{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:01:01Z","timestamp":1790884861482,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,18]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The spine is a frequent location for metastatic disease. As local control of primary tumor pathology continues to improve, survival rates improve and, by extension, the opportunity for metastasis increases. Breast, lung, and prostate cancer are the leading contributors to spinal metastases. Spinal metastases can manifest as bone pain, pathologic fractures, spinal instability, nerve root compression, and, in its most severe form, spinal cord compression. The global extent of disease, the spinal burden, neurologic status, and life expectancy help to categorize patients as to their candidacy for treatment options. Efficient identification and workup of those with spinal metastases will expedite the treatment cascade and improve quality of life.<\/jats:p>","DOI":"10.1093\/nop\/npaa046","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T13:00:40Z","timestamp":1605704440000},"page":"i5-i9","source":"Crossref","is-referenced-by-count":67,"title":["Epidemiology of spinal cord and column tumors"],"prefix":"10.1093","volume":"7","author":[{"given":"Joshua T","family":"Wewel","sequence":"first","affiliation":[{"name":"Atlanta Brain and Spine Care, Piedmont Healthcare, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E","family":"O\u2019Toole","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Medical Center, Chicago, Illinois, US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"issue":"3","key":"2020111806262430200_CIT0001","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10549-010-0981-1","article-title":"Prognostic factors for skeletal complications from metastatic bone disease in breast cancer","volume":"123","author":"Brown","year":"2010","journal-title":"Breast Cancer Res Treat."},{"issue":"6","key":"2020111806262430200_CIT0002","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3171\/SPI-07\/12\/579","article-title":"Degenerative lumbar spinal stenosis: analysis of results in a series of 374 patients treated with unilateral laminotomy for bilateral microdecompression","volume":"7","author":"Costa","year":"2007","journal-title":"J Neurosurg Spine."},{"issue":"1","key":"2020111806262430200_CIT0003","first-page":"321","article-title":"Bone metastases: an overview","volume":"11","author":"Macedo","year":"2017","journal-title":"Oncol Rev."},{"issue":"1","key":"2020111806262430200_CIT0004","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/pcan.2016.62","article-title":"Skeletal-related events significantly impact health-related quality of life in metastatic castration-resistant prostate cancer: data from PREVAIL and AFFIRM trials","volume":"20","author":"Saad","year":"2017","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"2","key":"2020111806262430200_CIT0005","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1055-3207(18)30063-2","article-title":"Critical steps in hematogenous metastasis: an overview","volume":"10","author":"Chambers","year":"2001","journal-title":"Surg Oncol Clin N Am."},{"issue":"3","key":"2020111806262430200_CIT0006","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0002-9440(10)65628-3","article-title":"Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases","volume":"153","author":"Luzzi","year":"1998","journal-title":"Am J Pathol."},{"issue":"1","key":"2020111806262430200_CIT0007","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12885-017-3922-0","article-title":"Incidence of bone metastases in patients with solid tumors: analysis of oncology electronic medical records in the United States","volume":"18","author":"Hernandez","year":"2018","journal-title":"BMC Cancer."},{"key":"2020111806262430200_CIT0008","first-page":"87","article-title":"Estimated number of prevalent cases of metastatic bone disease in the US adult population","volume":"4","author":"Li","year":"2012","journal-title":"Clin Epidemiol."},{"issue":"15","key":"2020111806262430200_CIT0009","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1200\/JCO.2005.04.754","article-title":"Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression","volume":"23","author":"Rades","year":"2005","journal-title":"J Clin Oncol."