{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T04:17:37Z","timestamp":1772511457717,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Patterns of recurrence and survival with different surgical and radiotherapy (RT) techniques were evaluated to guide RT target volumes for patients with temporal lobe glioma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and Materials<\/jats:title>\n                  <jats:p>This retrospective cohort study included patients with World Health Organization grades II to IV temporal lobe glioma treated with either partial (PTL) or complete temporal lobectomy (CTL) followed by RT covering both the parenchymal and dural resection bed (whole-cavity radiotherapy [WCRT]) or the parenchymal resection bed only (partial-cavity radiotherapy [PCRT]). Patterns of recurrence, progression-free survival (PFS) and overall survival (OS) were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty-one patients were included and 84.3% of patients had high-grade glioma (HGG). CTL and PTL were performed for 11 (21.6%) and 40 (78.4%) patients, respectively. Median RT dose was 60 Gy (range, 40-76 Gy). There were 82.4% and 17.6% of patients who received WCRT and PCRT, respectively. Median follow-up time was 18.4 months (range, 4-161 months). Forty-six patients (90.2%) experienced disease recurrence, most commonly at the parenchymal resection bed (76.5%). No patients experienced an isolated dural recurrence. The median PFS and OS for the PCRT and WCRT cohorts were 8.6 vs 10.8 months (P\u2005=\u2005.979) and 19.9 vs 18.6 months (P\u2005=\u2005.859), respectively. PCRT was associated with a lower RT dose to the brainstem, optic, and ocular structures, hippocampus, and pituitary.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We identified no isolated dural recurrence and similar PFS and OS regardless of postoperative RT volume, whereas PCRT was associated with dose reduction to critical structures. Omission of dural RT may be considered a reasonable alternative approach. Further validation with larger comparative studies is warranted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nop\/npaa073","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T16:53:59Z","timestamp":1604508839000},"page":"190-198","source":"Crossref","is-referenced-by-count":4,"title":["Does the dural resection bed need to be irradiated? Patterns of recurrence and implications for postoperative radiotherapy for temporal lobe gliomas"],"prefix":"10.1093","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-4248","authenticated-orcid":false,"given":"Achiraya","family":"Teyateeti","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, US"},{"name":"Division of Radiation Oncology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connie S","family":"Geno","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott S","family":"Stafford","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth S","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth W","family":"Merrell","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia N","family":"Laack","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian F","family":"Parney","sequence":"additional","affiliation":[{"name":"Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, US"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishan R","family":"Jethwa","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, US"},{"name":"Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, US"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"2021041517345271200_CIT0001","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noy131","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011\u20132015","volume":"20","author":"Ostrom","year":"2018","journal-title":"Neuro Oncol"},{"issue":"11","key":"2021041517345271200_CIT0002","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/S1470-2045(16)30313-8","article-title":"Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study","volume":"17","author":"Baumert","year":"2016","journal-title":"Lancet Oncol."},{"issue":"14","key":"2021041517345271200_CIT0003","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1056\/NEJMoa1500925","article-title":"Radiation plus procarbazine, CCNU, and vincristine in low-grade glioma","volume":"374","author":"Buckner","year":"2016","journal-title":"N Engl J Med."},{"issue":"3","key":"2021041517345271200_CIT0004","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1200\/JCO.2012.43.2674","article-title":"Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402","volume":"31","author":"Cairncross","year":"2013","journal-title":"J Clin Oncol."},{"issue":"10","key":"2021041517345271200_CIT0005","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N Engl J Med."