{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T12:08:58Z","timestamp":1767182938087,"version":"3.41.2"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":153,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The introduction of the 2016 WHO Classification of Tumors of the Central Nervous System has resulted in tumor groupings with improved prognostic value for diffuse glioma patients. Molecular subtype, primarily based on IDH-mutational status and 1p\/19q-status, is a strong predictor of survival. It is unclear to what extent this finding may be mediated by differences in anatomical location and surgical resectability among molecular subgroups. Our aim was to elucidate possible correlations between (1) molecular subtype and anatomical location and (2) molecular subtype and extent of resection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a systematic review of literature searching for studies on molecular subtype in relation to anatomical location and extent of resection. Only original data concerning adult participants suffering from cerebral diffuse glioma were included. Studies adopting similar outcomes measures were included in our meta-analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In the systematic analysis for research questions 1 and 2, totals of 20 and 9 studies were included, respectively. Study findings demonstrated that IDH-mutant tumors were significantly more frequently located in the frontal lobe and less often in the temporal lobe compared with IDH-wildtype gliomas. Within the IDH-mutant group, 1p\/19q-codeleted tumors were associated with more frequent frontal and less frequent temporal localization compared with 1p\/19q-intact tumors. In IDH-mutant gliomas, greater extent of resection was achieved than in IDH-wildtype tumors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Genetic profile of diffuse cerebral glioma influences their anatomical location and seems to affect tumor resectability.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/noajnl\/vdz032","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T04:07:34Z","timestamp":1569902854000},"source":"Crossref","is-referenced-by-count":5,"title":["Interrelationships between molecular subtype, anatomical location, and extent of resection in diffuse glioma: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"1","author":[{"given":"Beverly I","family":"De Leeuw","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten M","family":"Van Baarsen","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands"},{"name":"Department of Neurosurgery, Alder Hey Children\u2019s NHS Foundation Trust, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0857-081X","authenticated-orcid":false,"given":"Tom J","family":"Snijders","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre A J T","family":"Robe","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"issue":"6","key":"2020050522084404400_CIT0001","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"26","key":"2020050522084404400_CIT0002","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1056\/NEJMe1506813","article-title":"Multiple molecular data sets and the classification of adult diffuse gliomas","volume":"372","author":"Ellison","year":"2015","journal-title":"N Engl J Med."},{"issue":"26","key":"2020050522084404400_CIT0003","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1056\/NEJMoa1402121","article-title":"Comprehensive, integrative genomic analysis of diffuse lower-grade gliomas","volume":"372","author":"Brat","year":"2015","journal-title":"N Engl J Med."},{"issue":"26","key":"2020050522084404400_CIT0004","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa1407279","article-title":"Glioma groups based on 1p\/19q, IDH, and TERT promoter mutations in tumors","volume":"372","author":"Eckel-Passow","year":"2015","journal-title":"N Engl J Med."},{"issue":"3","key":"2020050522084404400_CIT0005","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2217\/cns-2016-0043","article-title":"Outcome evaluation of patients with newly diagnosed anaplastic gliomas treated in a single institution","volume":"6","author":"Pessina","year":"2017","journal-title":"CNS Oncol"},{"issue":"6","key":"2020050522084404400_CIT0006","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/neuonc\/not027","article-title":"1p\/19q codeletion and IDH1\/2 mutation identified a subtype of anaplastic oligoastrocytomas with prognosis as favorable as anaplastic oligodendrogliomas","volume":"15","author":"Jiang","year":"2013","journal-title":"Neuro Oncol."