{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:09:32Z","timestamp":1793232572535,"version":"4.5.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171009"],"award-info":[{"award-number":["82171009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171568"],"award-info":[{"award-number":["82171568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51673156"],"award-info":[{"award-number":["51673156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["310201911fz051"],"award-info":[{"award-number":["310201911fz051"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005200","name":"New Jersey Commission on Spinal Cord Research","doi-asserted-by":"publisher","award":["CSCR17IRG010"],"award-info":[{"award-number":["CSCR17IRG010"]}],"id":[{"id":"10.13039\/100005200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005200","name":"New Jersey Commission on Spinal Cord Research","doi-asserted-by":"publisher","award":["CSCR16ERG019"],"award-info":[{"award-number":["CSCR16ERG019"]}],"id":[{"id":"10.13039\/100005200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cartilage injuries are often devastating and most cannot be cured because of the intrinsically low regenerative capacity of cartilage tissues. Although stem-cell therapy has shown enormous potential for cartilage repair, the therapeutic outcome has been restricted by low survival rates and poor chondrocyte differentiation in vivo. Here, we report an injectable hybrid inorganic (IHI) nanoscaffold that facilitates fast assembly, enhances survival and regulates chondrogenic differentiation of stem cells. IHI nanoscaffolds that strongly bind to extracellular matrix (ECM) proteins assemble stem cells through synergistic 3D cell\u2013cell and cell\u2013matrix interactions, creating a favorable physical microenvironment for stem-cell survival and differentiation in vitro and in vivo. Additionally, chondrogenic factors can be loaded into nanoscaffolds with a high capacity, which allows deep, homogenous drug delivery into assembled 3D stem-cell-derived tissues for effective control over the soluble microenvironment of stem cells. The developed IHI nanoscaffolds that assemble with stem cells are injectable. They also scavenge reactive oxygen species and timely biodegrade for proper integration into injured cartilage tissues. Implantation of stem-cell-assembled IHI nanoscaffolds into injured cartilage results in accelerated tissue regeneration and functional recovery. By establishing our IHI nanoscaffold-templated 3D stem-cell assembly method, we provide a promising approach to better overcoming the inhibitory microenvironment associated with cartilage injuries and to advance current stem-cell-based tissue engineering.<\/jats:p>","DOI":"10.1093\/nsr\/nwac037","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T07:24:06Z","timestamp":1645773846000},"source":"Crossref","is-referenced-by-count":25,"title":["Injectable hybrid inorganic nanoscaffold as rapid stem cell assembly template for cartilage repair"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8579-6367","authenticated-orcid":false,"given":"Shenqiang","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University , Xi\u2019an 710129 , China"},{"name":"Xi\u2019an Key Laboratory of Functional Organic Porous Materials, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University , Xi\u2019an 710072 , China"},{"name":"Department of Chemistry and Chemical Biology, Rutgers University , Piscataway, NJ 08854 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Rutgers University , Piscataway, NJ 08854 , USA"},{"name":"Department of Biomedical Engineering, Columbia University , New York , NY 10032 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bolei","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University , Xi\u2019an 710032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuwei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University , Xi\u2019an 710032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannan","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Rutgers University , Piscataway, NJ 08854 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University , Xi\u2019an 710129 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University , Xi\u2019an 710129 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hepeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University , Xi\u2019an 710129 , China"},{"name":"Research & Development Institute of Northwestern Polytechnical University in Shenzhen , Shenzhen 518057 , China"},{"name":"Xi\u2019an Key Laboratory of Functional Organic Porous Materials, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University , Xi\u2019an 710072 