},{"issue":"42","key":"2020111806262430200_CIT0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta17420","article-title":"A systematic review of evidence on malignant spinal metastases: natural history and technologies for identifying patients at high risk of vertebral fracture and spinal cord compression","volume":"17","author":"Sutcliffe","year":"2013","journal-title":"Health Technol Assess."},{"key":"2020111806262430200_CIT0011","first-page":"004","article-title":"Metastatic bone disease: pathogenesis and therapeutic options: up-date on bone metastasis management","volume":"15","author":"D\u2019Oronzo","year":"2019","journal-title":"J Bone Oncol."},{"issue":"3","key":"2020111806262430200_CIT0012","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/os.12465","article-title":"Relationship between visceral metastases and survival in patients with metastasis-related spinal cord compression","volume":"11","author":"Lun","year":"2019","journal-title":"Orthop Surg"},{"issue":"6","key":"2020111806262430200_CIT0013","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1111\/os.12552","article-title":"Epidemiological characteristics of 1196 patients with spinal metastases: a retrospective study","volume":"11","author":"Wang","year":"2019","journal-title":"Orthop Surg."},{"issue":"8 suppl","key":"2020111806262430200_CIT0014","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1628::AID-CNCR13>3.0.CO;2-1","article-title":"Radiation for bone metastases: conventional techniques and the role of systemic radiopharmaceuticals","volume":"80","author":"Janjan","year":"1997","journal-title":"Cancer."},{"issue":"5","key":"2020111806262430200_CIT0015","doi-asserted-by":"crossref","first-page":"iii, xi","DOI":"10.3310\/hta13050","article-title":"Use of classical and novel biomarkers as prognostic risk factors for localised prostate cancer: a systematic review","volume":"13","author":"Sutcliffe","year":"2009","journal-title":"Health Technol Assess."},{"issue":"3","key":"2020111806262430200_CIT0016","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.critrevonc.2005.03.011","article-title":"Management of bone metastases in cancer: a review","volume":"56","author":"Selvaggi","year":"2005","journal-title":"Crit Rev Oncol Hematol."},{"issue":"7","key":"2020111806262430200_CIT0017","doi-asserted-by":"crossref","first-page":"834","DOI":"10.2174\/156800909789760375","article-title":"Denosumab: the era of targeted therapies in bone metastatic diseases","volume":"9","author":"Santini","year":"2009","journal-title":"Curr Cancer Drug Targets."},{"issue":"4","key":"2020111806262430200_CIT0018","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0305-7372(96)90021-3","article-title":"Effects of bone metastases on bone metabolism: implications for diagnosis, imaging and assessment of response to cancer treatment","volume":"22","author":"Vinholes","year":"1996","journal-title":"Cancer Treat Rev."},{"issue":"8 suppl","key":"2020111806262430200_CIT0019","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1002\/(SICI)1097-0142(19971015)80:8+<1595::AID-CNCR10>3.0.CO;2-V","article-title":"Radiologic diagnosis of bone metastases","volume":"80","author":"Rosenthal","year":"1997","journal-title":"Cancer."},{"issue":"8","key":"2020111806262430200_CIT0020","doi-asserted-by":"crossref","first-page":"653; author reply 653","DOI":"10.1053\/crad.2000.0417","article-title":"Magnetic resonance imaging versus radionuclide scintigraphy for screening in bone metastases","volume":"55","author":"Evans","year":"2000","journal-title":"Clin Radiol."},{"issue":"3","key":"2020111806262430200_CIT0021","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1148\/radiology.199.3.8638000","article-title":"Metastatic prostate cancer: initial findings of PET with 2-deoxy-2-[F-18]fluoro-D-glucose","volume":"199","author":"Shreve","year":"1996","journal-title":"Radiology."},{"issue":"6","key":"2020111806262430200_CIT0022","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s00432-002-0342-5","article-title":"Comparing whole body (18)F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphonate bone scan to detect bone metastases in patients with breast cancer","volume":"128","author":"Yang","year":"2002","journal-title":"J Cancer Res Clin Oncol."},{"issue":"1","key":"2020111806262430200_CIT0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nec.2007.10.005","article-title":"Epidemiology and demographics for primary vertebral tumors","volume":"19","author":"Chi","year":"2008","journal-title":"Neurosurg Clin N Am."