{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:12:11Z","timestamp":1772899931576,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medulloblastoma (MB) is a rare tumor in adults, with treatment strategies derived largely from pediatric data. Prognostic factors have not been uniformly defined in adults to date.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the medical records of 89 adult MB patients treated between 1995 and 2019 in our institution. Patient\u2019s characteristics, disease features, and treatment modalities were analyzed for prognostic factors using univariate and multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 89 patients, 66% were male. Most MBs were in the cerebellum (48%), with desmoplastic\/nodular histology (43%), Sonic Hedgehog molecular type (79%), and M0 Chang\u00b4s stage (72%). Intermediate- and high-risk MBs were identified in ~46% and ~47% of cases, respectively. Complete\/near complete tumor resection was achieved in 62% of cases. Surgery followed by chemoradiotherapy (CT\/RT) was the most frequent treatment (76%) with carboplatin-based regimens used in 70% of cases. After the first-line treatment, complete response (CR) was achieved in 80% of patients. Median overall survival (mOS) was 124.4 months (95%CI 68.5-180.1) and the median progression free survival (mPFS) was 30.5 months (95%CI 13.5-47.5), the 5-year OS was 67% and the 5-year PFS was 51%. In multivariate analysis, Chang\u00b4s stage\u2005\u2265\u2005M2 metastatic classification (P\u2005=\u2005.001), RT without CT in first line setting (P\u2005=\u2005.005), and craniospinal RT\u2005&amp;lt;\u200530 Gy (P\u2005=\u2005.015) were associated with worse survival outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Chang\u2019s stage\u2005\u2265\u2005M2, first-line treatment lacking CT, and first-line treatment with craniospinal RT\u2005&amp;lt;\u200530\u2005Gy were significant predictors of poor survival. Chemoradiotherapy with craniospinal RT\u2005\u2265\u200530\u2005Gy improved survival outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/nop\/npaf084","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:37:17Z","timestamp":1756467437000},"page":"112-125","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic factors in adult patients with medulloblastoma"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6154-1511","authenticated-orcid":false,"given":"Ytel","family":"Garcilazo-Reyes","sequence":"first","affiliation":[{"name":"Neuro Oncology Division, Centro Oncol\u00f3gico Internacional, Hospital San Angel Inn Universidad , Mexico City ,","place":["Mexico"]},{"name":"Sorbonne Universit\u00e9, AP-HP, Institut du Cerveau \u2013 Paris Brain Institute \u2013 ICM, Inserm, CNRS, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, DMU Neurosciences, Service de Neuro-oncologie , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Dal Col","sequence":"additional","affiliation":[{"name":"Pathology Department, University hospital of Grenoble Alpes , Grenoble ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6564-6388","authenticated-orcid":false,"given":"Franck","family":"Bielle","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, Institut du Cerveau \u2013 Paris Brain Institute \u2013 ICM, Inserm, CNRS, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, Department of Neuropathology , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karima","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, Institut du Cerveau \u2013 Paris Brain Institute \u2013 ICM, Inserm, CNRS, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, Department of Neuropathology , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lo\u00efc","family":"Feuvret","sequence":"additional","affiliation":[{"name":"Oncology Radiotherapy Department, Hopital Neurologique, Hospices Civils de Lyon , Bron ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Jacob","sequence":"additional","affiliation":[{"name":"Radiotherapy department, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, Sorbonne Universit\u00e9, IHU, ICM , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Duran-Pen\u0303a","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, Institut du Cerveau \u2013 Paris Brain Institute \u2013 ICM, Inserm, CNRS, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, DMU Neurosciences, Service de Neuro-oncologie , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Capelle","sequence":"additional","affiliation":[{"name":"Neurosurgery Department, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re - Charles Foix, Sorbonne Universit\u00e9, IHU, ICM , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Savatovsky","sequence":"additional","affiliation":[{"name":"Radiology Department, Hopital Priv\u00e9 des Peupliers , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-6781","authenticated-orcid":false,"given":"Franck","family":"Bourdeaut","sequence":"additional","affiliation":[{"name":"INSERM U830, Laboratory of Translational Research in Pediatric Oncology, SIREDO , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-3926","authenticated-orcid":false,"given":"Julien","family":"Masliah-Planchon","sequence":"additional","affiliation":[{"name":"Department of Genetics. P\u00f4le de M\u00e9decine Diagnostique et Th\u00e9ranostique, CLCC Institut Curie , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Cacho-D\u00edaz","sequence":"additional","affiliation":[{"name":"Neuro-oncology Department, National Cancer Institute (INCan) , Mexico City ,","place":["Mexico"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kh\u00ea","family":"Hoang- Xuan","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, Institut du Cerveau \u2013 Paris Brain Institute \u2013 ICM, Inserm, CNRS, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, DMU Neurosciences, Service de Neuro-oncologie , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-1204","authenticated-orcid":false,"given":"Ahmed","family":"Idbaih","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, Institut du Cerveau \u2013 Paris Brain Institute \u2013 ICM, Inserm, CNRS, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, DMU Neurosciences, Service de Neuro-oncologie , Paris ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9907-703X","authenticated-orcid":false,"given":"Florence","family":"Laigle-Donadey","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, AP-HP, Institut du Cerveau \u2013 Paris Brain Institute \u2013 ICM, Inserm, CNRS, H\u00f4pitaux Universitaires La Piti\u00e9 Salp\u00eatri\u00e8re \u2013 Charles Foix, DMU Neurosciences, Service de Neuro-oncologie , Paris 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