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University , Xi\u2019an 710032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University , Xi\u2019an 710032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxin","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University , Xi\u2019an 710032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Kong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University , Xi\u2019an 710032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki-Bum","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Rutgers University , Piscataway, NJ 08854 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4823-5031","authenticated-orcid":false,"given":"Qiuyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Special Functional and Smart Polymer Materials of Ministry of Industry and Information Technology, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University , Xi\u2019an 710129 , China"},{"name":"Research & Development Institute of Northwestern Polytechnical University in Shenzhen , Shenzhen 518057 , China"},{"name":"Xi\u2019an Key Laboratory of Functional Organic Porous Materials, School of Chemistry and Chemical Engineering, Northwestern Polytechnical University , Xi\u2019an 710072 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"2022062701410242100_bib1","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/nrrheum.2014.200","article-title":"Origin and function of cartilage stem\/progenitor cells in osteoarthritis","volume":"11","author":"Jiang","year":"2015","journal-title":"Nat Rev Rheumatol"},{"key":"2022062701410242100_bib2","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/s41584-019-0255-1","article-title":"Surgical and tissue engineering strategies for articular cartilage and meniscus repair","volume":"15","author":"Kwon","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"2022062701410242100_bib3","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/35102181","article-title":"Stem cells in tissue engineering","volume":"414","author":"Bianco","year":"2001","journal-title":"Nature"},{"key":"2022062701410242100_bib4","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ncprheum0216","article-title":"Technology Insight: Adult stem cells in cartilage regeneration and tissue engineering","volume":"2","author":"Chen","year":"2006","journal-title":"Nat Rev Rheumatol"},{"key":"2022062701410242100_bib5","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1126\/science.1215157","article-title":"A stem cell-based approach to cartilage repair","volume":"336","author":"Johnson","year":"2012","journal-title":"Science"},{"key":"2022062701410242100_bib6","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nrrheum.2013.109","article-title":"Mesenchymal stem cells in joint disease and repair","volume":"9","author":"Barry","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"2022062701410242100_bib7","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1007\/s00167-012-2329-3","article-title":"Mesenchymal stem cells for the treatment of cartilage lesions: from preclinical findings to clinical application in orthopaedics","volume":"21","author":"Filardo","year":"2013","journal-title":"Knee Surg Sports Tr A"},{"key":"2022062701410242100_bib8","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.joca.2005.04.002","article-title":"Oxygen and reactive oxygen species in cartilage degradation: friends or foes?","volume":"13","author":"Henrotin","year":"2005","journal-title":"Osteoarthr Cartilage"},{"key":"2022062701410242100_bib9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.biomaterials.2018.08.055","article-title":"Preconditioning of bone marrow-derived mesenchymal stem cells with N-acetyl-L-cysteine enhances bone regeneration via reinforced resistance to oxidative stress","volume":"185","author":"Watanabe","year":"2018","journal-title":"Biomaterials"},{"key":"2022062701410242100_bib10","doi-asserted-by":"publisher","first-page":"eaaz5913","DOI":"10.1126\/sciadv.aaz5913","article-title":"Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell\u2013based cartilage tissue engineering","volume":"6","author":"Lee","year":"2020","journal-title":"Sci Adv"},{"key":"2022062701410242100_bib11","doi-asserted-by":"publisher","first-page":"1807860","DOI":"10.1002\/adfm.201807860","article-title":"Biomimetic composite scaffolds to manipulate stem cells for aiding rheumatoid arthritis management","volume":"29","author":"Zhao","year":"2019","journal-title":"Adv Funct