016.00016","article-title":"Genetics and epigenetics of glioblastoma: applications and overall incidence of IDH1 mutation","volume":"6","author":"Liu","year":"2016","journal-title":"Front Oncol"},{"key":"2026080313313974000_vdag177-B89","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.mrrev.2016.05.005","article-title":"DNA repair mechanisms and their clinical impact in glioblastoma","volume":"769","author":"Erasimus","year":"2016","journal-title":"Mutat Res Rev Mutat Res"},{"key":"2026080313313974000_vdag177-B90","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-020-2363-0","article-title":"Oncometabolites suppress DNA repair by disrupting local chromatin signalling","volume":"582","author":"Sulkowski","year":"2020","journal-title":"Nature"},{"key":"2026080313313974000_vdag177-B91","doi-asserted-by":"publisher","first-page":"zcab018","DOI":"10.1093\/narcan\/zcab018","article-title":"Targeting IDH1\/2 mutant cancers with combinations of ATR and PARP inhibitors","volume":"3","author":"Sule","year":"2021","journal-title":"NAR Cancer"},{"key":"2026080313313974000_vdag177-B92","doi-asserted-by":"publisher","author":"Tsai","year":"2026","DOI":"10.64898\/2026.04.14.715350"},{"key":"2026080313313974000_vdag177-B93","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/ncb3626","article-title":"EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation","volume":"19","author":"Rondinelli","year":"2017","journal-title":"Nat Cell Biol"},{"key":"2026080313313974000_vdag177-B94","doi-asserted-by":"publisher","first-page":"v369","DOI":"10.1093\/neuonc\/noaf201.1459","article-title":"EXTH-126. The H3K27M oncoprotein induces replication stress and ATR inhibitor sensitivity","volume":"27","author":"Pal","year":"2025","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B95","doi-asserted-by":"publisher","first-page":"e1009868","DOI":"10.1371\/journal.pgen.1009868","article-title":"The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma","volume":"17","author":"Bockaj","year":"2021","journal-title":"PLoS Genet"},{"key":"2026080313313974000_vdag177-B96","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.tig.2023.02.009","article-title":"ATRX, a guardian of chromatin","volume":"39","author":"Aguilera","year":"2023","journal-title":"Trends Genet"},{"key":"2026080313313974000_vdag177-B97","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/ng.3273","article-title":"Mutational landscape and clonal architecture in grade II and III gliomas","volume":"47","author":"Suzuki","year":"2015","journal-title":"Nat Genet"},{"key":"2026080313313974000_vdag177-B98","doi-asserted-by":"publisher","first-page":"110216","DOI":"10.1016\/j.celrep.2021.110216","article-title":"ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization","volume":"38","author":"Qin","year":"2022","journal-title":"Cell Rep"},{"key":"2026080313313974000_vdag177-B99","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf939","article-title":"ATRX cooperates with TOP2B for replication fork stability and DNA damage response through G-quadruplex regulation","volume":"53","author":"Pang","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B100","doi-asserted-by":"publisher","first-page":"1496","DOI":"10.1093\/nar\/gkw012","article-title":"New players in heterochromatin silencing: histone variant H3.3 and the ATRX\/DAXX chaperone","volume":"44","author":"Voon","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B101","doi-asserted-by":"publisher","first-page":"10227","DOI":"10.1093\/nar\/gkv847","article-title":"Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres","volume":"43","author":"Udugama","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B102","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/nature14345","article-title":"Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells","volume":"522","author":"Elsasser","year":"2015","journal-title":"Nature"},{"key":"2026080313313974000_vdag177-B103","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026567","article-title":"ATRX and DAXX: mechanisms and mutations","volume":"7","author":"Dyer","year":"2017","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2026080313313974000_vdag177-B104","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1093\/nar\/gkad1141","article-title":"DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks","volume":"52","author":"Pinto","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B105","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/s41467-019-08905-8","article-title":"G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma","volume":"10","author":"Wang","year":"2019","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B106","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1093\/neuonc\/noaf300","article-title":"SMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use alternative lengthening of telomeres","volume":"28","author":"Brown","year":"2026","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B107","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature10833","article-title":"Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma","volume":"482","author":"Schwartzentruber","year":"2012","journal-title":"Nature"},{"key":"2026080313313974000_vdag177-B108","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1126\/science.1207313","article-title":"Altered telomeres in tumors with ATRX and DAXX mutations","volume":"333","author":"Heaphy","year":"2011","journal-title":"Science (1979)"},{"key":"2026080313313974000_vdag177-B109","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.1038\/s41467-021-22543-z","article-title":"Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas","volume":"12","author":"Udugama","year":"2021","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B110","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/neuonc\/noac205","article-title":"Translational significance of CDKN2A\/B homozygous deletion in isocitrate dehydrogenase-mutant astrocytoma","volume":"25","author":"Fortin Ensign","year":"2023","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B111","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature07385","article-title":"Comprehensive genomic characterization defines human glioblastoma genes and core pathways","volume":"455","author":"Cancer Genome Atlas Research Network","year":"2008","journal-title":"Nature"},{"key":"2026080313313974000_vdag177-B112","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1002\/jmri.28743","article-title":"The 2021 WHO classification for gliomas and implications on imaging diagnosis: part 1-key points of the fifth edition and summary of imaging findings on adult-type diffuse gliomas","volume":"58","author":"Park","year":"2023","journal-title":"J Magn Reson Imaging"},{"key":"2026080313313974000_vdag177-B113","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N Engl J Med"},{"key":"2026080313313974000_vdag177-B114","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s11060-017-2564-z","article-title":"Treatment outcome of patients with recurrent glioblastoma multiforme: a retrospective multicenter analysis","volume":"135","author":"van Linde","year":"2017","journal-title":"J Neurooncol"},{"key":"2026080313313974000_vdag177-B115","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15174279","article-title":"Recurrent glioblastoma: a review of the treatment options","volume":"15","author":"Vaz-Salgado","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2026080313313974000_vdag177-B116","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1093\/neuonc\/noab269","article-title":"Cancer cell heterogeneity and plasticity: a paradigm shift in glioblastoma","volume":"24","author":"Yabo","year":"2022","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B117","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1093\/neuonc\/noae072","article-title":"DNA damage response in brain tumors: a society for neuro-oncology consensus review on mechanisms and translational efforts in neuro-oncology","volume":"26","author":"Rahman","year":"2024","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B118","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","article-title":"Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1","volume":"17","author":"Verhaak","year":"2010","journal-title":"Cancer Cell"},{"key":"2026080313313974000_vdag177-B119","doi-asserted-by":"publisher","DOI":"10.3390\/ph14070626","article-title":"Novel receptor tyrosine kinase pathway inhibitors for targeted radionuclide therapy of glioblastoma","volume":"14","author":"Bolcaen","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"2026080313313974000_vdag177-B120","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/s41392-025-02299-4","article-title":"Glioblastoma at the crossroads: current understanding and future therapeutic horizons","volume":"10","author":"Singh","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"2026080313313974000_vdag177-B121","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041831","article-title":"Receptor tyrosine kinase signaling and targeting in glioblastoma multiforme","volume":"22","author":"Tilak","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026080313313974000_vdag177-B122","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3892\/ol.2017.6221","article-title":"Epidermal growth factor receptor in glioblastoma","volume":"14","author":"Xu","year":"2017","journal-title":"Oncol Lett"},{"key":"2026080313313974000_vdag177-B123","doi-asserted-by":"publisher","first-page":"4252","DOI":"10.1158\/0008-5472.CAN-08-4853","article-title":"EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma","volume":"69","author":"Mukherjee","year":"2009","journal-title":"Cancer Res"},{"key":"2026080313313974000_vdag177-B124","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.radonc.2009.06.031","article-title":"Receptor signaling as a regulatory mechanism of DNA repair","volume":"92","author":"Meyn","year":"2009","journal-title":"Radiother Oncol"},{"key":"2026080313313974000_vdag177-B125","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1038\/s41388-020-1208-5","article-title":"EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma","volume":"39","author":"Struve","year":"2020","journal-title":"Oncogene"},{"key":"2026080313313974000_vdag177-B126","doi-asserted-by":"publisher","first-page":"e10767","DOI":"10.1371\/journal.pone.0010767","article-title":"Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy","volume":"5","author":"Nitta","year":"2010","journal-title":"PLoS