},{"issue":"2","key":"2020111806262430200_CIT0024","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3171\/jns.1996.85.2.0225","article-title":"The surgical treatment of metastatic spinal tumors within the intradural extramedullary compartment","volume":"85","author":"Chow","year":"1996","journal-title":"J Neurosurg."},{"issue":"2","key":"2020111806262430200_CIT0025","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3171\/jns.1985.62.2.0227","article-title":"Intramedullary spinal cord metastasis. A clinicopathological study of 13 cases","volume":"62","author":"Costigan","year":"1985","journal-title":"J Neurosurg."},{"issue":"10","key":"2020111806262430200_CIT0026","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.3174\/ajnr.A3526","article-title":"Intramedullary spinal cord metastases: MRI and relevant clinical features from a 13-year institutional case series","volume":"34","author":"Rykken","year":"2013","journal-title":"AJNR Am J Neuroradiol."},{"issue":"1","key":"2020111806262430200_CIT0027","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13256-019-2155-z","article-title":"Intradural metastasis to the cauda equina found as the initial presentation of breast cancer: a case report","volume":"13","author":"Koyama","year":"2019","journal-title":"J Med Case Rep."},{"issue":"1","key":"2020111806262430200_CIT0028","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/cncr.30911","article-title":"Leptomeningeal metastasis from systemic cancer: review and update on management","volume":"124","author":"Wang","year":"2018","journal-title":"Cancer."},{"issue":"9","key":"2020111806262430200_CIT0029","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S1470-2045(10)70034-6","article-title":"Intrathecal chemotherapy for treatment of leptomeningeal dissemination of metastatic tumours","volume":"11","author":"Beauchesne","year":"2010","journal-title":"Lancet Oncol."},{"issue":"12","key":"2020111806262430200_CIT0030","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/1097-0142(19831215)52:12<2349::AID-CNCR2820521231>3.0.CO;2-B","article-title":"Central nervous system metastasis from breast carcinoma. Autopsy study","volume":"52","author":"Tsukada","year":"1983","journal-title":"Cancer."},{"issue":"2","key":"2020111806262430200_CIT0031","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/1097-0142(197808)42:2<660::AID-CNCR2820420237>3.0.CO;2-E","article-title":"Malignant melanoma and central nervous system metastases: incidence, diagnosis, treatment and survival","volume":"42","author":"Amer","year":"1978","journal-title":"Cancer."},{"issue":"1","key":"2020111806262430200_CIT0032","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0002-9343(81)90254-0","article-title":"Meningeal carcinomatosis in small cell carcinoma of the lung","volume":"71","author":"Aroney","year":"1981","journal-title":"Am J Med."},{"issue":"7","key":"2020111806262430200_CIT0033","doi-asserted-by":"crossref","first-page":"E264","DOI":"10.1097\/BRS.0b013e3181c11748","article-title":"Spinal metastasis of glioblastoma multiforme: an uncommon suspect?","volume":"35","author":"Birbilis","year":"2010","journal-title":"Spine (Phila Pa 1976)."},{"key":"2020111806262430200_CIT0034","doi-asserted-by":"crossref","first-page":"26","DOI":"10.21037\/acr.2018.03.02","article-title":"Diagnosis and management of spinal metastasis of primary brain tumours","volume":"2","author":"Chen-Zhao","year":"2018","journal-title":"AME Case Rep."},{"issue":"5","key":"2020111806262430200_CIT0035","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0090-3019(91)90049-F","article-title":"Spinal leptomeningeal metastasis from cerebral glioblastoma. Appearance on magnetic resonance imaging","volume":"35","author":"Lam","year":"1991","journal-title":"Surg Neurol."},{"issue":"2","key":"2020111806262430200_CIT0036","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s11060-012-0955-8","article-title":"Malignant spinal cord compression in cerebral glioblastoma multiforme: a multicenter case series and review of the literature","volume":"110","author":"Tinchon","year":"2012","journal-title":"J Neurooncol."},{"issue":"1","key":"2020111806262430200_CIT0037","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/bjc.1987.13","article-title":"The clinical course of bone metastases from breast cancer","volume":"55","author":"Coleman","year":"1987","journal-title":"Br J Cancer."