{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:40:20Z","timestamp":1790628020074,"version":"4.1.0"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2019,11,10]],"date-time":"2019-11-10T00:00:00Z","timestamp":1573344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01 CA166593"],"award-info":[{"award-number":["R01 CA166593"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["F30AG056075"],"award-info":[{"award-number":["F30AG056075"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014804","name":"Neurofibromatosis Therapeutic Acceleration Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,25]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neurofibromatosis type I (NF1) is a debilitating inherited tumor syndrome affecting around 1 in 3000 people. Patients present with a variety of tumors caused by biallelic loss of the tumor suppressor neurofibromin (NF1), a negative regulator of Ras signaling. While the mechanism of tumor formation is similar in the majority of NF1 cases, the clinical spectrum of tumors can vary depending on spatiotemporal loss of heterozygosity of NF1 in cells derived from the neural crest during development. The hallmark lesions that give NF1 its namesake are neurofibromas, which are benign Schwann cell tumors composed of nervous and fibrous tissue. Neurofibromas can be found in the skin (cutaneous neurofibroma) or deeper in body near nerve plexuses (plexiform neurofibroma). While neurofibromas have been known to be Schwann cell tumors for many years, the exact timing and initiating cell has remained elusive. This has led to difficulties in developing animal models and successful therapies for NF1. A culmination of recent genetic studies has finally begun to shed light on the detailed cellular origins of neurofibromatosis. In this review, we will examine the hunt for neurofibroma tumor cells of origin through a historical lens, detailing the genetic systems used to delineate the source of plexiform and cutaneous neurofibromas. Through these novel findings, we can better understand the cellular, temporal, and developmental context during tumor initiation. By leveraging this data, we hope to uncover new therapeutic targets and mechanisms to treat NF1 patients.<\/jats:p>","DOI":"10.1093\/noajnl\/vdz044","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T21:38:47Z","timestamp":1573508327000},"page":"i13-i22","source":"Crossref","is-referenced-by-count":19,"title":["New insights into the neurofibroma tumor cells of origin"],"prefix":"10.1093","volume":"2","author":[{"given":"Stephen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center, Dallas"},{"name":"Medical Scientist Training Program, University of Texas Southwestern Medical Center, Dallas"},{"name":"Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2817-5382","authenticated-orcid":false,"given":"Lu Q","family":"Le","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of Texas Southwestern Medical Center, Dallas"},{"name":"Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas"},{"name":"Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas"},{"name":"Neurofibromatosis Clinic, University of Texas Southwestern Medical Center, Dallas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,10]]},"reference":[{"issue":"1","key":"2020062601034849800_CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<1::AID-AJMG3>3.0.CO;2-8","article-title":"Epidemiology of neurofibromatosis type 1","volume":"89","author":"Friedman","year":"1999","journal-title":"Am J Med Genet."},{"issue":"4","key":"2020062601034849800_CIT0002","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(90)90150-D","article-title":"The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21","volume":"63","author":"Martin","year":"1990","journal-title":"Cell."},{"issue":"2","key":"2020062601034849800_CIT0003","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0092-8674(92)90407-4","article-title":"Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis","volume":"69","author":"DeClue","year":"1992","journal-title":"Cell."},{"issue":"1","key":"2020062601034849800_CIT0004","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1055\/s-0038-1627471","article-title":"Neurofibromatosis and Schwannomatosis","volume":"38","author":"Plotkin","year":"2018","journal-title":"Semin Neurol."},{"key":"2020062601034849800_CIT0005","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1212\/WNL.0000000000005788","article-title":"The biology of cutaneous neurofibromas: consensus recommendations for setting research priorities","volume":"91","author":"Brosseau","year":"2018","journal-title":"Neurology."},{"issue":"1","key":"2020062601034849800_CIT0006","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000057688","article-title":"Tissue stem cells: definition, plasticity, heterogeneity, self-organization and models\u2013a conceptual approach","volume":"171","author":"Loeffler","year":"2002","journal-title":"Cells Tissues Organs."