One"},{"key":"2026080313313974000_vdag177-B127","doi-asserted-by":"publisher","first-page":"vdab180","DOI":"10.1093\/noajnl\/vdab180","article-title":"Increased replication stress and R-loop accumulation in EGFRvIII-expressing glioblastoma present new therapeutic opportunities","volume":"4","author":"Struve","year":"2022","journal-title":"Neurooncol Adv"},{"key":"2026080313313974000_vdag177-B128","doi-asserted-by":"publisher","first-page":"13057","DOI":"10.1093\/nar\/gkae938","article-title":"EGFR-mediated HSP70 phosphorylation facilitates PCNA association with chromatin and DNA replication","volume":"52","author":"Wang","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B129","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41573-019-0046-z","article-title":"Synthetic lethality as an engine for cancer drug target discovery","volume":"19","author":"Huang","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"2026080313313974000_vdag177-B130","doi-asserted-by":"publisher","first-page":"31182","DOI":"10.1074\/jbc.M506591200","article-title":"Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase","volume":"280","author":"Dittmann","year":"2005","journal-title":"J Biol Chem"},{"key":"2026080313313974000_vdag177-B131","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1016\/j.dnarep.2008.06.017","article-title":"PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro","volume":"7","author":"Toulany","year":"2008","journal-title":"DNA Repair (Amst)"},{"key":"2026080313313974000_vdag177-B132","doi-asserted-by":"publisher","first-page":"701291","DOI":"10.3389\/fonc.2021.701291","article-title":"Targeting glioblastoma stem cells: a review on biomarkers, signal pathways and targeted therapy","volume":"11","author":"Tang","year":"2021","journal-title":"Front Oncol"},{"key":"2026080313313974000_vdag177-B133","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1101\/gad.324301.119","article-title":"Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer","volume":"33","author":"Gimple","year":"2019","journal-title":"Genes Dev"},{"key":"2026080313313974000_vdag177-B134","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.cell.2019.06.024","article-title":"An integrative model of cellular states, plasticity, and genetics for glioblastoma","volume":"178","author":"Neftel","year":"2019","journal-title":"Cell"},{"key":"2026080313313974000_vdag177-B135","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/s41588-021-00926-8","article-title":"Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response","volume":"53","author":"Johnson","year":"2021","journal-title":"Nat Genet"},{"key":"2026080313313974000_vdag177-B136","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1093\/annonc\/mdx169","article-title":"Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma","volume":"28","author":"Qazi","year":"2017","journal-title":"Ann Oncol"},{"key":"2026080313313974000_vdag177-B137","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.stemcr.2014.11.003","article-title":"Genetic and functional diversity of propagating cells in glioblastoma","volume":"4","author":"Piccirillo","year":"2015","journal-title":"Stem Cell Reports"},{"key":"2026080313313974000_vdag177-B138","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1126\/science.1254257","article-title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","volume":"344","author":"Patel","year":"2014","journal-title":"Science"},{"key":"2026080313313974000_vdag177-B139","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/nature05236","article-title":"Glioma stem cells promote radioresistance by preferential activation of the DNA damage response","volume":"444","author":"Bao","year":"2006","journal-title":"Nature"},{"key":"2026080313313974000_vdag177-B140","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.molonc.2014.08.003","article-title":"Abrogation of radioresistance in glioblastoma stem-like cells by inhibition of ATM kinase","volume":"9","author":"Carruthers","year":"2015","journal-title":"Mol Oncol"},{"key":"2026080313313974000_vdag177-B141","doi-asserted-by":"publisher","first-page":"5095","DOI":"10.1038\/onc.2010.249","article-title":"Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas","volume":"29","author":"Bartkova","year":"2010","journal-title":"Oncogene"},{"key":"2026080313313974000_vdag177-B142","doi-asserted-by":"publisher","first-page":"5060","DOI":"10.1158\/0008-5472.CAN-18-0569","article-title":"Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells","volume":"78","author":"Carruthers","year":"2018","journal-title":"Cancer Res"},{"key":"2026080313313974000_vdag177-B143","doi-asserted-by":"publisher","first-page":"13398","DOI":"10.1038\/ncomms13398","article-title":"BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity","volume":"7","author":"Rasmussen","year":"2016","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B144","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1056\/NEJMoa043331","article-title":"MGMT gene silencing and benefit from temozolomide in glioblastoma","volume":"352","author":"Hegi","year":"2005","journal-title":"N Engl J Med"},{"key":"2026080313313974000_vdag177-B145","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1073\/pnas.1720355115","article-title":"ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage","volume":"115","author":"Gupta","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080313313974000_vdag177-B146","doi-asserted-by":"publisher","first-page":"168","DOI":"10.4161\/cc.9.1.10363","article-title":"Processing of O6-methylguanine into DNA double-strand breaks requires two rounds of replication whereas apoptosis is also induced in subsequent cell cycles","volume":"9","author":"Quiros","year":"2010","journal-title":"Cell Cycle"},{"key":"2026080313313974000_vdag177-B147","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1083\/jcb.201312078","article-title":"DNA breaks and chromosomal aberrations arise when replication meets base excision repair","volume":"206","author":"Ensminger","year":"2014","journal-title":"J Cell Biol"},{"key":"2026080313313974000_vdag177-B148","doi-asserted-by":"publisher","first-page":"eade7236","DOI":"10.1126\/sciadv.ade7236","article-title":"Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production","volume":"9","author":"Perrault","year":"2023","journal-title":"Sci Adv"},{"key":"2026080313313974000_vdag177-B149","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1158\/2159-8290.CD-14-0157","article-title":"ATM regulates 3-methylpurine-DNA glycosylase and promotes therapeutic resistance to alkylating agents","volume":"4","author":"Agnihotri","year":"2014","journal-title":"Cancer Discov"},{"key":"2026080313313974000_vdag177-B150","doi-asserted-by":"publisher","first-page":"5294","DOI":"10.1038\/s41467-024-49316-8","article-title":"ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma","volume":"15","author":"Laverty","year":"2024","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B151","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/00005072-200606000-00001","article-title":"Pseudopalisading\u2019 necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis","volume":"65","author":"Rong","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"2026080313313974000_vdag177-B152","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ccr.2006.11.020","article-title":"A perivascular niche for brain tumor stem cells","volume":"11","author":"Calabrese","year":"2007","journal-title":"Cancer Cell"},{"key":"2026080313313974000_vdag177-B153","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1002\/glia.20334","article-title":"Transplanted glioma cells migrate and proliferate on host brain vasculature: a dynamic analysis","volume":"53","author":"Farin","year":"2006","journal-title":"Glia"},{"key":"2026080313313974000_vdag177-B154","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17010015","article-title":"Pericytes in glioblastoma: hidden regulators of tumor vasculature and therapy resistance","volume":"17","author":"Salazar-Saura","year":"2024","journal-title":"Cancers (Basel)"},{"key":"2026080313313974000_vdag177-B155","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1093\/neuonc\/nox058","article-title":"Blood-brain barrier pericyte importance in malignant gliomas: what we can learn from stroke and Alzheimer\u2019s disease","volume":"19","author":"Jackson","year":"2017","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B156","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1111\/nan.12714","article-title":"TGF-beta activates pericytes via induction of the epithelial-to-mesenchymal transition protein SLUG in glioblastoma","volume":"47","author":"Wirsik","year":"2021","journal-title":"Neuropathol Appl Neurobiol"},{"key":"2026080313313974000_vdag177-B157","doi-asserted-by":"publisher","first-page":"4","DOI":"10.17879\/freeneuropathology-2024-5188","article-title":"Blocking TGF-beta- and Epithelial-to-Mesenchymal Transition (EMT)-mediated activation of vessel-associated mural cells in glioblastoma impacts tumor angiogenesis","volume":"5","author":"Merk","year":"2024","journal-title":"Free Neuropathol"},{"key":"2026080313313974000_vdag177-B158","doi-asserted-by":"publisher","first-page":"24041","DOI":"10.18632\/oncotarget.25275","article-title":"Pericytes\/vessel-associated mural cells (VAMCs) are the major source of key epithelial-mesenchymal transition (EMT) factors SLUG and TWIST in human glioma","volume":"9","author":"Mader","year":"2018","journal-title":"Oncotarget"},{"key":"2026080313313974000_vdag177-B159","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/s41422-021-00528-3","article-title":"Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling","volume":"31","author":"Zhang","year":"2021","journal-title":"Cell Res"},{"key":"2026080313313974000_vdag177-B160","doi-asserted-by":"publisher","DOI":"10.3390\/cells14141057","article-title":"Influence of hypoxia on tumor heterogeneity, DNA repair, and cancer therapy: from molecular insights to therapeutic strategies","volume":"14","author":"Kunachowicz","year":"2025","journal-title":"Cells"},{"key":"2026080313313974000_vdag177-B161","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1158\/0008-5472.CAN-09-2715","article-title":"Effects of acute versus chronic hypoxia on DNA