{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T15:43:09Z","timestamp":1770133389038,"version":"3.49.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Wernicke's encephalopathy is a serious medical condition associated with high morbidity and mortality caused by deficiency of thiamine. This disease is classically associated with alcoholism, but is underappreciated in the nonalcoholic population. There is growing acknowledgement of the development of Wernicke's encephalopathy in patients with malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a literature review in PubMed for cases of Wernicke's encephalopathy occurring in patients with malignancy. We also present the case of a 47-year-old woman with recurrent laryngeal cancer and multiple hospital admissions for malnutrition. Neurological examination was notable for pendular nystagmus, severe gait ataxia, confusion, and poor memory consolidation. MRI of the brain was significant for T2-weighted fluid-attenuated inversion recovery hyperintensities in periaqueductal regions, medial thalami, and the tectal plate, typical for Wernicke's encephalopathy. She was treated with thiamine repletion, and had marked improvement in her mental status and some improvement in her vision problems and ataxia, although some nystagmus and significant short-term memory impairment persisted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature review yielded dozens of case reports of Wernicke's encephalopathy in patients with malignancy, dominated by cases of patients with malignancies of the gastrointestinal system, followed by those with hematologic malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Malignancy is an important risk factor for the development of Wernicke's encephalopathy. This diagnosis is underappreciated and difficult for the clinician to discern from multifactorial delirium. Clinicians should be aware to treat at-risk patients with thiamine immediately, especially if multiple risk factors are present.<\/jats:p><\/jats:sec>","DOI":"10.1093\/nop\/npv036","type":"journal-article","created":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T03:25:05Z","timestamp":1442978705000},"page":"196-207","source":"Crossref","is-referenced-by-count":7,"title":["Association between malignancy and non-alcoholic Wernicke's encephalopathy: a case report and literature review"],"prefix":"10.1093","volume":"3","author":[{"given":"Evan Y.","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (E.Y.C, J.J.G.); Assistant Professor, Department of Radiology, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (W.A.G.); Associate Professor of Clinical Medicine, Department of Medicine (Oncology), Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (M.H."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (E.Y.C, J.J.G.); Assistant Professor, Department of Radiology, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (W.A.G.); Associate Professor of Clinical Medicine, Department of Medicine (Oncology), Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (M.H."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Missak","family":"Haigentz","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (E.Y.C, J.J.G.); Assistant Professor, Department of Radiology, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (W.A.G.); Associate Professor of Clinical Medicine, Department of Medicine (Oncology), Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (M.H."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome J.","family":"Graber","sequence":"additional","affiliation":[{"name":"Department of Neurology, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (E.Y.C, J.J.G.); Assistant Professor, Department of Radiology, Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (W.A.G.); Associate Professor of Clinical Medicine, Department of Medicine (Oncology), Albert Einstein College of Medicine\/Montefiore Medical Center, Bronx, NY (M.H."