Mater"},{"key":"2022062701410242100_bib12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.biomaterials.2019.04.031","article-title":"Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules","volume":"210","author":"Xu","year":"2019","journal-title":"Biomaterials"},{"key":"2022062701410242100_bib13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41584-018-0125-2","article-title":"Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair","volume":"15","author":"Cucchiarini","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"2022062701410242100_bib14","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1093\/nsr\/nww037","article-title":"Three-dimensional bioprinting speeds up smart regenerative medicine","volume":"3","author":"Gu","year":"2016","journal-title":"Natl Sci Rev"},{"key":"2022062701410242100_bib15","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S1369-7021-(11)70058-X","article-title":"Biomaterials & scaffolds for tissue engineering","volume-title":"Mater Today","author":"O\u2019brien","year":"2011"},{"key":"2022062701410242100_bib16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/s41551-018-0335-6","article-title":"Soft and elastic hydrogel-based microelectronics for localized low-voltage neuromodulation","volume":"3","author":"Liu","year":"2019","journal-title":"Nat Biomed Eng"},{"key":"2022062701410242100_bib17","doi-asserted-by":"publisher","first-page":"eaaf3627","DOI":"10.1126\/science.aaf3627","article-title":"Advances in engineering hydrogels","volume":"356","author":"Zhang","year":"2017","journal-title":"Science"},{"key":"2022062701410242100_bib18","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/nmat4407","article-title":"Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation","volume":"14","author":"Huebsch","year":"2015","journal-title":"Nat Mater"},{"key":"2022062701410242100_bib19","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1021\/acs.accounts.9b00114","article-title":"Design of nanocomposite injectable hydrogels for minimally invasive surgery","volume":"52","author":"Piantanida","year":"2019","journal-title":"Acc Chem Res"},{"key":"2022062701410242100_bib20","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1039\/b713009k","article-title":"Injectable hydrogels as unique biomedical materials","volume":"37","author":"Yu","year":"2008","journal-title":"Chem Soc Rev"},{"key":"2022062701410242100_bib21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.biomaterials.2018.02.049","article-title":"Engineering spheroids potentiating cell-cell and cell-ECM interactions by self-assembly of stem cell microlayer","volume":"165","author":"Lee","year":"2018","journal-title":"Biomaterials"},{"key":"2022062701410242100_bib22","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jconrel.2012.04.045","article-title":"Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy","volume":"164","author":"Mehta","year":"2012","journal-title":"J Controlled Release"},{"key":"2022062701410242100_bib23","doi-asserted-by":"publisher","first-page":"1705388","DOI":"10.1002\/adma.201705388","article-title":"Looking into the future: toward advanced 3D biomaterials for stem-cell-based regenerative medicine","volume":"30","author":"Liu","year":"2018","journal-title":"Adv Mater"},{"key":"2022062701410242100_bib24","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.stem.2015.12.005","article-title":"Engineering stem cell organoids","volume":"18","author":"Yin","year":"2016","journal-title":"Cell Stem Cell"},{"key":"2022062701410242100_bib25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.tibtech.2012.12.003","article-title":"Spheroid culture as a tool for creating 3D complex tissues","volume":"31","author":"Fennema","year":"2013","journal-title":"Trends Biotechnol"},{"key":"2022062701410242100_bib26","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1038\/s41467-018-05599-2","article-title":"A biodegradable hybrid inorganic nanoscaffold for advanced stem cell therapy","volume":"9","author":"Yang","year":"2018","journal-title":"Nat Commun"},{"key":"2022062701410242100_bib27","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.actbio.2020.05.034","article-title":"Design and evaluation of collagen-inspired mineral-hydrogel nanocomposites for bone regeneration","volume":"112","author":"Patel","year":"2020","journal-title":"Acta Biomater"},{"key":"2022062701410242100_bib28","doi-asserted-by":"publisher","first-page":"2002578","DOI":"10.1002\/adma.202002578","article-title":"Effective modulation of CNS inhibitory microenvironment using bioinspired hybrid-nanoscaffold-based therapeutic interventions","volume":"32","author":"Yang","year":"2020","journal-title":"Adv Mater"},{"key":"2022062701410242100_bib29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/micronano.2016.22","article-title":"Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks","volume":"2","author":"Misun","year":"2016","journal-title":"Microsyst