damage responses and genomic instability","volume":"70","author":"Pires","year":"2010","journal-title":"Cancer Res"},{"key":"2026080313313974000_vdag177-B162","doi-asserted-by":"publisher","first-page":"1563","DOI":"10.1111\/febs.14377","article-title":"Challenges to DNA replication in hypoxic conditions","volume":"285","author":"Ng","year":"2018","journal-title":"Febs J"},{"key":"2026080313313974000_vdag177-B163","doi-asserted-by":"publisher","first-page":"11584","DOI":"10.1093\/nar\/gkad858","article-title":"Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops","volume":"51","author":"Ma","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B164","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1158\/0008-5472.CAN-13-3131","article-title":"Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone","volume":"75","author":"Piccirillo","year":"2015","journal-title":"Cancer Res"},{"key":"2026080313313974000_vdag177-B165","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s13287-023-03325-4","article-title":"Targeting the neural stem cells in subventricular zone for the treatment of glioblastoma: an update from preclinical evidence to clinical interventions","volume":"14","author":"Li","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"2026080313313974000_vdag177-B166","doi-asserted-by":"publisher","first-page":"614930","DOI":"10.3389\/fonc.2020.614930","article-title":"The subventricular zone, a hideout for adult and pediatric high-grade glioma stem cells","volume":"10","author":"Lombard","year":"2020","journal-title":"Front Oncol"},{"key":"2026080313313974000_vdag177-B167","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1093\/neuonc\/now136","article-title":"CXCL12 mediates glioblastoma resistance to radiotherapy in the subventricular zone","volume":"19","author":"Goffart","year":"2017","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B168","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1093\/neuonc\/nou144","article-title":"Adult mouse subventricular zones stimulate glioblastoma stem cells specific invasion through CXCL12\/CXCR4 signaling","volume":"17","author":"Goffart","year":"2015","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B169","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41388-018-0437-3","article-title":"Aurora a plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration","volume":"38","author":"Willems","year":"2019","journal-title":"Oncogene"},{"key":"2026080313313974000_vdag177-B170","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.cell.2017.07.016","article-title":"Neural precursor-derived pleiotrophin mediates subventricular zone invasion by glioma","volume":"170","author":"Qin","year":"2017","journal-title":"Cell"},{"key":"2026080313313974000_vdag177-B171","doi-asserted-by":"publisher","first-page":"115149","DOI":"10.1016\/j.celrep.2024.115149","article-title":"Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma","volume":"44","author":"Licon-Munoz","year":"2025","journal-title":"Cell Rep"},{"key":"2026080313313974000_vdag177-B172","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1093\/carcin\/bgz151","article-title":"MKP1 phosphatase is recruited by CXCL12 in glioblastoma cells and plays a role in DNA strand breaks repair","volume":"41","author":"Dedobbeleer","year":"2020","journal-title":"Carcinogenesis"},{"key":"2026080313313974000_vdag177-B173","doi-asserted-by":"publisher","first-page":"670","DOI":"10.3389\/fonc.2020.00670","article-title":"Replication fork remodeling and therapy escape in DNA damage response-deficient cancers","volume":"10","author":"Liptay","year":"2020","journal-title":"Front Oncol"},{"key":"2026080313313974000_vdag177-B174","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.trecan.2020.10.010","article-title":"Beyond kinases: targeting replication stress proteins in cancer therapy","volume":"7","author":"Baillie","year":"2021","journal-title":"Trends Cancer"},{"key":"2026080313313974000_vdag177-B175","doi-asserted-by":"publisher","first-page":"838637","DOI":"10.3389\/fonc.2022.838637","article-title":"Replication stress: a review of novel targets to enhance radiosensitivity-from bench to clinic","volume":"12","author":"Zhang","year":"2022","journal-title":"Front Oncol"},{"key":"2026080313313974000_vdag177-B176","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/s41420-025-02418-8","article-title":"Perspectives on cancer therapy-synthetic lethal precision medicine strategies, molecular mechanisms, therapeutic targets and current technical challenges","volume":"11","author":"Peng","year":"2025","journal-title":"Cell Death Discov"},{"key":"2026080313313974000_vdag177-B177","doi-asserted-by":"publisher","first-page":"3204","DOI":"10.3390\/biom5043204","article-title":"DNA damage signalling and repair inhibitors: the long-sought-after achilles\u2019 heel of cancer","volume":"5","author":"Velic","year":"2015","journal-title":"Biomolecules"},{"key":"2026080313313974000_vdag177-B178","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/s41392-020-00358-6","article-title":"Development of synthetic lethality in cancer: molecular and cellular classification","volume":"5","author":"Li","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"2026080313313974000_vdag177-B179","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1038\/s41571-018-0055-6","article-title":"Synthetic lethal therapies for cancer: what\u2019s next after PARP inhibitors?","volume":"15","author":"Ashworth","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"key":"2026080313313974000_vdag177-B180","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.3389\/fonc.2019.01388","article-title":"Harnessing DNA double-strand break repair for cancer treatment","volume":"9","author":"Trenner","year":"2019","journal-title":"Front Oncol"},{"key":"2026080313313974000_vdag177-B181","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41586-024-07217-2","article-title":"Transcription-replication conflicts underlie sensitivity to PARP inhibitors","volume":"628","author":"Petropoulos","year":"2024","journal-title":"Nature"},{"key":"2026080313313974000_vdag177-B182","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/s41571-021-00532-x","article-title":"Understanding and overcoming resistance to PARP inhibitors in cancer therapy","volume":"18","author":"Dias","year":"2021","journal-title":"Nat Rev Clin Oncol"},{"key":"2026080313313974000_vdag177-B183","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41392-023-01548-8","article-title":"A new wave of innovations within the DNA damage response","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026080313313974000_vdag177-B184","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s11523-023-00970-w","article-title":"PARP inhibitors in ovarian cancer: a review","volume":"18","author":"O\u2019Malley","year":"2023","journal-title":"Target Oncol"},{"key":"2026080313313974000_vdag177-B185","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41571-018-0114-z","article-title":"State-of-the-art strategies for targeting the DNA damage response in cancer","volume":"16","author":"Pilie","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"2026080313313974000_vdag177-B186","doi-asserted-by":"publisher","first-page":"e788","DOI":"10.1002\/mco2.788","article-title":"Targeting the DNA damage response in cancer","volume":"5","author":"Federica","year":"2024","journal-title":"MedComm (2020)"},{"key":"2026080313313974000_vdag177-B187","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/s12957-025-04101-9","article-title":"Research progress of DNA damage repair (DDR) and DDR inhibitors in tumor immunotherapy","volume":"23","author":"Liu","year":"2025","journal-title":"World J Surg Oncol"},{"key":"2026080313313974000_vdag177-B188","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41573-024-01060-w","article-title":"DNA damage response inhibitors in cancer therapy: lessons from the past, current status and future implications","volume":"24","author":"Drew","year":"2025","journal-title":"Nat Rev Drug Discov"},{"key":"2026080313313974000_vdag177-B189","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18632\/oncotarget.28551","article-title":"ATR inhibition using gartisertib enhances cell death and synergises with temozolomide and radiation in patient-derived glioblastoma cell lines","volume":"15","author":"Lozinski","year":"2024","journal-title":"Oncotarget"},{"key":"2026080313313974000_vdag177-B190","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1093\/neuonc\/noad210","article-title":"Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalization via macropinocytosis","volume":"26","author":"Derby","year":"2024","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B191","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14123015","article-title":"Therapeutic vulnerability to ATR inhibition in concurrent NF1 and ATRX-deficient\/ALT-positive high-grade solid tumors","volume":"14","author":"Yuan","year":"2022","journal-title":"Cancers (Basel)"},{"key":"2026080313313974000_vdag177-B192","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1093\/neuonc\/noad064","article-title":"ATM inhibition enhances the efficacy of radiation across distinct molecular subgroups of pediatric high-grade glioma","volume":"25","author":"Xie","year":"2023","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B193","doi-asserted-by":"publisher","first-page":"4416","DOI":"10.1158\/0008-5472.CAN-14-3790","article-title":"Selective inhibition of parallel DNA damage response pathways optimizes radiosensitization of glioblastoma stem-like cells","volume":"75","author":"Ahmed","year":"2015","journal-title":"Cancer Res"},{"key":"2026080313313974000_vdag177-B194","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1093\/neuonc\/noaf102","article-title":"The novel brain penetrant ataxia-telangiectasia mutated inhibitor WSD0628 provides robust radiosensitization of brain tumor patient-derived xenografts","volume":"27","author":"Xue","year":"2025","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B195","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1124\/jpet.123.001971","article-title":"Preclinical systemic pharmacokinetics, dose proportionality, and central nervous system distribution of the ATM inhibitor WSD0628, a novel radiosensitizer for the treatment of brain tumors","volume":"390","author":"Rathi","year":"2024","journal-title":"J