},{"issue":"3","key":"2020050522084404400_CIT0007","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/neuonc\/nov182","article-title":"Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial","volume":"18","author":"Dubbink","year":"2016","journal-title":"Neuro Oncol."},{"issue":"4","key":"2020050522084404400_CIT0008","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s00401-014-1315-x","article-title":"Integrated DNA methylation and copy-number profiling identify three clinically and biologically relevant groups of anaplastic glioma","volume":"128","author":"Wiestler","year":"2014","journal-title":"Acta Neuropathol."},{"issue":"8","key":"2020050522084404400_CIT0009","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.clineuro.2012.02.054","article-title":"The assessment of prognostic factors in surgical treatment of low-grade gliomas: a prospective study","volume":"114","author":"Majchrzak","year":"2012","journal-title":"Clin Neurol Neurosurg."},{"issue":"6","key":"2020050522084404400_CIT0010","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.3171\/2013.1.JNS121","article-title":"Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases: clinical article","volume":"118","author":"Capelle","year":"2013","journal-title":"J Neurosurg."},{"issue":"8","key":"2020050522084404400_CIT0011","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1200\/JCO.2007.13.9337","article-title":"Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas","volume":"26","author":"Smith","year":"2008","journal-title":"J Clin Oncol."},{"issue":"1","key":"2020050522084404400_CIT0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2017.3.JNS162383","article-title":"Threshold of the extent of resection for WHO Grade III gliomas: retrospective volumetric analysis of 122 cases using intraoperative MRI","volume":"129","author":"Fujii","year":"2018","journal-title":"J Neurosurg."},{"issue":"4","key":"2020050522084404400_CIT0013","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0090-3019(99)00103-2","article-title":"The effect of extent of resection on time to tumor progression and survival in patients with glioblastoma multiforme of the cerebral hemisphere","volume":"52","author":"Keles","year":"1999","journal-title":"Surg Neurol."},{"issue":"1","key":"2020050522084404400_CIT0014","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/neuonc\/not159","article-title":"IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection","volume":"16","author":"Beiko","year":"2014","journal-title":"Neuro Oncol."},{"key":"2020050522084404400_CIT0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev."},{"author":"National Heart, Lung, and Blood Institute","key":"2020050522084404400_CIT0016"},{"issue":"1","key":"2020050522084404400_CIT0017","doi-asserted-by":"crossref","first-page":"11773","DOI":"10.1038\/s41598-018-30273-4","article-title":"Lesion location implemented magnetic resonance imaging radiomics for predicting IDH and TERT promoter mutations in grade II\/III gliomas","volume":"8","author":"Arita","year":"2018","journal-title":"Sci Rep."},{"issue":"6","key":"2020050522084404400_CIT0018","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.prp.2018.04.002","article-title":"Clinical implications of TERT promoter mutation on IDH mutation and MGMT promoter methylation in diffuse gliomas","volume":"214","author":"Kim","year":"2018","journal-title":"Pathol Res Pract."},{"key":"2020050522084404400_CIT0019","doi-asserted-by":"crossref","first-page":"e407","DOI":"10.1016\/j.wneu.2018.01.055","article-title":"Correlation Between Tumor Location and Clinical Properties of Glioblastomas in Frontal and Temporal Lobes","volume":"112","author":"Li","year":"2018","journal-title":"World Neurosurg"},{"issue":"1","key":"2020050522084404400_CIT0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3174\/ajnr.A5421","article-title":"Prediction of IDH1-Mutation and 1p\/19q-Codeletion Status Using Preoperative MR Imaging Phenotypes in Lower Grade Gliomas","volume":"39","author":"Park","year":"2018","journal-title":"AJNR Am J Neuroradiol."},{"issue":"1","key":"2020050522084404400_CIT0021","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11060-017-2421-0","article-title":"IDH mutation and 1p19q codeletion distinguish two radiological patterns of diffuse low-grade gliomas","volume":"133","author":"Darlix","year":"2017","journal-title":"J Neurooncol."