},{"issue":"9490","key":"2021041517345271200_CIT0006","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0140-6736(05)67070-5","article-title":"Long-term efficacy of early versus delayed radiotherapy for low-grade astrocytoma and oligodendroglioma in adults: the EORTC 22845 randomised trial","volume":"366","author":"van den Bent","year":"2005","journal-title":"Lancet"},{"issue":"3","key":"2021041517345271200_CIT0007","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1200\/JCO.2012.43.2229","article-title":"Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC Brain Tumor Group Study 26951","volume":"31","author":"van den Bent","year":"2013","journal-title":"J Clin Oncol."},{"issue":"5","key":"2021041517345271200_CIT0008","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol."},{"issue":"10103","key":"2021041517345271200_CIT0009","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/S0140-6736(17)31442-3","article-title":"Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p\/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study","volume":"390","author":"van den Bent","year":"2017","journal-title":"Lancet."},{"issue":"8","key":"2021041517345271200_CIT0010","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1200\/JCO.2008.19.4969","article-title":"Recurrence pattern after temozolomide concomitant with and adjuvant to radiotherapy in newly diagnosed patients with glioblastoma: correlation with MGMT promoter methylation status","volume":"27","author":"Brandes","year":"2009","journal-title":"J Clin Oncol."},{"issue":"6","key":"2021041517345271200_CIT0011","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1200\/JCO.2002.20.6.1635","article-title":"Survival and failure patterns of high-grade gliomas after three-dimensional conformal radiotherapy","volume":"20","author":"Chan","year":"2002","journal-title":"J Clin Oncol."},{"issue":"1","key":"2021041517345271200_CIT0012","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijrobp.2006.12.009","article-title":"Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma","volume":"68","author":"Chang","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"1","key":"2021041517345271200_CIT0013","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1754-9485.2010.02232.x","article-title":"Patterns of failure for glioblastoma multiforme following concurrent radiation and temozolomide","volume":"55","author":"Dobelbower","year":"2011","journal-title":"J Med Imaging Radiat Oncol"},{"issue":"2","key":"2021041517345271200_CIT0014","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0167-8140(91)90143-5","article-title":"Outcome and patterns of failure following limited-volume irradiation for malignant astrocytomas","volume":"20","author":"Garden","year":"1991","journal-title":"Radiother Oncol."},{"issue":"1","key":"2021041517345271200_CIT0015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.prro.2018.06.001","article-title":"Using smaller-than-standard radiation treatment margins does not change survival outcomes in patients with high-grade gliomas","volume":"9","author":"Guram","year":"2019","journal-title":"Pract Radiat Oncol."},{"issue":"9","key":"2021041517345271200_CIT0016","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1212\/WNL.30.9.907","article-title":"Assumptions in the radiotherapy of glioblastoma","volume":"30","author":"Hochberg","year":"1980","journal-title":"Neurology."},{"issue":"1","key":"2021041517345271200_CIT0017","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0360-3016(98)00266-1","article-title":"Patterns of failure following high-dose 3-D conformal radiotherapy for high-grade astrocytomas: a quantitative dosimetric study","volume":"43","author":"Lee","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"4","key":"2021041517345271200_CIT0018","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3171\/jns.1991.75.4.0559","article-title":"Malignant astrocytomas: focal tumor recurrence after focal external beam radiation therapy","volume":"75","author":"Liang","year":"1991","journal-title":"J Neurosurg."},{"issue":"1","key":"2021041517345271200_CIT0019","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ijrobp.2009.10.048","article-title":"Pattern of failure after limited margin radiotherapy and temozolomide for glioblastoma","volume":"79","author":"McDonald","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"4","key":"2021041517345271200_CIT0020","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.ijrobp.2009.09.018","article-title":"Patterns and timing of recurrence after temozolomide-based chemoradiation for glioblastoma","volume":"78","author":"Milano","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"3","key":"2021041517345271200_CIT0021","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.radonc.2010.08.020","article-title":"Patterns of failure and comparison of different target volume delineations in patients with glioblastoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide","volume":"97","author":"Minniti","year":"2010","journal-title":"Radiother Oncol."