Pharmacol Exp Ther"},{"key":"2026080313313974000_vdag177-B196","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/s41419-025-08226-3","article-title":"LMNA-PRKDC axis enhances DNA repair and promotes chemoresistance in glioblastoma","volume":"17","author":"Saathoff","year":"2025","journal-title":"Cell Death Dis"},{"key":"2026080313313974000_vdag177-B197","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abc7275","article-title":"Inhibiting DNA-PK induces glioma stem cell differentiation and sensitizes glioblastoma to radiation in mice","volume":"13","author":"Fang","year":"2021","journal-title":"Sci Transl Med"},{"key":"2026080313313974000_vdag177-B198","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1158\/1535-7163.MCT-24-0003","article-title":"DNA-PK inhibition shows differential radiosensitization in orthotopic GBM PDX models based on DDR pathway deficits","volume":"24","author":"Dragojevic","year":"2025","journal-title":"Mol Cancer Ther"},{"key":"2026080313313974000_vdag177-B199","doi-asserted-by":"publisher","first-page":"5524","DOI":"10.1200\/JCO.23.00493","article-title":"Inaugural results of the individualized screening trial of innovative glioblastoma therapy: a phase II platform trial for newly diagnosed glioblastoma using bayesian adaptive randomization","volume":"41","author":"Rahman","year":"2023","journal-title":"J Clin Oncol"},{"key":"2026080313313974000_vdag177-B200","doi-asserted-by":"publisher","first-page":"379","DOI":"10.4161\/cbt.19240","article-title":"Enhancing CHK1 inhibitor lethality in glioblastoma","volume":"13","author":"Tang","year":"2012","journal-title":"Cancer Biol Ther"},{"key":"2026080313313974000_vdag177-B201","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1186\/s13046-019-1434-2","article-title":"The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment","volume":"38","author":"Patties","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"2026080313313974000_vdag177-B202","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23137051","article-title":"Chronically radiation-exposed survivor glioblastoma cells display poor response to Chk1 inhibition under hypoxia","volume":"23","author":"Pinarbasi-Degirmenci","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026080313313974000_vdag177-B203","doi-asserted-by":"publisher","first-page":"e1223","DOI":"10.1038\/cddis.2014.188","article-title":"Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo","volume":"5","author":"Signore","year":"2014","journal-title":"Cell Death Dis"},{"key":"2026080313313974000_vdag177-B204","doi-asserted-by":"publisher","first-page":"9101","DOI":"10.1021\/acs.jmedchem.5c00279","article-title":"Discovery of a potent, selective, and brain-penetrant checkpoint kinase 1 inhibitor, BEN-28010, for the treatment of glioblastoma","volume":"68","author":"Rawling","year":"2025","journal-title":"J Med Chem"},{"key":"2026080313313974000_vdag177-B205","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1038\/s41467-023-36878-2","article-title":"Checkpoint kinase 1\/2 inhibition potentiates anti-tumoral immune response and sensitizes gliomas to immune checkpoint blockade","volume":"14","author":"Dmello","year":"2023","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B206","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1093\/neuonc\/noaf227","article-title":"YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas","volume":"28","author":"Ali","year":"2026","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B207","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1158\/1078-0432.CCR-14-2588","article-title":"The efficacy of the Wee1 inhibitor MK-1775 combined with temozolomide is limited by heterogeneous distribution across the blood-brain barrier in glioblastoma","volume":"21","author":"Pokorny","year":"2015","journal-title":"Clin Cancer Res"},{"key":"2026080313313974000_vdag177-B208","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13014-023-02210-x","article-title":"G2 checkpoint targeting via Wee1 inhibition radiosensitizes EGFRvIII-positive glioblastoma cells","volume":"18","author":"Cetin","year":"2023","journal-title":"Radiat Oncol"},{"key":"2026080313313974000_vdag177-B209","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1158\/1078-0432.CCR-24-2311","article-title":"Phase I study of adavosertib with radiotherapy and temozolomide in newly diagnosed glioblastoma and intratumoral drug levels in recurrent glioblastoma","volume":"31","author":"Lee","year":"2025","journal-title":"Clin Cancer Res"},{"key":"2026080313313974000_vdag177-B210","doi-asserted-by":"publisher","first-page":"103093","DOI":"10.1016\/j.tice.2025.103093","article-title":"Combined inhibition of WEE1 by AZD1775 synergistically enhances CX-5461 mediated DNA damage and induces cytotoxicity in glioblastoma","volume":"97","author":"Cheng","year":"2025","journal-title":"Tissue Cell"},{"key":"2026080313313974000_vdag177-B211","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1038\/s41419-023-06167-3","article-title":"Targeted inhibition of the methyltransferase SETD8 synergizes with the Wee1 inhibitor adavosertib in restraining glioblastoma growth","volume":"14","author":"Della Monica","year":"2023","journal-title":"Cell Death Dis"},{"key":"2026080313313974000_vdag177-B212","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.1158\/1535-7163.MCT-11-0469","article-title":"Targeting radiation-induced G(2) checkpoint activation with the Wee-1 inhibitor MK-1775 in glioblastoma cell lines","volume":"10","author":"Sarcar","year":"2011","journal-title":"Mol Cancer Ther"},{"key":"2026080313313974000_vdag177-B213","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.tranon.2018.01.003","article-title":"CDC7-dependent transcriptional regulation of RAD54L is essential for tumorigenicity and radio-resistance of glioblastoma","volume":"11","author":"Li","year":"2018","journal-title":"Transl Oncol"},{"key":"2026080313313974000_vdag177-B214","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s12935-016-0364-8","article-title":"Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness","volume":"16","author":"Erbayraktar","year":"2016","journal-title":"Cancer Cell Int"},{"key":"2026080313313974000_vdag177-B215","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1093\/neuonc\/noad252","article-title":"Abrogation of the G2\/M checkpoint as a chemosensitization approach for alkylating agents","volume":"26","author":"Lang","year":"2024","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B216","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.bbagrm.2018.10.005","article-title":"Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression","volume":"1861","author":"Melhuish","year":"2018","journal-title":"Biochim Biophys Acta Gene Regul Mech"},{"key":"2026080313313974000_vdag177-B217","doi-asserted-by":"publisher","first-page":"216308","DOI":"10.1016\/j.canlet.2023.216308","article-title":"Inhibition of RRM2 radiosensitizes glioblastoma and uncovers synthetic lethality in combination with targeting CHK1","volume":"570","author":"Corrales-Guerrero","year":"2023","journal-title":"Cancer Lett"},{"key":"2026080313313974000_vdag177-B218","doi-asserted-by":"publisher","first-page":"84671","DOI":"10.18632\/oncotarget.19404","article-title":"Glioblastoma and glioblastoma stem cells are dependent on functional MTH1","volume":"8","author":"Pudelko","year":"2017","journal-title":"Oncotarget"},{"key":"2026080313313974000_vdag177-B219","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051588","article-title":"Replication protein A (RPA) mediates radio-resistance of glioblastoma cancer stem-like cells","volume":"21","author":"Pedersen","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026080313313974000_vdag177-B220","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25179134","article-title":"Poltheta inhibitor (ART558) demonstrates a synthetic lethal effect with PARP and RAD52 inhibitors in glioblastoma cells","volume":"25","author":"Barszczewska-Pietraszek","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026080313313974000_vdag177-B221","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32100541","article-title":"Phase Ib\/II study of pamiparib plus radiation therapy and\/or temozolomide in adult patients with treatment-naive or recurrent\/refractory glioblastoma","volume":"32","author":"Piotrowski","year":"2025","journal-title":"Curr Oncol"},{"key":"2026080313313974000_vdag177-B222","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1158\/1078-0432.CCR-19-2549","article-title":"EGFR amplification induces increased DNA damage response and renders selective sensitivity to talazoparib (PARP inhibitor) in glioblastoma","volume":"26","author":"Wu","year":"2020","journal-title":"Clin Cancer Res"},{"key":"2026080313313974000_vdag177-B223","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1038\/s41467-019-10993-5","article-title":"Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma","volume":"10","author":"Ning","year":"2019","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B224","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1200\/JCO.2023.41.16_suppl.2069","article-title":"A phase 0\/2 trigger trial of niraparib in patients with newly diagnosed glioblastoma","volume":"41","author":"Mehta","year":"2023","journal-title":"JCO"},{"key":"2026080313313974000_vdag177-B225","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.canlet.2020.06.023","article-title":"Sustained inhibition of PARP-1 activity delays glioblastoma recurrence by enhancing radiation-induced senescence","volume":"490","author":"Ghorai","year":"2020","journal-title":"Cancer Lett"},{"key":"2026080313313974000_vdag177-B226","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ctro.2017.11.003","article-title":"PARADIGM-2: two parallel phase I studies of olaparib and radiotherapy or olaparib and radiotherapy plus temozolomide in patients with newly diagnosed glioblastoma, with treatment stratified by MGMT status","volume":"8","author":"Fulton","year":"2018","journal-title":"Clin Transl Radiat Oncol"},{"key":"2026080313313974000_vdag177-B227","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1748-717X-8-65","article-title":"Evaluation of poly (ADP-ribose) polymerase inhibitor ABT-888 combined with radiotherapy and temozolomide in glioblastoma","volume":"8","author":"Barazzuol","year":"2013","journal-title":"Radiat