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"issue":"(5)","key":"2019073107103975200_NPV036C1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S1474-4422(07)70104-7","article-title":"Wernicke's encephalopathy: new clinical settings and recent advances in diagnosis and management","volume":"6","author":"Sechi","year":"2007","journal-title":"Lancet Neurol"},{"issue":"(7)","key":"2019073107103975200_NPV036C2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1136\/jnnp.46.7.593","article-title":"The incidence of Wernicke's encephalopathy in Australia - a neuropathological study of 131 cases","volume":"46","author":"Harper","year":"1983","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"(1)","key":"2019073107103975200_NPV036C3","first-page":"27","article-title":"Ethanol, thiamine, and brain damage","volume":"18","author":"Thomson","year":"1983","journal-title":"Alcohol Alcohol"},{"issue":"(2)","key":"2019073107103975200_NPV036C4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0022-510X(89)90095-6","article-title":"Wernicke's encephalopathy in non-alcoholics. An autopsy study","volume":"90","author":"Lindboe","year":"1989","journal-title":"J Neurol Sci"},{"issue":"(4)","key":"2019073107103975200_NPV036C5","first-page":"241","article-title":"Wernicke-Korsakoff amnestic syndrome secondary to malnutrition in a patient with schizoaffective disorder","volume":"11","author":"Newman","year":"1998","journal-title":"Neuropsychiatry Neuropsychol Behav Neurol"},{"issue":"(8538)","key":"2019073107103975200_NPV036C6","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/S0140-6736(87)92892-3","article-title":"Wernicke's encephalopathy in AIDS patient treated with zidovudine","volume":"1","author":"Davtyan","year":"1987","journal-title":"Lancet"},{"issue":"(7)","key":"2019073107103975200_NPV036C7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/BF00314738","article-title":"Wernicke's encephalopathy in two patients with acquired immunodeficiency syndrome","volume":"237","author":"Schwenk","year":"1990","journal-title":"J Neurol"},{"issue":"(4)","key":"2019073107103975200_NPV036C8","first-page":"192","article-title":"Wernicke's encephalopathy in acquired immune deficiency syndrome (AIDS): a case report","volume":"8","author":"Soffer","year":"1989","journal-title":"Clin Neuropathol"},{"issue":"(5)","key":"2019073107103975200_NPV036C9","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1053\/ajkd.2001.28578","article-title":"Thiamine deficiency and unexplained encephalopathy in hemodialysis and peritoneal dialysis patients","volume":"38","author":"Hung","year":"2001","journal-title":"Am J Kidney Dis"},{"issue":"(1)","key":"2019073107103975200_NPV036C10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/ana.410210114","article-title":"Wernicke's encephalopathy in patients on peritoneal dialysis or hemodialysis","volume":"21","author":"Jagadha","year":"1987","journal-title":"Ann Neurol"},{"issue":"(4)","key":"2019073107103975200_NPV036C11","first-page":"171","article-title":"Acute encephalopathy due to thiamine deficiency (Wernicke's encephalopathy) in a chronic hemodialyzed patient: a case report","volume":"35","author":"Descombes","year":"1991","journal-title":"Clin Nephrol"},{"issue":"(5)","key":"2019073107103975200_NPV036C12","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/SLA.0b013e3181884308","article-title":"Wernicke encephalopathy after bariatric surgery: a systematic review","volume":"248","author":"Aasheim","year":"2008","journal-title":"Ann Surg"},{"issue":"(4)","key":"2019073107103975200_NPV036C13","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1093\/oxfordjournals.jjco.a023220","article-title":"Severe acute metabolic acidosis and Wernicke's encephalopathy following chemotherapy with 5-fluorouracil and cisplatin: case report and review of the literature","volume":"26","author":"Kondo","year":"1996","journal-title":"Jpn J Clin Oncol"},{"issue":"(4)","key":"2019073107103975200_NPV036C14","first-page":"1073","article-title":"Effect of the fluoropyrimidines 5-fluorouracil and doxifluridine on cellular uptake of thiamin","volume":"9","author":"Heier","year":"1989","journal-title":"Anticancer Res"},{"issue":"(1)","key":"2019073107103975200_NPV036C15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/jnnp.62.1.51","article-title":"Operational criteria for the classification of chronic alcoholics: identification of Wernicke's encephalopathy","volume":"62","author":"Caine","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"(4)","key":"2019073107103975200_NPV036C16","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.2214\/ajr.171.4.9763009","article-title":"Usefulness of CT and MR imaging in the diagnosis of acute Wernicke's encephalopathy","volume":"171","author":"Antunez","year":"1998","journal-title":"AJR Am J Roentgenol"},{"key":"2019073107103975200_NPV036C17","first-page":"2301","article-title":"MR Imaging of Nonalcoholic