{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:52:16Z","timestamp":1790121136216,"version":"4.0.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In Brazil, 5870 new cases of malignant central nervous system tumors (MCNST) were estimated for men and 5220 for women for each year of the 2020\u20132022 triennium. The objective of this study was to analyze incidence rate trends and compare demographic characteristics of new MCNST cases according to tumor topographies in Brazil from 2000 to 2015.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study comprises an analytical cross-sectional assessment of secondary databases extracted from the Brazilian National Cancer Institute (INCA) website. Data comprised new neoplasm cases of meninges (C70), brain (C71), spinal cord, cranial nerves, and other central nervous system parts (C72) retrieved from 23 population-based cancer registries. A descriptive analysis was performed. Crude and age-adjusted incidence rates were calculated. Linear trends were calculated using a linear least squares regression for adjusted incidence rates versus time.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 24 986 new MCNST cases were recorded. The main topography was the brain (91.5%). Except for meninges tumors, where 62.4% of the cases were observed in women, MCNST cases were more frequent among men concerning the other evaluated topographies. All 3 topographies occurred predominantly in adult patients aged from 40- to 64-year-old. Between 2000 and 2015, incidence rates ranged from 5.12 to 4.95 (a 1.4% increase of per year; 95% CI \u22124.0 to 6.8; P = .584) in men and from 4.35 to 3.61 (a 3.1% increase per year; 95% CI \u22121.7 to 8.0; P = .189).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The most frequent topography was the brain. Incidence rates of MCNST remained relatively stable over time in both sexes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nop\/npac063","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T21:38:32Z","timestamp":1660858712000},"page":"34-40","source":"Crossref","is-referenced-by-count":5,"title":["Trends in the incidence of malignant central nervous system tumors in Brazil, 2000\u20132015"],"prefix":"10.1093","volume":"10","author":[{"given":"Let\u00edcia Lima","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Federal University of Rio de Janeiro State (UNIRIO), Rua Mariz e Barros , 775\u2014Maracan\u00e3\/ZIPCODE 20270-004, Rio de Janeiro, RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Brazilian National Cancer Institute (INCA), Rua Andr\u00e9 Cavalcanti , 37\/2nd floor\u2014Centro\/ZIPCODE 20231-050, Rio de Janeiro, RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-6537","authenticated-orcid":false,"given":"Luiz Claudio Santos","family":"Thuler","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro State (UNIRIO), Rua Mariz e Barros , 775\u2014Maracan\u00e3\/ZIPCODE 20270-004, Rio de Janeiro, RJ , Brazil"},{"name":"Brazilian National Cancer Institute (INCA), Rua Andr\u00e9 Cavalcanti , 37\/2nd floor\u2014Centro\/ZIPCODE 20231-050, Rio de Janeiro, RJ , Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"issue":"4","key":"2023011310285856800_CIT0001","first-page":"778","article-title":"Cancer statistics for the year 2020: an overview","volume":"149","author":"Ferlay","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"2023011310285856800_CIT0002","volume-title":"Estimativa 2020: incid\u00eancia de c\u00e2ncer no Brasil.","author":"Instituto Nacional de C\u00e2ncer Jos\u00e9 Alencar Gomes da Silva","year":"2020"},{"issue":"6","key":"2023011310285856800_CIT0003","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"GLOBOCAN 2018. 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