Oncol"},{"key":"2026080313313974000_vdag177-B228","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1001\/jamaoncol.2024.4361","article-title":"Efficacy of adding veliparib to temozolomide for patients with MGMT-methylated glioblastoma: a randomized clinical trial","volume":"10","author":"Sarkaria","year":"2024","journal-title":"JAMA Oncol"},{"key":"2026080313313974000_vdag177-B229","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s41419-021-03805-6","article-title":"BKM120 sensitizes glioblastoma to the PARP inhibitor rucaparib by suppressing homologous recombination repair","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis"},{"key":"2026080313313974000_vdag177-B230","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14020289","article-title":"ATX-101, a peptide targeting PCNA, has antitumor efficacy alone or in combination with radiotherapy in murine models of human glioblastoma","volume":"14","author":"Gravina","year":"2022","journal-title":"Cancers (Basel)"},{"key":"2026080313313974000_vdag177-B231","doi-asserted-by":"publisher","first-page":"zcab044","DOI":"10.1093\/narcan\/zcab044","article-title":"NAD(+) bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells","volume":"3","author":"Li","year":"2021","journal-title":"NAR Cancer"},{"key":"2026080313313974000_vdag177-B232","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1186\/s12885-016-2647-9","article-title":"A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells","volume":"16","author":"Balbous","year":"2016","journal-title":"BMC Cancer"},{"key":"2026080313313974000_vdag177-B233","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.stemcr.2016.12.005","article-title":"RAD51 is a selective DNA repair target to radiosensitize glioma stem cells","volume":"8","author":"King","year":"2017","journal-title":"Stem Cell Reports"},{"key":"2026080313313974000_vdag177-B234","doi-asserted-by":"publisher","first-page":"103715","DOI":"10.1016\/j.dnarep.2024.103715","article-title":"Human translesion DNA polymerases iota and kappa mediate tolerance to temozolomide in MGMT-deficient glioblastoma cells","volume":"141","author":"Latancia","year":"2024","journal-title":"DNA Repair (Amst)"},{"key":"2026080313313974000_vdag177-B235","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1038\/s41467-024-45979-5","article-title":"Trans-lesion synthesis and mismatch repair pathway crosstalk defines chemoresistance and hypermutation mechanisms in glioblastoma","volume":"15","author":"Cheng","year":"2024","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B236","doi-asserted-by":"publisher","author":"Brakel","year":"2025","DOI":"10.1101\/2025.06.18.660339"},{"key":"2026080313313974000_vdag177-B237","doi-asserted-by":"publisher","first-page":"117634","DOI":"10.1016\/j.biopha.2024.117634","article-title":"The cell cycle inhibitor p21(CIP1) is essential for irinotecan-induced senescence and plays a decisive role in re-sensitization of temozolomide-resistant glioblastoma cells to irinotecan","volume":"181","author":"Sallbach","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"2026080313313974000_vdag177-B238","doi-asserted-by":"publisher","first-page":"vdad102","DOI":"10.1093\/noajnl\/vdad102","article-title":"Combined inhibition of topoisomerase I and poly(ADP-ribose) polymerase: a synergistic therapeutic strategy for glioblastoma with phosphatase and tensin homolog deficiency","volume":"5","author":"Kim","year":"2023","journal-title":"Neurooncol Adv"},{"key":"2026080313313974000_vdag177-B239","doi-asserted-by":"publisher","first-page":"105144","DOI":"10.1016\/j.critrevonc.2026.105144","article-title":"Innovative approaches to irinotecan-based therapies for glioblastoma: advancements in drug delivery and combination strategies","volume":"219","author":"Hsu","year":"2026","journal-title":"Crit Rev Oncol Hematol"},{"key":"2026080313313974000_vdag177-B240","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16173008","article-title":"Local delivery of irinotecan to recurrent GBM patients at reoperation offers a safe route of administration","volume":"16","author":"McConville","year":"2024","journal-title":"Cancers (Basel)"},{"key":"2026080313313974000_vdag177-B241","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s11060-025-05415-0","article-title":"Bevacizumab combined with irinotecan or temozolomide in recurrent glioblastoma: a Turkish Oncology Group (TOG) study","volume":"176","author":"Akbas","year":"2026","journal-title":"J Neurooncol"},{"key":"2026080313313974000_vdag177-B242","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s11060-008-9774-3","article-title":"Topotecan in combination with radiotherapy in unresectable glioblastoma: a phase 2 study","volume":"93","author":"Lesimple","year":"2009","journal-title":"J Neurooncol"},{"key":"2026080313313974000_vdag177-B243","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s11060-011-0758-3","article-title":"Higher topoisomerase 2 alpha gene transcript levels predict better prognosis in GBM patients receiving temozolomide chemotherapy: identification of temozolomide as a TOP2A inhibitor","volume":"107","author":"Arivazhagan","year":"2012","journal-title":"J Neurooncol"},{"key":"2026080313313974000_vdag177-B244","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1093\/neuonc\/nou026","article-title":"Convection-enhanced delivery of etoposide is effective against murine proneural glioblastoma","volume":"16","author":"Sonabend","year":"2014","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B245","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1017\/cjn.2023.276","article-title":"The value of etoposide for recurrent glioma","volume":"51","author":"van der Meulen","year":"2024","journal-title":"Can J Neurol Sci"},{"key":"2026080313313974000_vdag177-B246","doi-asserted-by":"publisher","first-page":"101706","DOI":"10.1016\/j.xcrm.2024.101706","article-title":"Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma","volume":"5","author":"Zhong","year":"2024","journal-title":"Cell Rep Med"},{"key":"2026080313313974000_vdag177-B247","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1093\/neuonc\/nov091","article-title":"USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistance","volume":"18","author":"Lee","year":"2016","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B248","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101416","article-title":"Tyrosyl-DNA phosphodiesterase 1 and topoisomerase I activities as predictive indicators for glioblastoma susceptibility to genotoxic agents","volume":"11","author":"Wang","year":"2019","journal-title":"Cancers (Basel)"},{"key":"2026080313313974000_vdag177-B249","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1093\/neuonc\/noaa104","article-title":"Pharmacokinetics, safety, and tolerability of olaparib and temozolomide for recurrent glioblastoma: results of the phase I OPARATIC trial","volume":"22","author":"Hanna","year":"2020","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B250","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1016\/j.ijrobp.2024.01.011","article-title":"Concurrent olaparib and radiation therapy in older patients with newly diagnosed glioblastoma: the phase 1 dose-escalation PARADIGM trial","volume":"118","author":"Derby","year":"2024","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2026080313313974000_vdag177-B251","doi-asserted-by":"publisher","first-page":"33670","DOI":"10.1038\/s41598-025-18255-9","article-title":"Assessment of brain penetration and tumor accumulation of niraparib and olaparib: insights from multimodal imaging in preclinical models","volume":"15","author":"Groseclose","year":"2025","journal-title":"Sci Rep"},{"key":"2026080313313974000_vdag177-B252","doi-asserted-by":"publisher","first-page":"vii73","DOI":"10.1093\/neuonc\/noac209.280","article-title":"CTNI-14. A phase 0 \u2018trigger\u2019 trial of niraparib in newly-diagnosed glioblastoma patients","volume":"24","author":"Nader Sanai","year":"2022","journal-title":"Neuro Oncol."},{"key":"2026080313313974000_vdag177-B253","doi-asserted-by":"publisher","first-page":"v84","DOI":"10.1093\/neuonc\/noad179.0324","article-title":"CTNI-42. PHASE I clinical trial of peposertib plus radiation in newly diagnosed mgmt-unmethylated glioblastoma","volume":"25","author":"azanin Majd","year":"2023","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B254","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1158\/1535-7163.MCT-09-0463","article-title":"Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents","volume":"8","author":"Hirai","year":"2009","journal-title":"Mol Cancer Ther"},{"key":"2026080313313974000_vdag177-B255","doi-asserted-by":"publisher","first-page":"eadj5962","DOI":"10.1126\/scitranslmed.adj5962","article-title":"Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization","volume":"16","author":"Chen","year":"2024","journal-title":"Sci Transl Med"},{"key":"2026080313313974000_vdag177-B256","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s40478-025-02068-y","article-title":"Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma","volume":"13","author":"Lin","year":"2025","journal-title":"Acta Neuropathol Commun"},{"key":"2026080313313974000_vdag177-B257","doi-asserted-by":"publisher","first-page":"2427","DOI":"10.1038\/s41388-025-03418-9","article-title":"Synthetic lethality through Gsk3beta inhibition in glioma stem cells via the WNT-WWC1-YAP axis","volume":"44","author":"Ren","year":"2025","journal-title":"Oncogene"},{"key":"2026080313313974000_vdag177-B258","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/neuonc\/noaf224","article-title":"Multiple patient-derived glioblastoma models reveal synthetic lethality through concurrent PI3K and CDK4\/6 inhibition by blocking trans-active cooperation","volume":"28","author":"Zhang","year":"2026","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B259","doi-asserted-by":"publisher","first-page":"3811","DOI":"10.1002\/1878-0261.13224","article-title":"Resistance to DNA repair inhibitors in cancer","volume":"16","author":"Baxter","year":"2022","journal-title":"Mol Oncol"},{"key":"2026080313313974000_vdag177-B260","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314672","article-title":"DNA damage response in cancer therapy and resistance: challenges and opportunities","volume":"23","author":"Jurkovicova","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026080313313974000_vdag177-B261","doi-asserted-by":"publisher","first-page":"103503","DOI":"10.1016\/j.redox.2025.103503","article-title":"Metabolic