},{"issue":"4","key":"2020062601034849800_CIT0007","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.stem.2015.09.003","article-title":"Adult mammalian neural stem cells and neurogenesis: five decades later","volume":"17","author":"Bond","year":"2015","journal-title":"Cell Stem Cell."},{"issue":"6320","key":"2020062601034849800_CIT0008","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.aah4307","article-title":"SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer","volume":"355","author":"Mu","year":"2017","journal-title":"Science."},{"issue":"1","key":"2020062601034849800_CIT0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.stem.2014.12.005","article-title":"Unraveling the TWIST between EMT and cancer stemness","volume":"16","author":"Jung","year":"2015","journal-title":"Cell Stem Cell."},{"issue":"19","key":"2020062601034849800_CIT0010","doi-asserted-by":"crossref","first-page":"4003","DOI":"10.1158\/0008-5472.CAN-15-0798","article-title":"Cell-of-Origin of cancer versus cancer stem cells: assays and interpretations","volume":"75","author":"Rycaj","year":"2015","journal-title":"Cancer Res."},{"issue":"3","key":"2020062601034849800_CIT0011","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.stem.2014.02.006","article-title":"Evolution of the cancer stem cell model","volume":"14","author":"Kreso","year":"2014","journal-title":"Cell Stem Cell."},{"issue":"7","key":"2020062601034849800_CIT0012","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat Med."},{"issue":"4","key":"2020062601034849800_CIT0013","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrc1590","article-title":"Tumour stem cells and drug resistance","volume":"5","author":"Dean","year":"2005","journal-title":"Nat Rev Cancer."},{"issue":"7","key":"2020062601034849800_CIT0014","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"Yang","year":"2004","journal-title":"Cell."},{"issue":"2","key":"2020062601034849800_CIT0015","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.celrep.2014.12.032","article-title":"Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation","volume":"10","author":"Schmidt","year":"2015","journal-title":"Cell Rep."},{"issue":"4","key":"2020062601034849800_CIT0016","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrg2046","article-title":"Epigenetic signatures of stem-cell identity","volume":"8","author":"Spivakov","year":"2007","journal-title":"Nat Rev Genet."},{"issue":"7330","key":"2020062601034849800_CIT0017","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature09781","article-title":"Cells of origin in cancer","volume":"469","author":"Visvader","year":"2011","journal-title":"Nature."},{"issue":"3","key":"2020062601034849800_CIT0018","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1053\/j.semdp.2018.01.001","article-title":"Uncovering hereditary tumor syndromes: emerging role of surgical pathology","volume":"35","author":"Agaimy","year":"2018","journal-title":"Semin Diagn Pathol."},{"issue":"2","key":"2020062601034849800_CIT0019","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/labinvest.2016.142","article-title":"The NF1 gene in tumor syndromes and melanoma","volume":"97","author":"Kiuru","year":"2017","journal-title":"Lab Invest."},{"key":"2020062601034849800_CIT0020","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/cncr.23648","article-title":"Inherited pancreatic endocrine tumor syndromes: advances in molecular pathogenesis, diagnosis, management, and controversies","volume":"113","author":"Jensen","year":"2008","journal-title":"Cancer."},{"key":"2020062601034849800_CIT0021","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-20086-1","volume-title":"Quick Reference Handbook for Surgical Pathologists","author":"Rekhtman","year":"2011"},{"issue":"8","key":"2020062601034849800_CIT0022","first-page":"585\u201391\u2013discussion602\u20134\u2013646\u201351","article-title":"Neurofibromas in children with neurofibromatosis 1","volume":"17","author":"Rosser","year":"2002","journal-title":"J Child Neurol"},{"issue":"2","key":"2020062601034849800_CIT0023","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/sj.ejhg.5201676","article-title":"Neurofibromatosis 1","volume":"15","author":"Ferner","year":"2007","journal-title":"Eur J Hum Genet."},{"issue":"5447","key":"2020062601034849800_CIT0024","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1126\/science.286.5447.2176","article-title":"Mouse tumor model for neurofibromatosis type 1","volume":"286","author":"Vogel","year":"1999","journal-title":"Science."},{"issue":"5","key":"2020062601034849800_CIT0025","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/jmg.39.5.311","article-title":"Malignant peripheral nerve sheath tumours in neurofibromatosis 1","volume":"39","author":"Evans","year":"2002","journal-title":"J Med Genet."