{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T04:02:40Z","timestamp":1749182560057,"version":"3.41.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>This analysis aims to provide insight into differences in symptom burden and general health status between young adults (YA; 18\u201339 years old) and older adults (OA; \u226540 years old) with primary central nervous system tumors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data were retrospectively analyzed from the National Cancer Institute Neuro-Oncology Branch\u2019s Natural History Study (NCT02851706 PI: T.S. Armstrong) to determine differences in patient-reported outcomes (general health status [EQ-5D-3L], symptom burden [MDASI-BT and MDASI-SP], anxiety\/depression [Patient-Reported Outcomes Measurement Information System], and perceived cognition [Neuro-QOL]) and demographic and clinical data using chi-square, one-way ANOVA, and Student\u2019s t-tests. Linear regression with backward elimination determined which characteristics impacted perceived symptom burden and general health status.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The sample included 271 YA (82% with a primary brain tumor (PBT); median age 31 [range, 18\u201339]) and 516 OA (88% with a PBT; median age 54 [range, 40\u201385]). YA were more likely to be single (P\u2005&amp;lt;\u2005.001), employed (P\u2005&amp;lt;\u2005.001), and make &amp;lt; $50 000 per year (P\u2005=\u2005.014). More YA reported pain (P\u2005=\u2005.008), nausea (P\u2005&amp;lt;\u2005.001), drowsiness (P\u2005=\u2005.043), and vomiting (P\u2005=\u2005.001) than OA. Among demographic and clinical characteristics, when controlling for age, Karnofsky Performance Scale score (P\u2005&amp;lt;\u2005.001) and employment status (P\u2005&amp;lt;\u2005.001) were predictors of symptom interference, activity- and mood-related interference in patients with PBTs. Compared to OA with spinal tumors, YA reported more moderate-severe anxiety (P\u2005=\u2005.050) and moderate-severe perceived cognitive deficits (P\u2005=\u2005.023).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Significant differences in characteristics and symptom burden exist between YA and OA. Developmentally tailored survivorship programs providing additional psychosocial support and resources to address symptom presentation in YA are needed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/nop\/npae116","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T09:08:52Z","timestamp":1732612132000},"page":"498-510","source":"Crossref","is-referenced-by-count":0,"title":["Implications of sociodemographic and clinical factors on symptom burden: Age-specific survivorship care in the primary central nervous system tumor population"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7423-9873","authenticated-orcid":false,"given":"Kimberly R","family":"Robins","sequence":"first","affiliation":[{"name":"Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 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