dependency mapping identifies peroxiredoxin 1 as a driver of resistance to ATM inhibition","volume":"80","author":"Li","year":"2025","journal-title":"Redox Biol"},{"key":"2026080313313974000_vdag177-B262","doi-asserted-by":"publisher","first-page":"8310","DOI":"10.1038\/s41467-023-44108-y","article-title":"Mapping combinatorial drug effects to DNA damage response kinase inhibitors","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B263","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/978-3-031-30065-3_11","article-title":"Combination DNA damage response (DDR) inhibitors to overcome drug resistance in ovarian cancer","volume":"186","author":"Nasioudis","year":"2023","journal-title":"Cancer Treat Res"},{"key":"2026080313313974000_vdag177-B264","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.molcel.2022.12.031","article-title":"Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control","volume":"83","author":"Concannon","year":"2023","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B265","doi-asserted-by":"publisher","first-page":"5520","DOI":"10.1038\/s41388-020-1383-4","article-title":"Resistance to the CHK1 inhibitor prexasertib involves functionally distinct CHK1 activities in BRCA wild-type ovarian cancer","volume":"39","author":"Nair","year":"2020","journal-title":"Oncogene"},{"key":"2026080313313974000_vdag177-B266","doi-asserted-by":"publisher","first-page":"2306","DOI":"10.1001\/jama.2017.18718","article-title":"Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial","volume":"318","author":"Stupp","year":"2017","journal-title":"JAMA"},{"key":"2026080313313974000_vdag177-B267","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.ijrobp.2021.12.152","article-title":"The impact of tumor treating fields on glioblastoma progression patterns","volume":"112","author":"Glas","year":"2022","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"2026080313313974000_vdag177-B268","doi-asserted-by":"publisher","first-page":"3288","DOI":"10.1158\/0008-5472.can-04-0083","article-title":"Disruption of cancer cell replication by alternating electric fields","volume":"64","author":"Kirson","year":"2004","journal-title":"Cancer Res"},{"key":"2026080313313974000_vdag177-B269","doi-asserted-by":"publisher","first-page":"e2753","DOI":"10.1038\/cddis.2017.171","article-title":"Biological activity of tumor-treating fields in preclinical glioma models","volume":"8","author":"Silginer","year":"2017","journal-title":"Cell Death Dis"},{"key":"2026080313313974000_vdag177-B270","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-6649-9-1","article-title":"Chemotherapeutic treatment efficacy and sensitivity are increased by adjuvant alternating electric fields (TTFields)","volume":"9","author":"Kirson","year":"2009","journal-title":"BMC Med Phys"},{"key":"2026080313313974000_vdag177-B271","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1080\/09553002.2020.1837984","article-title":"An overview of potential novel mechanisms of action underlying tumor treating fields-induced cancer cell death and their clinical implications","volume":"97","author":"Karanam","year":"2021","journal-title":"Int J Radiat Biol"},{"key":"2026080313313974000_vdag177-B272","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.trsl.2019.10.003","article-title":"Tumor treating fields cause replication stress and interfere with DNA replication fork maintenance: implications for cancer therapy","volume":"217","author":"Karanam","year":"2020","journal-title":"Transl Res"},{"key":"2026080313313974000_vdag177-B273","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.lungcan.2021.08.011","article-title":"Tumor treating fields (TTFields) downregulate the Fanconi anemia-BRCA pathway and increase the efficacy of chemotherapy in malignant pleural mesothelioma preclinical models","volume":"160","author":"Mumblat","year":"2021","journal-title":"Lung Cancer"},{"key":"2026080313313974000_vdag177-B274","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1038\/s41416-023-02454-0","article-title":"DNA damage response inhibitors enhance tumour treating fields (TTFields) potency in glioma stem-like cells","volume":"129","author":"Vanderlinden","year":"2023","journal-title":"Br J Cancer"},{"key":"2026080313313974000_vdag177-B275","doi-asserted-by":"publisher","DOI":"10.3390\/biom12101348","article-title":"Tumor treating fields (TTFields) reversibly permeabilize the blood-brain barrier In vitro and In vivo","volume":"12","author":"Salvador","year":"2022","journal-title":"Biomolecules"},{"key":"2026080313313974000_vdag177-B276","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020265","article-title":"Immunotherapy of glioblastoma: current strategies and challenges in tumor model development","volume":"10","author":"Majc","year":"2021","journal-title":"Cells"},{"key":"2026080313313974000_vdag177-B277","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s11912-020-01007-5","article-title":"Current advances in immunotherapy for glioblastoma","volume":"23","author":"Mende","year":"2021","journal-title":"Curr Oncol Rep"},{"key":"2026080313313974000_vdag177-B278","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1038\/s41416-018-0258-8","article-title":"Harnessing the immune system in glioblastoma","volume":"119","author":"Brown","year":"2018","journal-title":"Br J Cancer"},{"key":"2026080313313974000_vdag177-B279","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1001\/jamaoncol.2020.1024","article-title":"Effect of nivolumab vs bevacizumab in patients with recurrent glioblastoma: the CheckMate 143 phase 3 randomized clinical trial","volume":"6","author":"Reardon","year":"2020","journal-title":"JAMA Oncol"},{"key":"2026080313313974000_vdag177-B280","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1038\/s41590-019-0433-y","article-title":"Mechanisms of immunotherapy resistance: lessons from glioblastoma","volume":"20","author":"Jackson","year":"2019","journal-title":"Nat Immunol"},{"key":"2026080313313974000_vdag177-B281","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1038\/s41591-025-03512-1","article-title":"Neoadjuvant triplet immune checkpoint blockade in newly diagnosed glioblastoma","volume":"31","author":"Long","year":"2025","journal-title":"Nat Med"},{"key":"2026080313313974000_vdag177-B282","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3389\/fonc.2019.00163","article-title":"Turning \u201cCold\u201d into \u201cHot\u201d tumors-opportunities and challenges for radio-immunotherapy against primary and metastatic brain cancers","volume":"9","author":"Sevenich","year":"2019","journal-title":"Front Oncol"},{"key":"2026080313313974000_vdag177-B283","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13046-022-02251-2","article-title":"Immunotherapy for glioblastoma: the promise of combination strategies","volume":"41","author":"Bausart","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"key":"2026080313313974000_vdag177-B284","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/s41392-025-02264-1","article-title":"Pattern recognition receptors: function, regulation and therapeutic potential","volume":"10","author":"Chen","year":"2025","journal-title":"Signal Transduct Target Ther"},{"key":"2026080313313974000_vdag177-B285","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020872","article-title":"Structure, activation and regulation of NLRP3 and AIM2 inflammasomes","volume":"22","author":"Sharma","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026080313313974000_vdag177-B286","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207504","article-title":"DNA damage response and immune defense","volume":"21","author":"Nastasi","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026080313313974000_vdag177-B287","doi-asserted-by":"publisher","first-page":"168424","DOI":"10.1016\/j.jmb.2023.168424","article-title":"Mechanisms of immune sensing of DNA damage","volume":"436","author":"Goddard","year":"2024","journal-title":"J Mol Biol"},{"key":"2026080313313974000_vdag177-B288","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nri.2016.78","article-title":"Discriminating self from non-self in nucleic acid sensing","volume":"16","author":"Schlee","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"2026080313313974000_vdag177-B289","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3390\/genes11040409","article-title":"Replication stress DNA damage, inflammatory cytokines and innate immun eresponse","volume":"11","author":"Ragu","year":"2020","journal-title":"Genes (Basel)"},{"key":"2026080313313974000_vdag177-B290","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/bs.pmbts.2014.11.014","article-title":"Role of extracellular damage-associated molecular pattern molecules (DAMPs) as mediators of persistent pain","volume":"131","author":"Kato","year":"2015","journal-title":"Prog Mol Biol Transl Sci"},{"key":"2026080313313974000_vdag177-B291","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12020162","article-title":"Endogenous retroviruses as modulators of innate immunity","volume":"12","author":"Russ","year":"2023","journal-title":"Pathogens"},{"key":"2026080313313974000_vdag177-B292","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/s41586-022-05545-9","article-title":"R-loop-derived cytoplasmic RNA-DNA hybrids activate an immune response","volume":"613","author":"Crossley","year":"2023","journal-title":"Nature"},{"key":"2026080313313974000_vdag177-B293","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s00018-024-05380-3","article-title":"R-loops and impaired autophagy trigger cGAS-dependent inflammation via micronuclei formation in Senataxin-deficient cells","volume":"81","author":"Zannini","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"2026080313313974000_vdag177-B294","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/s41423-023-01086-x","article-title":"Mitochondrial DNA-triggered innate immune response: mechanisms and diseases","volume":"20","author":"Hu","year":"2023","journal-title":"Cell Mol Immunol"},{"key":"2026080313313974000_vdag177-B295","doi-asserted-by":"publisher","first-page":"903781","DOI":"10.3389\/fcell.2022.903781","article-title":"Nucleic acid sensing pathways in DNA repair targeted cancer therapy","volume":"10","author":"Xie","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2026080313313974000_vdag177-B296","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","article-title":"DNA sensing by the cGAS-STING pathway in health and disease","volume":"20","author":"Motwani","year":"2019","journal-title":"Nat Rev Genet"},{"key":"2026080313313974000_vdag177-B297","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1093\/intimm\/dxaf037","article-title":"TREX1 exonuclease in immunity and disease","volume":"37","author":"Shang","year":"2025","journal-title":"Int Immunol"},{"key":"2026080313313974000_vdag177-B298","doi-asserted-by":"publisher","first-page":"2861","DOI":"10.1038\/s41467-022-30311-w","article-title":"Synthetic lethality between TP53 and ENDOD1","volume":"13","author":"Tang","year":"2022","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B299","doi-asserted-by":"publisher","first-page":"e00047","DOI":"10.7554\/eLife.00047","article-title":"DNA-PK is a DNA sensor for IRF-3-dependent innate immunity","volume":"1","author":"Ferguson","year":"2012","journal-title":"Elife."