},{"issue":"9","key":"2020062601034849800_CIT0026","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1007\/s00234-003-0964-6","article-title":"Malignant peripheral nerve sheath tumours in neurofibromatosis type 1: MRI supports the diagnosis of malignant plexiform neurofibroma","volume":"45","author":"Mautner","year":"2003","journal-title":"Neuroradiology."},{"issue":"1","key":"2020062601034849800_CIT0027","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/(SICI)1096-8628(19961202)66:1<7::AID-AJMG2>3.0.CO;2-R","article-title":"Neurofibromatosis type 1 and pregnancy","volume":"66","author":"Dugoff","year":"1996","journal-title":"Am J Med Genet."},{"key":"2020062601034849800_CIT0028","volume-title":"Ueber Die Multiplen Fibrome Der Haut Und Ihre Beziehung Zu Den Multiplen Neuromen","author":"von Recklinghuasen","year":"1882"},{"issue":"3","key":"2020062601034849800_CIT0029","first-page":"393","article-title":"Study on the ultrastructure and acetylcholinesterase activity in von Recklinghausen\u2019s neurofibromatosis","volume":"28","author":"Kamata","year":"1978","journal-title":"Acta Pathol Jpn."},{"issue":"2","key":"2020062601034849800_CIT0030","first-page":"261","article-title":"S-100 protein in soft-tissue tumors derived from Schwann cells and melanocytes","volume":"106","author":"Stefansson","year":"1982","journal-title":"Am J Pathol."},{"issue":"3","key":"2020062601034849800_CIT0031","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1086\/515504","article-title":"Confirmation of a double-hit model for the NF1 gene in benign neurofibromas","volume":"61","author":"Serra","year":"1997","journal-title":"Am J Hum Genet."},{"issue":"2","key":"2020062601034849800_CIT0032","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1083\/jcb.111.2.645","article-title":"Angiogenic and invasive properties of neurofibroma Schwann cells","volume":"111","author":"Sheela","year":"1990","journal-title":"J Cell Biol."},{"issue":"3","key":"2020062601034849800_CIT0033","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/(SICI)1098-2264(199903)24:3<283::AID-GCC15>3.0.CO;2-K","article-title":"Loss of NF1 allele in Schwann cells but not in fibroblasts derived from an NF1-associated neurofibroma","volume":"24","author":"Kluwe","year":"1999","journal-title":"Genes Chromosomes Cancer."},{"issue":"6500","key":"2020062601034849800_CIT0034","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/371796a0","article-title":"Krox-20 controls myelination in the peripheral nervous system","volume":"371","author":"Topilko","year":"1994","journal-title":"Nature."},{"issue":"5569","key":"2020062601034849800_CIT0035","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.1068452","article-title":"Neurofibromas in NF1: Schwann cell origin and role of tumor environment","volume":"296","author":"Zhu","year":"2002","journal-title":"Science."},{"issue":"1","key":"2020062601034849800_CIT0036","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1084\/jem.191.1.181","article-title":"Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo","volume":"191","author":"Ingram","year":"2000","journal-title":"J Exp Med."},{"key":"2020062601034849800_CIT0037","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3389\/fnmol.2019.00069","article-title":"Schwann cell precursors; multipotent glial cells in embryonic nerves","volume":"12","author":"Jessen","year":"2019","journal-title":"Front Mol Neurosci."},{"issue":"22","key":"2020062601034849800_CIT0038","doi-asserted-by":"crossref","first-page":"5599","DOI":"10.1242\/dev.01429","article-title":"Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells","volume":"131","author":"Joseph","year":"2004","journal-title":"Development."},{"issue":"27","key":"2020062601034849800_CIT0039","doi-asserted-by":"crossref","first-page":"9879","DOI":"10.1523\/JNEUROSCI.1239-15.2015","article-title":"Neuronal differentiation in Schwann cell lineage underlies postnatal neurogenesis in the enteric nervous system","volume":"35","author":"Uesaka","year":"2015","journal-title":"J Neurosci."},{"issue":"45","key":"2020062601034849800_CIT0040","doi-asserted-by":"crossref","first-page":"11980","DOI":"10.1073\/pnas.1710308114","article-title":"Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest","volume":"114","author":"Espinosa-Medina","year":"2017","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"3","key":"2020062601034849800_CIT0041","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/0896-6273(94)90209-7","article-title":"The Schwann cell precursor and its fate: a study of cell death and differentiation during gliogenesis in rat embryonic nerves","volume":"12","author":"Jessen","year":"1994","journal-title":"Neuron."},{"issue":"3","key":"2020062601034849800_CIT0042","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0896-6273(95)90147-7","article-title":"Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat Schwann cell precursors","volume":"15","author":"Dong","year":"1995","journal-title":"Neuron."