},{"key":"2021041517345271200_CIT0022","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1748-717X-8-97","article-title":"Initial and cumulative recurrence patterns of glioblastoma after temozolomide-based chemoradiotherapy and salvage treatment: a retrospective cohort study in a single institution","volume":"8","author":"Ogura","year":"2013","journal-title":"Radiat Oncol."},{"issue":"1022","key":"2021041517345271200_CIT0023","doi-asserted-by":"crossref","first-page":"20120414","DOI":"10.1259\/bjr.20120414","article-title":"Patterns of relapse in glioblastoma multiforme following concomitant chemoradiotherapy with temozolomide","volume":"86","author":"Sherriff","year":"2013","journal-title":"Br J Radiol."},{"issue":"6","key":"2021041517345271200_CIT0024","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/0360-3016(89)90941-3","article-title":"Patterns of failure following treatment for glioblastoma multiforme and anaplastic astrocytoma","volume":"16","author":"Wallner","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"3","key":"2021041517345271200_CIT0025","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/0360-3016(94)00400-F","article-title":"Low grade gliomas: preliminary analysis of failure patterns among patients treated using 3D conformal external beam irradiation","volume":"31","author":"Pu","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"3","key":"2021041517345271200_CIT0026","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0360-3016(89)90482-3","article-title":"Postoperative radiotherapy of supratentorial low-grade gliomas","volume":"16","author":"Shaw","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"1","key":"2021041517345271200_CIT0027","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1148\/radiology.201.1.8816559","article-title":"Low-grade astrocytoma: treatment with conventionally fractionated stereotactic radiation therapy","volume":"201","author":"van Kampen","year":"1996","journal-title":"Radiology."},{"issue":"1","key":"2021041517345271200_CIT0028","first-page":"5","article-title":"Temporal lobectomy for high grade gliomas: impact on outcomes and implications for postoperative radiation treatment field design","volume":"2","author":"Marsh","year":"2013","journal-title":"Cancer Clin Oncol"},{"issue":"11","key":"2021041517345271200_CIT0029","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1016\/j.joms.2019.06.171","article-title":"Unusual case of transdural extension of glioblastoma multiforme in the maxillofacial region and a review of the literature","volume":"77","author":"Taghikhan","year":"2019","journal-title":"J Oral Maxillofac Surg"},{"issue":"8","key":"2021041517345271200_CIT0030","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1056\/NEJMoa1308573","article-title":"A randomized trial of bevacizumab for newly diagnosed glioblastoma","volume":"370","author":"Gilbert","year":"2014","journal-title":"N Engl J Med."},{"issue":"3","key":"2021041517345271200_CIT0031","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0360-3016(96)00352-5","article-title":"A randomized trial on dose-response in radiation therapy of low-grade cerebral glioma: European Organization for Research and Treatment of Cancer (EORTC) Study 22844","volume":"36","author":"Karim","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"1","key":"2021041517345271200_CIT0032","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.radonc.2015.12.003","article-title":"ESTRO-ACROP guideline \u201ctarget delineation of glioblastomas\u201d","volume":"118","author":"Niyazi","year":"2016","journal-title":"Radiother Oncol."},{"issue":"1","key":"2021041517345271200_CIT0033","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11060-012-0983-4","article-title":"Failure pattern following complete resection plus radiotherapy and temozolomide is at the resection margin in patients with glioblastoma","volume":"111","author":"Petrecca","year":"2013","journal-title":"J Neurooncol."},{"key":"2021041517345271200_CIT0034","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1748-717X-9-130","article-title":"Patterns of failure for glioblastoma multiforme following limited-margin radiation and concurrent temozolomide","volume":"9","author":"Gebhardt","year":"2014","journal-title":"Radiat Oncol."