{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T17:51:37Z","timestamp":1785520297073,"version":"3.56.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30CA042014"],"award-info":[{"award-number":["P30CA042014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>A post-operative MRI (MRIpost-op) performed within 72 h is routinely used for radiation treatment planning in glioblastoma (GBM) patients, with radiotherapy starting about 4\u20136 weeks after surgery. Some patients undergo an additional pre-radiotherapy MRI (MRIpre-RT) about 2\u20136 weeks after surgery. We sought to analyze the incidence of rapid early progression (REP) between surgery and initiation of radiotherapy seen on MRIpre-RT and the impact on radiation target volumes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with GBM diagnosed between 2018 and 2020 who had an MRIpost-op and MRIpre-RT were retrospectively identified. Criteria for REP was based on Modified RANO criteria. Radiation target volumes were created and compared using the MRIpost-op and MRIpre-RT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Fifty patients met inclusion criteria. The median time between MRIpost-op and MRIpre-RT was 26 days. Indications for MRIpre-RT included clinical trial enrollment in 41\/50 (82%), new symptoms in 5\/50 (10%), and unspecified in 4\/50 (8%). REP was identified in 35\/50 (70%) of patients; 9\/35 (26%) had disease progression outside of the MRIpost-op-based high dose treatment volumes. Treatment planning with MRIpost-op yielded a median undertreatment of 27.1% of enhancing disease and 11.2% of surrounding subclinical disease seen on MRIpre-RT. Patients without REP had a 38% median volume reduction of uninvolved brain if target volumes were planned with MRIpre-RT.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Given the incidence of REP and its impact on treatment volumes, we recommend using MRIpre-RT for radiation treatment planning to improve coverage of gross and subclinical disease, allow for early identification of REP, and decrease radiation treatment volumes in patients without REP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nop\/npac044","type":"journal-article","created":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T19:25:28Z","timestamp":1654025128000},"page":"380-389","source":"Crossref","is-referenced-by-count":5,"title":["Incidence and extent of disease progression on MRI between surgery and initiation of radiotherapy in glioblastoma patients"],"prefix":"10.1093","volume":"9","author":[{"given":"Ryan D","family":"Kraus","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah , Salt Lake City, UT , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R","family":"Weil","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah , Salt Lake City, UT , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan-Chi","family":"Frances Su","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah , Salt Lake City, UT , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald M","family":"Cannon","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah , Salt Lake City, UT , 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