Nanoeng"},{"key":"2022062701410242100_bib30","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/nrrheum.2010.198","article-title":"The role of the cartilage matrix in osteoarthritis","volume":"7","author":"Heineg\u00e5rd","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"2022062701410242100_bib31","doi-asserted-by":"publisher","first-page":"10117","DOI":"10.1073\/pnas.1214100110","article-title":"Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis","volume":"110","author":"Bian","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022062701410242100_bib32","doi-asserted-by":"publisher","first-page":"119681","DOI":"10.1016\/j.biomaterials.2019.119681","article-title":"Role of lineage-specific matrix in stem cell chondrogenesis","volume":"231","author":"Li","year":"2020","journal-title":"Biomaterials"},{"key":"2022062701410242100_bib33","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.biomaterials.2006.10.006","article-title":"Inhibition of in vitro chondrogenesis in RGD-modified three-dimensional alginate gels","volume":"28","author":"Connelly","year":"2007","journal-title":"Biomaterials"},{"key":"2022062701410242100_bib34","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.biomaterials.2018.12.028","article-title":"Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers","volume":"197","author":"Daly","year":"2019","journal-title":"Biomaterials"},{"key":"2022062701410242100_bib35","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1002\/smll.201401635","article-title":"Cell-assembled graphene biocomposite for enhanced chondrogenic differentiation","volume":"11","author":"Lee","year":"2015","journal-title":"Small"},{"key":"2022062701410242100_bib36","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.freeradbiomed.2018.08.038","article-title":"Reactive oxygen species, aging and articular cartilage homeostasis","volume":"132","author":"Bolduc","year":"2019","journal-title":"Free Radical Biol Med"},{"key":"2022062701410242100_bib37","doi-asserted-by":"publisher","first-page":"5149","DOI":"10.1021\/acs.nanolett.0c01371","article-title":"Nanoenzyme-reinforced injectable hydrogel for healing diabetic wounds infected with multidrug resistant bacteria","volume":"20","author":"Wang","year":"2020","journal-title":"Nano Lett"},{"key":"2022062701410242100_bib38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.04.018","article-title":"Cell-based tissue engineering strategies used in the clinical repair of articular cartilage","volume":"98","author":"Huang","year":"2016","journal-title":"Biomaterials"},{"key":"2022062701410242100_bib39","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/s41536-018-0055-2","article-title":"Trends in clinical trials for articular cartilage repair by cell therapy","volume":"3","author":"Negoro","year":"2018","journal-title":"NPJ Regen Med"},{"key":"2022062701410242100_bib40","doi-asserted-by":"publisher","first-page":"120314","DOI":"10.1016\/j.biomaterials.2020.120314","article-title":"Injectable redox and light responsive MnO2 hybrid hydrogel for simultaneous melanoma therapy and multidrug-resistant bacteria-infected wound healing","volume":"260","author":"Wang","year":"2020","journal-title":"Biomaterials"},{"key":"2022062701410242100_bib41","doi-asserted-by":"publisher","first-page":"4620","DOI":"10.1038\/s41467-019-12545-3","article-title":"In vivo engineered extracellular matrix scaffolds with instructive niches for oriented tissue regeneration","volume":"10","author":"Zhu","year":"2019","journal-title":"Nat Commun"},{"key":"2022062701410242100_bib42","doi-asserted-by":"publisher","first-page":"119456","DOI":"10.1016\/j.biomaterials.2019.119456","article-title":"Chiral geometry regulates stem cell fate and activity","volume":"222","author":"Dong","year":"2019","journal-title":"Biomaterials"}],"container-title":["National Science Review"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/nsr\/advance-article-pdf\/doi\/10.1093\/nsr\/nwac037\/42634688\/nwac037.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nsr\/article-pdf\/9\/4\/nwac037\/44253568\/nwac037.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/nsr\/article-pdf\/9\/4\/nwac037\/44253568\/nwac037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T21:41:18Z","timestamp":1656279678000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/nsr\/article\/doi\/10.1093\/nsr\/nwac037\/6539353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,28]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4,11]]}},"URL":"https:\/\/doi.org\/10.1093\/nsr\/nwac037","relation":{},"ISSN":["2095-5138","2053-714X"],"issn-type":[{"value":"2095-5138","type":"print"},{"value":"2053-714X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,4]]},"published":{"date-parts":[[2022,2,28]]},"article-number":"nwac037"}}