},{"issue":"3","key":"2020050522084404400_CIT0022","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11060-017-2613-7","article-title":"Imaging correlates for the 2016 update on WHO classification of grade II\/III gliomas: implications for IDH, 1p\/19q and ATRX status","volume":"135","author":"Delfanti","year":"2017","journal-title":"J Neurooncol."},{"key":"2020050522084404400_CIT0023","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jocn.2017.01.007","article-title":"Reliability of noncontrast-enhancing tumor as a biomarker of IDH1 mutation status in glioblastoma","volume":"39","author":"Lasocki","year":"2017","journal-title":"J Clin Neurosci."},{"issue":"6","key":"2020050522084404400_CIT0024","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/neuros\/nyx265","article-title":"The role of extent of resection in IDH1 wild-type or mutant low-grade gliomas","volume":"82","author":"Patel","year":"2018","journal-title":"Neurosurgery."},{"issue":"1","key":"2020050522084404400_CIT0025","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/neuonc\/nox176","article-title":"The impact of surgery in molecularly defined low-grade glioma: an integrated clinical, radiological, and molecular analysis","volume":"20","author":"Wijnenga","year":"2018","journal-title":"Neuro Oncol."},{"key":"2020050522084404400_CIT0026","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jocn.2015.11.030","article-title":"An analysis of 170 glioma patients and systematic review to investigate the association between IDH-1 mutations and preoperative glioma-related epilepsy","volume":"31","author":"Yang","year":"2016","journal-title":"J Clin Neurosci."},{"issue":"9","key":"2020050522084404400_CIT0027","first-page":"11485","article-title":"TERT promoter mutated WHO grades II and III gliomas are located preferentially in the frontal lobe and avoid the midline","volume":"8","author":"Sun","year":"2015","journal-title":"Int J Clin Exp Pathol."},{"issue":"1","key":"2020050522084404400_CIT0028","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11060-014-1520-4","article-title":"The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma","volume":"120","author":"Kizilbash","year":"2014","journal-title":"J Neurooncol."},{"issue":"6","key":"2020050522084404400_CIT0029","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.3892\/ol.2014.2013","article-title":"Isocitrate dehydrogenase mutation is associated with tumor location and magnetic resonance imaging characteristics in astrocytic neoplasms","volume":"7","author":"Qi","year":"2014","journal-title":"Oncol Lett."},{"issue":"2","key":"2020050522084404400_CIT0030","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10143-018-0981-x","article-title":"Imaging scoring systems for preoperative molecular diagnoses of lower-grade gliomas","volume":"42","author":"Kanazawa","year":"2019","journal-title":"Neurosurg Rev."},{"issue":"1","key":"2020050522084404400_CIT0031","doi-asserted-by":"crossref","first-page":"26","DOI":"10.5114\/fn.2013.34193","article-title":"Loss of genetic material within 1p and 19q chromosomal arms in low grade gliomas of central nervous system","volume":"51","author":"R\u0119c\u0142awowicz","year":"2013","journal-title":"Folia Neuropathol."},{"issue":"2","key":"2020050522084404400_CIT0032","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1227\/NEU.0b013e318212bcd8","article-title":"Whole genome analysis from microdissected tissue revealed adult supratentorial grade II-III gliomas are divided into clinically relevant subgroups by genetic profile","volume":"69","author":"Hirose","year":"2011","journal-title":"Neurosurgery."},{"issue":"2","key":"2020050522084404400_CIT0033","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1136\/jnnp.2009.178806","article-title":"Relationship between radiological characteristics and combined 1p and 19q deletion in World Health Organization grade III oligodendroglial tumours","volume":"82","author":"Kim","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry."},{"issue":"11","key":"2020050522084404400_CIT0034","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1007\/s00701-010-0743-1","article-title":"MR imaging characteristics of oligodendroglial tumors with assessment of 1p\/19q deletion status","volume":"152","author":"Sherman","year":"2010","journal-title":"Acta Neurochir (wien)."},{"issue":"5","key":"2020050522084404400_CIT0035","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1365-2559.2008.03160.x","article-title":"Can morphology predict 1p\/19q loss in oligodendroglial tumours?","volume":"53","author":"Scheie","year":"2008","journal-title":"Histopathology."