Wernicke Encephalopathy: A Follow-Up Study","volume":"26","author":"Zhong","year":"2005","journal-title":"AJNR"},{"issue":"(2)","key":"2019073107103975200_NPV036C18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s11065-012-9200-7","article-title":"Wernicke's encephalopathy: expanding the diagnostic toolbox","volume":"22","author":"Lough","year":"2012","journal-title":"Neuropsychol Rev"},{"issue":"(12)","key":"2019073107103975200_NPV036C19","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.revmed.2005.02.008","article-title":"Ataxia and confusion after treatment with 5 Fluorouracile","volume":"26","author":"Guilloton","year":"2005","journal-title":"Rev Med Interne"},{"issue":"(10)","key":"2019073107103975200_NPV036C20","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1111\/j.1399-6576.2005.00879.x","article-title":"Wernicke's encephalopathy in a malnourished surgical patient: clinical features and magnetic resonance imaging","volume":"49","author":"Nolli","year":"2005","journal-title":"Acta Anaesthesiol Scand"},{"issue":"(6)","key":"2019073107103975200_NPV036C21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s003300050499","article-title":"Magnetic resonance imaging in a case of Wernicke's encephalopathy","volume":"8","author":"Pagnan","year":"1998","journal-title":"Eur Radiol"},{"issue":"(3)","key":"2019073107103975200_NPV036C22","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1159\/000321457","article-title":"Wernicke's Encephalopathy in Colon Cancer","volume":"3","author":"Papila","year":"2010","journal-title":"Case Rep Oncol"},{"issue":"(8)","key":"2019073107103975200_NPV036C23","first-page":"604","article-title":"Successful treatment of Wernicke encephalopathy in terminally ill cancer patients: report of 3 cases and review of the literature","volume":"12","author":"Onishi","year":"2004","journal-title":"Support Care Cancer"},{"issue":"(1)","key":"2019073107103975200_NPV036C24","first-page":"59","article-title":"A case of Wernicke-Korsakoff syndrome with dramatic improvement in consciousness immediately after intravenous infusion of thiamine","volume":"52","author":"Kikuchi","year":"2000","journal-title":"No To Shinkei"},{"issue":"(11)","key":"2019073107103975200_NPV036C25","first-page":"1027","article-title":"Wernicke's encephalopathy developed several years after total gastrectomy. Report of 2 cases","volume":"37","author":"Arai","year":"1997","journal-title":"Rinsho Shinkeigaku"},{"issue":"(1)","key":"2019073107103975200_NPV036C26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000075093","article-title":"Diffusion-weighted imaging in Wernicke encephalopathy associated with stomach cancer: case report and review of the literature","volume":"51","author":"Weidauer","year":"2004","journal-title":"Eur Neurol"},{"issue":"2014","key":"2019073107103975200_NPV036C27","article-title":"Wernicke's encephalopathy in a patient with gastric carcinoma: a diagnosis not to miss","author":"Kudru","year":"2014","journal-title":"BMJ Case Rep"},{"issue":"(2)","key":"2019073107103975200_NPV036C28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4143\/crt.2010.42.2.77","article-title":"Wernicke's Encephalopathy in Advanced Gastric Cancer","volume":"42","author":"Jung","year":"2010","journal-title":"Cancer Res Treat"},{"issue":"(4)","key":"2019073107103975200_NPV036C29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1017\/S1478951505050510","article-title":"Wernicke encephalopathy presented in the form of postoperative delirium in a patient with hepatocellular carcinoma and liver cirrhosis: a case report and review of the literature","volume":"3","author":"Onishi","year":"2005","journal-title":"Palliat Support Care"},{"issue":"(7)","key":"2019073107103975200_NPV036C30","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1097\/MPA.0b013e31822182f5","article-title":"Wernicke encephalopathy after pancreaticoduodenectomy for pancreatic cancer","volume":"40","author":"Karayiannakis","year":"2011","journal-title":"Pancreas"},{"issue":"(1)","key":"2019073107103975200_NPV036C31","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1365-2265.2008.03328.x","article-title":"Well-differentiated endocrine pancreatic tumour and Wernicke's encephalopathy","volume":"70","author":"Grunenwald","year":"2009","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"(1)","key":"2019073107103975200_NPV036C32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1001\/archneur.59.1.123","article-title":"Diffusion-weighted