{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:28:37Z","timestamp":1788791317801,"version":"build-2803163510"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":222,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High-grade gliomas are the most prevalent type of malignant brain tumor in adults and the second leading cause of cancer-related death. This study assesses epidemiology, pattern of care, and treatment outcome of high-grade glioma in Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A Prospective cohort study. Data collected were analyzed using SPSS. Frequency distribution was used to describe the characteristics of the study participants. Chi-squared tests and survival analysis were used to assess the treatment outcomes. Variables with P\u2009&amp;lt;\u2009.05 were considered as significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was a total of 40 patients. The median age at diagnosis was 47 years. Headache was the commonest presenting symptom (97.5%), followed by seizure (52.5%) and weakness (50%). The pre-operative tumor volume ranged between 3.9 and 168 cm3, with a mean volume of 80.38 cm3. A total of 22 patients had \u226597% extent of resection. About 17.5% of the patients died post-treatment. The mean survival time was 20.77 months (95% CI: 18.46-23.09 months). There was significant association with higher Karnofsky performance status (KPS) scale (\u226570), pre-operative GCS, and post-operative adjuvant therapy with survival outcome (\u03c72\u2009=\u200910.19 P\u2009=\u2009.006, \u03c72\u2009=\u200912.9 P\u2009=\u2009.005, \u03c72\u2009=\u20096.716 P\u2009=\u2009.035), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our study, the mean survival time was 20.77 months. Higher KPS, pre-operative Glasgow Coma Scale (GCS) of 15, and patients receiving post-op adjuvant therapy had a significant favorable association with survival in our study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/noajnl\/vdag207","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:53:19Z","timestamp":1786189999000},"source":"Crossref","is-referenced-by-count":0,"title":["Pattern of care and treatment outcome of high-grade glioma patients at 4 Ethiopian teaching hospitals: a prospective cohort study"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-6305","authenticated-orcid":false,"given":"Dawit Workneh","family":"Gechu","sequence":"first","affiliation":[{"name":"Neurosurgery Unit, Department of Surgery, University of Gondar , 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