},{"issue":"3","key":"2020111806262430200_CIT0038","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/ctrv.2000.0210","article-title":"Metastatic bone disease: clinical features, pathophysiology and treatment strategies","volume":"27","author":"Coleman","year":"2001","journal-title":"Cancer Treat Rev."},{"issue":"4","key":"2020111806262430200_CIT0039","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1210\/jc.2012-4231","article-title":"Bone metastases and skeletal-related events in patients with malignant pheochromocytoma and sympathetic paraganglioma","volume":"98","author":"Ayala-Ramirez","year":"2013","journal-title":"J Clin Endocrinol Metab."},{"issue":"4","key":"2020111806262430200_CIT0040","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1159\/000358258","article-title":"Management of bone metastases in patients with castration-resistant prostate cancer","volume":"92","author":"Cathomas","year":"2014","journal-title":"Urol Int."},{"issue":"4","key":"2020111806262430200_CIT0041","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/pcan.2016.26","article-title":"Do skeletal-related events predict overall survival in men with metastatic castration-resistant prostate cancer?","volume":"19","author":"Howard","year":"2016","journal-title":"Prostate Cancer Prostatic Dis."},{"issue":"9","key":"2020111806262430200_CIT0042","doi-asserted-by":"crossref","first-page":"693","DOI":"10.18553\/jmcp.2010.16.9.693","article-title":"Payer costs for inpatient treatment of pathologic fracture, surgery to bone, and spinal cord compression among patients with multiple myeloma or bone metastasis secondary to prostate or breast cancer","volume":"16","author":"Barlev","year":"2010","journal-title":"J Manag Care Pharm."},{"issue":"7","key":"2020111806262430200_CIT0043","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00520-006-0203-x","article-title":"Effects of skeletal morbidities on longitudinal patient-reported outcomes and survival in patients with metastatic prostate cancer","volume":"15","author":"DePuy","year":"2007","journal-title":"Support Care Cancer."},{"issue":"2","key":"2020111806262430200_CIT0044","first-page":"98","article-title":"The distribution of secondary growths in cancer of the breast. 1889","volume":"8","author":"Paget","year":"1989","journal-title":"Cancer Metastasis Rev."},{"issue":"3-4","key":"2020111806262430200_CIT0045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10555-013-9420-1","article-title":"The pre-metastatic niche: finding common ground","volume":"32","author":"Sceneay","year":"2013","journal-title":"Cancer Metastasis Rev."},{"issue":"1","key":"2020111806262430200_CIT0046","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S1470-2045(05)70022-X","article-title":"Malignant spinal-cord compression","volume":"6","author":"Prasad","year":"2005","journal-title":"Lancet Oncol."},{"issue":"1","key":"2020111806262430200_CIT0047","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0167-8140(94)90411-1","article-title":"A comparison of the palliative effects of strontium-89 and external beam radiotherapy in metastatic prostate cancer","volume":"31","author":"Quilty","year":"1994","journal-title":"Radiother Oncol."},{"issue":"24","key":"2020111806262430200_CIT0048","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1056\/NEJM199612123352401","article-title":"Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. Protocol 19 Aredia Breast Cancer Study Group","volume":"335","author":"Hortobagyi","year":"1996","journal-title":"N Engl J Med."},{"issue":"7","key":"2020111806262430200_CIT0049","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/neuonc\/not318","article-title":"Prognostic factors associated with survival in patients with symptomatic spinal bone metastases: a retrospective cohort study of 1043 patients","volume":"16","author":"Bollen","year":"2014","journal-title":"Neuro Oncol."},{"issue":"4","key":"2020111806262430200_CIT0050","doi-asserted-by":"crossref","first-page":"E671","DOI":"10.1093\/neuros\/nyz070","article-title":"Predicting 90-day and 1-year mortality in spinal metastatic disease: development and internal validation","volume":"85","author":"Karhade","year":"2019","journal-title":"Neurosurgery."},{"issue":"10","key":"2020111806262430200_CIT0051","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1002\/cncr.23888","article-title":"Prognostic factors and a scoring system for survival after radiotherapy for metastases to the spinal column: a review of 544 patients at Shizuoka Cancer Center Hospital","volume":"113","author":"Mizumoto","year":"2008","journal-title":"Cancer."