{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:37:22Z","timestamp":1790681842322,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["75D30119C06056"],"award-info":[{"award-number":["75D30119C06056"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001453","name":"American Brain Tumor Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006064","name":"The Sontag Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012634","name":"Novocure","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012634","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003156","name":"Musella Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001512","name":"National Brain Tumor Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001512","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001794","name":"Pediatric Brain Tumor Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019451","name":"Uncle Kory Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100019451","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Zelda Dorin Tetenbaum Memorial Fund"},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Pineoblastoma (PB) is a rare malignant brain tumor originating in the pineal gland. Here, we provide a comprehensive epidemiological analysis of PB in the United States from 2000 to 2017.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data on 1133 patients with PB were acquired from the Central Brain Tumor Registry of the United States, in collaboration with the Centers for Disease Control and Prevention and the National Cancer Institute, from 2000 to 2017. Age-adjusted incidence rates (AAIRs) per 100 000 and incidence rate ratios (IRRs) were reported for age, sex, race, and ethnicity. Using the National Program of Cancer Registries survival database, median survival and hazard ratios (HRs) were evaluated for overall survival from 2001 to 2016.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Incidence was highest in ages 0\u20134 years (AAIR: 0.049, 95% CI: 0.042\u20130.056), decreasing as age increased. Incidence was higher among patients who are Black compared to patients who are White (IRR: 1.71, 95% CI: 1.48\u20131.98, P &amp;lt; .001), and was impacted by age at diagnosis, with Black-to-White incidence highest in children ages 5\u20139 years (IRR: 3.43, 95% CI: 2.36\u20134.94, P &amp;lt; .001). Overall survival was lower for males (HR: 1.39, 95% CI: 1.07\u20131.79, P = .013). All age groups, excluding those over 40, had improved survival compared to ages 0\u20134 years. Those who received surgical intervention had better survival compared to those who did not receive surgical treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>PB incidence is highest among children and patients who are Black, and there may be a potential interaction between these factors. Survival is worse among males, young children, and elderly adults, and those who received no surgery. Comprehensive, population-based statistics provide critical information on PB characteristics that could be useful in impacting patient care and prognosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nop\/npac009","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T15:20:01Z","timestamp":1643296801000},"page":"149-157","source":"Crossref","is-referenced-by-count":11,"title":["Epidemiology of pineoblastoma in the United States, 2000\u20132017"],"prefix":"10.1093","volume":"9","author":[{"given":"Kaitlyn","family":"Greppin","sequence":"first","affiliation":[{"name":"Hathaway Brown School, Science Research & Engineering Program, Shaker Heights, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino","family":"Cioffi","sequence":"additional","affiliation":[{"name":"Trans Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Bethesda, Maryland, USA"},{"name":"Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin A","family":"Waite","sequence":"additional","affiliation":[{"name":"Trans Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Bethesda, Maryland, USA"},{"name":"Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn T","family":"Ostrom","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA"},{"name":"The Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, North Carolina, USA"},{"name":"Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA"},{"name":"Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Landi","sequence":"additional","affiliation":[{"name":"The Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailey","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Hathaway Brown School, Science Research & Engineering Program, Shaker Heights, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7212-035X","authenticated-orcid":false,"given":"Carol","family":"Kruchko","sequence":"additional","affiliation":[{"name":"Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-9304","authenticated-orcid":false,"given":"Jill S","family":"Barnholtz-Sloan","sequence":"additional","affiliation":[{"name":"Trans Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Bethesda, Maryland, USA"},{"name":"Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA"},{"name":"Center for Biomedical Informatics & Information Technology (CBIIT), National Cancer Institute, Bethesda, Maryland, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"2022033005005017400_CIT0001","doi-asserted-by":"crossref","first-page":"iv1","DOI":"10.1093\/neuonc\/noaa200","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013\u20132017","volume":"22","author":"Ostrom","year":"2020","journal-title":"Neuro 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Released June 2020, Based on the 2019 Submission. Lyon, France","author":"National Program of Cancer Registries SEER*Stat Database: NPCR Survival Analytic file (2001-2016)"},{"key":"2022033005005017400_CIT0007","author":"SEER*Stat: Surveillance Epidemiology and End Results (SEER) Program","year":"2020"},{"issue":"6","key":"2022033005005017400_CIT0008","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.wneu.2014.07.010","article-title":"Clinical outcomes and patterns of failure in pineoblastoma: a 30-year, single-institution retrospective review","volume":"82","author":"Farnia","year":"2014","journal-title":"World Neurosurg"},{"key":"2022033005005017400_CIT0009","doi-asserted-by":"crossref","first-page":"e871","DOI":"10.1016\/j.wneu.2018.07.079","article-title":"Prognosis of pediatric patients with pineoblastoma: a SEER analysis 1990\u20132013","volume":"118","author":"Deng","year":"2018","journal-title":"World Neurosurg"},{"issue":"5","key":"2022033005005017400_CIT0010","doi-asserted-by":"crossref","first-page":"E426","DOI":"10.1093\/neuros\/nyaa023","article-title":"Patterns of care and age-specific impact of extent of resection and adjuvant radiotherapy in pediatric pineoblastoma","volume":"86","author":"Jin","year":"2020","journal-title":"Neurosurgery"},{"issue":"1","key":"2022033005005017400_CIT0011","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1002\/cncr.26300","article-title":"The long-term postsurgical prognosis of patients with pineoblastoma","volume":"118","author":"Tate","year":"2012","journal-title":"Cancer"},{"issue":"3","key":"2022033005005017400_CIT0012","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1227\/00006123-199509000-00003","article-title":"Pineoblastoma in adults","volume":"37","author":"Chang","year":"1995","journal-title":"Neurosurgery"},{"issue":"17","key":"2022033005005017400_CIT0013","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1007\/s00018-015-1930-2","article-title":"An integrative view on sex differences in brain tumors","volume":"72","author":"Sun","year":"2015","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"2022033005005017400_CIT0014","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1158\/1055-9965.EPI-20-0036","article-title":"Sex Differences in cancer incidence and survival: a pan-cancer analysis","volume":"29","author":"Dong","year":"2020","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"2022033005005017400_CIT0015","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/neuros\/nyx005","article-title":"Pineoblastoma\u2014the experience at St. Jude Children\u2019s Research Hospital","volume":"81","author":"Parikh","year":"2017","journal-title":"Neurosurgery"}],"container-title":["Neuro-Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nop\/advance-article-pdf\/doi\/10.1093\/nop\/npac009\/42580658\/npac009.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nop\/article-pdf\/9\/2\/149\/43152745\/npac009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nop\/article-pdf\/9\/2\/149\/43152745\/npac009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T05:01:19Z","timestamp":1648616479000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nop\/article\/9\/2\/149\/6515917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,27]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,1,27]]},"published-print":{"date-parts":[[2022,3,30]]}},"URL":"https:\/\/doi.org\/10.1093\/nop\/npac009","relation":{},"ISSN":["2054-2577","2054-2585"],"issn-type":[{"value":"2054-2577","type":"print"},{"value":"2054-2585","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4,1]]},"published":{"date-parts":[[2022,1,27]]}}}