{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:54:13Z","timestamp":1786964053318,"version":"build-2736575974"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) recommendations are commonly used guidelines for adjuvant radiotherapy in glioblastoma. In our institutional protocol, we delineate T2-FLAIR alterations as gross target volume (GTV) with reduced clinical target volume (CTV) margins. We aimed to present our oncologic outcomes and compare the recurrence patterns and planning parameters with EORTC and RTOG delineation strategies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Eighty-one patients who received CRT between 2014 and 2021 were evaluated retrospectively. EORTC and RTOG delineations performed on the simulation computed tomography and recurrence patterns and planning parameters were compared between delineation strategies. Statistical Package for the Social Sciences (SPSS) version 23.0 (IBM, Armonk, NY, USA) was utilized for statistical analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Median overall survival and progression-free survival were 21 months and 11 months, respectively. At a median 18 month follow-up, of the 48 patients for whom recurrence pattern analysis was performed, recurrence was encompassed by only our institutional protocol\u2019s CTV in 13 (27%) of them. For the remaining 35 (73%) patients, recurrence was encompassed by all separate CTVs. In addition to the 100% rate of in-field recurrence, the smallest CTV and lower OAR doses were obtained by our protocol.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The current study provides promising results for including the T2-FLAIR alterations to the GTV with smaller CTV margins with impressive survival outcomes without any marginal recurrence. The fact that our protocol did not result in larger irradiated brain volume is further encouraging in terms of toxicity.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nop\/npae009","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T06:53:42Z","timestamp":1706770422000},"page":"275-283","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of different target volume delineation strategies based on recurrence patterns in adjuvant radiotherapy for glioblastoma"],"prefix":"10.1093","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9813-9286","authenticated-orcid":false,"given":"Melek Tugce","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Hacettepe University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alper","family":"Kahvecioglu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Hacettepe University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazli Yagiz","family":"Yedekci","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Hacettepe University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ecem","family":"Yigit","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Hacettepe University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokcen Coban","family":"Ciftci","sequence":"additional","affiliation":[{"name":"Radiology Department, Faculty of Medicine, Hacettepe University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neyran","family":"Kertmen","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Faculty of Medicine, Hacettepe University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faruk","family":"Zorlu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Hacettepe University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7430-6729","authenticated-orcid":false,"given":"Gozde","family":"Yazici","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Faculty of Medicine, Hacettepe University , Ankara , Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"issue":"Suppl 5","key":"2024051013154014700_CIT0001","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/noac202","article-title":"CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2015\u20132019","volume":"24","author":"Ostrom","year":"2022","journal-title":"Neuro Oncol"},{"issue":"1","key":"2024051013154014700_CIT0002","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11060-011-0738-7","article-title":"Improved survival time trends for glioblastoma using the SEER 17 population-based registries","volume":"107","author":"Koshy","year":"2012","journal-title":"J Neurooncol."},{"issue":"2","key":"2024051013154014700_CIT0003","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3171\/jns.2001.95.2.0190","article-title":"A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival","volume":"95","author":"Lacroix","year":"2001","journal-title":"J Neurosurg."},{"issue":"11","key":"2024051013154014700_CIT0004","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1001\/jamaoncol.2016.1373","article-title":"Association of the extent of resection with survival in glioblastoma: a systematic review and meta-analysis","volume":"2","author":"Brown","year":"2016","journal-title":"JAMA Oncol"},{"issue":"5","key":"2024051013154014700_CIT0005","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S1470-2045(09)70025-7","article-title":"Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial","volume":"10","author":"Stupp","year":"2009","journal-title":"Lancet Oncol."},{"issue":"3","key":"2024051013154014700_CIT0006","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3171\/jns.1978.49.3.0333","article-title":"Evaluation of BCNU and\/or radiotherapy in the treatment of anaplastic gliomas. 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