},{"issue":"415 suppl","key":"2020111806262430200_CIT0052","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1097\/01.blo.0000093844.72468.f4","article-title":"Breast cancer metastasis to bone: it is not all about PTHrP","author":"Bendre","year":"2003","journal-title":"Clin Orthop"},{"issue":"1","key":"2020111806262430200_CIT0053","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bone.2010.05.037","article-title":"Advances in management of bone disease in breast cancer","volume":"48","author":"Walkington","year":"2011","journal-title":"Bone."},{"issue":"7","key":"2020111806262430200_CIT0054","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1002\/cncr.20545","article-title":"Metastatic breast carcinoma confined to bone: portrait of a clinical entity","volume":"101","author":"Briasoulis","year":"2004","journal-title":"Cancer."},{"issue":"3","key":"2020111806262430200_CIT0055","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5306\/wjco.v5.i3.263","article-title":"Diagnosis and surgical management of breast cancer metastatic to the spine","volume":"5","author":"Ju","year":"2014","journal-title":"World J Clin Oncol."},{"issue":"4","key":"2020111806262430200_CIT0056","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0959-8049(99)00331-7","article-title":"Risk of complications from bone metastases in breast cancer. Implications for management","volume":"36","author":"Plunkett","year":"2000","journal-title":"Eur J Cancer."},{"issue":"2","key":"2020111806262430200_CIT0057","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/bjc.1998.52","article-title":"Clinical course and prognostic factors following bone recurrence from breast cancer","volume":"77","author":"Coleman","year":"1998","journal-title":"Br J Cancer."},{"issue":"2","key":"2020111806262430200_CIT0058","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/JTO.0b013e31819518fc","article-title":"Prevention and management of bone metastases in lung cancer: a review","volume":"4","author":"Al Husaini","year":"2009","journal-title":"J Thorac Oncol."},{"issue":"6","key":"2020111806262430200_CIT0059","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3171\/2010.6.SPINE10167","article-title":"Predictors of survival in patients with prostate cancer and spinal metastasis. Presented at the 2009 joint spine section meeting. Clinical article","volume":"13","author":"Drzymalski","year":"2010","journal-title":"J Neurosurg Spine."},{"issue":"1","key":"2020111806262430200_CIT0060","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12957-017-1136-1","article-title":"Epidemiological characteristics of primary spinal osseous tumors in Eastern China","volume":"15","author":"Zhou","year":"2017","journal-title":"World J Surg Oncol."},{"issue":"10","key":"2020111806262430200_CIT0061","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3928\/0147-7447-19951001-09","article-title":"Primary bone tumors of the spine: a survey of the evaluation and treatment at the Istituto Ortopedico Rizzoli","volume":"18","author":"Boriani","year":"1995","journal-title":"Orthopedics."},{"issue":"3","key":"2020111806262430200_CIT0062","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00586-006-0188-7","article-title":"Primary bone tumours of the spine: a 42-year survey from the Leeds Regional Bone Tumour Registry","volume":"16","author":"Kelley","year":"2007","journal-title":"Eur Spine J."}],"container-title":["Neuro-Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nop\/article-pdf\/7\/Supplement_1\/i5\/34372214\/npaa046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nop\/article-pdf\/7\/Supplement_1\/i5\/34372214\/npaa046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T16:31:47Z","timestamp":1669653107000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nop\/article\/7\/Supplement_1\/i5\/5987745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":62,"journal-issue":{"issue":"Supplement_1","published-online":{"date-parts":[[2020,11,18]]},"published-print":{"date-parts":[[2020,11,18]]}},"URL":"https:\/\/doi.org\/10.1093\/nop\/npaa046","relation":{},"ISSN":["2054-2577","2054-2585"],"issn-type":[{"value":"2054-2577","type":"print"},{"value":"2054-2585","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,11]]},"published":{"date-parts":[[2020,11]]}}}