imaging abnormalities in wernicke encephalopathy: reversible cytotoxic edema?","volume":"59","author":"Chu","year":"2002","journal-title":"Arch Neurol"},{"issue":"(3)","key":"2019073107103975200_NPV036C33","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0929-693X(97)87238-7","article-title":"Antineoplastic chemotherapy and Wernicke's encephalopathy","volume":"4","author":"Vanhulle","year":"1997","journal-title":"Arch Pediatr"},{"issue":"(3)","key":"2019073107103975200_NPV036C34","first-page":"331","article-title":"Wernicke's encephalopathy in a child with acute lymphoblastic leukemia","volume":"15","author":"Miyajima","year":"1993","journal-title":"Am J Pediatr Hematol Oncol"},{"issue":"(3)","key":"2019073107103975200_NPV036C35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1442-200X.1998.tb01926.x","article-title":"Successful treatment of Wernicke's encephalopathy in a boy with acute mixed lineage leukemia","volume":"40","author":"Onodera","year":"1998","journal-title":"Acta Paediatr Jpn"},{"issue":"(8)","key":"2019073107103975200_NPV036C36","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.bmt.1704893","article-title":"Wernicke's encephalopathy after allogeneic stem cell transplantation","volume":"35","author":"Baek","year":"2005","journal-title":"Bone Marrow Transplant"},{"issue":"(5)","key":"2019073107103975200_NPV036C37","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1055\/s-0030-1248244","article-title":"Wernicke's encephalopathy during total parenteral nutrition in a child with acute lymphoblastic leukemia and acute pancreatitis","volume":"40","author":"Muwakkit","year":"2009","journal-title":"Neuropediatrics"},{"issue":"(3)","key":"2019073107103975200_NPV036C38","first-page":"134","article-title":"Wernicke's encephalopathy in a child with acute lymphoblastic leukemia treated with polychemotherapy","volume":"10","author":"Br\u00fcck","year":"1991","journal-title":"Clin Neuropathol"},{"issue":"(1)","key":"2019073107103975200_NPV036C39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1017\/S0317167100002894","article-title":"Wernicke encephalopathy in a patient with T-cell leukemia and severe malnutrition","volume":"31","author":"Lacasse","year":"2004","journal-title":"Can J Neurol Sci"},{"issue":"(10)","key":"2019073107103975200_NPV036C40","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s002340000393","article-title":"Wernicke's encephalopathy induced by total parenteral nutrition in patient with acute leukaemia: unusual involvement of caudate nuclei and cerebral cortex on MRI","volume":"42","author":"D'Aprile","year":"2000","journal-title":"Neuroradiology"},{"issue":"(19)","key":"2019073107103975200_NPV036C41","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.1200\/JCO.2004.12.020","article-title":"Medical problems in patients with malignancy: case 2. Wernicke's encephalopathy: an unusual acute neurologic complication of lymphoma and its therapy","volume":"22","author":"Turner","year":"2004","journal-title":"J Clin Oncol"},{"issue":"(4)","key":"2019073107103975200_NPV036C42","doi-asserted-by":"crossref","first-page":"E53","DOI":"10.1176\/appi.neuropsych.11110344","article-title":"Wernicke encephalopathy in a non-alcoholic patient with metastatic CNS lymphoma and new-onset occipital lobe seizures","volume":"24","author":"Gregory","year":"2012","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"(3)","key":"2019073107103975200_NPV036C43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1191\/026921600668593115","article-title":"Wernicke's encephalopathy and terminal cancer: case report","volume":"14","author":"Macleod","year":"2000","journal-title":"Palliat Med"},{"issue":"(7)","key":"2019073107103975200_NPV036C44","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/SMJ.0b013e318061920a","article-title":"Wernicke encephalopathy complicating lymphoma therapy: case report and literature review","volume":"100","author":"Boniol","year":"2007","journal-title":"South Med J"},{"issue":"(1)","key":"2019073107103975200_NPV036C45","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/0004867411427817","article-title":"Wernicke's encephalopathy confirmed via brain MRI in cancer patient","volume":"46","author":"Lee","year":"2012","journal-title":"Aust N Z J Psychiatry"},{"issue":"(6)","key":"2019073107103975200_NPV036C46","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1111\/j.1365-2141.2010.08112.x","article-title":"Patients