},{"issue":"9","key":"2020062601034849800_CIT0043","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0960-9822(00)00183-4","article-title":"Neural development. Fate diverted","volume":"4","author":"Jessen","year":"1994","journal-title":"Curr Biol."},{"issue":"3","key":"2020062601034849800_CIT0044","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/1073858415572361","article-title":"How Schwann cells sort axons: new concepts","volume":"22","author":"Feltri","year":"2016","journal-title":"Neuroscientist."},{"issue":"9","key":"2020062601034849800_CIT0045","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nn1299","article-title":"Neural crest boundary cap cells constitute a source of neuronal and glial cells of the PNS","volume":"7","author":"Maro","year":"2004","journal-title":"Nat Neurosci."},{"issue":"13","key":"2020062601034849800_CIT0046","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/glia.20862","article-title":"Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers","volume":"57","author":"Coulpier","year":"2009","journal-title":"Glia."},{"key":"2020062601034849800_CIT0047","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.conb.2017.11.003","article-title":"Boundary cap cells in development and disease","volume":"47","author":"Radomska","year":"2017","journal-title":"Curr Opin Neurobiol."},{"issue":"2","key":"2020062601034849800_CIT0048","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.stemcr.2015.06.005","article-title":"Boundary caps give rise to neurogenic stem cells and terminal glia in the skin","volume":"5","author":"Gresset","year":"2015","journal-title":"Stem Cell Rep."},{"key":"2020062601034849800_CIT0049","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fncel.2019.00033","article-title":"The success and failure of the Schwann cell response to nerve injury","volume":"13","author":"Jessen","year":"2019","journal-title":"Front Cell Neurosci."},{"issue":"11","key":"2020062601034849800_CIT0050","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.celrep.2017.08.064","article-title":"Changes in the coding and non-coding transcriptome and DNA methylome that define the Schwann cell repair phenotype after nerve injury","volume":"20","author":"Arthur-Farraj","year":"2017","journal-title":"Cell Rep."},{"issue":"7","key":"2020062601034849800_CIT0051","doi-asserted-by":"crossref","first-page":"a020487","DOI":"10.1101\/cshperspect.a020487","article-title":"Schwann cells: development and role in nerve repair","volume":"7","author":"Jessen","year":"2015","journal-title":"Cold Spring Harb Perspect Biol."},{"issue":"13","key":"2020062601034849800_CIT0052","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1113\/JP270874","article-title":"The repair Schwann cell and its function in regenerating nerves","volume":"594","author":"Jessen","year":"2016","journal-title":"J Physiol."},{"issue":"37","key":"2020062601034849800_CIT0053","doi-asserted-by":"crossref","first-page":"9086","DOI":"10.1523\/JNEUROSCI.1453-17.2017","article-title":"After nerve injury, lineage tracing shows that myelin and remak Schwann cells elongate extensively and branch to form repair Schwann cells, which shorten radically on remyelination","volume":"37","author":"Gomez-Sanchez","year":"2017","journal-title":"J Neurosci."},{"issue":"2","key":"2020062601034849800_CIT0054","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2009.07.049","article-title":"Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin","volume":"139","author":"Adameyko","year":"2009","journal-title":"Cell."},{"issue":"8","key":"2020062601034849800_CIT0055","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1056\/NEJMra043666","article-title":"Neural stem cells and the origin of gliomas","volume":"353","author":"Sanai","year":"2005","journal-title":"N Engl J Med."},{"issue":"4","key":"2020062601034849800_CIT0056","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1053\/j.gastro.2016.11.048","article-title":"Liver cancer cell of origin, molecular class, and effects on patient prognosis","volume":"152","author":"Sia","year":"2017","journal-title":"Gastroenterology."},{"issue":"1","key":"2020062601034849800_CIT0057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2004.04.007","article-title":"Stem cell origin of cancer and differentiation therapy","volume":"51","author":"Sell","year":"2004","journal-title":"Crit Rev Oncol Hematol."},{"issue":"3 Suppl","key":"2020062601034849800_CIT0058","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/1097-0142(19930801)72:3+<962::AID-CNCR2820721303>3.0.CO;2-H","article-title":"The molecular biology of carcinogenesis","volume":"72","author":"Pitot","year":"1993","journal-title":"Cancer."},{"issue":"5","key":"2020062601034849800_CIT0059","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.stem.2009.03.017","article-title":"Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas","volume":"4","author":"Le","year":"2009","journal-title":"Cell Stem Cell."