},{"issue":"3","key":"2020050522084404400_CIT0036","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s11060-015-1989-5","article-title":"Subgroup characteristics of insular low-grade glioma based on clinical and molecular analysis of 42 cases","volume":"126","author":"Tang","year":"2016","journal-title":"J Neurooncol."},{"issue":"12","key":"2020050522084404400_CIT0037","first-page":"8627","article-title":"Surgically treated incidentally discovered low-grade gliomas are mostly IDH mutated and 1p19q co-deleted with favorable prognosis","volume":"7","author":"Zhang","year":"2014","journal-title":"Int J Clin Exp Pathol."},{"issue":"1","key":"2020050522084404400_CIT0038","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/neuonc\/nox132","article-title":"Prognostic relevance of genetic alterations in diffuse lower-grade gliomas","volume":"20","author":"Aoki","year":"2018","journal-title":"Neuro Oncol."},{"issue":"6","key":"2020050522084404400_CIT0039","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00401-010-0777-8","article-title":"Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis","volume":"120","author":"Metellus","year":"2010","journal-title":"Acta Neuropathol."},{"issue":"3","key":"2020050522084404400_CIT0040","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2214\/AJR.17.18457","article-title":"MRI features and IDH mutational status of grade II diffuse gliomas: impact on diagnosis and prognosis","volume":"210","author":"Villanueva-Meyer","year":"2018","journal-title":"AJR Am J Roentgenol."},{"issue":"4","key":"2020050522084404400_CIT0041","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.18632\/oncotarget.5456","article-title":"Biomarker-based prognostic stratification of young adult glioblastoma","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget."},{"issue":"2","key":"2020050522084404400_CIT0042","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s10143-013-0515-5","article-title":"Radiological features of supratentorial gliomas are associated with their genetic aberrations","volume":"37","author":"Nishiyama","year":"2014","journal-title":"Neurosurg Rev."},{"issue":"2","key":"2020050522084404400_CIT0043","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11060-016-2177-y","article-title":"Prognostic value of the extent of resection in supratentorial WHO grade II astrocytomas stratified for IDH1 mutation status: a single-center volumetric analysis","volume":"129","author":"Jungk","year":"2016","journal-title":"J Neurooncol."},{"issue":"1","key":"2020050522084404400_CIT0044","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11060-014-1623-y","article-title":"A better surgical resectability of WHO grade II gliomas is independent of favorable molecular markers","volume":"121","author":"Cordier","year":"2015","journal-title":"J Neurooncol."},{"issue":"3","key":"2020050522084404400_CIT0045","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11060-017-2673-8","article-title":"Regional specificity of 1p\/19q co-deletion combined with radiological features for predicting the survival outcomes of anaplastic oligodendroglial tumor patients","volume":"136","author":"Wang","year":"2018","journal-title":"J Neurooncol."},{"issue":"1","key":"2020050522084404400_CIT0046","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/0028-3886.198195","article-title":"Histological spectrum of oligodendroglial tumors: only a subset shows 1p\/19q codeletion","volume":"65","author":"Pai","year":"2017","journal-title":"Neurol India."},{"key":"2020050522084404400_CIT0047","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.wneu.2017.04.002","article-title":"Volumetric analysis of extent of resection, survival, and surgical outcomes for insular gliomas","volume":"103","author":"Eseonu","year":"2017","journal-title":"World Neurosurg."}],"container-title":["Neuro-Oncology Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/noa\/advance-article-pdf\/doi\/10.1093\/noajnl\/vdz032\/30088911\/vdz032.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/noa\/article-pdf\/1\/1\/vdz032\/33172159\/vdz032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/noa\/article-pdf\/1\/1\/vdz032\/33172159\/vdz032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T02:14:29Z","timestamp":1588731269000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/noa\/article\/doi\/10.1093\/noajnl\/vdz032\/5579374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/noajnl\/vdz032","relation":{},"ISSN":["2632-2498"],"issn-type":[{"type":"electronic","value":"2632-2498"}],"subject":[],"published-other":{"date-parts":[[2019,5]]},"published":{"date-parts":[[2019,5,1]]},"article-number":"vdz032"}}