},{"issue":"2","key":"2021041517345271200_CIT0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/COC.0b013e318271ae03","article-title":"Limited margins using modern radiotherapy techniques does not increase marginal failure rate of glioblastoma","volume":"37","author":"Paulsson","year":"2014","journal-title":"Am J Clin Oncol."},{"key":"2021041517345271200_CIT0036","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.ijrobp.2009.02.091","article-title":"Radiation dose-volume effects in the brain","volume":"76","author":"Lawrence","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2021041517345271200_CIT0037","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1016\/j.ijrobp.2009.07.1753","article-title":"Radiation dose-volume effects of optic nerves and chiasm","volume":"76","author":"Mayo","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys."},{"key":"2021041517345271200_CIT0038","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.ijrobp.2009.08.078","article-title":"Radiation associated brainstem injury","volume":"76","author":"Mayo","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"4","key":"2021041517345271200_CIT0039","doi-asserted-by":"crossref","first-page":"e487","DOI":"10.1016\/j.ijrobp.2011.10.021","article-title":"Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors","volume":"83","author":"Gondi","year":"2012","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"3","key":"2021041517345271200_CIT0040","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.radonc.2010.09.013","article-title":"Why avoid the hippocampus? A comprehensive review","volume":"97","author":"Gondi","year":"2010","journal-title":"Radiother Oncol."},{"issue":"4","key":"2021041517345271200_CIT0041","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.ijrobp.2006.10.032","article-title":"Intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: does IMRT increase the integral dose to normal brain?","volume":"67","author":"Hermanto","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys."},{"issue":"5","key":"2021041517345271200_CIT0042","doi-asserted-by":"crossref","first-page":"411","DOI":"10.7785\/tcrt.2012.500341","article-title":"IMRT or 3D-CRT in glioblastoma? A dosimetric criterion for patient selection","volume":"12","author":"Lorentini","year":"2013","journal-title":"Technol Cancer Res Treat."},{"issue":"2","key":"2021041517345271200_CIT0043","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1120\/jacmp.v8i2.2423","article-title":"Intensity modulated radiation therapy versus three-dimensional conformal radiation therapy for the treatment of high grade glioma: a dosimetric comparison","volume":"8","author":"MacDonald","year":"2007","journal-title":"J Appl Clin Med Phys."},{"issue":"1","key":"2021041517345271200_CIT0044","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/0284186X.2018.1529424","article-title":"Intensity-modulated proton therapy decreases dose to organs at risk in low-grade glioma patients: results of a multicentric in silico ROCOCO trial","volume":"58","author":"Eekers","year":"2019","journal-title":"Acta Oncol."},{"issue":"1","key":"2021041517345271200_CIT0045","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12885-019-5317-x","article-title":"Dose-painting multicenter phase III trial in newly diagnosed glioblastoma: the SPECTRO-GLIO trial comparing arm A standard radiochemotherapy to arm B radiochemotherapy with simultaneous integrated boost guided by MR spectroscopic imaging","volume":"19","author":"Laprie","year":"2019","journal-title":"BMC Cancer."},{"issue":"2","key":"2021041517345271200_CIT0046","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/neuros\/nyy461","article-title":"The role of standard and advanced imaging for the management of brain malignancies from a radiation oncology standpoint","volume":"85","author":"Press","year":"2019","journal-title":"Neurosurgery."}],"container-title":["Neuro-Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nop\/advance-article-pdf\/doi\/10.1093\/nop\/npaa073\/34130351\/npaa073.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nop\/article-pdf\/8\/2\/190\/37080805\/npaa073.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/nop\/article-pdf\/8\/2\/190\/37080805\/npaa073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T06:09:14Z","timestamp":1618639754000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nop\/article\/8\/2\/190\/5955971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"references-count":46,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,11,4]]},"published-print":{"date-parts":[[2021,4,15]]}},"URL":"https:\/\/doi.org\/10.1093\/nop\/npaa073","relation":{},"ISSN":["2054-2577","2054-2585"],"issn-type":[{"value":"2054-2577","type":"print"},{"value":"2054-2585","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,4,1]]},"published":{"date-parts":[[2020,11,4]]}}}