},{"issue":"2","key":"2020062601034849800_CIT0060","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.ccr.2008.01.003","article-title":"The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells","volume":"13","author":"Joseph","year":"2008","journal-title":"Cancer Cell."},{"issue":"6","key":"2020062601034849800_CIT0061","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1242\/dev.120.6.1399","article-title":"Negative regulation of the P0 gene in Schwann cells: suppression of P0 mRNA and protein induction in cultured Schwann cells by FGF2 and TGF beta 1, TGF beta 2 and TGF beta 3","volume":"120","author":"Morgan","year":"1994","journal-title":"Development."},{"issue":"2","key":"2020062601034849800_CIT0062","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ccr.2008.01.002","article-title":"Induction of abnormal proliferation by nonmyelinating Schwann cells triggers neurofibroma formation","volume":"13","author":"Zheng","year":"2008","journal-title":"Cancer Cell."},{"issue":"2","key":"2020062601034849800_CIT0063","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ccr.2007.12.027","article-title":"Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells","volume":"13","author":"Wu","year":"2008","journal-title":"Cancer Cell."},{"issue":"2","key":"2020062601034849800_CIT0064","first-page":"325","article-title":"Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes","volume":"11","author":"Kim","year":"1995","journal-title":"Oncogene."},{"issue":"13","key":"2020062601034849800_CIT0065","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.1158\/0008-5472.CAN-10-4577","article-title":"Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development","volume":"71","author":"Le","year":"2011","journal-title":"Cancer Res."},{"issue":"5","key":"2020062601034849800_CIT0066","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ccell.2014.09.009","article-title":"Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma","volume":"26","author":"Chen","year":"2014","journal-title":"Cancer Cell."},{"issue":"32","key":"2020062601034849800_CIT0067","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1038\/sj.onc.1210250","article-title":"Conditional N-rasG12V expression promotes manifestations of neurofibromatosis in a mouse model","volume":"26","author":"Saito","year":"2007","journal-title":"Oncogene."},{"issue":"1","key":"2020062601034849800_CIT0068","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.expneurol.2006.03.018","article-title":"Analysis of the neurogenic potential of multipotent skin-derived precursors","volume":"201","author":"Fernandes","year":"2006","journal-title":"Exp Neurol."},{"issue":"24","key":"2020062601034849800_CIT0069","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1523\/JNEUROSCI.1007-06.2006","article-title":"Skin-derived precursors generate myelinating Schwann cells for the injured and dysmyelinated nervous system","volume":"26","author":"McKenzie","year":"2006","journal-title":"J Neurosci."},{"issue":"6","key":"2020062601034849800_CIT0070","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1634\/stemcells.2004-0134","article-title":"Isolation and characterization of multipotent skin-derived precursors from human skin","volume":"23","author":"Toma","year":"2005","journal-title":"Stem Cells."},{"issue":"9","key":"2020062601034849800_CIT0071","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/ncb0901-778","article-title":"Isolation of multipotent adult stem cells from the dermis of mammalian skin","volume":"3","author":"Toma","year":"2001","journal-title":"Nat Cell Biol."},{"issue":"1","key":"2020062601034849800_CIT0072","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1158\/2159-8290.CD-18-0151","article-title":"Spatiotemporal loss of NF1 in Schwann cell lineage leads to different types of cutaneous neurofibroma susceptible to modification by the hippo pathway","volume":"9","author":"Chen","year":"2019","journal-title":"Cancer Discov."},{"issue":"4","key":"2020062601034849800_CIT0073","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/aja.1002040411","article-title":"Differential effects of retinoic acid and a retinoid antagonist on the spatial distribution of the homeoprotein Hoxb-7 in vertebrate embryos","volume":"204","author":"L\u00f3pez","year":"1995","journal-title":"Dev Dyn."},{"issue":"4","key":"2020062601034849800_CIT0074","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2012.06.021","article-title":"c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration","volume":"75","author":"Arthur-Farraj","year":"2012","journal-title":"Neuron."},{"issue":"1","key":"2020062601034849800_CIT0075","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1158\/2159-8290.CD-18-0156","article-title":"Cellular origin, tumor progression, and pathogenic mechanisms of cutaneous neurofibromas revealed by mice with nf1 knockout in boundary cap cells","volume":"9","author":"Radomska","year":"2019","journal-title":"Cancer Discov."