undergoing high dose chemotherapy for primary CNS lymphoma should receive prophylactic thiamine to prevent Wernike's encephalopathy","volume":"149","author":"Richardson","year":"2010","journal-title":"Br J Haematol"},{"issue":"(5)","key":"2019073107103975200_NPV036C47","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1001\/archneur.61.5.775","article-title":"Wernicke encephalopathy","volume":"61","author":"Morcos","year":"2004","journal-title":"Arch Neurol"},{"issue":"(5)","key":"2019073107103975200_NPV036C48","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/00007611-199005000-00024","article-title":"Wernicke's encephalopathy manifested as Korsakoff's syndrome in a patient with promyelocytic leukemia","volume":"83","author":"Pittella","year":"1990","journal-title":"South Med J"},{"issue":"(2)","key":"2019073107103975200_NPV036C49","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00007611-199102000-00026","article-title":"Wernicke-Korsakoff syndrome complicating T-cell lymphoma: unusual or unrecognized?","volume":"84","author":"Engel","year":"1991","journal-title":"South Med J"},{"issue":"(4)","key":"2019073107103975200_NPV036C50","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1017\/S1478951505050509","article-title":"Development of Wernicke encephalopathy in a terminally ill cancer patient consuming an adequate diet: a case report and review of the literature","volume":"3","author":"Yae","year":"2005","journal-title":"Palliat Support Care"},{"issue":"(11)","key":"2019073107103975200_NPV036C51","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1212\/01.wnl.0000232728.18186.23","article-title":"A clinical and radiographic variant of Wernicke-Korsakoff syndrome in a nonalcoholic patient","volume":"67","author":"Flint","year":"2006","journal-title":"Neurology"},{"issue":"(4)","key":"2019073107103975200_NPV036C52","doi-asserted-by":"crossref","first-page":"747","DOI":"10.3346\/jkms.2009.24.4.747","article-title":"A case of Wernicke's encephalopathy following fluorouracil-based chemotherapy","volume":"24","author":"Cho","year":"2009","journal-title":"J Korean Med Sci"},{"issue":"(12)","key":"2019073107103975200_NPV036C53","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s00415-005-0877-x","article-title":"Wernicke's encephalopathy in a patient with rhinopharyngeal carcinoma","volume":"252","author":"Kosta","year":"2005","journal-title":"J Neurol"},{"issue":"(12)","key":"2019073107103975200_NPV036C54","doi-asserted-by":"crossref","first-page":"NP181","DOI":"10.1177\/0883073813510355","article-title":"Wernicke encephalopathy in pediatric neuro-oncology: presentation of 2 cases and review of literature","volume":"29","author":"Cefalo","year":"2014","journal-title":"J Child Neurol"},{"issue":"(2)","key":"2019073107103975200_NPV036C55","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/mpo.2950220214","article-title":"Wernicke-encephalopathy in children with cancer","volume":"22","author":"K\u00e1lm\u00e1nchey","year":"1994","journal-title":"Med Pediatr Oncol"},{"issue":"(3)","key":"2019073107103975200_NPV036C56","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1159\/000357519","article-title":"Wernicke-Korsakoff Syndrome in Primary Peritoneal Cancer","volume":"6","author":"Kim","year":"2013","journal-title":"Case Rep Oncol"},{"issue":"(3)","key":"2019073107103975200_NPV036C57","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.amjoto.2010.01.009","article-title":"Wernicke's encephalopathy in the course of chemoradiotherapy for head and neck cancer","volume":"32","author":"Fikhman","year":"2011","journal-title":"Am J Otolaryngol"}],"container-title":["Neuro-Oncology Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/nop\/article-pdf\/3\/3\/196\/29023232\/npv036.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T04:24:44Z","timestamp":1653193484000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nop\/article\/3\/3\/196\/1751837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,22]]},"references-count":57,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,9,22]]},"published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/nop\/npv036","relation":{},"ISSN":["2054-2585","2054-2577"],"issn-type":[{"value":"2054-2585","type":"electronic"},{"value":"2054-2577","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,9]]},"published":{"date-parts":[[2015,9,22]]}}}