{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:09:33Z","timestamp":1790179773692,"version":"4.1.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":249,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Surgical resection remains standard of care for high-grade glioma. It is unclear, however, whether re-resection at the time of first recurrence confers further survival benefit in young patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multi-center, retrospective cohort study included patients age 0-21 years with supratentorial high-grade glioma who underwent gross total or near total resection at time of initial diagnosis which subsequently recurred. Patients were grouped by therapeutic re-resection at first recurrence. Post-recurrence overall survival was assessed with Kaplan-Meier methods, multivariable Cox regression, and propensity score-matched analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Forty-four patients with a median age of 12.5 years from 7 institutions were included. 61% (n\u2009=\u200927) underwent re-resection and 39% (n\u2009=\u200917) did not. The 2 groups (re-resection and no re-resection) did not significantly differ in sex, age at recurrence, functional status, pathology, chemotherapy and radiation exposure, or institution (all P\u2009&amp;gt;\u2009.05). Kaplan-Meier analysis demonstrated significantly longer post-recurrence overall survival with re-resection compared with no re-resection (median 24.6 vs 8.5 months; log-rank P\u2009=\u2009.0001). Patients who underwent re-resection had a 73% lower hazard of death after recurrence compared with patients who did not undergo re-resection by multivariable Cox regression (HR 0.27, 95% CI, 0.10-0.69; P\u2009=\u2009.006) or by propensity score matching analyses (HR 0.27, 95% CI, 0.11-0.68; P\u2009=\u2009.005).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Therapeutic re-resection at first recurrence was associated with improved post-recurrence survival, which remained significant after multivariable adjustment or propensity score matching. This study provides evidence for re-resection in recurrent high-grade glioma in young patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/noajnl\/vdag237","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:10:12Z","timestamp":1788520212000},"source":"Crossref","is-referenced-by-count":0,"title":["Re-resection at first recurrence is associated with prolonged survival in young patients with high-grade glioma: A multi-center study"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2745-4374","authenticated-orcid":false,"given":"David A","family":"Giles","sequence":"first","affiliation":[{"name":"Taylor Family Department of Neurosurgery, WashU Medicine , St. Louis, Missouri,","place":["USA"]},{"name":"The Brain Tumor Center at Siteman Cancer Center , St. Louis, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Taylor Family Department of Neurosurgery, WashU Medicine , St. Louis, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Anzaldua-Campos","sequence":"additional","affiliation":[{"name":"Taylor Family Department of Neurosurgery, WashU Medicine , St. Louis, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma","family":"Mani","sequence":"additional","affiliation":[{"name":"Taylor Family Department of Neurosurgery, WashU Medicine , St. Louis, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Harrigan","sequence":"additional","affiliation":[{"name":"Taylor Family Department of Neurosurgery, WashU Medicine , St. Louis, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaethe","family":"Leonard","sequence":"additional","affiliation":[{"name":"Ann & Robert H. 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Lurie Children\u2019s Hospital of Chicago , Chicago, Illinois,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Chiarelli","sequence":"additional","affiliation":[{"name":"Phoenix Children\u2019s Hospital , Phoenix, Arizona,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Hauptman","sequence":"additional","affiliation":[{"name":"Phoenix Children\u2019s Hospital , Phoenix, Arizona,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"Strahle","sequence":"additional","affiliation":[{"name":"Taylor Family Department of Neurosurgery, WashU Medicine , St. Louis, Missouri,","place":["USA"]},{"name":"The Brain Tumor Center at Siteman Cancer Center , St. Louis, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarod L","family":"Roland","sequence":"additional","affiliation":[{"name":"Taylor Family Department of Neurosurgery, WashU Medicine , St. Louis, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"DeCuypere","sequence":"additional","affiliation":[{"name":"Monroe Carell Jr. Children\u2019s Hospital at Vanderbilt , Nashville, Tennessee,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2796-9914","authenticated-orcid":false,"given":"Eric M","family":"Thompson","sequence":"additional","affiliation":[{"name":"Taylor Family Department of Neurosurgery, WashU Medicine , St. Louis, Missouri,","place":["USA"]},{"name":"The Brain Tumor Center at Siteman Cancer Center , St. Louis, Missouri,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"2026092311553040400_vdag237-B1","doi-asserted-by":"publisher","first-page":"iv1","DOI":"10.1093\/neuonc\/noaf194","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2018\u20132022","volume":"27","author":"Price","year":"2025","journal-title":"Neuro Oncol"},{"key":"2026092311553040400_vdag237-B2","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3171\/2020.7.PEDS20389","article-title":"High-grade gliomas in children and adolescents: is there a role for reoperation?","volume":"27","author":"Costa","year":"2020","journal-title":"J Neurosurg. 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