},{"key":"2026080313313974000_vdag177-B300","doi-asserted-by":"publisher","first-page":"eaba4219","DOI":"10.1126\/sciimmunol.aba4219","article-title":"Human DNA-PK activates a STING-independent DNA sensing pathway","volume":"5","author":"Burleigh","year":"2020","journal-title":"Sci Immunol"},{"key":"2026080313313974000_vdag177-B301","doi-asserted-by":"publisher","first-page":"4541","DOI":"10.4049\/jimmunol.1003389","article-title":"Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN","volume":"186","author":"Zhang","year":"2011","journal-title":"J Immunol"},{"key":"2026080313313974000_vdag177-B302","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aah5054","article-title":"STING is an essential mediator of the Ku70-mediated production of IFN-lambda1 in response to exogenous DNA","volume":"10","author":"Sui","year":"2017","journal-title":"Sci Signal"},{"key":"2026080313313974000_vdag177-B303","doi-asserted-by":"publisher","first-page":"6182","DOI":"10.1038\/s41467-020-19941-0","article-title":"DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity","volume":"11","author":"Sun","year":"2020","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B304","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.str.2004.12.006","article-title":"Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs)","volume":"13","author":"Rivera-Calzada","year":"2005","journal-title":"Structure"},{"key":"2026080313313974000_vdag177-B305","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1073\/pnas.95.2.525","article-title":"DNA-dependent protein kinase: DNA binding and activation in the absence of Ku","volume":"95","author":"Hammarsten","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080313313974000_vdag177-B306","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s00018-024-05214-2","article-title":"When DNA-damage responses meet innate and adaptive immunity","volume":"81","author":"Tong","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"2026080313313974000_vdag177-B307","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.mad.2016.09.001","article-title":"Sensing of dangerous DNA","volume":"165","author":"Gasser","year":"2017","journal-title":"Mech Ageing Dev"},{"key":"2026080313313974000_vdag177-B308","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1111\/imm.13318","article-title":"Cytoplasmic-translocated Ku70 senses intracellular DNA and mediates interferon-lambda1 induction","volume":"163","author":"Sui","year":"2021","journal-title":"Immunology"},{"key":"2026080313313974000_vdag177-B309","doi-asserted-by":"publisher","first-page":"155405","DOI":"10.1016\/j.prp.2024.155405","article-title":"The molecular crosstalk between innate immunity and DNA damage repair\/response: interactions and effects in cancers","volume":"260","author":"Omidvar","year":"2024","journal-title":"Pathol Res Pract"},{"key":"2026080313313974000_vdag177-B310","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41467-018-07927-y","article-title":"BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity","volume":"10","author":"Heijink","year":"2019","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B311","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nrc3181","article-title":"BRCA1 and BRCA2: different roles in a common pathway of genome protection","volume":"12","author":"Roy","year":"2011","journal-title":"Nat Rev Cancer"},{"key":"2026080313313974000_vdag177-B312","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.cels.2024.03.003","article-title":"DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage","volume":"15","author":"Justice","year":"2024","journal-title":"Cell Syst"},{"key":"2026080313313974000_vdag177-B313","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/s41419-024-06911-3","article-title":"ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC class I","volume":"15","author":"Li","year":"2024","journal-title":"Cell Death Dis"},{"key":"2026080313313974000_vdag177-B314","doi-asserted-by":"publisher","DOI":"10.3390\/cells12091288","article-title":"ATM inhibition-induced ISG15\/IFI27\/OASL is correlated with immunotherapy response and inflamed immunophenotype","volume":"12","author":"Huang","year":"2023","journal-title":"Cells"},{"key":"2026080313313974000_vdag177-B315","doi-asserted-by":"publisher","first-page":"6378","DOI":"10.1523\/JNEUROSCI.0774-19.2019","article-title":"Accumulation of cytoplasmic DNA due to ATM deficiency activates the microglial viral response system with neurotoxic consequences","volume":"39","author":"Song","year":"2019","journal-title":"J Neurosci"},{"key":"2026080313313974000_vdag177-B316","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/imm.13602","article-title":"Ataxia telangiectasia mutated kinase inhibition promotes irradiation-induced PD-L1 expression in tumour-associated macrophages through IFN-I\/JAK signalling pathway","volume":"168","author":"Gao","year":"2023","journal-title":"Immunology"},{"key":"2026080313313974000_vdag177-B317","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.immuni.2015.01.012","article-title":"DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity","volume":"42","author":"Hartlova","year":"2015","journal-title":"Immunity"},{"key":"2026080313313974000_vdag177-B318","doi-asserted-by":"publisher","first-page":"2117321","DOI":"10.1080\/2162402X.2022.2117321","article-title":"Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation","volume":"11","author":"Lopez-Pelaez","year":"2022","journal-title":"Oncoimmunology"},{"key":"2026080313313974000_vdag177-B319","doi-asserted-by":"publisher","first-page":"e104036","DOI":"10.15252\/embj.2019104036","article-title":"ATR inhibition potentiates ionizing radiation-induced interferon response via cytosolic nucleic acid-sensing pathways","volume":"39","author":"Feng","year":"2020","journal-title":"EMBO J"},{"key":"2026080313313974000_vdag177-B320","doi-asserted-by":"publisher","first-page":"5951","DOI":"10.1172\/JCI130445","article-title":"Inhibition of the ATM\/Chk2 axis promotes cGAS\/STING signaling in ARID1A-deficient tumors","volume":"130","author":"Wang","year":"2020","journal-title":"J Clin Invest"},{"key":"2026080313313974000_vdag177-B321","doi-asserted-by":"publisher","first-page":"110669","DOI":"10.1016\/j.radonc.2024.110669","article-title":"Interferon signaling is enhanced by ATR inhibition in glioblastoma cells irradiated with X-rays, protons or carbon ions","volume":"203","author":"Rodland","year":"2025","journal-title":"Radiother Oncol"},{"key":"2026080313313974000_vdag177-B322","doi-asserted-by":"publisher","first-page":"3926","DOI":"10.1172\/JCI96519","article-title":"ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation","volume":"128","author":"Vendetti","year":"2018","journal-title":"J Clin Invest"},{"key":"2026080313313974000_vdag177-B323","doi-asserted-by":"publisher","first-page":"45588","DOI":"10.1074\/jbc.M106528200","article-title":"The enzymatic and DNA binding activity of PARP-1 are not required for NF-kappa B coactivator function","volume":"276","author":"Hassa","year":"2001","journal-title":"J Biol Chem"},{"key":"2026080313313974000_vdag177-B324","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1056\/NEJMoa0900212","article-title":"Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers","volume":"361","author":"Fong","year":"2009","journal-title":"N Engl J Med"},{"key":"2026080313313974000_vdag177-B325","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1158\/0008-5472.CAN-18-1003","article-title":"PARPi triggers the STING-dependent immune response and enhances the therapeutic efficacy of immune checkpoint blockade independent of BRCAness","volume":"79","author":"Shen","year":"2019","journal-title":"Cancer Res"},{"key":"2026080313313974000_vdag177-B326","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1007\/s00018-002-8527-2","article-title":"The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders","volume":"59","author":"Hassa","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"2026080313313974000_vdag177-B327","doi-asserted-by":"publisher","first-page":"11752","DOI":"10.1038\/ncomms11752","article-title":"RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA","volume":"7","author":"Wolf","year":"2016","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B328","doi-asserted-by":"publisher","first-page":"e2206344","DOI":"10.1002\/advs.202206344","article-title":"Loss of RPA1 impairs peripheral T cell homeostasis and exacerbates inflammatory damage through triggering T cell necroptosis","volume":"10","author":"Song","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"2026080313313974000_vdag177-B329","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/s41419-025-07912-6","article-title":"CHK1 inhibition increases the therapeutic response to radiotherapy via antitumor immunity in ARID1A-deficient colorectal cancer","volume":"16","author":"Chen","year":"2025","journal-title":"Cell Death Dis"},{"key":"2026080313313974000_vdag177-B330","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/s41573-024-00920-9","article-title":"Targeting immunogenic cell stress and death for cancer therapy","volume":"23","author":"Galluzzi","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"2026080313313974000_vdag177-B331","doi-asserted-by":"publisher","first-page":"eabc4764","DOI":"10.1126\/scisignal.abc4764","article-title":"The injury