},{"issue":"1","key":"2020062601034849800_CIT0076","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrg1748","article-title":"The epigenetic progenitor origin of human cancer","volume":"7","author":"Feinberg","year":"2006","journal-title":"Nat Rev Genet."},{"issue":"5","key":"2020062601034849800_CIT0077","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nrg.2016.13","article-title":"Epigenetic modulators, modifiers and mediators in cancer aetiology and progression","volume":"17","author":"Feinberg","year":"2016","journal-title":"Nat Rev Genet."},{"issue":"2","key":"2020062601034849800_CIT0078","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.stem.2016.10.018","article-title":"Cell-type-specific chromatin states differentially prime squamous cell carcinoma tumor-initiating cells for epithelial to mesenchymal transition","volume":"20","author":"Latil","year":"2017","journal-title":"Cell Stem Cell."},{"issue":"2","key":"2020062601034849800_CIT0079","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/ng1941","article-title":"Epigenetic stem cell signature in cancer","volume":"39","author":"Widschwendter","year":"2007","journal-title":"Nat Genet."},{"issue":"6","key":"2020062601034849800_CIT0080","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/00005072-199511000-00001","article-title":"Genetic and epigenetic mechanisms in the pathogenesis of neurofibromatosis type I","volume":"54","author":"Metheny","year":"1995","journal-title":"J Neuropathol Exp Neurol."},{"issue":"4","key":"2020062601034849800_CIT0081","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41588-018-0044-9","article-title":"Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma","volume":"50","author":"Zeid","year":"2018","journal-title":"Nat Genet."},{"issue":"3\u20134","key":"2020062601034849800_CIT0082","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1615\/CritRevOncog.2015013713","article-title":"Osteosarcoma genetics and epigenetics: emerging biology and candidate therapies","volume":"20","author":"Morrow","year":"2015","journal-title":"Crit Rev Oncog."},{"issue":"4","key":"2020062601034849800_CIT0083","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1128\/MCB.00916-12","article-title":"Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors","volume":"33","author":"MacQuarrie","year":"2013","journal-title":"Mol Cell Biol."},{"issue":"6","key":"2020062601034849800_CIT0084","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1073\/pnas.92.6.2159","article-title":"Epigenetic changes encompassing the IGF2\/H19 locus associated with relaxation of IGF2 imprinting and silencing of H19 in Wilms tumor","volume":"92","author":"Taniguchi","year":"1995","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"7381","key":"2020062601034849800_CIT0085","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature10733","article-title":"A novel retinoblastoma therapy from genomic and epigenetic analyses","volume":"481","author":"Zhang","year":"2012","journal-title":"Nature."},{"issue":"11\u201312","key":"2020062601034849800_CIT0086","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1101\/gad.324467.119","article-title":"Twist2 amplification in rhabdomyosarcoma represses myogenesis and promotes oncogenesis by redirecting MyoD DNA binding","volume":"33","author":"Li","year":"2019","journal-title":"Genes Dev."},{"issue":"7539","key":"2020062601034849800_CIT0087","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature14221","article-title":"Cell-of-origin chromatin organization shapes the mutational landscape of cancer","volume":"518","author":"Polak","year":"2015","journal-title":"Nature."},{"issue":"11","key":"2020062601034849800_CIT0088","first-page":"S5","article-title":"Robust surgical approach for cutaneous neurofibroma in neurofibromatosis type 1","volume":"5","author":"Chamseddin","year":"2019","journal-title":"JCI Insight"}],"container-title":["Neuro-Oncology Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/noa\/advance-article-pdf\/doi\/10.1093\/noajnl\/vdz044\/30606233\/vdz044.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/noa\/article-pdf\/2\/Supplement_1\/i13\/33429920\/vdz044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/noa\/article-pdf\/2\/Supplement_1\/i13\/33429920\/vdz044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T10:05:32Z","timestamp":1664877932000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/noa\/article\/2\/Supplement_1\/i13\/5618780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,10]]},"references-count":88,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[2020,6,25]]}},"URL":"https:\/\/doi.org\/10.1093\/noajnl\/vdz044","relation":{},"ISSN":["2632-2498"],"issn-type":[{"value":"2632-2498","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2019,11,10]]}}}