response to DNA damage in live tumor cells promotes antitumor immunity","volume":"14","author":"Sriram","year":"2021","journal-title":"Sci Signal"},{"key":"2026080313313974000_vdag177-B332","doi-asserted-by":"publisher","first-page":"eadj8691","DOI":"10.1126\/science.adj8691","article-title":"Micronuclear collapse from oxidative damage","volume":"385","author":"Di Bona","year":"2024","journal-title":"Science"},{"key":"2026080313313974000_vdag177-B333","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature23449","article-title":"cGAS surveillance of micronuclei links genome instability to innate immunity","volume":"548","author":"Mackenzie","year":"2017","journal-title":"Nature"},{"key":"2026080313313974000_vdag177-B334","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature23470","article-title":"Mitotic progression following DNA damage enables pattern recognition within micronuclei","volume":"548","author":"Harding","year":"2017","journal-title":"Nature"},{"key":"2026080313313974000_vdag177-B335","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1016\/j.molcel.2024.04.017","article-title":"Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STING","volume":"84","author":"Takaki","year":"2024","journal-title":"Mol Cell"},{"key":"2026080313313974000_vdag177-B336","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2103585118","article-title":"Chromatin bridges, not micronuclei, activate cGAS after drug-induced mitotic errors in human cells","volume":"118","author":"Flynn","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080313313974000_vdag177-B337","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202302424","article-title":"Micronucleus is not a potent inducer of the cGAS\/STING pathway","volume":"7","author":"Sato","year":"2024","journal-title":"Life Sci Alliance"},{"key":"2026080313313974000_vdag177-B338","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1038\/bjc.2017.376","article-title":"Combining DNA damaging therapeutics with immunotherapy: more haste, less speed","volume":"118","author":"Brown","year":"2018","journal-title":"Br J Cancer"},{"key":"2026080313313974000_vdag177-B339","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ccell.2022.04.009","article-title":"Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition","volume":"40","author":"Low","year":"2022","journal-title":"Cancer Cell"},{"key":"2026080313313974000_vdag177-B340","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163452","article-title":"Understanding and therapeutically exploiting cGAS\/STING signaling in glioblastoma","volume":"134","author":"Low","year":"2024","journal-title":"J Clin Invest"},{"key":"2026080313313974000_vdag177-B341","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1038\/s41467-021-22572-8","article-title":"STING enhances cell death through regulation of reactive oxygen species and DNA damage","volume":"12","author":"Hayman","year":"2021","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B342","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1038\/s41467-023-37328-9","article-title":"STING agonist-loaded, CD47\/PD-L1-targeting nanoparticles potentiate antitumor immunity and radiotherapy for glioblastoma","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B343","doi-asserted-by":"publisher","first-page":"e2111003119","DOI":"10.1073\/pnas.2111003119","article-title":"STING activation promotes robust immune response and NK cell-mediated tumor regression in glioblastoma models","volume":"119","author":"Berger","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026080313313974000_vdag177-B344","doi-asserted-by":"publisher","DOI":"10.1172\/JCI175033","article-title":"STING agonist 8803 reprograms the immune microenvironment and increases survival in preclinical models of glioblastoma","volume":"134","author":"Najem","year":"2024","journal-title":"J Clin Invest"},{"key":"2026080313313974000_vdag177-B345","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1038\/nsmb.3498","article-title":"Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway","volume":"24","author":"Chen","year":"2017","journal-title":"Nat Struct Mol Biol"},{"key":"2026080313313974000_vdag177-B346","doi-asserted-by":"publisher","first-page":"4061","DOI":"10.1038\/s41467-024-48443-6","article-title":"Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence","volume":"15","author":"Siametis","year":"2024","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B347","doi-asserted-by":"publisher","first-page":"6673","DOI":"10.1093\/nar\/gkab500","article-title":"G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells","volume":"49","author":"Miglietta","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2026080313313974000_vdag177-B348","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1186\/s12943-022-01649-y","article-title":"Ligands stimulating antitumour immunity as the next G-quadruplex challenge","volume":"21","author":"Miglietta","year":"2022","journal-title":"Mol Cancer"},{"key":"2026080313313974000_vdag177-B349","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ebiom.2019.01.067","article-title":"DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma","volume":"41","author":"Meng","year":"2019","journal-title":"EBioMedicine"},{"key":"2026080313313974000_vdag177-B350","doi-asserted-by":"publisher","first-page":"875648","DOI":"10.3389\/fimmu.2022.875648","article-title":"DNA damage response evaluation provides novel insights for personalized immunotherapy in glioma","volume":"13","author":"Chen","year":"2022","journal-title":"Front Immunol"},{"key":"2026080313313974000_vdag177-B351","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41417-025-00980-y","article-title":"Defining treatment-resistant brain cancer: genetic screening to identify oncogene-driven immunomodulation and therapy resistance","volume":"33","author":"Myers","year":"2026","journal-title":"Cancer Gene Ther"},{"key":"2026080313313974000_vdag177-B352","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/s41392-023-01481-w","article-title":"The blood-brain barrier: structure, regulation, and drug delivery","volume":"8","author":"Wu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026080313313974000_vdag177-B353","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1093\/neuonc\/nox175","article-title":"Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data","volume":"20","author":"Sarkaria","year":"2018","journal-title":"Neuro Oncol"},{"key":"2026080313313974000_vdag177-B354","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17040701","article-title":"Progress in drug delivery systems based on nanoparticles for improved glioblastoma therapy: addressing challenges and investigating opportunities","volume":"17","author":"Rahman","year":"2025","journal-title":"Cancers (Basel)"},{"key":"2026080313313974000_vdag177-B355","doi-asserted-by":"publisher","first-page":"8021","DOI":"10.1038\/s41467-024-52329-y","article-title":"Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier","volume":"15","author":"Guo","year":"2024","journal-title":"Nat Commun"},{"key":"2026080313313974000_vdag177-B356","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1016\/S1470-2045(25)00492-9","article-title":"Microbubble-enhanced transcranial focused ultrasound with temozolomide for patients with high-grade glioma (BT008NA): a multicentre, open-label, phase 1\/2 trial","volume":"26","author":"Woodworth","year":"2025","journal-title":"Lancet Oncol"},{"key":"2026080313313974000_vdag177-B357","doi-asserted-by":"publisher","DOI":"10.3390\/ph16111599","article-title":"Brain delivery of cisplatin using microbubbles in combination with ultrasound as an effective therapy for glioblastoma","volume":"16","author":"Hagiwara","year":"2023","journal-title":"Pharmaceuticals (Basel)"},{"key":"2026080313313974000_vdag177-B358","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1080\/1061186X.2019.1706095","article-title":"Intranasal delivery of cancer-targeting doxorubicin-loaded PLGA nanoparticles arrests glioblastoma growth","volume":"28","author":"Chung","year":"2020","journal-title":"J Drug Target"},{"key":"2026080313313974000_vdag177-B359","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1021\/acs.molpharmaceut.9b01215","article-title":"Nose-to-brain delivery of cancer-targeting paclitaxel-loaded nanoparticles potentiates antitumor effects in malignant glioblastoma","volume":"17","author":"Ullah","year":"2020","journal-title":"Mol Pharm"},{"key":"2026080313313974000_vdag177-B360","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1038\/s41419-024-06653-2","article-title":"Nose-to-brain selective drug delivery to glioma via ferritin-based nanovectors reduces tumor growth and improves survival rate","volume":"15","author":"Marrocco","year":"2024","journal-title":"Cell Death Dis"},{"key":"2026080313313974000_vdag177-B361","doi-asserted-by":"publisher","first-page":"e2102816","DOI":"10.1002\/adhm.202102816","article-title":"Targeted delivery of DNA topoisomerase inhibitor SN38 to intracranial tumors of glioblastoma using Sub-5 ultrafine iron oxide nanoparticles","volume":"11","author":"Li","year":"2022","journal-title":"Adv Healthc Mater"},{"key":"2026080313313974000_vdag177-B362","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s11910-024-01338-x","article-title":"Strategies to improve drug delivery across the blood-brain barrier for glioblastoma","volume":"24","author":"Narsinh","year":"2024","journal-title":"Curr Neurol Neurosci Rep"}],"container-title":["Neuro-Oncology Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/noa\/advance-article-pdf\/doi\/10.1093\/noajnl\/vdag177\/68738699\/vdag177.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/noa\/article-pdf\/8\/1\/vdag177\/68738699\/vdag177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/noa\/article-pdf\/8\/1\/vdag177\/68738699\/vdag177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:31:58Z","timestamp":1785778318000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/noa\/article\/doi\/10.1093\/noajnl\/vdag177\/8729065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":362,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,12]]}},"URL":"https:\/\/doi.org\/10.1093\/noajnl\/vdag177","relation":{},"ISSN":["2632-2498"],"issn-type":[{"value":"2632-2498","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,1]]},"published":{"date-parts":[[2026,1]]},"article-number":"vdag177"}}